CN1589847A - Traditional Chinese medicine compound preparation for preventing and treating coccidiosis - Google Patents
Traditional Chinese medicine compound preparation for preventing and treating coccidiosis Download PDFInfo
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- CN1589847A CN1589847A CN 03150699 CN03150699A CN1589847A CN 1589847 A CN1589847 A CN 1589847A CN 03150699 CN03150699 CN 03150699 CN 03150699 A CN03150699 A CN 03150699A CN 1589847 A CN1589847 A CN 1589847A
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Abstract
A Chinese medicine used as the additive of feed or drinking water by dissolving it in water for preventing and treating coccidiosis is prepared from 8 Chinese-medicinal materials including pulsatilla root, sweet wormwood, portulaca, oriental wormwood, etc through pulverizing, mixing or extracting in solvent, concentrating, drying and breaking. It can reduce cost 50%.
Description
Technical field
The present invention relates to a kind of Chinese herbal medicine anticoccidial preparation.Be applicable to chicken, rabbit and goat.
Background technology
Coccidiosis is one of disease of serious harm livestock breeding industry, especially chicken coccidiosis, is worldwide popular.According to statistics, in order to control chicken coccidiosis, the annual anticoccidial drug that consumes in the whole world is worth more than 500,000,000 dollar.China is poultry husbandry big country, about 3,000,000,000 plumages of the amount of livestock on hand of annual chicken, and the expense of the chicken control coccidiosis by 50% is on average by 0.2 yuan of calculating, and China is used to prevent and treat this sick expense up to more than 300,000,000 yuan.Therefore, the control of coccidiosis is extremely paid attention in countries in the world.Up to the present, being used to of having succeeded in developing prevented and treated existing 50 kinds of the medicine of all kinds of chemistry of this disease.Yet coccidiosis very easily produces drug resistance to medicine, though the speed that occurs far away from drug-resistant worm plant constantly appears in new anti-ball medicine.In addition, the drug residue problem that the life-time service anticoccidial drug causes is also quite serious, therefore causes harm and loses huge in foreign trade to the people.For above-mentioned reasons, impel people to consider to use other method and control coccidiosis.
Summary of the invention
Purpose of the present invention aims to provide a kind of natural Chinese medicinal herb compound preparation that is used to prevent and treat coccidiosis, and it had had both prevented and treated coccidiosis, is difficult for producing left drug in drug resistance and the body again.
The object of the present invention is achieved like this:
The Chinese medicine preparation of control coccidiosis is made up of main active material and auxiliary activity component substances, through pulverize, mix or with the useable solvents extraction, concentrate, dry, pulverizing is prepared into preparation; The main active material is: Radix Dichroae, Herba Artemisiae Annuae, the Radix Pulsatillae; The auxiliary activity component substances is: Herba Verbenae, Herba Portulacae, Herba Artemisiae Scopariae, Herba Chenopodii Hybridi, Herba Pteridis Multifidae.
The weight ratio of described main active material is 50～70%, and the weight ratio of auxiliary activity component substances is 30～50%.
The present invention mixes pre-mixing agent capable of using as feed with adjuvant; Molten water can be made drinking agent.
Described useable solvents is selected from: water, methanol, ethanol, isopropyl alcohol, ether, chloroform, ethyl acetate, petroleum ether, acetone and possible mixture thereof.
Described adjuvant is selected from: Semen Maydis powder, starch, Testa oryzae, bean cake, corn cob, zeolite, wheat bran, Maifanitum and composition thereof.
The granularity of described pre-mixing agent is less than 0.45mm, greater than 0.10mm.
The present invention can be used as the feedstuff pre-mixing agent and the livestock and fowl drinking water agent is used.
The present invention is used to prevent and treat chicken coccidiosis, and its anticoccidial index (ACI) is between 175～198.Research (the LD of acute toxicity
50) result's demonstration: this Chinese herbal medicine powder of oral administration dosage average out to 20276.91mg/kg on the one does not cause any acute toxic reaction to white mice; The drug test group of 1% dosage in subchronic toxicity test, growth of chicken and weightening finish are normal, and each organ and hematology, serum biochemistry index are not all found the abnormal results relevant with medicine.The oral acute toxicity of the mice of extract is 21435.88mg/kg.Show that this poison of drug is very low.The present invention compared with prior art can reduce by 50% cost.
The specific embodiment
Embodiment 1
With the preparation aqueous solvent is example:
Radix Dichroae 28%, Herba Artemisiae Annuae 20%, Herba Portulacae 13%, Herba Artemisiae Scopariae 12%, Herba Pteridis Multifidae 10%, Herba Verbenae 10%, Herba Chenopodii Hybridi 7%.
