CN1646186A - 可植入压力启动式微型阀 - Google Patents

可植入压力启动式微型阀 Download PDF

Info

Publication number
CN1646186A
CN1646186A CNA038076373A CN03807637A CN1646186A CN 1646186 A CN1646186 A CN 1646186A CN A038076373 A CNA038076373 A CN A038076373A CN 03807637 A CN03807637 A CN 03807637A CN 1646186 A CN1646186 A CN 1646186A
Authority
CN
China
Prior art keywords
valve
ground floor
pressure
layer
deformable membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CNA038076373A
Other languages
English (en)
Other versions
CN100493648C (zh
Inventor
大卫·A·布罗登
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rosemount Inc
Original Assignee
Rosemount Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rosemount Inc filed Critical Rosemount Inc
Publication of CN1646186A publication Critical patent/CN1646186A/zh
Application granted granted Critical
Publication of CN100493648C publication Critical patent/CN100493648C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14513—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0244—Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Reciprocating Pumps (AREA)
  • Prostheses (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Check Valves (AREA)
  • Fluid-Driven Valves (AREA)

Abstract

本申请公开了一种可植入压力启动式微型阀(10)。该阀(10)包括能与外部贮液室(1)相连的室(28)。可变形隔膜(20)与室(28)液体连接并设置成使外部液体的压力(P0)施加到可变形隔膜(20)上。当压力(P0)超过选定的阈值时，隔膜(20)产生变形并使室(28)中的物质(34)与外部液体混合。

Description

可植入压力启动式微型阀
技术领域
本发明涉及一种可植入压力启动式微型阀。
背景技术
现代医疗由很多方法和装置辅助将物质如药品输送给病人。一个此系统的例子为可植入药物输送系统。然而，一般地，大多数可植入药物输送系统都相对复杂和昂贵。通常由于植入药物输送是一种非常重要和/或方便的事情，就需要忍受在此系统上的花费。然而，能够提供至少可植入药物输送的一部分方便并大量减少花费的装置和方法就会使病人受益。
发明内容
本申请公开一种可植入压力启动式微型阀。所述阀包括能与外部贮液室配合的室。可变形隔膜液动地连接到室，并且设置成外部液体的压力施加到可变形隔膜上。当压力达到选择的阈值时，隔膜变形并使室中的物质与外部液体混合。
附图说明
图1是示出根据本发明的一个实施例植入病人体内的压力启动式微型阀的示意图。
图2是示出根据本发明的一个实施例的压力启动式微型阀放大的透视图。
图3A是示出根据本发明的一个实施例中阀10的俯视图。
图3B是示出根据本发明的一个实施例中阀10处于“关闭”状态的侧视截面图。
图3C是示出根据本发明的一个实施例中阀10处于打开状态或分配状态的侧视截面图。
具体实施方式
本发明的实施例包括一简单的可植入压力启动式微型阀，其适于体外使用并可以选择地提供响应于身体液体如血液达到选定的阈值的压力的物质，如药品。可以预想本发明的实施例对控制高血压有益。例如，可以直接响应血压信号本身以分配治疗这种状况的药品。可以相信这样的药物传输可以帮助改善短期的血压中的“压力高峰”。
尽管下面将描述的本发明的各个方面特征都是关于分配降低血压药物的，也可以使用任何响应于体外的液体压力的合适的药品或物质。根据一些方面，附加的药品或者其他合适的物质储存在设置在体外的贮液器中。优选地，阀本身采用基本与外部手术相适应的微电机械装置系统(MEMs)为基础的材料，但是并不限于硅、蓝宝石、陶瓷和其他已知的生物亲和材料。也可以使用金属如钛。而且，最好压力阀本身的尺寸能够植入用于皮下注射的针。根据本发明的各个方面，压力阀是全机械而且高度可靠。而且，压力阀的隔膜可以设计成容许非常准确范围内的开启压力。这样压力的例子包括180、200、220托(Torr)。可以理解，用压力启动的微型阀会根据需要进行响应，从而当压力低于选定的阈值时，就会关闭或通常地停止进行分配。
图1示出植入病人体内的压力启动式微型阀10的示意图。根据本发明的一方面，微型阀10通过线12与外部贮液器14液体地相连。
图2示出了阀10放大的透视图。优选地，阀10位于帮助将阀10导入身体的不锈钢外壳16内。阀10总体上由微电机械装置系统(MEMs)的夹层结构构成。阀10包括采用公知技术连接在一起的底层18、可变形隔膜20和顶层22。底层18包括能允许可变形隔膜20在其中变形的凹部，同时顶层22包括当隔膜20变形时能够提供所需要的物质的室28。本领域熟练的技术人员能够认识到在不脱离本发明的精神和范围内可以进行几何变化。这样，更一般地说，第一层包括用于隔膜变形的凹部，同时第二层包括用于选定的医药物质的室。
用于底层18、可变形隔膜20和顶层22选定的物质优选使用如硅、蓝宝石和陶瓷。同时最优选为这些物质为同一种材料，虽然并不要求如此。
图3A示出了阀10的俯视图。可变形隔膜20可以延伸到超出顶层22的边24。顶层22在区域25处与可变形隔膜22粘结，而不是在区域26处。隔膜20最接近边24的部分变形，这样当其收到足够压力时，隔膜20在用相交线表示的阴影处变形就能够使室28中的物质通过。
图3B示出阀10处于“关闭”状态的侧视截面图。这种状态下，阀10受到的外部压力为P°。隔膜20的下部区域30施加压力为P，当压力P°和P的差超过预加载的可变形隔膜20的密封力，隔膜20本身就会沿远离顶层22的表面32变形，由此使得室28中的物质34被分配出去。
图3C示出阀10处于分配状态的侧视截面图。图3C示出可变形隔膜20从表面32处变形以产生缝隙36，从而使得室28中的物质通过。
尽管本发明已经通过优选实施例进行了说明，本领域熟练的人员会意识到在不偏离本发明精神和范围的情况下对本发明作出各种形式和细节的改变。

