CN101653198B - Feed additives for preventing and controlling coccidiosis and preparation methods thereof - Google Patents
Feed additives for preventing and controlling coccidiosis and preparation methods thereof Download PDFInfo
- Publication number
- CN101653198B CN101653198B CN2008101186322A CN200810118632A CN101653198B CN 101653198 B CN101653198 B CN 101653198B CN 2008101186322 A CN2008101186322 A CN 2008101186322A CN 200810118632 A CN200810118632 A CN 200810118632A CN 101653198 B CN101653198 B CN 101653198B
- Authority
- CN
- China
- Prior art keywords
- extract
- parts
- weight
- dandelion
- crushed material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to feed additives for preventing and controlling coccidiosis and preparation methods thereof. A feed additive for preventing and controlling the coccidiosis comprises the following components in portion by weight: 1 to 10 portions of ground quassia wood and 1 to 10 portions of ground tea plant; and another feed additive for preventing and controlling the coccidiosis comprises the following components in portion by weight: 1 to 10 portions of quassia wood extract and 1 to 10 portions of tea plant extract. The feed additives can improve the immunocompetence of animal organisms, effectively reduce the incidence of the coccidiosis of animals, reduce cultivation investment, have the functions of disease prevention and healthcare, no residues such as heavy metals, chemicals and the like left in animal bodies, impossibility of generating resistance to drugs, and stable and reliable effects, can meet requirements of people on the safe production of animal products, and are applied as a veterinary medicament by increasing the dosage of the additives.
Description
Technical field
The present invention relates to a kind of feed addictive, particularly relate to a kind of in livestock and poultry cultivation, utilize natural plant extracts prevent and treat global-worm illness feed addictive and preparation method thereof.
Background technology
Global-worm illness is a kind of common acute popular protozoosis.Thisly sick distribute extensively, morbidity is general, is prone to invasion and attack chick, piglet, and is generally acute outburst, and can cause chick and piglet white scour after the morbidity, have blood in stool, anaemia, so that mortality (death rate is above 80%); When global-worm illness takes place chronicly when popular in livestock and poultry, also can influence the growth, weightening finish of livestock and poultry etc., production performance is descended, food consumption increases, and causes serious economy loss.
Antibiotic or the chemicalses of adopting are treated after livestock and poultry infect global-worm illness more in livestock and poultry cultivation at present, and these medicines have following shortcoming:
(1) expense is high;
(2) residual and develop immunity to drugs in the livestock and poultry body easily;
(3) treat to come into the market after livestock and poultry are cured, bring hidden danger for human food security;
(4) this antibiotic or chemotherapy belong to remedial measure after being ill, can't retrieve the loss that has caused.
Summary of the invention
The purpose of this invention is to provide a kind of global-worm illness feed addictive and preparation method thereof of preventing and treating, it is high, residual and develop immunity to drugs, give human food security to bring defectives such as hidden danger in the livestock and poultry body easily effectively to solve the prior art expense.
For realizing above-mentioned purpose, the invention provides a kind of preparation method who prevents and treats the global-worm illness feed addictive, comprising:
Step 1, the quassia plant tissue after will cleaning and tea tree plant tissue be in temperature 50-60 ℃ of oven dry 2-3 hour down respectively;
Step 2, quassia plant tissue and tea tree plant tissue after will drying are crushed to 80-120 order fineness, obtain quassia crushed material and tea tree crushed material respectively;
Step 3, be that said quassia crushed material of 1-10 part and said tea tree crushed material that parts by weight are 1-10 part are mixed into crushed mixture, stirred 10-15 minute parts by weight.
On the basis of technique scheme; Before step 3, also comprise: faenum graecum seed, dandelion or the balloonflower root after will cleaning was dried 2-3 hour down in temperature 50-60 ℃; Faenum graecum seed, dandelion or balloonflower powder after the oven dry are broken to 80-120 order fineness, obtain faenum graecum seed crushed material, dandelion crushed material or balloonflower powder and mince; After step 3, also comprise: with said crushed mixture and parts by weight is that said faenum graecum seed crushed material, dandelion crushed material or the balloonflower powder of 1-3 part minces and mix and stirred 10-15 minute.
For realizing above-mentioned purpose, the present invention also provides a kind of global-worm illness feed addictive of preventing and treating, and comprising: parts by weight are quassia crushed material of 1-10 part and the tea tree crushed material that parts by weight are 1-10 part.
On the basis of technique scheme; The said global-worm illness feed addictive of preventing and treating comprises that also parts by weight are that faenum graecum seed crushed material, dandelion crushed material or the balloonflower powder of 1-3 part minces, or parts by weight are the combination in any that faenum graecum seed crushed material, dandelion crushed material and the balloonflower powder of 1-3 part minces.
For realizing above-mentioned purpose, the present invention also provides a kind of said feed of preventing and treating the global-worm illness feed addictive that adopts, and comprises the constituent of following percentage by weight: said global-worm illness feed addictive 0.1-0.4% and the auxiliary material 99.6-99.9% of preventing and treating.
For realizing above-mentioned purpose, the present invention also provides the another kind of preparation method who prevents and treats the global-worm illness feed addictive, comprising:
Step 1, quassia plant tissue and the tea tree plant tissue after will cleaning is cut into 1-2cm respectively
2Fragment;
It is that 95% alcohol reflux extracts 2-3 time that step 2, the quassia plant tissue after will shredding use mass fraction; The each extraction 45-60 minute; Merging the quassia extract, is to concentrate under the 0.05-0.08Mpa at pressure, and the quassia extract after concentrating was descended dry 2-3 hour in temperature 50-60 ℃; Be crushed to 100-200 order fineness again, obtain Ramulus et Folium Picrasmae; Use the distillation range to be temperature 105-140 ℃ steam distillation extraction tea tree extract the tea tree plant tissue after the chopping;
Step 3, be that said Ramulus et Folium Picrasmae of 1-10 part and said tea tree extract that parts by weight are 1-10 part fully are mixed into the extraction mixture with parts by weight, the coefficient of variation that makes its uniformity is less than 0.05.
On the basis of technique scheme, before step 3, also comprise: the faenum graecum seed after will cleaning uses mass fraction to soak ultrasonic Extraction 2-3 time 10-14 hour as the methanol solution of 70-80%; The each extraction 1 hour merges faenum graecum seed extract, is to concentrate under the 0.05-0.08Mpa at pressure; Faenum graecum seed extract after concentrating is used the 0.45Bm membrane filtration; Filter residue in temperature 50-60 ℃ time dry 2-3 hour, is crushed to 100-200 order fineness again, obtains the faenum graecum seed extract; Dandelion after maybe will cleaning is cut into 1-2cm
2Fragment; It is that 60% alcohol reflux extracts 2-3 time that dandelion after the chopping is used mass fraction, extracts merging dandelion extract 45-60 minute at every turn; At pressure is to concentrate under the 0.05-0.10Mpa; Dandelion extract after concentrating in temperature 50-60 ℃ time dry 2-3 hour, is crushed to 100-200 order fineness again, obtains dandelion extract; Balloonflower root after maybe will cleaning is cut into 1-2cm
2Fragment; It is that 70% alcohol reflux extracts 3-4 time that balloonflower root after the chopping is used mass fraction, extracts merging balloonflower root extract 1 hour at every turn; At pressure is to concentrate under the 0.06-0.12Mpa; Balloonflower root extract after concentrating in temperature 50-60 ℃ time dry 2-3 hour, is crushed to 100-200 order fineness again, obtains Radix Platycodonis extract; After step 3, also comprise: with said extraction mixture and parts by weight is that said faenum graecum seed extract, dandelion extract or the Radix Platycodonis extract of 1-3 part mixes, and the coefficient of variation that makes its uniformity is less than 0.05.
For realizing above-mentioned purpose, the present invention also provides another kind to prevent and treat the global-worm illness feed addictive, comprising: parts by weight are that the Ramulus et Folium Picrasmae and the parts by weight of 1-10 part are the tea tree extract of 1-10 part.
On the basis of technique scheme; The said global-worm illness feed addictive of preventing and treating comprises that also parts by weight are faenum graecum seed extract, dandelion extract or the Radix Platycodonis extract of 1-3 part, or parts by weight are the combination in any of faenum graecum seed extract, dandelion extract and the Radix Platycodonis extract of 1-3 part.
