KR101348102B1 - A composition comprising extracts of herbal mixture for treating or preventing interstitial cystitis - Google Patents

A composition comprising extracts of herbal mixture for treating or preventing interstitial cystitis Download PDF

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KR101348102B1
KR101348102B1 KR1020120127520A KR20120127520A KR101348102B1 KR 101348102 B1 KR101348102 B1 KR 101348102B1 KR 1020120127520 A KR1020120127520 A KR 1020120127520A KR 20120127520 A KR20120127520 A KR 20120127520A KR 101348102 B1 KR101348102 B1 KR 101348102B1
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손기정
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/40Cornaceae (Dogwood family)
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/886Inflammation, skin

Abstract

The present invention relates to a composition for the prophylaxis or treatment of interstitial cystitis, which contains extracts of the herbal mixtures of cornus oil, ho jang-geun, bokbunja, sterling silver, earthenware, turmeric, and medicinal herb. It can be alleviated and used as an excellent treatment for interstitial cystitis.

Description

A composition comprising extracts of herbal mixture for treating or preventing interstitial cystitis

The present invention relates to a composition for the prevention or treatment of interstitial cystitis containing the extract of the herbal mixture, in detail interstitial cystitis containing the extract of the herbal mixture of cornus oil, kojanggeun, bokbunja, gold and silver, earth and sand, turmeric and five drugs It relates to a composition for the prophylaxis or treatment of.

Interstitial cystitis is an unexplained chronic nonspecific cystitis, characterized by a decrease in bladder volume due to fibrosis in the bladder wall, resulting in lower abdominal pain during urinary, urgency, and fullness of bladder (Non-Patent Document 1-). 3). Due to the reduced volume of the bladder, patients have to urinate countless times a day and sleep at night, causing insomnia and the urge to commit suicide due to depression (Non-Patent Document 11). And reduction are repeated (Non-Patent Documents 2-4, 11). On the other hand, a small number of patients with interstitial cystitis suffer from severe deterioration in quality of life, but the cause of the occurrence is not clear (Non-Patent Documents 2-4, 11). However, the causes identified so far include abnormal functions of mast cells in the detrusor and bladder mucosa, abnormalities of the GAG (glycosaminoglycan) layer of the bladder mucosa, infections caused by viral or toxic substances, toxic substances released into the urine, infections and neurological There are abnormalities of the bladder and spinal cord and autoimmune abnormalities caused by hypersensitivity reactions (Non-Patent Documents 1-4). In particular, mast cells are thought to play a major role through the secretion of mediators (Non-Patent Document 2, 3 and 5).

90% of patients with interstitial cystitis are women, and the average age is reported to be 40 years old. In Europe, 18 / 100,000 patients, 3-4 patients / 100,000 in Japan and 2.6 / 100,000 patients in the United States (non-patent) Document 4). In addition, as a result of referencing interstitial cystitis medical data to the Health Insurance Review and Assessment Service, the number of patients diagnosed with interstitial cystitis, except for pharmacies and oriental medicines, between January 2007 and December 2011, was about 12000-16000 (average 13,967 patients), and the incidence rate was higher than that of Europe (20 ~ 30/10/10), and about 1.1 billion won was spent.

Currently, treatment of interstitial cystitis has been tried in various ways such as behavioral therapy, drug treatment, intrathecal bladder infusion therapy, and surgery (Non Patent Literature 2-4). Is estimated to be about 4.4 months (Non-Patent Document 6). It also undergoes a wide variety of clinical procedures, but is characterized by repeated improvement and deterioration.

In Chinese medicine, interstitial cystitis is a symptom that includes symptomatically encompassing inflammation of the urinary system, and oriental medicine research for interstitial cystitis is reduced by pain and frequent urination by using herbal medicine and electroacupuncture. (Non-Patent Document 7-9), and in the interstitial cystitis animal model, the inflammation-related cytokine (cytokine) is significantly reduced due to the administration of Yumijihwangtanggamibang, and the inflammatory tissue Although it has been reported that the normal tissue level has been restored (Non-Patent Document 10), clinical and experimental studies have not been actively conducted. In addition, although most patients with interstitial cystitis rely on bilateral treatment, there is a need for more aggressive oriental medical research based on these clinical results.

