CN1615961A - Concentratend liuweidihuang lozenge and its preparing method - Google Patents

Abstract

The concentrated Liuweidihuang lozenge with excellent Yin nourishing and kidney invigorating effect is prepared with prepared rhizome of rehmannia, tree peony bark, Chinese yam, dogwood, oriental water plantain and tuckahoe. It is prepared based on ancient recipe and through modern technological process, including microwave radiation to break cell wall, and comprehensive extraction with alkali, acid, alcohol, water, etc. Compared with available Liuweidihuang tablet, the concentrated Liuweidihuang lozenge has much higher effective component content, and thus less taken amount and easy absorption.

Description

Concentrated type six drugs containing rehmanniae buccal tablet and preparation method thereof

Technical field

The present invention relates to Chinese medicine buccal tablet of a kind of enriching yin and nourishing kidney and preparation method thereof, particularly a kind ofly form six drugs containing rehmanniae buccal tablet and preparation method thereof, belong to the field of Chinese medicines by Radix Rehmanniae Preparata, Cortex Moutan, Rhizoma Dioscoreae, Fructus Corni, Rhizoma Alismatis and Poria Six-element Chinese medicine.

Background technology

It is remarkable because of its yin enriching and kidney nourishing effect to form LIUWEI DIHUANG WAN by Radix Rehmanniae Preparata, Cortex Moutan, Rhizoma Dioscoreae, Fructus Corni, Rhizoma Alismatis and Poria Six-element Chinese medicine, have effects such as blood sugar lowering, blood fat reducing, raise immunity, resisting fatigue, anti-stress, plaing of rising body superoxides enzyme level, reduction body lipid peroxide, by clinical each section's extensive use, it is the classical ancient prescription of generally acknowledging on the Chinese patent medicine market, but traditional LIUWEI DIHUANG WAN is a kind of big honeyed pills, need chew clothes, because mouthfeel is bad, youngster is beyond affordability; Present LIUWEI DIHUANG WAN adopts Chinese medicine west method for making to make a kind of water-honeyed pill, need not chew clothes, but day dose is bigger, takes also inconvenient; Take inconvenient weak point in order to overcome above-mentioned pill existence, developed a kind of six drugs containing rehmanniae sheet recently, per 1000 finished medicines are used Radix Rehmanniae Preparata 176g, Cortex Moutan 66g, Rhizoma Dioscoreae 88g, Fructus Corni 88g, Rhizoma Alismatis 66g and Poria 66g make, its method for making is: with Cortex Moutan, Fructus Corni, Poria is ground into fine powder, sieves mixing, all the other Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis three flavors decoct with water first three times, two respectively is 2 hours, be 1 hour for the third time, collecting decoction filters, filtrate is condensed into cream, with above-mentioned powder mixing, cold drying, pulverize, add right amount of auxiliary materials, mixing is made granule, drying, be pressed into is 1000, every 0.5 gram, sugar coating, promptly.Have and take advantage comparatively easily, but because the preparation method of extracting solution has still been continued to use traditional pulverizing and decocting method merely, do not take preferred manufacturing procedure respectively according to the heterogeneity of crude drug, make some effective active component particularly low to thermal sensitivity active component such as ursolic acid equal size, need take 8 at every turn, dose is big, and needs water to swallow, and takes also inconvenient.

Summary of the invention

Purpose of the present invention mainly is on the basis that Radix Rehmanniae Preparata, Cortex Moutan, Rhizoma Dioscoreae, Fructus Corni, Rhizoma Alismatis and Poria Six-element Chinese medicine are furtherd investigate, ancient prescription is newly done, utilize modern technologies, improve its preparation method, make traditional ancient prescription shine new vitality, a kind of active component content height is provided, effective, dose is little, takes the concentrated type six drugs containing rehmanniae buccal tablet of novel form extremely easily.

Another object of the present invention has provided the preferred manufacturing procedure of this concentrated type six drugs containing rehmanniae buccal tablet.

Concentrated type six drugs containing rehmanniae buccal tablet of the present invention, including following bulk drugs makes: 33 parts in 88 parts of Radix Rehmanniae Preparata, 33 parts of Cortex Moutans, 44 parts of Rhizoma Dioscoreaes, 44 parts of Fructus Corni, 33 parts of Rhizoma Alismatis and Poria is characterized in that the buccal tablet adjuvant that also includes following weight portion makes: 1 part of 34 parts of starch, 4 parts in dextrin, 5 parts of arabic gums, 1 part of steviol glycosides, 0.3 part of Oleum menthae and magnesium stearate.