For realizing above-mentioned purpose, the present invention also provides another kind of employing the said feed of preventing and treating the global-worm illness feed addictive, comprises the constituent of following percentage by weight: said global-worm illness feed addictive 0.01-0.04% and the auxiliary material 99.96-99.99% of preventing and treating.
The invention provides a kind of global-worm illness feed addictive and preparation method thereof of preventing and treating, have the following advantages:
1, the present invention prevents and treats the immunocompetence that the global-worm illness feed addictive can improve animal body, effectively reduces the incidence of coccidiosis of livestock and poultry, reduces to culture and drops into, and has the effect of disease-prevention health;
2, the present invention prevents and treats the livestock and poultry animal that the global-worm illness feed addictive is applicable to each growth phase, because it derives from natural plants, therefore heavy metal free, chemicals etc. are residual in the livestock and poultry body, and can not develop immunity to drugs simultaneously;
3, it is reliable that the present invention prevents and treats the effect stability of global-worm illness feed addictive, can satisfy people to the animal products requirement of safe production;
4, the present invention prevents and treats the global-worm illness feed addictive and can also use as veterinary drug through improving its using dosage.
Through accompanying drawing and embodiment, technical scheme of the present invention is done further detailed description below.
Description of drawings
Fig. 1 is a kind of preparation method's flow chart of preventing and treating the global-worm illness feed addictive of the present invention;
Fig. 2 prevents and treats preparation method's flow chart of global-worm illness feed addictive for another kind of the present invention.
The specific embodiment
Fig. 1 is a kind of preparation method's flow chart of preventing and treating the global-worm illness feed addictive of the present invention, is specially:
Steps A 1, the quassia plant tissue after will cleaning and tea tree plant tissue be in temperature 50-60 ℃ of oven dry 2-3 hour down respectively;
Steps A 2, quassia plant tissue and tea tree plant tissue after will drying are crushed to 80-120 order fineness, obtain quassia crushed material and tea tree crushed material respectively;
Steps A 3, be that said quassia crushed material of 1-10 part and said tea tree crushed material that parts by weight are 1-10 part are mixed into crushed mixture, stirred 10-15 minute parts by weight.
In technique scheme; Before steps A 3, can also comprise: faenum graecum seed, dandelion or the balloonflower root after will cleaning was dried 2-3 hour down in temperature 50-60 ℃; Faenum graecum seed, dandelion or balloonflower powder after the oven dry are broken to 80-120 order fineness, obtain faenum graecum seed crushed material, dandelion crushed material or balloonflower powder and mince; After steps A 3, can also comprise: with said crushed mixture and parts by weight is that said faenum graecum seed crushed material, dandelion crushed material or the balloonflower powder of 1-3 part minces and mix and stirred 10-15 minute.
Further specify technical scheme of the present invention through specific embodiment below.
A kind of preparation method first embodiment that prevents and treats the global-worm illness feed addictive of the present invention
Steps A 101, the quassia plant tissue after will cleaning and tea tree plant tissue be in the oven dry 2.5 hours down of 55 ℃ of temperature respectively;
Steps A 102, quassia plant tissue and tea tree plant tissue after will drying are crushed to 100 order fineness, obtain quassia crushed material and tea tree crushed material respectively;
Steps A 103, be that the tea tree crushed material that 5 parts quassia crushed material and parts by weight are 5 parts mixes, stirred 12 minutes with mixer with parts by weight.
A kind of preparation method second embodiment that prevents and treats the global-worm illness feed addictive of the present invention
Steps A 201, quassia plant tissue, tea tree plant tissue and the faenum graecum seed after will cleaning be in the oven dry 3 hours down of 50 ℃ of temperature respectively;
Steps A 202, quassia plant tissue, tea tree plant tissue and faenum graecum seed after will drying are crushed to 80 order fineness, obtain quassia crushed material, tea tree crushed material and faenum graecum seed crushed material respectively;
Steps A 203, be that the faenum graecum seed crushed material that 1 part quassia crushed material, tea tree crushed material that parts by weight are 10 parts and parts by weight are 2 parts mixes, stirred 10 minutes with mixer with parts by weight.
In the present embodiment, the faenum graecum seed can also be dandelion or balloonflower root, and dandelion or balloonflower root obtain the dandelion crushed material after dried, crushed or balloonflower powder minces, and mix with quassia crushed material and tea tree crushed material again; The parts by weight that dandelion crushed material or balloonflower powder mince can be 1-3 part.
A kind of preparation method the 3rd embodiment that prevents and treats the global-worm illness feed addictive of the present invention
Steps A 301, quassia plant tissue, tea tree plant tissue, faenum graecum seed and the dandelion after will cleaning be in the oven dry 2 hours down of 60 ℃ of temperature respectively;
Steps A 302, quassia plant tissue, tea tree plant tissue, faenum graecum seed and dandelion after will drying are crushed to 120 order fineness, obtain quassia crushed material, tea tree crushed material, faenum graecum seed crushed material and dandelion crushed material respectively;
Steps A 303, the dandelion crushed material that parts by weight are 10 parts quassia crushed material, tea tree crushed material that parts by weight are 1 part, parts by weight are 1 part faenum graecum seed crushed material and parts by weight are 2 parts mix, and stir 15 minutes with mixer.
In the present embodiment; Faenum graecum seed and dandelion can also be faenum graecum seed and balloonflower root or dandelion and balloonflower root; Faenum graecum seed and balloonflower root or dandelion and balloonflower root obtain faenum graecum seed crushed material after dried, crushed and balloonflower powder minces or dandelion crushed material and balloonflower powder mince, and mix with quassia crushed material and tea tree crushed material again; Faenum graecum seed crushed material and balloonflower powder mince, or the parts by weight that dandelion crushed material and balloonflower powder mince can be 1-3 part.
A kind of preparation method the 4th embodiment that prevents and treats the global-worm illness feed addictive of the present invention
Steps A 401, quassia plant tissue, tea tree plant tissue, faenum graecum seed, dandelion and the balloonflower root after will cleaning is in the oven dry 2.5 hours down of 55 ℃ of temperature respectively;
Steps A 402, quassia plant tissue, tea tree plant tissue, faenum graecum seed, dandelion and balloonflower powder after will drying are broken to 100 order fineness, obtain quassia crushed material, tea tree crushed material, faenum graecum seed crushed material, dandelion crushed material and balloonflower powder respectively and mince;
The mixing of mincing of steps A 403, the balloonflower powder that parts by weight are 5 parts quassia crushed material, tea tree crushed material that parts by weight are 5 parts, parts by weight are 1 part faenum graecum seed crushed material, dandelion crushed material that parts by weight are 1 part and parts by weight are 1 part was stirred 12 minutes with mixer.
In the present embodiment, the parts by weight that faenum graecum seed crushed material, dandelion crushed material and balloonflower powder mince can be 1-3 part.
A kind of global-worm illness feed addictive first embodiment that prevents and treats of the present invention
Preventing and treating the global-worm illness feed addictive comprises: parts by weight are the tea tree crushed material that 5 parts quassia crushed material and parts by weight are 5 parts.
A kind of global-worm illness feed addictive second embodiment that prevents and treats of the present invention
Preventing and treating the global-worm illness feed addictive comprises: parts by weight are the faenum graecum seed crushed material that 1 part quassia crushed material, tea tree crushed material that parts by weight are 10 parts and parts by weight are 2 parts.
In the present embodiment, faenum graecum seed crushed material can also mince for dandelion crushed material or balloonflower powder, and the parts by weight that dandelion crushed material or balloonflower powder mince can be 1-3 part.
A kind of global-worm illness feed addictive the 3rd embodiment that prevents and treats of the present invention
Preventing and treating the global-worm illness feed addictive comprises: the dandelion crushed material that faenum graecum seed crushed material that parts by weight are 10 parts quassia crushed material, tea tree crushed material that parts by weight are 1 part, parts by weight are 1 part and parts by weight are 2 parts.
In the present embodiment; Faenum graecum seed crushed material and dandelion crushed material can also mince for faenum graecum seed crushed material and balloonflower powder; Or dandelion crushed material and balloonflower powder mince, and faenum graecum seed crushed material and balloonflower powder mince, or the parts by weight that dandelion crushed material and balloonflower powder mince can be 1-3 part.