Hojang-geun is called Polygonum cuspidata SIEB. et ZUCC. Ho Jang Geun grows to the side as the root stem grows aside to form abandonment. It grows to around 1m in height and grows mainly in the mountains. The leaves are shifted and ovate. The tip of the leaf is short, pointed at the bottom, and the edge is wavy. Jaw leaves are membranous, 6 mm long. Flowers bloom in June-August, white, conical inflorescences, divalent. Hwapiche fragment is 5, and the outer 3 of the female flower grows after the flower grows, surrounds the fruit and has wings on the back. There are eight surgeries and three pistils. Fruits are triangular ovate oval, dark brown, glossy. In oriental medicine, it is used for relief, diuresis, and economy. When he was young, the stems looked like hopi, so they were named Ho Jang-geun. It is distributed in Korea, Japan, Taiwan, and China.

Bokbunja (覆盆子) is a medicinal herb ( Rubus coreanus Miquel) made from unripe fruits (Korea, China), and is not harvested as a process herb in Japan. Appearance is a small bunch of small clusters formed into a conical or pressed sphere. The outer side is yellowish green or light brown, and the end is round and round, and the center of the calyx is recessed. Bokbunja is named after eating this to turn the urine into the urine stem. In addition, the ripe fruit of May in the lunar calendar has a dark red color, so it is also called as a five mark (자 子), a large falcon (大 삽), an insertion table (揷 田), a catastrophe (栽秧 子). , Bokbun (覆盆), Seogukcho (西 國 草), Philneunga (畢 楞伽), Gyu (), also known as (분). Bokbunja reinforces the function of the kidney (유 精), mongjeong (夢 精), urea (遺尿), etc. are used for weakening eyesight, lighten the body and blacken the head. It also makes the skin soft and beautiful.

Geumeunhwa is a honeysuckle ( Lonicera ) with honeysuckle in Korea japonica Thunberg) or a bud of its variant. The same is true in China and Japan. The name 'Indong' is due to the vines that do not wither even in the cold winter. The name of the gold and silver coin is named after the first blooming flowers are white but gradually yellow. The appearance is a mixture of small rods or funnel-shaped buds and often lip-shaped flowers. The outer surface is yellowish white or greenish white, and the longer it is stored, the darker it is. Magnifying glass has light brown hairs and calyx is green with 5 ends. The fragment is hairy and about 2㎜ long. 5 stamens are yellow, 1 pistil, and hairless. This drug has a peculiar smell, tastes sweet and cold. Gold and silver coins are used when the heat is lowered and the chest is thirsty and thirsty. It is good for inflammation, and it causes boils, skin toxins, organ inflammation, and pus. Also used for dysentery, skin tissue necrosis due to heat poisoning, mastitis. It is applied to colitis, gastric ulcer, cystitis, sore throat, tonsillitis, bronchitis, conjunctivitis and swelling, mumps and high fever, purulent infection. Pharmacological action has been reported antibacterial, anti-inflammatory, antipyretic, leukocyte phagocytosis, central nervous system excitability, serum cholesterol lowering, ulcer prevention effect. Other Names: Indonghua, Ewha, Silver, Ssanghwa, Geumhwa, Geumdeunghwa, Geumeundeung, Mandarin Duck Lantern, Rosa lanterns, Noh Onsu, left-handed lanterns, Geumchaego, Tongyeongcho, wheat-tung lanterns Etc.

Dodder is a perennial vine, Cuscuta japonica Chois.), also known as Saesam. The new ginseng is parasitic or wormwood to absorb nutrients, so there is no root in the ground and no chlorophyll in the whole. Yellow or yellow chestnut vines grow up around other plants. Stems are 1.5mm in diameter, yellowish brown, often with purple spots. Leaves are 2 mm or less in length and scaly. Small white flowers bloom in the shape of Isaac in August-October. Fruits are perilla size and brown in color. The taste of Tosa is very sweet and the property is flat. Mainly known as a medicine that protects the liver and kidneys, brightens the eyes, helps yang (yang 氣), and strengthens kidney function. Impaired sexual intercourse of the male due to weak kidneys, semen flowing spontaneously, it is effective for dreams (夢 精). It strengthens the bones and strengthens the strength of the lower back, and weak kidney function to heal the sore and sore back and knees. In addition, it is known to be effective in treating diabetes and diarrhea, which are difficult to pee and urinate.