Claims (12)

1.一种可植入压力启动式微型阀，包括：
其中具有凹部的第一层；
粘结到第一层并具有设置成变形进入凹部的可变形部的可变形隔膜；
部分粘结到可变形隔膜且其中具有室的第二层，其中所述室与隔膜液体连通；
其中当隔膜变形进入凹部时，至少室的一部分开启以释放出物质。
2.如权利要求1所述的阀，其特征在于，第一层是底层。
3.如权利要求1所述的阀，其特征在于，第二层是顶层。
4.如权利要求1所述的阀，其特征在于：
第一层、可变形隔膜和第二层由同一种材料制成。
5.如权利要求1所述的阀，其特征在于：
第一层、第二层和可变形隔膜由陶瓷制成。
6.如权利要求1所述的阀，其特征在于：
至少第一层、第二层和可变形隔膜之一由硅制成。
7.如权利要求1所述的阀，其特征在于：
至少第一层、第二层和可变形隔膜之一由蓝宝石制成。
8.如权利要求1所述的阀，其特征在于，所述隔膜设置成在选定的压力下产生变形。
9.如权利要求1所述的阀，其特征在于，所述室可与外部贮液器相连接。
10.如权利要求1所述的阀，其特征在于，所述室中的材料包括医药物质。
11.如权利要求1所述的阀，其特征在于：
至少第一层、第二层和可变形隔膜之一由金属制成。
12.如权利要求1所述的阀，其特征在于，所述金属为钛。
CNB038076373A 2002-04-08 2003-04-07 可植入压力启动式微型阀 Expired - Fee Related CN100493648C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37081902P 2002-04-08 2002-04-08
US60/370,819 2002-04-08

Publications (2)

Publication Number Publication Date
CN1646186A true CN1646186A (zh) 2005-07-27
CN100493648C CN100493648C (zh) 2009-06-03

Family

ID=29250588

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038076373A Expired - Fee Related CN100493648C (zh) 2002-04-08 2003-04-07 可植入压力启动式微型阀

Country Status (7)

Country Link
US (1) US7115118B2 (zh)
JP (1) JP4282489B2 (zh)
CN (1) CN100493648C (zh)
AU (1) AU2003221830A1 (zh)
DE (1) DE10392512T5 (zh)
GB (1) GB2403421B (zh)
WO (1) WO2003086526A1 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7105131B2 (en) * 2002-09-05 2006-09-12 Xerox Corporation Systems and methods for microelectromechanical system based fluid ejection
US7364564B2 (en) * 2004-03-02 2008-04-29 Becton, Dickinson And Company Implant having MEMS flow module with movable, flow-controlling baffle
DE202006009375U1 (de) * 2006-06-14 2007-10-18 Reinmüller, Johannes, Dr.med. Implantierbare Vorrichtung
US20080033431A1 (en) * 2006-06-29 2008-02-07 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Position augmenting mechanism
US20130032235A1 (en) * 2011-08-02 2013-02-07 Teledyne Dalsa Semiconductor, Inc. Integrated microfluidic check valve and device including such a check valve
TWI547269B (zh) * 2015-05-15 2016-09-01 國立清華大學 齒列矯正裝置
CA3099745A1 (en) 2018-05-17 2019-11-21 Rosemount Inc. Measuring element and measuring device comprising the same