A kind of global-worm illness feed addictive the 4th embodiment that prevents and treats of the present invention
Preventing and treating the global-worm illness feed addictive comprises: the balloonflower powder that the faenum graecum seed crushed material that parts by weight are 5 parts quassia crushed material, tea tree crushed material that parts by weight are 5 parts, parts by weight are 1 part, the dandelion crushed material that parts by weight are 1 part and parts by weight are 1 part minces.
In the present embodiment, the parts by weight that faenum graecum seed crushed material, dandelion crushed material and balloonflower powder mince can be 1-3 part.
A kind of feed first embodiment of the present invention
Feed comprises the constituent of following percentage by weight: prevent and treat global-worm illness feed addictive 0.1% and auxiliary material 99.9%.The addition of promptly preventing and treating the global-worm illness feed addictive in 1 ton of feed is 1 kilogram.Feed can specifically comprise the constituent of following parts by weight: 0.05 part of quassia crushed material, 0.05 part of tea tree crushed material; 65 parts of corns, 1 part in inferior powder, 23 parts of dregs of beans, 3 parts of cotton dregs; 2 parts of corn protein powders, 1.5 parts of greases, 1.4 parts of hydrogen calcium, 1.5 parts of stone flours; 0.4 part of salt, 0.03 part of phytase, 0.3 part of lysine, 0.3 part of methionine; 0.13 part of Choline Chloride, 0.04 part of B B-complex pre-mixing agent, 0.3 part of composite trace element pre-mixing agent.
A kind of feed second embodiment of the present invention
Feed comprises the constituent of following percentage by weight: prevent and treat global-worm illness feed addictive 0.2% and auxiliary material 99.8%.The addition of promptly preventing and treating the global-worm illness feed addictive in 1 ton of feed is 2 kilograms.Feed can specifically comprise the constituent of following parts by weight: 0.09 part of quassia crushed material, 0.09 part of tea tree crushed material, 0.02 part of faenum graecum seed crushed material; 62 parts of corns, 2.6 parts in inferior powder, 23 parts of dregs of beans, 3 parts of cotton dregs; 3.6 parts of corn protein powders, 1.6 parts of greases, 1.3 parts of hydrogen calcium, 1.4 parts of stone flours; 0.35 part of salt, 0.025 part of phytase, 0.25 part of lysine, 0.25 part of methionine; 0.14 part of Choline Chloride, 0.035 part of B B-complex pre-mixing agent, 0.25 part of composite trace element pre-mixing agent.
In the concrete constituent of present embodiment, faenum graecum seed crushed material can also mince for dandelion crushed material or balloonflower powder.
A kind of feed the 3rd embodiment of the present invention
Feed comprises the constituent of following percentage by weight: prevent and treat global-worm illness feed addictive 0.3% and auxiliary material 99.7%.The addition of promptly preventing and treating the global-worm illness feed addictive in 1 ton of feed is 3 kilograms.Feed can specifically comprise the constituent of following parts by weight: 0.12 part of quassia crushed material, 0.12 part of tea tree crushed material, 0.02 part of faenum graecum seed crushed material, 0.04 part of dandelion crushed material; 58 parts of corns, 1.7 parts in inferior powder, 27 parts of dregs of beans, 7 parts of cotton dregs; 2 parts of corn protein powders, 1 part of grease, 1 part of hydrogen calcium, 1.2 parts of stone flours; 0.24 part of salt, 0.015 part of phytase, 0.14 part of lysine, 0.14 part of methionine; 0.1 part of Choline Chloride, 0.025 part of B B-complex pre-mixing agent, 0.14 part of composite trace element pre-mixing agent.
In the concrete constituent of present embodiment, faenum graecum seed crushed material and dandelion crushed material can also mince for faenum graecum seed crushed material and balloonflower powder, or dandelion crushed material and balloonflower powder mince.
A kind of feed the 4th embodiment of the present invention
Feed comprises the constituent of following percentage by weight: prevent and treat global-worm illness feed addictive 0.4% and auxiliary material 99.6%.The addition of promptly preventing and treating the global-worm illness feed addictive in 1 ton of feed is 4 kilograms.Feed can specifically comprise the constituent of following parts by weight: 0.15 part of quassia crushed material, and 0.16 part of tea tree crushed material, 0.03 part of faenum graecum seed crushed material, 0.03 part of dandelion crushed material, balloonflower powder mince 0.03 part; 55 parts of corns, 1 part in inferior powder, 30 parts of dregs of beans, 9 parts of cotton dregs; 1 part of corn protein powder, 0.5 part of grease, 0.8 part of hydrogen calcium, 1 part of stone flour; 0.3 part of salt, 0.01 part of phytase, 0.3 part of lysine, 0.3 part of methionine; 0.07 part of Choline Chloride, 0.02 part of B B-complex pre-mixing agent, 0.3 part of composite trace element pre-mixing agent.
A kind of application that prevents and treats the global-worm illness feed addictive as veterinary drug.Wherein, prevent and treat the global-worm illness feed addictive and can comprise that parts by weight are quassia crushed material of 1-10 part and the tea tree crushed material that parts by weight are 1-10 part; Can also comprise that parts by weight are that faenum graecum seed crushed material, dandelion crushed material or the balloonflower powder that the quassia crushed material of 1-10 part, tea tree crushed material that parts by weight are 1-10 part and parts by weight are 1-3 part minces; Can also comprise that parts by weight are the quassia crushed material of 1-10 part, tea tree crushed material that parts by weight are 1-10 part and the parts by weight faenum graecum seed crushed material and dandelion crushed material, the faenum graecum seed crushed material that are 1-3 part and balloonflower powder minces or dandelion crushed material and balloonflower powder mince; Can also comprise that parts by weight are that faenum graecum seed crushed material, dandelion crushed material and the balloonflower powder that the quassia crushed material of 1-10 part, tea tree crushed material that parts by weight are 1-10 part and parts by weight are 1-3 part minces.
Taken place at livestock and poultry animal under the situation of global-worm illness, can the above-mentioned use amount raising 5-10 that prevents and treats the global-worm illness feed addictive extraordinarily have been gone into feed and be used as the veterinary drug use, can play therapeutic action.
Fig. 2 prevents and treats preparation method's flow chart of global-worm illness feed addictive for another kind of the present invention, is specially:
Step B1, quassia plant tissue and the tea tree plant tissue after will cleaning is cut into 1-2cm respectively
2Fragment;
It is that 95% alcohol reflux extracts 2-3 time that step B2, the quassia plant tissue after will shredding use mass fraction; The each extraction 45-60 minute; Merging the quassia extract, is to concentrate under the 0.05-0.08Mpa at pressure, and the quassia extract after concentrating was descended dry 2-3 hour in temperature 50-60 ℃; Be crushed to 100-200 order fineness again, obtain Ramulus et Folium Picrasmae; Use the distillation range to be temperature 105-140 ℃ steam distillation extraction tea tree extract the tea tree plant tissue after the chopping;
Step B3, be that said Ramulus et Folium Picrasmae of 1-10 part and said tea tree extract that parts by weight are 1-10 part fully are mixed into the extraction mixture with parts by weight, the coefficient of variation that makes its uniformity is less than 0.05.
In technique scheme, before step B3, can also comprise: the faenum graecum seed after will cleaning uses mass fraction to soak ultrasonic Extraction 2-3 time 10-14 hour as the methanol solution of 70-80%; The each extraction 1 hour merges faenum graecum seed extract, is to concentrate under the 0.05-0.08Mpa at pressure; Faenum graecum seed extract after concentrating is used the 0.45Bm membrane filtration; Filter residue in temperature 50-60 ℃ time dry 2-3 hour, is crushed to 100-200 order fineness again, obtains the faenum graecum seed extract; Dandelion after maybe will cleaning is cut into 1-2cm
2Fragment; It is that 60% alcohol reflux extracts 2-3 time that dandelion after the chopping is used mass fraction, extracts merging dandelion extract 45-60 minute at every turn; At pressure is to concentrate under the 0.05-0.10Mpa; Dandelion extract after concentrating in temperature 50-60 ℃ time dry 2-3 hour, is crushed to 100-200 order fineness again, obtains dandelion extract; Balloonflower root after maybe will cleaning is cut into 1-2cm
2Fragment; It is that 70% alcohol reflux extracts 3-4 time that balloonflower root after the chopping is used mass fraction, extracts merging balloonflower root extract 1 hour at every turn; At pressure is to concentrate under the 0.06-0.12Mpa; Balloonflower root extract after concentrating in temperature 50-60 ℃ time dry 2-3 hour, is crushed to 100-200 order fineness again, obtains Radix Platycodonis extract; After step B3, can also comprise: with said extraction mixture and parts by weight is that said faenum graecum seed extract, dandelion extract or the Radix Platycodonis extract of 1-3 part mixes, and the coefficient of variation that makes its uniformity is less than 0.05.