Ulgeum (鬱 金) refers to the root of the tuber of Curcuma longa Linn, which is a plant of ginger family in Korea, or dried by removing the bark. In China, the dongsok plant of turmeric and ginger Guangxi ahchul (Curcuma kwangsiensis SG Lee & CF Liang: Curcuma wenyujin YH Chen & C. Ling, Curcuma phaeocaulis Valeton: refers to the rootstock of蓬莪朮). It has a similar appearance to turmeric, but both sides of the leaf have a smooth feature. It is grown and cultivated in South China, India, Okinawa, and Southeast Asia. Appearance can be divided into one root stem and side root stem. The one root stem is ovate, and the side root stem is a columnar with dull ends, slightly bent, and has side buds. Jupiter is yellowish brown and glossy. The outer skin is dark reddish and the outer surface has dark red powder. When mixed with alcohol, it is yellowish gold and is named. It is similar in shape to Azul and treats diseases of horses. This medicine has a peculiar smell, chews the sting, and it is irritating. The taste is hot and bitter and the nature is cool (辛苦 凉). Ulgum communicates the muscles and helps the blood circulation to cure menstrual cramps, menstrual irregularities and flank pain, treats blood clots, nosebleeds, papules, cleanses the mind, removes the victims' parts and promotes bile secretion and treats gallstones. Pharmacological actions have been reported to reduce bile secretion, excretion, and the formation of nodules in the coronary arteries. Other names include magic (horse), magic (horse), yellow wool (鬱), eul (옥), galum (,), jade (금), king gold (王 金), turmeric, etc. There is this. Ulugum has been recorded since BC and has been used as a coloring agent for dyes and foodstuffs and is the raw material for Indian curry. In Japan, it is used as a coloring material for radishes, and it is cultivated as a special crop in Okinawa, Japan, known as a world longevity village, and is used as a health food.

Ojak is the root of Lindera aggregata , and it is a medicine that has the effect of smoothly running the qi, releasing the wool, removing cold, and relieving pain. It grows in the south and Taiwan and is mostly wild in the south of Japan. The leaves are alternate, wide oval, with flat edges, and have three large veins. When young, it is covered with long hair, but soon disappears and the back is grayish white. Flowers bloom in March-April and form umbel on axillary leaves. Flowers are single flower, yellowish green, and flowers are divided into 6, and there are 9 stamens in male flower, 1 pistil and degenerated stamen in female flower. Fruits are nucleus, oval, mature from green to black. Roots are enlarged, beads, dark brown. Essential oils are contained in the roots and used as a stimulant for abdominal pain, earth and sand. Although one person is a five-star, it is also called Cheon-Ta-Yi because of the good quality of the five-lead springs in China.

On the other hand, the present inventors, while studying the interstitial cystitis, by confirming that the extract of the herbal mixture of cornus, Ho Jang-geun, bokbunja, gold and silver, earth and sand, turmeric and five pills have the effect of treating interstitial cystitis, The invention could be completed.

Korean Patent Publication No. 2012-0040026 discloses a composition for treating cystitis containing an extract of a herbal mixture containing Baek Bok-Ryung (Patent Document 1), and Korean Patent No. 232671 (Patent Document 2), Sohhoe, Baek Bok-Ryung, A composition for the treatment of gynecological diseases in the form of suppositories containing a herbal mixture comprising corydalis, oak, velvet and other herbal medicines is disclosed and although the cystic disease includes cystitis, The constituents of the herbal mixture of the present invention are different from each other, and the present invention can be said to be different from the above-mentioned prior document.

Korean Unexamined Patent Publication No. 2012-0040026 (Pharmaceutical composition for preventing and treating renal failure, including Dansam, published on Apr. 26, 2012) Korean Registered Patent No. 232671 (Medicine composition for treating obesity diseases and women's obesity and manufacturing method using the same, 1999.09.07. Registered)