Above component is made decoction pieces, and the decocting of 5 times of amounts boils twice, and each 1.5～2 hours, be cooled to room temperature, filter cleaner, merging filtrate, when being concentrated into every 1ml medicinal liquid and being equivalent to above-mentioned crude drug 2g, 0.05% sodium benzoate is added in cooling, and mixing is canned, promptly.
Dilution allows chicken freely drink the treatment chicken coccidiosis for 50 times during use.
Embodiment 2
With the preparation pre-mixing agent is example:
Radix Dichroae 18%, Herba Artemisiae Annuae 20%, Herba Pteridis Multifidae 14%, Herba Portulacae 13%, Herba Artemisiae Scopariae 12%, the Radix Pulsatillae 10%, Herba Verbenae 7%, Herba Chenopodii Hybridi 6%.
Above component is pulverized, is mixed; Cross the Semen Maydis powder that adds etc. weight behind No. 3 sieves and make pre-mixing agent.But this pre-mixing agent adds 0.5% prevention infection coccidiosis in the rabbit feedstuff.
Claims (7)
1, a kind of compound Chinese medicinal preparation of preventing and treating coccidiosis is characterized in that it is made up of main active material and auxiliary activity component substances, through pulverize, mix or with the useable solvents extraction, concentrate, dry, pulverize and be prepared into preparation; The main active material is: Radix Dichroae, Herba Artemisiae Annuae, the Radix Pulsatillae, the auxiliary activity component substances is: Herba Verbenae, Herba Portulacae, Herba Artemisiae Scopariae, Herba Pteridis Multifidae, Herba Chenopodii Hybridi.
2, compound Chinese medicinal preparation according to claim 1, the weight ratio that it is characterized in that the main active material is 50～70%, the weight ratio of auxiliary activity component substances is 30～50%.
3, compound Chinese medicinal preparation according to claim 1 is characterized in that it mixes pre-mixing agent capable of using as feed with adjuvant.
4, compound Chinese medicinal preparation according to claim 1 is characterized in that it can be used as drinking agent.
5, compound Chinese medicinal preparation according to claim 1 is characterized in that useable solvents is selected from: water, methanol, ethanol, isopropyl alcohol, ether, chloroform, ethyl acetate, petroleum ether, acetone and possible mixture thereof.
6, compound Chinese medicinal preparation according to claim 3 is characterized in that adjuvant is selected from: Semen Maydis powder, starch, Testa oryzae, bean cake, corn cob, zeolite, wheat bran, Maifanitum and composition thereof.
7, compound Chinese medicinal preparation according to claim 3, the granularity that it is characterized in that pre-mixing agent is less than 0.45mm, greater than 0.10mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031506992A CN1294952C (en) | 2003-09-03 | 2003-09-03 | Traditional Chinese medicine compound preparation for preventing and treating coccidiosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031506992A CN1294952C (en) | 2003-09-03 | 2003-09-03 | Traditional Chinese medicine compound preparation for preventing and treating coccidiosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1589847A true CN1589847A (en) | 2005-03-09 |
| CN1294952C CN1294952C (en) | 2007-01-17 |
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ID=34597646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031506992A Expired - Fee Related CN1294952C (en) | 2003-09-03 | 2003-09-03 | Traditional Chinese medicine compound preparation for preventing and treating coccidiosis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1294952C (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100512835C (en) * | 2006-09-01 | 2009-07-15 | 浙江省农业科学院 | Chinese herbal medicine slow release agent for preventing and treating rabbit and chicken coccidiosis and preparing method thereof |
| FR2926190A1 (en) * | 2008-01-14 | 2009-07-17 | Thiomed Soc Par Actions Simpli | PROCESS FOR PREPARING PLANT EXTRACTS FOR OBTAINING A NEW GALENIC FORM |
| CN101579451B (en) * | 2009-07-07 | 2011-06-29 | 广东溢多利生物科技股份有限公司 | Chicken coccidia powder and preparation method thereof |
| CN102274314A (en) * | 2011-08-13 | 2011-12-14 | 江西中成药业集团有限公司 | Evergreen coccidian powder and preparation method thereof |
| CN102370060A (en) * | 2011-09-24 | 2012-03-14 | 长治市雄丰清真养殖屠宰有限公司 | Feed for preventing and treating coccidiosis of flocks and herds |
| CN101653198B (en) * | 2008-08-20 | 2012-05-23 | 北京康华远景科技有限公司 | Feed additives for preventing and controlling coccidiosis and preparation methods thereof |
| CN103330788A (en) * | 2013-07-10 | 2013-10-02 | 北京九草堂药物研究院有限公司 | Traditional Chinese medicinal composition for treating chicken whitecomb |