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4152098A (en) * 1977-01-03 1979-05-01 Clark Ivan P Micropump
US4505710A (en) * 1983-05-13 1985-03-19 Collins Earl R Implantable fluid dispensing system
US4604090A (en) 1983-11-22 1986-08-05 Consolidated Controls Corporation Compact implantable medication infusion device
US4776838A (en) * 1983-12-08 1988-10-11 Cordis Corporation Three stage valve
US4840615A (en) * 1985-09-30 1989-06-20 Mcghan Medical Corporation Self-sealing injection reservoir
US4760837A (en) * 1987-02-19 1988-08-02 Inamed Development Company Apparatus for verifying the position of needle tip within the injection reservoir of an implantable medical device
US5062841A (en) * 1988-08-12 1991-11-05 The Regents Of The University Of California Implantable, self-regulating mechanochemical insulin pump
DE3915251A1 (de) * 1989-05-10 1990-11-22 Annemarie Schloegl Ges M B H Implantierbare vorrichtung zur dosierten abgabe von medikamenten in den menschlichen koerper
CH681168A5 (en) 1989-11-10 1993-01-29 Westonbridge Int Ltd Micro-pump for medicinal dosing
GB9009331D0 (en) * 1990-04-26 1990-06-20 Polysystems Limited Sustained release
DE4140251A1 (de) * 1991-12-06 1993-06-09 Hans 8500 Nuernberg De Deinlein-Kalb Einrichtung zur begrenzung des systolischen blutdruckes bei hochdruckkranken personen
US5308348A (en) * 1992-02-18 1994-05-03 Alza Corporation Delivery devices with pulsatile effect
JP3756184B2 (ja) * 1994-12-09 2006-03-15 メッドトロニック・ゾームド・インコーポレイテッド 関節滑液の圧力を解放するためのバルブアセンブリ
US6682500B2 (en) * 1998-01-29 2004-01-27 David Soltanpour Synthetic muscle based diaphragm pump apparatuses
US6048328A (en) * 1998-02-02 2000-04-11 Medtronic, Inc. Implantable drug infusion device having an improved valve
US5993414A (en) * 1998-04-23 1999-11-30 Medtronic, Inc. Implantable device
CA2350595A1 (en) * 1998-11-16 2000-05-25 California Institute Of Technology Parylene micro check valve and fabrication method thereof
US6349740B1 (en) * 1999-04-08 2002-02-26 Abbott Laboratories Monolithic high performance miniature flow control unit
US6899137B2 (en) * 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6273117B1 (en) * 1999-07-09 2001-08-14 I-Flow Corporation Pressure regulator
JP3852734B2 (ja) * 1999-12-20 2006-12-06 セイコーインスツル株式会社 圧力可変弁装置及び該弁装置の設定圧力調整装置
US6283949B1 (en) * 1999-12-27 2001-09-04 Advanced Cardiovascular Systems, Inc. Refillable implantable drug delivery pump

Also Published As

Publication number Publication date
GB0422188D0 (en) 2004-11-03
US20030229337A1 (en) 2003-12-11
US7115118B2 (en) 2006-10-03
WO2003086526A1 (en) 2003-10-23
AU2003221830A1 (en) 2003-10-27
GB2403421A (en) 2005-01-05
CN100493648C (zh) 2009-06-03
DE10392512T5 (de) 2005-04-07
JP2005522279A (ja) 2005-07-28
GB2403421B (en) 2005-07-13
JP4282489B2 (ja) 2009-06-24

Similar Documents

Publication Publication Date Title
Ma et al. A PZT insulin pump integrated with a silicon micro needle array for transdermal drug delivery
US6039712A (en) Implantable injection port
JP4776139B2 (ja) マイクロ加工された流体装置およびその製造方法
EP2331169B1 (en) Passive fluid flow regulator for the administration of medicaments with constant flow rate and drug infusion device comprising the same.
JPH09512075A (ja) マイクロポンプ
JPH04501449A (ja) マイクロポンプ
EP2359886A1 (en) Micromechanic passive flow regulator
EP1920791A2 (en) Wound suction device with multi-lumen connector
JPH07505542A (ja) 外科用器具
EP1310267A3 (en) Infusion-suction cassette with dual suction pump
SG191562A1 (en) Compression cold welding process for forming vias
CN100493648C (zh) 可植入压力启动式微型阀
CN102781507A (zh) 减压敷料连接垫、系统以及方法
KR20090102741A (ko) 마이크로-밸브
CN108472420B (zh) 带有压力调节的流体容器
EP0993835A3 (en) Electrochemical syringe pump
EP1093828A3 (en) Anti-siphon valve for medical infusion lines and the like
US10240596B2 (en) Sterilizable pump unit
AU763397B2 (en) Ophthalmic aspiration system with selectable vent method
US9205203B2 (en) Liquid drug degassing device and ambulatory infusion system including a degassing device
US20220193324A1 (en) Negative-pressure source with service timer
WO2010128399A2 (en) Low-dead volume microfluidic circuit and methods
AU2013234359B2 (en) Valve system and method with multi-directional pumping
EP2665500A2 (en) Reduced sized programmable implantable pump
JPH03199682A (ja) マイクロポンプ

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20090603

Termination date: 20160407