Department of New Internal Medicine, College of Korean Medicine. New Internal Medicine. Seoul: Gunja Publishing House; 2011, p. 40, 149. Korean Society of Urology. Urology. Seoul: fragments; 2007, p. 169-70. Korean Society of Urination Disorders and Urinary Incontinence. Urination disorders and incontinence. Seoul: fragments; 2004, p. 518-26. Cho Hyun-hee. Diagnostic treatment of interstitial cystitis and bladder pain syndrome. Korean Journal of Obstetrics and Gynecology 2009; 52 (10): 987-93. Suh Yong Sun, Hyun Soo Ahn, Young Soo Kim. Smooth Muscle Contraction and Mast Cell Changes in Airway, Small Intestine and Bladder in Sensitized White Paper. Korean Journal of Urology 2001; 42 (9): 998-1003. Kim Sung-han, Kim Soo-woong, Oh Seung-jun. Clinical Manifestations of Pain in Patients with Interstitial Cystitis and Changes in Pain Level after Hydroplasty. Korean Journal of Urology 2008; 49 (10): 931-6. Kim Sung-ah, Yoon Kyung-sun, Kang Yoon-ho, Yoon Cheol-ho. A Case of Interstitial Cystitis with Herbal Medicine and Electroacupuncture. Paper presented at the Korean Academy of Oriental Medical Society 2005; 128-134. Choi Woo-sik, Song In-gwang, Park Jun-sung. Seungduk Lee. Kim Kap-sung. Report of Four Cases of Interstitial Streptomyitis Treated with Compost and Electroacupuncture. The Journal of The Korean Acupuncture Society 2002; 19-6: 193-204. Yoo Choi Haeng, Seungduk Lee, Kap Sung Kim. Acupuncture effect on interstitial cystitis. Journal of The Korean Acupuncture Society 2001; 18 (4): 212-20. Lee, Jeong-Won, Experimental Study of Yukmijihwang-tang Bakbang for Interstitial Cystitis. Doctoral dissertation. Dongguk University Graduate School; 2010. Cho Yong-hyun, Kim Min-ui, Kim Jang-ap, Park Jong-yun, Shin Myung-sik, Cho In-rae, etc. Urinary tract infections. Seoul: Hydrological History; p. 155-61.

An object of the present invention is to provide a composition for the prevention or treatment of interstitial cystitis containing the extract of the herbal mixture, and in detail the extract of the herbal mixture of cornus oil, Hojang-geun, bokbunja, gold and silver, earth and sand, turmeric and five drugs The present invention provides a composition for preventing or treating interstitial cystitis.

The present invention relates to a composition for the prophylaxis or treatment of interstitial cystitis, which contains an extract of a herbal mixture of cornus milk, ho jang-geun, bokbunja, sterling silver, earthenware, turmeric, and five drops.

Preferably, the herbal mixture, based on 100 parts by weight of cornus oil, 50 to 200 parts by weight, 50 to 200 parts by weight of bokbunja, 50 to 200 parts by weight of gold and silver coins, 20 to 80 parts by weight of earthenware, 20 to 80 parts of turmeric 20 to 80 parts by weight and five parts by weight may be mixed.

In addition, in the herbal mixture, based on 100 parts by weight of cornus oil, 20 to 300 parts by weight of sucrose, 10 to 250 parts by weight, 10 to 250 parts by weight of Baekbokyeong, 10 to 250 parts by weight of bark skin, 10 to 200 parts by weight of Schizandra chinensis 10-200 parts by weight, raw 10-200 parts by weight, 10-200 parts by weight of small fennel, 10-200 parts by weight of corydalis and 10-200 parts by weight of golgol may be added.

The extract of the herbal mixture may be prepared by extracting the herbal mixture of cornus oil, kojang-geun, bokbunja, gold and silver, earth and sand, turmeric and five drops with water, a lower alcohol of C1 to C4 or a mixed solvent thereof.

The present invention also provides a health functional food for the prevention or improvement of interstitial cystitis containing the extract of the herbal mixture.

According to another aspect of the present invention,

(Step 1) 100 parts by weight of cornus oil, 50-200 parts by weight of jangjang-geun, 50-200 parts by weight of bokbunja, 50-200 parts by weight of silver and silver coins, 20-80 parts by weight of earthenware, 20-80 parts by weight of turmeric and 20-80 weights of urine Mixing the parts to prepare a herbal mixture;

(Step 2) mixing the crude drug mixture of step 1, the extraction solvent of the total weight 2 ~ 10 times the total weight of the herbal mixture to extract for 1 to 10 hours at 70 ~ 100 ℃; And

(Step 3) The solid content of the extract of the above two steps is removed and the filtrate is collected.

The extraction solvent may be water, C1 to C4 lower alcohols or a mixed solvent thereof.

Hereinafter, the present invention will be described in detail.

The extract of the crude drug mixture can be used by concentrating the extract at a reduced pressure when a C1 to C4 lower alcohol or a mixed solvent with water is used. In addition, in the case of extraction using water, the filtrate from which the solid content has been removed can be immediately used, and it can also be used in the form of a concentrated liquid under reduced pressure.

