CN1602850A - 一种注射用n(2)-l-丙氨酰-l-谷氨酰胺及其制备方法 - Google Patents
一种注射用n(2)-l-丙氨酰-l-谷氨酰胺及其制备方法 Download PDFInfo
- Publication number
- CN1602850A CN1602850A CN 200410070336 CN200410070336A CN1602850A CN 1602850 A CN1602850 A CN 1602850A CN 200410070336 CN200410070336 CN 200410070336 CN 200410070336 A CN200410070336 A CN 200410070336A CN 1602850 A CN1602850 A CN 1602850A
- Authority
- CN
- China
- Prior art keywords
- alanyl
- glutamine
- charcoal
- add
- mannitol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002347 injection Methods 0.000 title claims abstract description 33
- 239000007924 injection Substances 0.000 title claims abstract description 33
- HJCMDXDYPOUFDY-WHFBIAKZSA-N Ala-Gln Chemical compound C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(N)=O HJCMDXDYPOUFDY-WHFBIAKZSA-N 0.000 title claims description 25
- 108010044940 alanylglutamine Proteins 0.000 title claims description 21
- 238000002360 preparation method Methods 0.000 title claims description 7
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 23
- 235000010355 mannitol Nutrition 0.000 claims abstract description 23
- 229960002648 alanylglutamine Drugs 0.000 claims abstract description 22
- 239000003610 charcoal Substances 0.000 claims description 40
- 239000000843 powder Substances 0.000 claims description 40
- 229930195725 Mannitol Natural products 0.000 claims description 22
- 239000000594 mannitol Substances 0.000 claims description 22
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 20
- 238000001914 filtration Methods 0.000 claims description 20
- 229940105082 medicinal charcoal Drugs 0.000 claims description 20
- 239000012528 membrane Substances 0.000 claims description 20
- 239000000243 solution Substances 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 238000001694 spray drying Methods 0.000 claims description 13
- 238000004108 freeze drying Methods 0.000 claims description 11
- 238000012856 packing Methods 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 4
- 206010020674 Hypermetabolism Diseases 0.000 abstract description 3
- 230000015556 catabolic process Effects 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract description 2
- 238000000034 method Methods 0.000 abstract 1
- 238000005303 weighing Methods 0.000 description 16
- 102000009127 Glutaminase Human genes 0.000 description 1
- 108010073324 Glutaminase Proteins 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 235000016236 parenteral nutrition Nutrition 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CNB2004100703361A CN100428931C (zh) | 2004-08-02 | 2004-08-02 | 一种注射用n(2)-l-丙氨酰-l-谷氨酰胺及其制备方法 |
Applications Claiming Priority (1)
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CNB2004100703361A CN100428931C (zh) | 2004-08-02 | 2004-08-02 | 一种注射用n(2)-l-丙氨酰-l-谷氨酰胺及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1602850A true CN1602850A (zh) | 2005-04-06 |
CN100428931C CN100428931C (zh) | 2008-10-29 |
Family
ID=34666794
Family Applications (1)
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CNB2004100703361A Expired - Fee Related CN100428931C (zh) | 2004-08-02 | 2004-08-02 | 一种注射用n(2)-l-丙氨酰-l-谷氨酰胺及其制备方法 |
Country Status (1)
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CN (1) | CN100428931C (zh) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102228444A (zh) * | 2011-04-13 | 2011-11-02 | 贵州益佰制药股份有限公司 | 一种注射用n(2)-l-丙氨酰-l-谷氨酰胺制剂及其制备方法 |