Further specify technical scheme of the present invention through specific embodiment below.
Another kind of the present invention is prevented and treated preparation method first embodiment of global-worm illness feed addictive
Step B101, quassia plant tissue and the tea tree plant tissue after will cleaning is cut into 1.5cm respectively
2Fragment;
It is that 95% alcohol reflux extracts 2 times that step B102, the quassia plant tissue after will shredding use mass fraction; The each extraction 50 minutes; Merging the quassia extract, is to concentrate 0.07Mpa under at pressure, with the quassia extract after concentrating in 55 ℃ of temperature drying 2.5 hours down; Be crushed to 150 order fineness again, obtain Ramulus et Folium Picrasmae; Tea tree plant tissue after the chopping is used the steam distillation extraction tea tree extract of distillation range as 120 ℃ of temperature;
Step B103, be that the tea tree extract that 5 parts Ramulus et Folium Picrasmae and parts by weight are 5 parts fully is mixed into the extraction mixture with parts by weight, the coefficient of variation that makes its uniformity is less than 0.05.
Another kind of the present invention is prevented and treated preparation method second embodiment of global-worm illness feed addictive
Step B201, quassia plant tissue and the tea tree plant tissue after will cleaning is cut into 1cm respectively
2Fragment, clean up the faenum graecum seed subsequent use;
It is that 95% alcohol reflux extracts 2 times that step B202, the quassia plant tissue after will shredding use mass fraction; The each extraction 60 minutes; Merging the quassia extract, is to concentrate 0.05Mpa under at pressure, with the quassia extract after concentrating in 50 ℃ of temperature drying 3 hours down; Be crushed to 100 order fineness again, obtain Ramulus et Folium Picrasmae; Tea tree plant tissue after the chopping is used the steam distillation extraction tea tree extract of distillation range as 105 ℃ of temperature; It is that 70% methanol solution soaked 10 hours that faenum graecum seed after cleaning is used mass fraction, and ultrasonic Extraction 2 times was extracted 1 hour at every turn; Merge faenum graecum seed extract; At pressure is to concentrate under the 0.05Mpa, and the faenum graecum seed extract after concentrating is used the 0.45Bm membrane filtration, and filter residue is following dry 3 hours in 50 ℃ of temperature; Be crushed to 100 order fineness again, obtain the faenum graecum seed extract;
Step B203, be that the faenum graecum seed extract that 1 part Ramulus et Folium Picrasmae, tea tree extract that parts by weight are 10 parts and parts by weight are 2 parts fully is mixed into the extraction mixture with parts by weight, the coefficient of variation that makes its uniformity is less than 0.05.
In the present embodiment, the faenum graecum seed can also be dandelion or balloonflower root, and dandelion or balloonflower root obtain dandelion extract or Radix Platycodonis extract after extracting, mix with Ramulus et Folium Picrasmae and tea tree extract again; The parts by weight of dandelion extract or Radix Platycodonis extract can be 1-3 part.
Another kind of the present invention is prevented and treated preparation method the 3rd embodiment of global-worm illness feed addictive
Step B301, quassia plant tissue, tea tree plant tissue and the dandelion after will cleaning is cut into 2cm respectively
2Fragment, clean up the faenum graecum seed subsequent use;
It is that 95% alcohol reflux extracts 3 times that step B302, the quassia plant tissue after will shredding use mass fraction; The each extraction 45 minutes; Merging the quassia extract, is to concentrate 0.08Mpa under at pressure, with the quassia extract after concentrating in 60 ℃ of temperature drying 2 hours down; Be crushed to 200 order fineness again, obtain Ramulus et Folium Picrasmae; Tea tree plant tissue after the chopping is used the steam distillation extraction tea tree extract of distillation range as 140 ℃ of temperature; It is that 80% methanol solution soaked 14 hours that faenum graecum seed after cleaning is used mass fraction, and ultrasonic Extraction 3 times was extracted 1 hour at every turn; Merge faenum graecum seed extract; At pressure is to concentrate under the 0.08Mpa, and the faenum graecum seed extract after concentrating is used the 0.45Bm membrane filtration, and filter residue is following dry 2 hours in 60 ℃ of temperature; Be crushed to 200 order fineness again, obtain the faenum graecum seed extract; It is that 60% alcohol reflux extracts 2 times that dandelion after the chopping is used mass fraction; The each extraction 60 minutes; Merging the dandelion extract, is to concentrate 0.05Mpa under at pressure, with the dandelion extract after concentrating in 50 ℃ of temperature drying 3 hours down; Be crushed to 100 order fineness again, obtain dandelion extract;
Step B303, the dandelion extract that parts by weight are 10 parts Ramulus et Folium Picrasmae, tea tree extract that parts by weight are 1 part, parts by weight are 1 part faenum graecum seed extract and parts by weight are 2 parts fully are mixed into the extraction mixture, and the coefficient of variation that makes its uniformity is less than 0.05.
In the present embodiment; Faenum graecum seed and dandelion can also be faenum graecum seed and balloonflower root or dandelion and balloonflower root; Faenum graecum seed and balloonflower root or dandelion and balloonflower root obtain faenum graecum seed extract and Radix Platycodonis extract or dandelion extract and Radix Platycodonis extract after extracting, mix with Ramulus et Folium Picrasmae and tea tree extract again; Faenum graecum seed extract and Radix Platycodonis extract, or the parts by weight of dandelion extract and Radix Platycodonis extract can be 1-3 part.
Another kind of the present invention is prevented and treated preparation method the 4th embodiment of global-worm illness feed addictive
Step B401, quassia plant tissue, tea tree plant tissue, dandelion and the balloonflower root after will cleaning is cut into 1.5cm respectively
2Fragment, clean up the faenum graecum seed subsequent use;
It is that 95% alcohol reflux extracts 2 times that step B402, the quassia plant tissue after will shredding use mass fraction; The each extraction 50 minutes; Merging the quassia extract, is to concentrate 0.07Mpa under at pressure, with the quassia extract after concentrating in 55 ℃ of temperature drying 2.5 hours down; Be crushed to 150 order fineness again, obtain Ramulus et Folium Picrasmae; Tea tree plant tissue after the chopping is used the steam distillation extraction tea tree extract of distillation range as 120 ℃ of temperature; It is that 75% methanol solution soaked 12 hours that faenum graecum seed after cleaning is used mass fraction, and ultrasonic Extraction 2 times was extracted 1 hour at every turn; Merge faenum graecum seed extract; At pressure is to concentrate under the 0.07Mpa, and the faenum graecum seed extract after concentrating is used the 0.45Bm membrane filtration, and filter residue is following dry 2.5 hours in 55 ℃ of temperature; Be crushed to 150 order fineness again, obtain the faenum graecum seed extract; It is that 60% alcohol reflux extracts 3 times that dandelion after the chopping is used mass fraction; The each extraction 50 minutes; Merging the dandelion extract, is to concentrate 0.08Mpa under at pressure, with the dandelion extract after concentrating in 55 ℃ of temperature drying 2.5 hours down; Be crushed to 150 order fineness again, obtain dandelion extract; It is that 70% alcohol reflux extracts 3 times that balloonflower root after the chopping is used mass fraction, extracts 1 hour at every turn, merges the balloonflower root extract; At pressure is to concentrate under the 0.09Mpa; Balloonflower root extract after concentrating was descended dry 2.5 hours in 55 ℃ of temperature, be crushed to 150 order fineness again, obtain Radix Platycodonis extract;
Step B403, the Radix Platycodonis extract that parts by weight are 5 parts Ramulus et Folium Picrasmae, tea tree extract that parts by weight are 5 parts, parts by weight are 1 part faenum graecum seed extract, dandelion extract that parts by weight are 1 part and parts by weight are 1 part fully are mixed into the extraction mixture, and the coefficient of variation that makes its uniformity is less than 0.05.