The extract of the crude drug mixture may be isolated by known methods used for separation and extraction of plant components, such as extraction with an organic solvent (alcohol, ether, acetone, etc.), partition with hexane and water, Or may be fractionated or purified by a suitable combination method.

The chromatography can be carried out using silica gel column chromatography, LH-20 column chromatography, ion exchange resin chromatography, medium pressure liquid chromatography chromatography, thin layer chromatography (TLC), silica gel vacuum liquid chromatography, and high performance liquid chromatography.

The present invention also provides a pharmaceutical composition for the prophylaxis or treatment of interstitial cystitis, which contains extracts of a herbal mixture of cornus, kojang-geun, bokbunja, gold and silver, earth and sand, turmeric, and five drops. The pharmaceutical composition containing the extract of the crude drug mixture may be formulated in the form of powders, granules, tablets, capsules, oral preparations such as suspensions, emulsions, syrups and aerosols, external preparations, suppositories and sterilized injection solutions, And can be used as formulations. Examples of carriers, excipients and diluents that can be contained in the pharmaceutical composition include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose , Methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil. In the case of formulation, a diluent or excipient such as a filler, an extender, a binder, a wetting agent, a disintegrant, or a surfactant is usually used. Solid formulations for oral administration include tablets, pills, powders, granules, capsules and the like, which may contain at least one excipient, such as starch, calcium carbonate, sucrose, Or lactose, gelatin and the like. In addition to simple excipients, lubricants such as magnesium stearate and talc are also used. Examples of the liquid preparation for oral use include suspensions, solutions, emulsions, and syrups. In addition to water and liquid paraffin, simple diluents commonly used, various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like may be included . Formulations for parenteral administration include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, and suppositories. Examples of the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. Examples of suppository bases include witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin, and the like.

The dosage of the pharmaceutical composition containing the extract of the herbal mixture of cornus, kojang-geun, bokbunja, sterling silver, earthenware, turmeric, and ointment of the present invention is determined by the age, sex, weight of the subject to be treated, and the specific disease or pathological condition to be treated. Or the severity of the pathology, the route of administration and the judgment of the prescriber. Dosage determinations based on these factors are within the level of ordinary skill in the art and generally the dosage ranges from 0.01 mg / kg / day to approximately 2000 mg / kg / day. A more preferable dosage is 1 mg / kg / day to 500 mg / kg / day. The administration may be carried out once a day or divided into several times. The dose is not intended to limit the scope of the invention in any way.

The pharmaceutical composition containing the extract of the herbal mixture of cornus, kojang-geun, bokbunja, sterling silver, earthenware, turmeric, and oak of the present invention can be administered to mammals such as rats, livestock, humans, and the like by various routes. All modes of administration may be expected, for example, by oral, rectal or intravenous, intramuscular, subcutaneous, intra-uterine dural or intracerebral injection. Since the compound of the present invention has little toxicity and side effects, it can be safely used even for long-term administration for preventive purposes.

In addition, the present invention provides a health functional food for preventing or improving interstitial cystitis, including extracts of herbal mixtures of cornus oil, Ho jang-geun, bokbunja, gold and silver, earth and sand, turmeric, and oak, and food supplements. . The health functional food of the present invention includes forms such as tablets, capsules, pills, and liquids. Examples of the foods to which the extract of the present invention can be added include various foods, beverages, gums, tea, vitamins , And health functional foods.

The present invention relates to a composition for the prophylaxis or treatment of interstitial cystitis, which contains extracts of the herbal mixtures of cornus oil, ho jang-geun, bokbunja, sterling silver, earthenware, turmeric, and medicinal herb. It can be alleviated and used as an excellent treatment for interstitial cystitis.

BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a flow chart showing a process for producing an extract of a crude drug mixture of the present invention. Fig.

Hereinafter, preferred embodiments of the present invention will be described in detail. However, the present invention is not limited to the embodiments described herein but may be embodied in other forms. Rather, the intention is to provide an exhaustive, complete, and complete disclosure of the principles of the invention to those skilled in the art.