Bring into play drug effect better in order to make each raw material, before the microwave assistant extracting in water, also Cortex Moutan is carried out microwave assistant and add alkali, acid neutralization and ethanol extraction, Fructus Corni is carried out microwave assistant add acid and ethanol extraction, the preferred manufacturing procedure of concentrated type six drugs containing rehmanniae buccal tablet of the present invention is as follows:

A) take by weighing 88 parts of each raw medicinal material Radix Rehmanniae Preparata, 33 parts of Cortex Moutans, 44 parts of Rhizoma Dioscoreaes, 44 parts of Fructus Corni, 33 parts of Rhizoma Alismatis, 33 parts in Poria and adjuvant: 34 parts of starch, 4 parts in dextrin, 5 parts of arabic gums, 1 part of steviol glycosides, 0.3 part of Oleum menthae, 1 part of magnesium stearate, standby;

B) the Cortex Moutan crushed after being dried with described weight proportion becomes fine powder, place microwave container again, add 85% ethanol and 0.5 times of NaOH that measures 1mol/L that 3-5 doubly measures, fully mixing soaked after 1 hour, added the HCL of the 1mol/L of 1 times of amount again, placed and used microwave exposure 10-60 minute in the microwave extraction device, pour in the multi-function extractor then, add 85% an amount of ethanol again, continuous backflow is extracted 1-3 time, filters; Merging filtrate, filtrate are condensed into the thick extractum 1 of pitchy that density is 1.15-1.20 in the time of 60 ℃; The filtering residue of microwave assistant alcohol extraction adds the water boiling and extraction that 5-10 doubly measures again, filters, and filtrate is condensed into the thick extractum 2 of pitchy that density is 1.15-1.20 in the time of 60 ℃; Cortex Moutan filtering residue after water is carried is standby;

C) Fructus Corni crushed after being dried a greater part of in the described weight proportion is become fine powder, add 3-5 and doubly measure 85% ethanol of preparing with 2%HCL, fully mixing soaked after 1 hour, place and use microwave exposure 10-60 minute in the microwave extraction device, pour into then in the multi-functional extractor, 85% ethanol that restock is an amount of with the 2%HCL preparation, continuous backflow is extracted 1-3 time, filter, merging filtrate, being condensed into density is the thick extractum 3 of pitchy of 1.15-1.20 in the time of 60 ℃; Filtering residue after the alcohol extraction adds an amount of 2%HCL solution, and continuous backflow is extracted, and filters, and filtrate is condensed into the thick extractum 4 of pitchy that density is 1.15-1.20 in the time of 60 ℃; Fructus Corni filtering residue after acid is carried is ground into impalpable powder after drying, and is standby;

D) Fructus Corni crushed after being dried a small half of in the described weight proportion is become fine powder, Radix Rehmanniae Preparata, Poria and the Rhizoma Alismatis of described weight proportion are cut into slices respectively, Cortex Moutan filtering residue after water is carried places microwave container again, adds an amount of water logging bubble after 1 hour, places and uses microwave exposure 10-60 minute in the microwave extraction device, pour in the multi-function extractor then, continuous backflow is extracted 1-3 time, filters waste, filtrate merges, and being condensed into density is the thick extractum 5 of pitchy of 1.35-1.40 in the time of 60 ℃;

E) the yam slices crushed after being dried with described weight proportion becomes impalpable powder, and is standby;

F) with behind the thick extractum 1 of above-mentioned pitchy, the thick extractum 2 of pitchy, the thick extractum 3 of pitchy, the thick extractum 4 of pitchy, the thick extractum 5 of pitchy, Fructus Corni filtering residue impalpable powder and the abundant mixing of Rhizoma Dioscoreae impalpable powder, after adding the abundant mixing of buccal tablet supplementary product starch, dextrin, arabic gum, steviol glycosides, Oleum menthae, magnesium stearate of described weight portion, be concentrated type six drugs containing rehmanniae buccal tablet behind the granulation of reuse conventional method, tabletting, the coating.