In the present embodiment, the parts by weight of faenum graecum seed extract, dandelion extract and Radix Platycodonis extract can be 1-3 part.
Another kind of the present invention is prevented and treated global-worm illness feed addictive first embodiment
Preventing and treating the global-worm illness feed addictive comprises: parts by weight are the tea tree extract that 5 parts Ramulus et Folium Picrasmae and parts by weight are 5 parts.
Another kind of the present invention is prevented and treated global-worm illness feed addictive second embodiment
Preventing and treating the global-worm illness feed addictive comprises: parts by weight are the faenum graecum seed extract that 1 part Ramulus et Folium Picrasmae, tea tree extract that parts by weight are 10 parts and parts by weight are 2 parts.
In the present embodiment, the faenum graecum seed extract can also be dandelion extract or Radix Platycodonis extract, and the parts by weight of dandelion extract or Radix Platycodonis extract can be 1-3 part.
Another kind of the present invention is prevented and treated global-worm illness feed addictive the 3rd embodiment
Preventing and treating the global-worm illness feed addictive comprises: the dandelion extract that faenum graecum seed extract that parts by weight are 10 parts Ramulus et Folium Picrasmae, tea tree extract that parts by weight are 1 part, parts by weight are 1 part and parts by weight are 2 parts.
In the present embodiment; Faenum graecum seed extract and dandelion extract can also be faenum graecum seed extract and Radix Platycodonis extract; Or dandelion extract and Radix Platycodonis extract, faenum graecum seed extract and Radix Platycodonis extract, or the parts by weight of dandelion extract and Radix Platycodonis extract can be 1-3 part.
Another kind of the present invention is prevented and treated global-worm illness feed addictive the 4th embodiment
Preventing and treating the global-worm illness feed addictive comprises: the Radix Platycodonis extract that the faenum graecum seed extract that parts by weight are 5 parts Ramulus et Folium Picrasmae, tea tree extract that parts by weight are 5 parts, parts by weight are 1 part, the dandelion extract that parts by weight are 1 part and parts by weight are 1 part.
In the present embodiment, the parts by weight of faenum graecum seed extract, dandelion extract and Radix Platycodonis extract can be 1-3 part.
Another kind of feed first embodiment of the present invention
Feed comprises the constituent of following percentage by weight: prevent and treat global-worm illness feed addictive 0.01% and auxiliary material 99.99%.The addition of promptly preventing and treating the global-worm illness feed addictive in 1 ton of feed is 100 grams.Feed can specifically comprise the constituent of following parts by weight: 0.005 part of Ramulus et Folium Picrasmae, 0.005 part of tea tree extract; 65 parts of corns, 1 part in inferior powder, 23 parts of dregs of beans, 3 parts of cotton dregs; 2 parts of corn protein powders, 1.6 parts of greases, 1.4 parts of hydrogen calcium, 1.5 parts of stone flours; 0.4 part of salt, 0.03 part of phytase, 0.3 part of lysine, 0.3 part of methionine; 0.12 part of Choline Chloride, 0.04 part of B B-complex pre-mixing agent, 0.3 part of composite trace element pre-mixing agent.
Another kind of feed second embodiment of the present invention
Feed comprises the constituent of following percentage by weight: prevent and treat global-worm illness feed addictive 0.02% and auxiliary material 99.98%.The addition of promptly preventing and treating the global-worm illness feed addictive in 1 ton of feed is 200 grams.Feed can specifically comprise the constituent of following parts by weight: 0.009 part of Ramulus et Folium Picrasmae, 0.009 part of tea tree extract, 0.002 part of faenum graecum seed extract; 62 parts of corns, 2.7 parts in inferior powder, 23 parts of dregs of beans, 3 parts of cotton dregs; 3.7 parts of corn protein powders, 1.6 parts of greases, 1.3 parts of hydrogen calcium, 1.4 parts of stone flours; 0.34 part of salt, 0.025 part of phytase, 0.25 part of lysine, 0.25 part of methionine; 0.14 part of Choline Chloride, 0.035 part of B B-complex pre-mixing agent, 0.24 part of composite trace element pre-mixing agent.
In the concrete constituent of present embodiment, the faenum graecum seed extract can also be dandelion extract or Radix Platycodonis extract,
Another kind of feed the 3rd embodiment of the present invention
Feed comprises the constituent of following percentage by weight: prevent and treat global-worm illness feed addictive 0.03% and auxiliary material 99.97%.The addition of promptly preventing and treating the global-worm illness feed addictive in 1 ton of feed is 300 grams.Feed can specifically comprise the constituent of following parts by weight: 0.012 part of Ramulus et Folium Picrasmae, 0.012 part of tea tree extract, 0.002 part of faenum graecum seed extract, 0.004 part of dandelion extract; 58 parts of corns, 1.8 parts in inferior powder, 27 parts of dregs of beans, 7 parts of cotton dregs; 2.2 parts of corn protein powders, 1 part of grease, 1 part of hydrogen calcium, 1.2 parts of stone flours; 0.24 part of salt, 0.015 part of phytase, 0.13 part of lysine, 0.13 part of methionine; 0.1 part of Choline Chloride, 0.025 part of B B-complex pre-mixing agent, 0.13 part of composite trace element pre-mixing agent.
In the concrete constituent of present embodiment, faenum graecum seed extract and dandelion extract can also be faenum graecum seed extract and Radix Platycodonis extract, or dandelion extract and Radix Platycodonis extract.
Another kind of feed the 4th embodiment of the present invention
Feed comprises the constituent of following percentage by weight: prevent and treat global-worm illness feed addictive 0.04% and auxiliary material 99.96%.The addition of promptly preventing and treating the global-worm illness feed addictive in 1 ton of feed is 400 grams.Feed can specifically comprise the constituent of following parts by weight: 0.014 part of Ramulus et Folium Picrasmae, 0.014 part of tea tree extract, 0.04 part of faenum graecum seed extract, 0.04 part of dandelion extract, 0.04 part of Radix Platycodonis extract; 55 parts of corns, 1.1 parts in inferior powder, 30 parts of dregs of beans, 9 parts of cotton dregs; 1 part of corn protein powder, 0.6 part of grease, 0.9 part of hydrogen calcium, 1.1 parts of stone flours; 0.3 part of salt, 0.01 part of phytase, 0.3 part of lysine, 0.3 part of methionine; 0.05 part of Choline Chloride, 0.02 part of B B-complex pre-mixing agent, 0.28 part of composite trace element pre-mixing agent.
Another kind is prevented and treated the application of global-worm illness feed addictive as veterinary drug.Wherein, prevent and treat the global-worm illness feed addictive and can comprise that parts by weight are that the Ramulus et Folium Picrasmae and parts by weight of 1-10 part are the tea tree extract of 1-10 part; Can also comprise that parts by weight are faenum graecum seed extract, dandelion extract or the Radix Platycodonis extract that the Ramulus et Folium Picrasmae of 1-10 part, tea tree extract that parts by weight are 1-10 part and parts by weight are 1-3 part; Can also comprise that parts by weight are faenum graecum seed extract and dandelion extract, faenum graecum seed extract and Radix Platycodonis extract or dandelion extract and the Radix Platycodonis extract that the Ramulus et Folium Picrasmae of 1-10 part, tea tree extract that parts by weight are 1-10 part and parts by weight are 1-3 part; Can also comprise that parts by weight are faenum graecum seed extract, dandelion extract and the Radix Platycodonis extract that the Ramulus et Folium Picrasmae of 1-10 part, tea tree extract that parts by weight are 1-10 part and parts by weight are 1-3 part.
Taken place at livestock and poultry animal under the situation of global-worm illness, can above-mentioned use amount of preventing and treating the global-worm illness feed addictive have been improved 5-10 and extraordinarily go into feed, be used as veterinary drug and use, can play therapeutic action.
Prevent and treat prevention and the result of treatment of global-worm illness feed addictive through concrete experimental evaluation different component below to global-worm illness.