< Example  1. Preparation of herbal extracts>

Cornus, Ho Jang-geun, Bokbunja, Geumhwahwa, Tosa, Turmeric and Silla, and additional herbs such as Sukjihwang, Sakum, Baekbokryeong, Mokjipi, Schisandra, Guja, ripen, Sohyanghyang and Hyunho colors are mixed in the weight of Tables 1 and 2 (total weight) 4160g), 10kg of water was added and extracted using a herbal extractor at 100 ° C. for 4 hours, and solids were removed to obtain respective herbal extracts.

Figure 112012092792411-pat00001

< Comparative Example  1. Preparation of Comparative Herbal Extracts>

The herbal mixture was mixed by the weight of Table 2 to extract the herbal mixture under the same conditions as in Example 1, and the solids were removed to obtain respective herbal extracts. At this time, Comparative Example 1-5 was mixed with a herbal composition contained in Yukmijihwangtang.

Figure 112012092792411-pat00002

< Experimental Example  1. Confirm the effect of herbal extracts on the treatment of interstitial cystitis>

Seven patients with interstitial cystitis for each extract of Example 1 and Comparative Example 1 were to take the extract for 30 days, three times a day 110ml 2 hours after meals, each patient treated with interstitial cystitis The effect was confirmed based on the 'symptom index' of Table 3 and the 'problem index' of Table 4. The patients with interstitial cystitis were diagnosed with interstitial cystitis at both university hospitals from January 1, 2009 to December 31, 2011. The average age was 53.3 ± 13.5 years. Was 69.0 ± 59.8 months.

Symptom Index 1. How often do you urinate suddenly and can't stand it?
0 points: None at all, 1 point: less than 1 out of 5, 2 points: less than 1 out of 2 , 3 points: 1 out of 2
4 points: At least 1 of 2, 5 points: almost always
2. Do I have to go again within 2 hours after urinating?
0 points: None, 1 point: less than 1 out of 5, 2 points: less than 1 out of 2 , 3 points: 1 out of 2
4 points: At least 1 of 2, 5 points: almost always
3. How many times do you pee until you start suddenly at night and get up in the morning?
0 points: 0 times, 1 point: 1 time, 2 points: 2 times, 3 points: 3 times, 4 points: 4 times, 5 points: 5 times or more
4. Do you feel pain or burning in your bladder (lower abdomen)?
0 points: none at all, 1 point: very often, 2 points: sometimes, 3 points: sometimes, 4 points: very often, 5 points: almost always
* The sum of each index is expressed as a total score

Problem Index 1. How hard is it to urinate frequently while awake?
0 points: not hard, 1 point: a little hard, 2 points: a little hard, 3 points: hard, 4 points: hard
2. How hard does it happen to urinate at night?
0 points: not hard, 1 point: very little, 2 points: little hard, 3 points: hard, 4 points: hard
3. How hard is it that you cannot suddenly stand urine?
0 points: not hard, 1 point: very little, 2 points: little hard, 3 points: hard, 4 points: hard
4. How strong is the bladder (lower abdomen) as if it is burning, feeling unpleasant or crushing?
0 points: not hard, 1 point: very little, 2 points: little hard, 3 points: hard, 4 points: hard
* The sum of each index is expressed as a total score

Condition Symptom Index Problem Index Example 1-1 8.4 ± 2.4 6.4 ± 1.2 Examples 1-2 8.7 ± 2.5 6.7 ± 2.3 Example 1-3 8.4 ± 1.6 6.5 ± 1.4 Example 1-4 9.0 ± 2.3 5.9 ± 2.2 Examples 1-5 7.8 ± 3.3 5.2 ± 2.5 Comparative Example 1-1 15.1 ± 2.0 11.6 ± 2.4 Comparative Example 1-2 14.3 ± 2.3 12.1 ± 2.2 Comparative Example 1-3 14.4 ± 1.2 11.4 ± 1.1 Comparative Example 1-4 16.6 ± 2.3 13.7 ± 2.3 Comparative Example 1-5 14.1 ± 1.1 11.3 ± 2.0 Control group (non-administration) 17.6 ± 2.6 14.4 ± 1.9

Referring to the results of Table 5, it was found that the composition of Example 1 has a significant therapeutic effect of interstitial cystitis compared to the composition and control of Comparative Example 1. In particular, the composition added with wild herbs in Hwangjihwang, Sanjang, Baekbokryeong, Mokpipi, Schisandra chinensis, Koji, Ikjiin, Sohyang and Hyunho colors in addition to Cornus, Hojang-geun, Bokbunja, Geumgumhwa, Tosaja, Ulgeum and Silla And it was found.