CN102429902A (zh) * | 2011-09-09 | 2012-05-02 | 海南灵康制药有限公司 | 一种丙氨酰谷氨酰胺和复方氨基酸的药物组合物 |
CN102631665A (zh) * | 2012-04-19 | 2012-08-15 | 海南灵康制药有限公司 | 一种丙氨酰谷氨酰胺注射液和复方氨基酸注射液的药物组合物 |
CN102698248A (zh) * | 2012-06-20 | 2012-10-03 | 海南灵康制药有限公司 | 一种喷雾干燥法制备的丙氨酰谷氨酰胺和复方氨基酸的药物组合物 |
CN103293236A (zh) * | 2012-12-26 | 2013-09-11 | 辰欣药业股份有限公司 | 一种测定丙胺酰谷氨酰胺含量的方法 |
CN103508077A (zh) * | 2012-06-25 | 2014-01-15 | 贵州益佰制药股份有限公司 | 一种药物包装系统及静脉给药的试剂盒 |
CN103610652A (zh) * | 2013-11-27 | 2014-03-05 | 海南通用康力制药有限公司 | 一种丙氨酰谷氨酰胺冻干粉的制备方法 |
CN105125497A (zh) * | 2015-09-20 | 2015-12-09 | 成都育芽科技有限公司 | 一种n(2)-l-丙氨酰-l-谷氨酰胺注射剂的制备方法 |
CN107281460A (zh) * | 2017-05-25 | 2017-10-24 | 海南全星制药有限公司 | 一种注射用丙氨酰谷氨酰胺的制备方法 |
-
2004
- 2004-08-02 CN CNB2004100703361A patent/CN100428931C/zh not_active Expired - Fee Related
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102228444A (zh) * | 2011-04-13 | 2011-11-02 | 贵州益佰制药股份有限公司 | 一种注射用n(2)-l-丙氨酰-l-谷氨酰胺制剂及其制备方法 |
CN102429902A (zh) * | 2011-09-09 | 2012-05-02 | 海南灵康制药有限公司 | 一种丙氨酰谷氨酰胺和复方氨基酸的药物组合物 |
CN102631665B (zh) * | 2012-04-19 | 2013-09-25 | 海南灵康制药有限公司 | 一种丙氨酰谷氨酰胺注射液和复方氨基酸注射液的药物组合物 |
CN102631665A (zh) * | 2012-04-19 | 2012-08-15 | 海南灵康制药有限公司 | 一种丙氨酰谷氨酰胺注射液和复方氨基酸注射液的药物组合物 |
CN102698248B (zh) * | 2012-06-20 | 2013-09-25 | 海南灵康制药有限公司 | 一种喷雾干燥法制备的丙氨酰谷氨酰胺和复方氨基酸的药物组合物 |
CN102698248A (zh) * | 2012-06-20 | 2012-10-03 | 海南灵康制药有限公司 | 一种喷雾干燥法制备的丙氨酰谷氨酰胺和复方氨基酸的药物组合物 |
CN103508077A (zh) * | 2012-06-25 | 2014-01-15 | 贵州益佰制药股份有限公司 | 一种药物包装系统及静脉给药的试剂盒 |
CN103293236A (zh) * | 2012-12-26 | 2013-09-11 | 辰欣药业股份有限公司 | 一种测定丙胺酰谷氨酰胺含量的方法 |
CN103610652A (zh) * | 2013-11-27 | 2014-03-05 | 海南通用康力制药有限公司 | 一种丙氨酰谷氨酰胺冻干粉的制备方法 |
CN105125497A (zh) * | 2015-09-20 | 2015-12-09 | 成都育芽科技有限公司 | 一种n(2)-l-丙氨酰-l-谷氨酰胺注射剂的制备方法 |
CN105125497B (zh) * | 2015-09-20 | 2018-11-20 | 南京恩泰医药科技有限公司 | 一种n(2)-l-丙氨酰-l-谷氨酰胺注射剂的制备方法 |
CN107281460A (zh) * | 2017-05-25 | 2017-10-24 | 海南全星制药有限公司 | 一种注射用丙氨酰谷氨酰胺的制备方法 |
CN107281460B (zh) * | 2017-05-25 | 2018-05-18 | 海南全星制药有限公司 | 一种注射用丙氨酰谷氨酰胺的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN100428931C (zh) | 2008-10-29 |
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Assignee: Hainan Lingkang Pharmaceutical Co., Ltd. Assignor: Tao Linggang Contract fulfillment period: 2009.6.1 to 2019.5.31 contract change Contract record no.: 2009460000004 Denomination of invention: N (2) -L- -L- glutamine for injection and preparation method thereof Granted publication date: 20081029 License type: Exclusive license Record date: 2009.6.8 |
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Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.6.1 TO 2019.5.31; CHANGE OF CONTRACT Name of requester: HAINAN PROV LINGKANG PHARMACEUTICAL CO., LTD. Effective date: 20090608 |
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Effective date of registration: 20140619 Address after: Naidong Zetang County of Tibet autonomous region in 856100 Prefecture is Naidong County Road No. 68 building second building a layer of Patentee after: Ling Kang Pharmaceutical Group Limited by Share Ltd Address before: 570216 No. 8 factory building, Haikou Free Trade Zone, Hainan Patentee before: Hainan Ling Kang Pharmaceutical Group Limited by Share Ltd |
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CF01 | Termination of patent right due to non-payment of annual fee |