Instance 1, prevent and treat the effect assessment experiment of global-worm illness feed addictive prevention global-worm illness
One, materials and methods
1, experiment material
The Eimeria tenella egg capsule is provided by Institute of Animal Husbandry, China Academy of Agriculture Scinces, be stored in 4 ℃ subsequent use.Before infecting with centrifugal washing with the potassium bichromate flush away in the egg capsule suspension, with the fresh tap water dilution, directly use the drinking method artificial challenge then by prescribed dose.
2, animal used as test and grouping
Select healthy meat chick 540 plumages (providing) of 1 age in days by laboratory of Institute of Animal Husbandry, China Academy of Agriculture Scinces; Under the non-ball worm condition, raise to 14 ages in days; Be divided into 18 groups then at random, every group 30 plumage, each basal diet of organizing chicken is identical; Institute is different: the interpolation of 1-16 group prevents and treats the global-worm illness feed addictive, and each group of 1-16 group is added the constituent of preventing and treating the global-worm illness feed addictive and is: 1 group is (quassia and tea tree) crushed material; 2 groups is (quassia, tea tree and dandelion) crushed material; 3 groups is (quassia, tea tree and balloonflower root) crushed material; 4 groups is (quassia, tea tree and faenum graecum seed) crushed material; 5 groups is (quassia, tea tree, dandelion and balloonflower root) crushed material; 6 groups is (quassia, tea tree, dandelion and faenum graecum seed) crushed material; 7 groups is (quassia, tea tree, balloonflower root and faenum graecum seed) crushed material; 8 groups is (quassia, tea tree, dandelion, balloonflower root and faenum graecum seed) crushed material; 9 groups is (quassia and tea tree) extract; 10 groups is (quassia, tea tree and dandelion) extract; 11 groups is (quassia, tea tree and balloonflower root) extract; 12 groups is (quassia, tea tree and faenum graecum seed) extract; 13 groups is (quassia, tea tree, dandelion and balloonflower root) extract; 14 groups is (quassia, tea tree, dandelion and faenum graecum seed) extract; 15 groups is (quassia, tea tree, balloonflower root and faenum graecum seed) extract; 16 groups is (quassia, tea tree, dandelion, balloonflower root and faenum graecum seed) extract.The addition of 1-8 group is 3000 gram/tons, and the addition that 9-16 organizes is 400 gram/tons, and 17,18 liang of groups are not added and prevented and treated the global-worm illness feed addictive.Raise after 7 days, during 21 ages in days, weigh, with 18 groups be the normal healthy controls group, 1-17 group infects Eimeria tenella egg capsule, a peroral infection 5 * 10 respectively
4Egg capsule/chicken.Experimental session is observed every day and the indexs such as incidence, death toll and bloody stool of record chicken change, and in infecting the back the 7th day, each component another name is weighed, slaughters, cuts open and look into caecum, writes down blind solarization pathology and weightening finish, after caecum homogenate, and egg sac number in the counting caecum.
Two, result and analysis
1, the bloody stool situation of each group of experimental session
Judgment criteria:
Respectively one day the most serious before death bloody stool of each group test chicken is kept the score.The average bloody stool of this day every chicken heap number is the 1-3.9 heap, then is designated as the 1-3.9 branch respectively, and 4 heaps and above count 4 fens do not have be designated as 0 fen of bloody stool always.The experimental result of bloody stool is as shown in table 1.
Table 1. is respectively organized the situation of keeping the score of bloody stool
| Group | The 4th day | The 5th day | The 6th day | On average |
| 1 group | 0.30 | 1.00 | 0.30 | 0.53 |
| 2 groups | 0.40 | 1.50 | 0.20 | 0.70 |
| 3 groups | 0.20 | 1.10 | 0.30 | 0.50 |
| 4 groups | 0.30 | 0.80 | 0.30 | 0.46 |
| 5 groups | 0.30 | 1.00 | 0.40 | 0.57 |
| 6 groups | 0.50 | 1.10 | 0.50 | 0.70 |
| 7 groups | 0.40 | 1.10 | 0.50 | 0.67 |
| 8 groups | 0.20 | 0.90 | 0.30 | 0.47 |
| 9 groups | 0.30 | 1.10 | 0.30 | 0.57 |
| 10 groups | 0.30 | 1.00 | 0.40 | 0.57 |
| 11 groups | 0.40 | 0.90 | 0.30 | 0.50 |
| 12 groups | 0.30 | 0.80 | 0.20 | 0.43 |
| 13 groups | 0.50 | 1.00 | 0.30 | 0.60 |
| 14 groups | 0.40 | 1.10 | 0.30 | 0.60 |
| 15 groups | 0.40 | 1.20 | 0.20 | 0.60 |
| 16 groups | 0.30 | 1.30 | 0.40 | 0.67 |
| 17 groups | 0.70 | 2.20 | 0.70 | 1.13 |
| 18 groups | 0.00 | 0.00 | 0.00 | 0.00 |
Experimental result in the above-mentioned table 1 shows, prevents and treats the global-worm illness feed addictive and has remarkable result to alleviating bloody stool.
2, anticoccidial index evaluation
The relative weight gain rate=experimental group rate of body weight gain/health group rate of body weight gain * 100%;
Survival rate=chicken number/30 * 100% when every group of experiment finishes;
Average pathology value=every group of lesion score sum/every group of chicken number;
The pathology standards of grading: caecum is normal, no egg capsule, 0 minute; Egg capsule is arranged, and cecum mucosa thickens, and the hemorrhage or a small amount of intestines core of being dispersed in property is on a small quantity arranged, 1 minute; Egg capsule is arranged, and cecum mucosa thickens, and obvious blood or blood content are arranged, 2 minutes; Egg capsule is arranged, and cecum mucosa thickens, and a large amount of blood clots or blood sample intestines core is arranged, 3 minutes; There is egg capsule outward appearance caecum to be dark reddish brown, obviously enlargement, content blood sample, 4 minutes; Dead because of coccidium infection, also remember 4 fens, and it is average to make full group.
Anticoccidial index (ACI)=(survival rate+the relative weight gain rate)-(pathology value+egg capsule value)
The experimental result of preventing and treating the global-worm illness effect is as shown in table 2.
Each group of table 2. is prevented and treated the result of global-worm illness
| Group | The relative weight gain rate (%) | Survival rate (%) | The pathology value | The egg capsule value | ACI |
| 1 group | 103.30 | 100.00 | 15.30 | 30.00 | 157.70 |
| 2 groups | 102.10 | 100.00 | 13.10 | 29.20 | 159.90 |
| 3 groups | 104.40 | 96.70 | 13.20 | 31.30 | 156.60 |
| 4 groups | 102.50 | 100.00 | 14.40 | 28.40 | 159.70 |
| 5 groups | 103.50 | 100.00 | 12.50 | 31.20 | 159.80 |
| 6 groups | 105.70 | 100.00 | 14.30 | 24.40 | 167.00 |
| 7 groups | 104.10 | 96.70 | 15.60 | 28.50 | 156.70 |
| 8 groups | 107.30 | 100.00 | 16.70 | 27.60 | 163.00 |
| 9 groups | 101.80 | 100.00 | 14.80 | 31.30 | 155.70 |
| 10 groups | 101.60 | 96.70 | 11.60 | 32.40 | 154.30 |
| 11 groups | 104.50 | 100.00 | 13.40 | 27.50 | 163.60 |
| 12 groups | 105.40 | 100.00 | 12.20 | 31.20 | 161.10 |
| 13 groups | 103.20 | 100.00 | 14.50 | 30.30 | 158.40 |
| 14 groups | 102.30 | 96.70 | 15.70 | 31.40 | 151.90 |
| 15 groups | 105.30 | 100.00 | 16.30 | 28.50 | 160.50 |
| 16 groups | 106.20 | 100.00 | 12.60 | 29.80 | 163.80 |
| 17 groups | 89.70 | 86.20 | 20.50 | 40.00 | 115.40 |
| 18 groups | 100.00 | 100.00 | 0.00 | 0.00 | 200.00 |
Experimental result from table 2 can be found out, prevents and treats the global-worm illness feed addictive and has higher anticoccidial index, promptly has and significantly prevents and treats the global-worm illness effect; Prevent and treat the global-worm illness feed addictive simultaneously and can improve the relative weight gain rate and guarantee survival rate, show the production performance that it can promote chicken.