Claims (11)

  1. A composition for the prophylaxis or treatment of interstitial cystitis, which contains an extract of a herbal mixture of cornus, hojang-geun, bokbunja, gold and silver, earth and sand, turmeric and five drops.
  2. The method of claim 1,
    The herbal mixture is 50 to 200 parts by weight, 50 to 200 parts by weight of bokbunja, 50 to 200 parts by weight of gold and silver coins, 20 to 80 parts by weight of earth and sand, 20 to 80 parts by weight of turmeric and 20 to 80 weights A composition for the prevention or treatment of interstitial cystitis, characterized in that the weight part is mixed.
  3. 3. The method of claim 2,
    In the herbal mixture, based on 100 parts by weight of cornus oil, 20 to 300 parts by weight of sucrose, 10 to 250 parts by weight, 10 to 250 parts by weight of Baekbokyeong, 10 to 250 parts by weight of bark skin, 10 to 200 parts by weight of Schizandra chinensis and 10 to 200 Interstitial characteristics, characterized in that one or more herbal medicines selected from the group consisting of 10 parts by weight, 10 to 200 parts by weight of raw, 10 to 200 parts by weight of small fennel, 10 to 200 parts by weight of corrugated rhizome and 10 to 200 parts by weight of bongol Composition for the prevention or treatment of cystitis.
  4. 4. The method according to any one of claims 1 to 3,
    The extract of the herbal mixture is an interstitial cystitis, characterized in that the extract of the herbal mixture of cornus oil, Ho jang-geun, bokbunja, gold and silver, earth and sand, turmeric and five oak, extracted with water, a lower alcohol of C1 to C4 or a mixed solvent thereof Composition for the prevention or treatment of
  5. A dietary supplement for the prevention or improvement of interstitial cystitis, which contains an extract of a herbal mixture of cornus, hojang-geun, bokbunja, gold and silver, earth and sand, turmeric, and five drops.
  6. The method of claim 5,
    The herbal mixture is 50 to 200 parts by weight, 50 to 200 parts by weight of bokbunja, 50 to 200 parts by weight of gold and silver coins, 20 to 80 parts by weight of earth and sand, 20 to 80 parts by weight of turmeric and 20 to 80 weights Health functional foods for the prevention or improvement of interstitial cystitis, characterized in that the weight part is mixed.
  7. The method according to claim 6,
    In the herbal mixture, based on 100 parts by weight of cornus oil, 20 to 300 parts by weight of sucrose, 10 to 250 parts by weight, 10 to 250 parts by weight of Baekbokyeong, 10 to 250 parts by weight of bark skin, 10 to 200 parts by weight of Schizandra chinensis and 10 to 200 Interstitial characteristics, characterized in that one or more herbal medicines selected from the group consisting of 10 parts by weight, 10 to 200 parts by weight of raw, 10 to 200 parts by weight of small fennel, 10 to 200 parts by weight of corrugated rhizome and 10 to 200 parts by weight of bongol Health functional food for the prevention or improvement of cystitis.
  8. 8. The method according to any one of claims 5 to 7,
    The extract of the herbal mixture is an interstitial cystitis, characterized in that the extract of the herbal mixture of cornus oil, Ho jang-geun, bokbunja, gold and silver, earth and sand, turmeric and five oak, extracted with water, a lower alcohol of C1 to C4 or a mixed solvent thereof Functional foods for the prevention or improvement of
  9. (Step 1) 100 parts by weight of cornus oil, 50-200 parts by weight of jangjang-geun, 50-200 parts by weight of bokbunja, 50-200 parts by weight of silver and silver coins, 20-80 parts by weight of earthenware, 20-80 parts by weight of turmeric and 20-80 weights of urine Mixing the parts to prepare a herbal mixture;
    (Step 2) mixing the crude drug mixture of step 1, the extraction solvent of the total weight 2 ~ 10 times the total weight of the herbal mixture to extract for 1 to 10 hours at 70 ~ 100 ℃; And
    (3 step) removing the solids of the extract of the 2 step and collecting the filtrate; a method of producing a herbal mixture extract characterized in that it is prepared through.
  10. 10. The method of claim 9,
    The herbal mixture of step 1 is based on 100 parts by weight of cornus oil, 20 to 300 parts by weight of sucrose sulfur, 10 to 250 parts by weight, 10 to 250 parts by weight of Baekbokryeong, 10 to 250 parts by weight of velvet skin, 10 to 200 parts by weight of Schizandra chinensis 10-200 parts by weight, ripe 10-200 parts by weight, small fennel 10-200 parts by weight, corrugated green color 10-200 parts by weight and bovine bone 10-200 parts by weight is characterized in that at least one herbal medicine selected from the group Method of producing a herbal medicine mixture extract.
  11. 10. The method of claim 9,
    The extraction solvent of the second step is water, a lower alcohol of C1 to C4 or a mixed solvent thereof, the method of producing a herbal mixture extract.
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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101549944B1 (en) 2014-01-09 2015-09-04 주식회사한국전통의학연구소 Composition for treating and preventing overavtive bladder and cystitis
CN105012645A (en) * 2015-08-06 2015-11-04 王玉成 Prescription for treating cystitis
CN105012646A (en) * 2015-08-06 2015-11-04 王玉成 Medicament for treating cystitis
CN105012696A (en) * 2015-08-06 2015-11-04 王玉成 Preparation for regulating cystitis and preparation method thereof
CN105031259A (en) * 2015-08-06 2015-11-11 王玉成 Composition for treating cystitis and preparing method
CN105125862A (en) * 2015-08-06 2015-12-09 王玉成 Preparation for treating urocystitis and preparation method thereof
KR20170020580A (en) * 2015-08-12 2017-02-23 주식회사 케미메디 Composition for preventing or treating of bladder fibrosis
WO2017164707A1 (en) * 2016-03-24 2017-09-28 주식회사 케미메디 Pharmaceutical composition and dietary supplement for preventing or treating overactive bladder caused by secondary bladder degeneration due to bladder outlet obstruction caused by benign prostatic hyperplasia