Six drugs containing rehmanniae buccal tablet of the present invention owing to adopt microwave assistant to extract, plays the breaking cellular wall effect to plant cell except the effect of enriching yin and nourishing kidney with traditional prescription, help extracting active component, more helps absorption of human body; Use again and add the new technology that alkali, acid, ethanol and water comprehensively extract, active component in the buccal tablet is multiplied, after measured, the important component in the buccal tablet of the present invention such as the content of paeonol are greater than 0.3%, be that paeonol content is 0.07% more than 4 times in the six drugs containing rehmanniae sheet, and for example content of ursolic acid is greater than 0.03%, and the six drugs containing rehmanniae sheet does not then have the content of ursolic acid index.Because the content of effective in the buccal tablet of the present invention is much larger than the content of traditional LIUWEI DIHUANG WAN and conventional tablet six drugs containing rehmanniae sheet, so dose is little, can reduce by half is the 2-4 sheet, need not water when taking, and directly containing taken in mouth, more help absorbing, take also more convenient.

The specific embodiment

Now to produce 500 tablets of six drugs containing rehmanniae buccal tablets, every 0.5 gram is example, and it is as follows that its step is described in further detail:

A) take by weighing each raw medicinal material Radix Rehmanniae Preparata 178 gram, Cortex Moutan 66 grams, Rhizoma Dioscoreae 88 grams, Fructus Corni 88 grams, Rhizoma Alismatis 66 grams, Poria 66 gram and buccal tablet adjuvants: starch 68 grams, dextrin 8 grams, arabic gum 10 grams, steviol glycosides 2 grams, Oleum menthae 0.6 gram, magnesium stearate 2 grams, standby;

B) 66 gram Cortex Moutan crushed after being dried are become fine powder, place microwave container again, add 85% ethanol and 0.5 times of NaOH that measures 1mol/L that 3-5 doubly measures, fully mixing soaked after 1 hour, added the HCL of the 1mol/L of 1 times of amount again, place in the microwave extraction device with microwave exposure 10 minutes (amount should suitably increase exposure time for a long time), pour into then in the multi-function extractor, add 85% an amount of ethanol again, be advisable to cover powder, continuous backflow is extracted 1-3 time, filters; Merging filtrate, filtrate are condensed into the thick extractum 1 of pitchy that density is 1.15-1.20 in the time of 60 ℃; The filtering residue of microwave assistant alcohol extraction adds the water boiling and extraction that 5-10 doubly measures again, filters, and filtrate is condensed into the thick extractum 2 of pitchy that density is 1.15-1.20 in the time of 60 ℃, be rich in the paeonol extract in thick extractum 1 of described pitchy and the thick extractum 2 of pitchy; Cortex Moutan filtering residue after water is carried is standby;

C) the Fructus Corni crushed after being dried with 61 grams becomes fine powder, add 3-5 and doubly measure 85% ethanol of preparing with 2%HCL, fully mixing soaked after 1 hour, place in the microwave extraction device with microwave exposure 10 minutes (amount should suitably increase exposure time for a long time), pour into then in the multi-function extractor, 85% ethanol of preparing with 2%HCL that restock is an amount of, continuous backflow is extracted 1-3 time, filter, merging filtrate, being condensed into density is the thick extractum 3 of pitchy of 1.15-1.20 in the time of 60 ℃; Filtering residue after the alcohol extraction adds an amount of 2%HCL solution, and continuous backflow is extracted, and filters, and filtrate is condensed into the thick extractum 4 of pitchy that density is 1.15-1.20 in the time of 60 ℃, be rich in Fel Ursi acids extract in thick extractum 3 of described pitchy and the thick extractum 4 of pitchy; Fructus Corni filtering residue after acid is carried is ground into impalpable powder after drying, and is standby;

D) the 27 Fructus Corni crushed after being dried that restrain with another part become fine powder, Radix Rehmanniae Preparata, Poria and the Rhizoma Alismatis of described weight proportion are cut into slices respectively, Cortex Moutan filtering residue after water is carried places microwave container again, add an amount of water logging bubble after 1 hour, place in the microwave extraction device with microwave exposure 10 minutes (amount should suitably increase exposure time for a long time), pour in the multi-function extractor then, continuous backflow is extracted 1-3 time, filter, waste, filtrate merges, and being condensed into density is the thick extractum 5 of pitchy of 1.35-1.40 in the time of 60 ℃;

E) with being ground into impalpable powder after the 88 Keshan medicines section oven dry, standby;

F) with behind the thick extractum 1 of above-mentioned pitchy, the thick extractum 2 of pitchy, the thick extractum 3 of pitchy, the thick extractum 4 of pitchy, the thick extractum 5 of pitchy, Fructus Corni filtering residue impalpable powder and the abundant mixing of Rhizoma Dioscoreae impalpable powder, after adding buccal tablet supplementary product starch 68 grams, dextrin 8 grams, arabic gum 10 grams, steviol glycosides 2 grams, Oleum menthae 0.6 gram, the abundant mixing of magnesium stearate 2 grams, the reuse conventional method is concentrated type six drugs containing rehmanniae buccal tablet after granulating, be pressed into about 500 buccal tablet of every 0.5 gram, coating.

