CN1660124A - 龙胆苦苷在制备抑制乙型肝炎病毒药物中的应用 - Google Patents
龙胆苦苷在制备抑制乙型肝炎病毒药物中的应用 Download PDFInfo
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实验 组别 剂量 鸭数 鸭血清DHBV-DNA OD490值(X±SD)批次 mg/kg (只) T0 T5 T10 P3bid×10 |
I 生理盐水 6 0.738±0.06 0.884±0.13 0.802±0.17 0.720±0.11龙胆苦苷50 6 0.801±0.08 0.770±0.08 0.735±0.11 0.664±0.09**100 6 0.655±0.11 0.636±0.08 0.566±0.05* 0.586±0.14200 6 0.733±0.19 0.566±0.05* 0.508±0.03* 0.738±0.08拉米夫定50 6 0.679±0.12 0.503±0.04* 0.492±0.05* 0.669±0.04 |
II 生理盐水 6 0.961±0.14 0.846±0.12 0.833±0.13* 0.820±0.08龙胆苦苷50 6 0.788±0.18 0.749±0.08 0.697±0.12 0.729±0.10100 6 0.717±0.09 0.614±0.04* 0.577±0.06** 0.658±0.10200 6 0.727±0.06 0.679±0.08 0.530±0.05** 0.718±0.06拉米夫定50 6 0.740±0.07 0.527±0.03** 0.532±0.07** 0.749±0.13 |
III 生理盐水 6 0.894±0.23 0.869±0.13 0.934±0.16 0.861±0.25龙胆苦苷50 6 0.898±0.10 0.868±0.23 0.903±0.17 0.883±0.21100 6 1.048±0.24 0.889±0.15 0.787±0.13* 0.760±0.13*200 6 1.068±0.13 1.021±0.15 0.583±0.09** 0.886±0.14*拉米夫定50 6 0.912±0.20 0.528±0.10** 0.503±0.05** 0.799±0.14* |
实验批次 | 药物 剂量mg/kg bid×10 | 鸭数(只) | 抑制率(%) | |||
T5 | T10 | P3 | ||||
I | 病毒对照龙胆苦苷 | 5010020050 | 66666 | -20.263.152.12*19.77**24.25** | -9.268.1012.3827.72*25.15* | 2.4717.279.78-4.45拉米夫定-0.90 |
II | 病毒对照龙胆苦苷拉米夫定 | 5010020050 | 66666 | 11.161.2113.616.1528.44** | 12.935.6418.9926.70*27.31 | 13.051.516.130.87-1.13 |
III | 病毒对照龙胆苦苷拉米夫定 | 5010020050 | 66666 | -1.394.1111.913.5241.06* | -9.01-1.3120.3345.06**43.14** | -0.071.3822.4416.5311.40 |
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CN 200410073488 CN1259054C (zh) | 2004-12-27 | 2004-12-27 | 龙胆苦苷在制备抑制乙型肝炎病毒药物中的应用 |
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CN 200410073488 CN1259054C (zh) | 2004-12-27 | 2004-12-27 | 龙胆苦苷在制备抑制乙型肝炎病毒药物中的应用 |
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CN1660124A true CN1660124A (zh) | 2005-08-31 |
CN1259054C CN1259054C (zh) | 2006-06-14 |
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102421889A (zh) * | 2009-03-10 | 2012-04-18 | 海罗西班牙有限公司 | 来自完全以母乳喂养的婴儿粪便的具有益生活性的菌株的分离、鉴定和表征 |
CN102670637A (zh) * | 2012-04-28 | 2012-09-19 | 西北大学 | 治疗肝炎的利胆药物 |
CN103655590A (zh) * | 2012-09-07 | 2014-03-26 | 哈尔滨誉衡药业股份有限公司 | 一种含有龙胆苦苷的药物组合物及其制剂和用途 |
CN103655591A (zh) * | 2012-09-07 | 2014-03-26 | 哈尔滨誉衡药业股份有限公司 | 一种药物组合物及其制剂和用途 |
CN103655589A (zh) * | 2012-09-07 | 2014-03-26 | 哈尔滨誉衡药业股份有限公司 | 一种药物组合物及制剂和用途 |
CN106963734A (zh) * | 2017-05-23 | 2017-07-21 | 甘肃中医药大学 | 一种龙胆苦苷纳米乳及其制备方法 |
CN109422807A (zh) * | 2017-09-05 | 2019-03-05 | 吉林农业科技学院 | 龙胆苦苷的偶联物及其制备方法 |
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2004
- 2004-12-27 CN CN 200410073488 patent/CN1259054C/zh not_active Expired - Fee Related
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102421889A (zh) * | 2009-03-10 | 2012-04-18 | 海罗西班牙有限公司 | 来自完全以母乳喂养的婴儿粪便的具有益生活性的菌株的分离、鉴定和表征 |
CN102670637A (zh) * | 2012-04-28 | 2012-09-19 | 西北大学 | 治疗肝炎的利胆药物 |
CN103655590A (zh) * | 2012-09-07 | 2014-03-26 | 哈尔滨誉衡药业股份有限公司 | 一种含有龙胆苦苷的药物组合物及其制剂和用途 |
CN103655591A (zh) * | 2012-09-07 | 2014-03-26 | 哈尔滨誉衡药业股份有限公司 | 一种药物组合物及其制剂和用途 |
CN103655589A (zh) * | 2012-09-07 | 2014-03-26 | 哈尔滨誉衡药业股份有限公司 | 一种药物组合物及制剂和用途 |
CN106963734A (zh) * | 2017-05-23 | 2017-07-21 | 甘肃中医药大学 | 一种龙胆苦苷纳米乳及其制备方法 |
CN109422807A (zh) * | 2017-09-05 | 2019-03-05 | 吉林农业科技学院 | 龙胆苦苷的偶联物及其制备方法 |
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