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KR100232671B1 (en) 1997-07-25 2000-02-01 김이현 Process for preparing the composition for treating gyncological disease and women's obesity
KR100699333B1 (en) 2005-01-19 2007-03-26 김원용 Antimicrobial composition containing the root extract of R. coreanus MIQ or R. crataegifolius
JP2007186457A (en) 2006-01-13 2007-07-26 Ichimaru Pharcos Co Ltd Tryptase activity inhibitor and its utilization
KR20110059189A (en) * 2009-11-27 2011-06-02 한국생명공학연구원 A compositions for the prevention and treatment of inflammatory diseases containing essential oil isolated from rhizome of curcuma wenyujin as an active ingredient

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
KR100232671B1 (en) 1997-07-25 2000-02-01 김이현 Process for preparing the composition for treating gyncological disease and women's obesity
KR100699333B1 (en) 2005-01-19 2007-03-26 김원용 Antimicrobial composition containing the root extract of R. coreanus MIQ or R. crataegifolius
JP2007186457A (en) 2006-01-13 2007-07-26 Ichimaru Pharcos Co Ltd Tryptase activity inhibitor and its utilization
KR20110059189A (en) * 2009-11-27 2011-06-02 한국생명공학연구원 A compositions for the prevention and treatment of inflammatory diseases containing essential oil isolated from rhizome of curcuma wenyujin as an active ingredient

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101549944B1 (en) 2014-01-09 2015-09-04 주식회사한국전통의학연구소 Composition for treating and preventing overavtive bladder and cystitis
CN105012645A (en) * 2015-08-06 2015-11-04 王玉成 Prescription for treating cystitis
CN105012646A (en) * 2015-08-06 2015-11-04 王玉成 Medicament for treating cystitis
CN105012696A (en) * 2015-08-06 2015-11-04 王玉成 Preparation for regulating cystitis and preparation method thereof
CN105031259A (en) * 2015-08-06 2015-11-11 王玉成 Composition for treating cystitis and preparing method
CN105125862A (en) * 2015-08-06 2015-12-09 王玉成 Preparation for treating urocystitis and preparation method thereof
KR20170020580A (en) * 2015-08-12 2017-02-23 주식회사 케미메디 Composition for preventing or treating of bladder fibrosis
KR101710115B1 (en) 2015-08-12 2017-02-28 주식회사 케미메디 Composition for preventing or treating of bladder fibrosis
WO2017164707A1 (en) * 2016-03-24 2017-09-28 주식회사 케미메디 Pharmaceutical composition and dietary supplement for preventing or treating overactive bladder caused by secondary bladder degeneration due to bladder outlet obstruction caused by benign prostatic hyperplasia

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