Claims (2)

1. concentrated type six drugs containing rehmanniae buccal tablet, including following bulk drugs makes: 33 parts in 88 parts of Radix Rehmanniae Preparata, 33 parts of Cortex Moutans, 44 parts of Rhizoma Dioscoreaes, 44 parts of Fructus Corni, 33 parts of Rhizoma Alismatis and Poria is characterized in that the buccal tablet adjuvant that also includes following weight portion makes: 1 part of 34 parts of starch, 4 parts in dextrin, 5 parts of arabic gums, 1 part of steviol glycosides, 0.3 part of Oleum menthae and magnesium stearate.

2. the preparation method of the described buccal tablet of claim 1 is characterized in that comprising the following steps:

A) take by weighing 88 parts of each raw medicinal material Radix Rehmanniae Preparata, 33 parts of Cortex Moutans, 44 parts of Rhizoma Dioscoreaes, 44 parts of Fructus Corni, 33 parts of Rhizoma Alismatis, 33 parts in Poria and adjuvant: 34 parts of starch, 4 parts in dextrin, 5 parts of arabic gums, 1 part of steviol glycosides, 0.5 part of Oleum menthae, 1 part of magnesium stearate, standby;

B) the Cortex Moutan crushed after being dried with described weight proportion becomes fine powder, place microwave container again, add 85% ethanol and 0.5 times of NaOH that measures 1mol/L that 3-5 doubly measures, fully mixing soaked after 1 hour, added the HCL of the 1mol/L of 1 times of amount again, placed and used microwave exposure 10-60 minute in the microwave extraction device, pour in the multi-function extractor then, add 85% an amount of ethanol again, reflux, extract, 1-3 time filters; Merging filtrate, filtrate are condensed into the thick extractum 1 of pitchy that density is 1.15-1.20 in the time of 60 ℃; The filtering residue of microwave assistant alcohol extraction adds the water boiling and extraction that 5-10 doubly measures again, filters, and filtrate is condensed into the thick extractum 2 of pitchy that density is 1.15-1.20 in the time of 60 ℃; Cortex Moutan filtering residue after water is carried is standby;

C) Fructus Corni crushed after being dried a greater part of in the described weight proportion is become fine powder, add 3-5 and doubly measure 85% ethanol of preparing with 2%HCL, fully mixing soaked after 1 hour, place and use microwave exposure 10-60 minute in the microwave extraction device, pour into then in the multi-function extractor, 85% ethanol that restock is an amount of with the 2%HCL preparation, continuous backflow is extracted 1-3 time, filter, merging filtrate, being condensed into density is the thick extractum 3 of pitchy of 1.15-1.20 in the time of 60 ℃; Filtering residue after the alcohol extraction adds an amount of 2%HCL solution, and continuous backflow is extracted, and filters, and filtrate is condensed into the thick extractum 4 of pitchy that density is 1.15-1.20 in the time of 60 ℃; Fructus Corni filtering residue after acid is carried is ground into impalpable powder after drying, and is standby;

D) dry powder after the Fructus Corni drying a small half of in the described weight proportion is broken into fine powder, Radix Rehmanniae Preparata, Poria and the Rhizoma Alismatis of described weight proportion are cut into slices respectively, Cortex Moutan filtering residue after water is carried places microwave container again, add an amount of water logging bubble after 1 hour, place and use microwave exposure 10-60 minute in the microwave extraction device, pour in the multi-function extractor then, continuous backflow is extracted 1-3 time, filter, waste, filtrate merges, and being condensed into density is the thick extractum 5 of pitchy of 1.35-1.40 in the time of 60 ℃;

E) the yam slices crushed after being dried with described weight proportion becomes impalpable powder, and is standby;

F) with behind the thick extractum 1 of above-mentioned pitchy, the thick extractum 2 of pitchy, the thick extractum 3 of pitchy, the thick extractum 4 of pitchy, the thick extractum 5 of pitchy, Fructus Corni filtering residue impalpable powder and the abundant mixing of Rhizoma Dioscoreae impalpable powder, after adding the abundant mixing of buccal tablet supplementary product starch, dextrin, arabic gum, steviol glycosides, Oleum menthae, magnesium stearate of described weight portion, be concentrated type six drugs containing rehmanniae buccal tablet behind the granulation of reuse conventional method, tabletting, the coating.