| CN103432435A (en) * | 2013-08-02 | 2013-12-11 | 刘佳 | Traditional Chinese medicine for preventing and treating coccidiosis in local chicken culture process and preparation method of traditional Chinese medicine |
| CN104474223A (en) * | 2014-12-01 | 2015-04-01 | 登封市博爱农林牧开发有限公司 | Traditional Chinese medicine preparation for preventing and treating coccidiosis in sheep and goat |
| CN105106484A (en) * | 2015-09-25 | 2015-12-02 | 全椒县大地种植专业合作社 | Medicine for treating sheep flock coccidiosis |
| CN113648345A (en) * | 2021-08-10 | 2021-11-16 | 生物源生物技术（深圳）股份有限公司 | Composition for preventing and treating coccidiosis and preparation method and application thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1082917A (en) * | 1993-04-02 | 1994-03-02 | 许桂华 | The herbal mixture agent of treatment coccidiosis |
| CN1145791A (en) * | 1995-09-20 | 1997-03-26 | 山东省鲁西兽药厂 | Coccidiosis-resisting Chinese herbal veterinary medicine and its prepn |
-
2003
- 2003-09-03 CN CNB031506992A patent/CN1294952C/en not_active Expired - Fee Related
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100512835C (en) * | 2006-09-01 | 2009-07-15 | 浙江省农业科学院 | Chinese herbal medicine slow release agent for preventing and treating rabbit and chicken coccidiosis and preparing method thereof |
| FR2926190A1 (en) * | 2008-01-14 | 2009-07-17 | Thiomed Soc Par Actions Simpli | PROCESS FOR PREPARING PLANT EXTRACTS FOR OBTAINING A NEW GALENIC FORM |
| EP2080436A3 (en) * | 2008-01-14 | 2010-01-20 | Thiomed | Method for preparing plant extracts allowing a new dosage form to be obtained |
| CN101653198B (en) * | 2008-08-20 | 2012-05-23 | 北京康华远景科技有限公司 | Feed additives for preventing and controlling coccidiosis and preparation methods thereof |
| CN101579451B (en) * | 2009-07-07 | 2011-06-29 | 广东溢多利生物科技股份有限公司 | Chicken coccidia powder and preparation method thereof |
| CN102274314A (en) * | 2011-08-13 | 2011-12-14 | 江西中成药业集团有限公司 | Evergreen coccidian powder and preparation method thereof |
| CN102370060A (en) * | 2011-09-24 | 2012-03-14 | 长治市雄丰清真养殖屠宰有限公司 | Feed for preventing and treating coccidiosis of flocks and herds |
| CN102370060B (en) * | 2011-09-24 | 2013-01-02 | 长治市雄丰清真养殖屠宰有限公司 | Feed for preventing and treating coccidiosis of flocks and herds |
| CN103330788A (en) * | 2013-07-10 | 2013-10-02 | 北京九草堂药物研究院有限公司 | Traditional Chinese medicinal composition for treating chicken whitecomb |
| CN103432435A (en) * | 2013-08-02 | 2013-12-11 | 刘佳 | Traditional Chinese medicine for preventing and treating coccidiosis in local chicken culture process and preparation method of traditional Chinese medicine |
| CN104474223A (en) * | 2014-12-01 | 2015-04-01 | 登封市博爱农林牧开发有限公司 | Traditional Chinese medicine preparation for preventing and treating coccidiosis in sheep and goat |
| CN105106484A (en) * | 2015-09-25 | 2015-12-02 | 全椒县大地种植专业合作社 | Medicine for treating sheep flock coccidiosis |
| CN113648345A (en) * | 2021-08-10 | 2021-11-16 | 生物源生物技术（深圳）股份有限公司 | Composition for preventing and treating coccidiosis and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1294952C (en) | 2007-01-17 |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: CHINA AGRICULTURE ACADEME SHANGHAI VETERINARY INST Free format text: FORMER NAME: SHANGHAI INST. OF LIVESTOCK PARASTITIC DISEASE, CHINESE ACADEMY OF AGRICULTURAL |
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| CP03 | Change of name, title or address |
Address after: No. 518, purple moon Road, Shanghai, Minhang District Patentee after: Shanghai Inst. of Animal Medicines, C.A.A.S Address before: No. 345, 3 Shilong Road, Shanghai Patentee before: Shanghai Institute of Animal Parasitology, Chinese Academy of Agriculture Sciences |
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| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Hebei Yuanzheng Pharmaceutical Co., Ltd. Assignor: Shanghai Inst. of Animal Medicines, C.A.A.S Contract fulfillment period: 2009.9.16 to 2014.9.16 contract change Contract record no.: 2009130000206 Denomination of invention: Traditional Chinese medicine compound preparation for preventing and treating coccidiosis Granted publication date: 20070117 License type: Exclusive license Record date: 20091015 |
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| LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.9.16 TO 2014.9.16; CHANGE OF CONTRACT Name of requester: HEBEI YUANZHENG MEDICINE CO., LTD. Effective date: 20091015 |
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| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20070117 Termination date: 20120903 |