Instance 2, prevent and treat the effect assessment experiment of global-worm illness feed addictive treatment global-worm illness
One, materials and methods
1, selects morbidity chicken crowd
The chicken crowd who selects the disease chicken to account for about 5% is the experimental chicken crowd, and clinical manifestation is a lassitude, and feather is disorderly loose, and two wings are sagging, long-pending heap, and defecating is thickness meat shape, the bloody stool stench is unpleasant, lacks and eats or do not eat.Through 30 sick chickens are cutd open inspection, caecum changes obviously, intestines wall thickening, hyperemia, hemorrhage, and intestinal contents is yellow bean curd slag specimen, is mixed with blood.During the intestinal contents microscopy, find the coccidia capsule.According to clinical symptoms, pathological change and microscopy egg capsule, comprehensive diagnos are chicken caecum type global-worm illness.
2, experimental technique
Selected chicken crowd is divided into 17 groups at random, and the interpolation of 1-16 group prevents and treats the global-worm illness feed addictive, and each group of 1-16 group is added the constituent of preventing and treating the global-worm illness feed addictive and is: 1 group is (quassia and tea tree) crushed material; 2 groups is (quassia, tea tree and dandelion) crushed material; 3 groups is (quassia, tea tree and balloonflower root) crushed material; 4 groups is (quassia, tea tree and faenum graecum seed) crushed material; 5 groups is (quassia, tea tree, dandelion and balloonflower root) crushed material; 6 groups is (quassia, tea tree, dandelion and faenum graecum seed) crushed material; 7 groups is (quassia, tea tree, balloonflower root and faenum graecum seed) crushed material; 8 groups is (quassia, tea tree, dandelion, balloonflower root and faenum graecum seed) crushed material; 9 groups is (quassia and tea tree) extract; 10 groups is (quassia, tea tree and dandelion) extract; 11 groups is (quassia, tea tree and balloonflower root) extract; 12 groups is (quassia, tea tree and faenum graecum seed) extract; 13 groups is (quassia, tea tree, dandelion and balloonflower root) extract; 14 groups is (quassia, tea tree, dandelion and faenum graecum seed) extract; 15 groups is (quassia, tea tree, balloonflower root and faenum graecum seed) extract; 16 groups is (quassia, tea tree, dandelion, balloonflower root and faenum graecum seed) extract.The addition of 1-8 group is 20 kg/ton, and the addition of 9-16 group is 3 kg/ton, and 17 groups is contrast, does not add and prevents and treats the global-worm illness feed addictive.To indivedual serious sick chickens, to isolate separately, manual work is filled out and is fed; With 4 days was a course of treatment.
3, result of treatment
The experimental result of treatment global-worm illness effect is as shown in table 3.
The result of each group treatment global-worm illness of table 3.
| Group | Cure rate (%) |
| 1 group | 85.30 |
| 2 groups | 87.10 |
| 3 groups | 86.40 |
| 4 groups | 88.50 |
| 5 groups | 85.50 |
| 6 groups | 85.70 |
| 7 groups | 89.10 |
| 8 groups | 90.30 |
| 9 groups | 87.80 |
| 10 groups | 86.60 |
| 11 groups | 88.50 |
| 12 groups | 87.40 |
| 13 groups | 86.20 |
| 14 groups | 88.30 |
| 15 groups | 86.30 |
| 16 groups | 91.20 |
| 17 groups | 0.00 |
Shown in table 3 result, prevent and treat the global-worm illness feed addictive for treating the evident in efficacy of global-worm illness: the diarrhea of medication sick chicken after 1 day alleviates, and bloody stool reduces; The spirit of medication sick chicken after 2 days is clearly better, and diet heightens; Diarrhea of medication sick chicken after 3 days and bloody stool disappear; Medication is sick chicken rehabilitation after 4 days.The total effective rate of preventing and treating global-worm illness feed addictive treatment global-worm illness can reach more than 85%.
The present invention prevents and treats the immunocompetence that the global-worm illness feed addictive can improve animal body, effectively reduces the incidence of coccidiosis of livestock and poultry, reduces to culture and drops into, and has the effect of disease-prevention health; Be applicable to the livestock and poultry animal of each growth phase, because it derives from natural plants, therefore heavy metal free, chemicals etc. are residual in the livestock and poultry body, and can not develop immunity to drugs simultaneously; Effect stability is reliable, can satisfy people to the animal products requirement of safe production; Can also use as veterinary drug through improving its using dosage.
It should be noted last that; Above embodiment is only unrestricted in order to technical scheme of the present invention to be described; Although the present invention is specified with reference to preferred embodiment; Those of ordinary skill in the art should be appreciated that and can make amendment or be equal to replacement technical scheme of the present invention, and do not break away from the spirit and the scope of technical scheme of the present invention.
Claims (10)
1. a preparation method who prevents and treats the global-worm illness feed addictive is characterized in that, comprising:
Step 1, the quassia plant tissue after will cleaning and tea tree plant tissue be in temperature 50-60 ℃ of oven dry 2-3 hour down respectively;
Step 2, quassia plant tissue and tea tree plant tissue after will drying are crushed to 80-120 order fineness, obtain quassia crushed material and tea tree crushed material respectively;
Step 3, be that said quassia crushed material of 1-10 part and said tea tree crushed material that parts by weight are 1-10 part are mixed into crushed mixture, stirred 10-15 minute parts by weight.
2. the preparation method who prevents and treats the global-worm illness feed addictive according to claim 1; It is characterized in that; Before step 3, also comprise: faenum graecum seed, dandelion or the balloonflower root after will cleaning was dried 2-3 hour down in temperature 50-60 ℃; Faenum graecum seed, dandelion or balloonflower powder after the oven dry are broken to 80-120 order fineness, obtain faenum graecum seed crushed material, dandelion crushed material or balloonflower powder and mince; After step 3, also comprise: with said crushed mixture and parts by weight is that said faenum graecum seed crushed material, dandelion crushed material or the balloonflower powder of 1-3 part minces and mix and stirred 10-15 minute.
3. prevent and treat the global-worm illness feed addictive for one kind, it is characterized in that, comprising: parts by weight are quassia crushed material of 1-10 part and the tea tree crushed material that parts by weight are 1-10 part.
4. the global-worm illness feed addictive of preventing and treating according to claim 3; It is characterized in that; Comprise that also parts by weight are that faenum graecum seed crushed material, dandelion crushed material or the balloonflower powder of 1-3 part minces, or said parts by weight are the combination in any that faenum graecum seed crushed material, dandelion crushed material and the balloonflower powder of 1-3 part minces.
5. one kind is adopted claim 3 or the 4 said feeds of preventing and treating the global-worm illness feed addictive, it is characterized in that, comprises the constituent of following percentage by weight: said global-worm illness feed addictive 0.1-0.4% and the auxiliary material 99.6-99.9% of preventing and treating.
6. a preparation method who prevents and treats the global-worm illness feed addictive is characterized in that, comprising:
Step 1, quassia plant tissue and the tea tree plant tissue after will cleaning is cut into 1-2cm respectively
2Fragment;
It is that 95% alcohol reflux extracts 2-3 time that step 2, the quassia plant tissue after will shredding use mass fraction; The each extraction 45-60 minute; Merging the quassia extract, is to concentrate under the 0.05-0.08Mpa at pressure, and the quassia extract after concentrating was descended dry 2-3 hour in temperature 50-60 ℃; Be crushed to 100-200 order fineness again, obtain Ramulus et Folium Picrasmae; Use the distillation range to be temperature 105-140 ℃ steam distillation extraction tea tree extract the tea tree plant tissue after the chopping;
Step 3, be that said Ramulus et Folium Picrasmae of 1-10 part and said tea tree extract that parts by weight are 1-10 part fully are mixed into the extraction mixture with parts by weight, the coefficient of variation that makes its uniformity is less than 0.05.
7. the preparation method who prevents and treats the global-worm illness feed addictive according to claim 6 is characterized in that, before step 3, also comprise: the dandelion after will cleaning is cut into 1-2cm
2Fragment; It is that 60% alcohol reflux extracts 2-3 time that dandelion after the chopping is used mass fraction, extracts merging dandelion extract 45-60 minute at every turn; At pressure is to concentrate under the 0.05-0.10Mpa; Dandelion extract after concentrating in temperature 50-60 ℃ time dry 2-3 hour, is crushed to 100-200 order fineness again, obtains dandelion extract; Balloonflower root after maybe will cleaning is cut into 1-2cm
2Fragment; It is that 70% alcohol reflux extracts 3-4 time that balloonflower root after the chopping is used mass fraction, extracts merging balloonflower root extract 1 hour at every turn; At pressure is to concentrate under the 0.06-0.12Mpa; Balloonflower root extract after concentrating in temperature 50-60 ℃ time dry 2-3 hour, is crushed to 100-200 order fineness again, obtains Radix Platycodonis extract; After step 3, also comprise: with said extraction mixture and parts by weight is that the said dandelion extract or the Radix Platycodonis extract of 1-3 part mixes, and the coefficient of variation that makes its uniformity is less than 0.05.
8. prevent and treat the global-worm illness feed addictive for one kind; It is characterized in that; Comprise: parts by weight are that the Ramulus et Folium Picrasmae and the parts by weight of 1-10 part are the tea tree extract of 1-10 part, and said Ramulus et Folium Picrasmae and said tea tree extract make according to the said method of claim 6 step 1-2.
9. the global-worm illness feed addictive of preventing and treating according to claim 8; It is characterized in that; Comprise that also parts by weight are the dandelion extract or the Radix Platycodonis extract of 1-3 part; Or parts by weight are the combination of the dandelion extract and the Radix Platycodonis extract of 1-3 part, and the preparation method of said dandelion extract comprises the dandelion after cleaning is cut into 1-2cm
2Fragment; It is that 60% alcohol reflux extracts 2-3 time that dandelion after the chopping is used mass fraction, extracts merging dandelion extract 45-60 minute at every turn; At pressure is to concentrate under 0.05-0.10Mpa; Dandelion extract after concentrating in temperature 50-60 ℃ time dry 2-3 hour, is crushed to 100-200 order fineness again, obtains dandelion extract; Balloonflower root after the preparation method of said Radix Platycodonis extract will clean is cut into 1-2cm
2Fragment; It is that 70% alcohol reflux extracts 3-4 time that balloonflower root after the chopping is used mass fraction, extracts merging balloonflower root extract 1 hour at every turn; At pressure is to concentrate under the 0.06-0.12Mpa; Balloonflower root extract after concentrating in temperature 50-60 ℃ time dry 2-3 hour, is crushed to 100-200 order fineness again, obtains Radix Platycodonis extract.
10. one kind is adopted claim 8 or the 9 said feeds of preventing and treating the global-worm illness feed addictive, it is characterized in that, comprises the constituent of following percentage by weight: said global-worm illness feed addictive 0.01-0.04% and the auxiliary material 99.96-99.99% of preventing and treating.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101186322A CN101653198B (en) | 2008-08-20 | 2008-08-20 | Feed additives for preventing and controlling coccidiosis and preparation methods thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101186322A CN101653198B (en) | 2008-08-20 | 2008-08-20 | Feed additives for preventing and controlling coccidiosis and preparation methods thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101653198A CN101653198A (en) | 2010-02-24 |
| CN101653198B true CN101653198B (en) | 2012-05-23 |
Family
ID=41707825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008101186322A Expired - Fee Related CN101653198B (en) | 2008-08-20 | 2008-08-20 | Feed additives for preventing and controlling coccidiosis and preparation methods thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101653198B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105029104A (en) * | 2015-08-28 | 2015-11-11 | 青岛大信饲料有限公司 | Feed specially used for strengthening growing and fattening pigs |
| CN106036132A (en) * | 2016-05-30 | 2016-10-26 | 青岛海之源智能技术有限公司 | Feed additive capable of preventing and treating coccidiosis of minks and preparation method of feed additive |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1328832A (en) * | 2000-06-19 | 2002-01-02 | 张世贵 | Preparation method of fowl and livestock medicine Qiuchongqing |
| CN1589847A (en) * | 2003-09-03 | 2005-03-09 | 中国农业科学院上海家畜寄生虫病研究所 | Traditional Chinese medicine compound preparation for preventing and treating coccidiosis |
| DE10337179A1 (en) * | 2003-08-13 | 2005-03-24 | Bönnighaus, Dieter | Composition for treating trichomoniasis and coccidiosis in birds and poultry comprises brewer's yeast, oil and propolis |
| CN1658765A (en) * | 2001-12-26 | 2005-08-24 | 植物合成公司 | Food supplement for animals |
| CN101129673A (en) * | 2007-08-17 | 2008-02-27 | 李培英 | Pure traditional Chinese medicine formulated product for preventing and treating coccidiosis |
-
2008
- 2008-08-20 CN CN2008101186322A patent/CN101653198B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1328832A (en) * | 2000-06-19 | 2002-01-02 | 张世贵 | Preparation method of fowl and livestock medicine Qiuchongqing |
| CN1658765A (en) * | 2001-12-26 | 2005-08-24 | 植物合成公司 | Food supplement for animals |
| DE10337179A1 (en) * | 2003-08-13 | 2005-03-24 | Bönnighaus, Dieter | Composition for treating trichomoniasis and coccidiosis in birds and poultry comprises brewer's yeast, oil and propolis |
| CN1589847A (en) * | 2003-09-03 | 2005-03-09 | 中国农业科学院上海家畜寄生虫病研究所 | Traditional Chinese medicine compound preparation for preventing and treating coccidiosis |
| CN101129673A (en) * | 2007-08-17 | 2008-02-27 | 李培英 | Pure traditional Chinese medicine formulated product for preventing and treating coccidiosis |
Non-Patent Citations (1)
| Title |
|---|
| 刘富国.苦木片预防和治疗仔猪白痢病效果初报.《中国兽医杂志》.1986, * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101653198A (en) | 2010-02-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102948641B (en) | Natural plant feed additive for poultry | |
| CN102178100B (en) | Low-tryptophan feed for hybrid chicken and preparation method of the low-tryptophan feed | |
| CN103859208B (en) | Piglet health protection fodder and preparation method thereof | |
| CN100559964C (en) | Improve the Chinese herb feed additive of chicken meat quality | |
| CN102038781B (en) | Pharmaceutical composition for inhibiting bacteria and preparation method and application thereof | |
| CN106107461A (en) | A kind of hyperglycemia population that is suitable for eats series food and preparation method thereof | |
| CN101829211B (en) | Fish compound traditional Chinese medicinal preparation and preparation method thereof | |
| CN103494002A (en) | Feed for pregnant sows and preparation method thereof | |
| CN103120273B (en) | Compound feed additive capable of improving pig immunity and feed nutrient utilization rate | |
| CN104026356A (en) | Pig feed for enhancing immunity and preparation method thereof | |
| CN106615870A (en) | Preparation method of dog food for enhancing pet immunity | |
| CN104957423A (en) | Health-care fodder for bamboo rats and preparation method thereof | |
| CN104012757A (en) | Nonreactive growth-promoting compound veterinary medicine preparation for livestock as well as preparation method and application of preparation | |
| CN101653198B (en) | Feed additives for preventing and controlling coccidiosis and preparation methods thereof | |
| CN102813850B (en) | Traditional Chinese medicine composition for preventing and treating poultry coccidiosis and preparation method of traditional Chinese medicine composition | |
| CN103815183A (en) | Pig feed capable of enhancing immunity and preparation method for pig feeds | |
| CN103931915A (en) | Bighead carp feed and its preparation method | |
| CN103815127A (en) | Disease-preventing functional pig feed and preparation method thereof | |
| CN103815181A (en) | Pig feed for promoting growth and preparation method thereof | |
| CN103784510A (en) | Chinese herbal medicine oral liquid for treating piglet diarrhea and production method thereof | |
| CN106107070A (en) | A kind of Chinese herbal medicine feed for goat and preparation method thereof | |
| CN104082565A (en) | Formula of chicken feed with good palatability and preparation method thereof | |
| CN107691301A (en) | A kind of method of fish fast-growth | |
| CN103892112A (en) | Efficient and health-care concentrated feed for broiler chicken | |
| CN103750069B (en) | Feed additive for prevention and treatment of fish bacteria and virus diseases |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120523 Termination date: 20130820 |