CN1583162A - 阿胶注射液及其制备方法 - Google Patents
阿胶注射液及其制备方法 Download PDFInfo
- Publication number
- CN1583162A CN1583162A CNA2004100227435A CN200410022743A CN1583162A CN 1583162 A CN1583162 A CN 1583162A CN A2004100227435 A CNA2004100227435 A CN A2004100227435A CN 200410022743 A CN200410022743 A CN 200410022743A CN 1583162 A CN1583162 A CN 1583162A
- Authority
- CN
- China
- Prior art keywords
- injection
- corii asini
- colla corii
- protolysate
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002347 injection Methods 0.000 title claims abstract description 82
- 239000007924 injection Substances 0.000 title claims abstract description 82
- 238000002360 preparation method Methods 0.000 title claims description 17
- 108010010803 Gelatin Proteins 0.000 title abstract description 7
- 229920000159 gelatin Polymers 0.000 title abstract description 7
- 239000008273 gelatin Substances 0.000 title abstract description 7
- 235000019322 gelatine Nutrition 0.000 title abstract description 7
- 235000011852 gelatine desserts Nutrition 0.000 title abstract description 7
- 241000283074 Equus asinus Species 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 claims abstract description 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 23
- 239000011573 trace mineral Substances 0.000 claims abstract description 12
- 235000013619 trace mineral Nutrition 0.000 claims abstract description 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 9
- 229920001184 polypeptide Polymers 0.000 claims abstract description 8
- 108010052008 colla corii asini Proteins 0.000 claims description 112
- 235000001014 amino acid Nutrition 0.000 claims description 32
- 239000000243 solution Substances 0.000 claims description 29
- 108090000790 Enzymes Proteins 0.000 claims description 24
- 102000004190 Enzymes Human genes 0.000 claims description 24
- 239000004365 Protease Substances 0.000 claims description 23
- 229940088598 enzyme Drugs 0.000 claims description 23
- 108090000526 Papain Proteins 0.000 claims description 22
- 229940055729 papain Drugs 0.000 claims description 22
- 235000019834 papain Nutrition 0.000 claims description 22
- 239000003531 protein hydrolysate Substances 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 16
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 16
- 238000001914 filtration Methods 0.000 claims description 11
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 108090000787 Subtilisin Proteins 0.000 claims description 9
- 239000012982 microporous membrane Substances 0.000 claims description 7
- 238000012856 packing Methods 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 6
- 210000004907 gland Anatomy 0.000 claims description 6
- 239000008215 water for injection Substances 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 238000001802 infusion Methods 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- 230000007071 enzymatic hydrolysis Effects 0.000 claims description 2
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 210000003462 vein Anatomy 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims 2
- 102000057297 Pepsin A Human genes 0.000 claims 1
- 108090000284 Pepsin A Proteins 0.000 claims 1
- 102000004142 Trypsin Human genes 0.000 claims 1
- 108090000631 Trypsin Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000003978 infusion fluid Substances 0.000 claims 1
- 229940111202 pepsin Drugs 0.000 claims 1
- 239000012588 trypsin Substances 0.000 claims 1
- 229960001322 trypsin Drugs 0.000 claims 1
- 230000029663 wound healing Effects 0.000 abstract description 13
- 230000036039 immunity Effects 0.000 abstract description 4
- 230000001965 increasing effect Effects 0.000 abstract description 3
- 230000001737 promoting effect Effects 0.000 abstract description 2
- 230000011132 hemopoiesis Effects 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 description 47
- 238000006460 hydrolysis reaction Methods 0.000 description 47
- 229940024606 amino acid Drugs 0.000 description 30
- 238000006243 chemical reaction Methods 0.000 description 25
- 239000000758 substrate Substances 0.000 description 21
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 18
- 210000004369 blood Anatomy 0.000 description 16
- 239000008280 blood Substances 0.000 description 16
- 241001465754 Metazoa Species 0.000 description 15
- 241000700159 Rattus Species 0.000 description 15
- 230000000694 effects Effects 0.000 description 15
- 238000000034 method Methods 0.000 description 14
- 239000002674 ointment Substances 0.000 description 14
- 238000012360 testing method Methods 0.000 description 13
- 238000000108 ultra-filtration Methods 0.000 description 13
- 241000700199 Cavia porcellus Species 0.000 description 11
- 102000008186 Collagen Human genes 0.000 description 11
- 108010035532 Collagen Proteins 0.000 description 11
- -1 Amino Acid Compound Chemical class 0.000 description 10
- 206010002198 Anaphylactic reaction Diseases 0.000 description 10
- 208000003455 anaphylaxis Diseases 0.000 description 10
- 239000003814 drug Substances 0.000 description 10
- 210000003743 erythrocyte Anatomy 0.000 description 10
- 239000003153 chemical reaction reagent Substances 0.000 description 9
- 229910052757 nitrogen Inorganic materials 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 8
- 230000004044 response Effects 0.000 description 8
- 210000002966 serum Anatomy 0.000 description 8
- 238000010171 animal model Methods 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 206010063560 Excessive granulation tissue Diseases 0.000 description 6
- 208000036581 Haemorrhagic anaemia Diseases 0.000 description 6
- 230000037396 body weight Effects 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 210000001126 granulation tissue Anatomy 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 239000011701 zinc Substances 0.000 description 6
- 206010052428 Wound Diseases 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 239000010949 copper Substances 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 238000010790 dilution Methods 0.000 description 5
- 239000012895 dilution Substances 0.000 description 5
- 210000004209 hair Anatomy 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 210000000056 organ Anatomy 0.000 description 5
- 239000000463 material Substances 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 108010058846 Ovalbumin Proteins 0.000 description 3
- 108010009736 Protein Hydrolysates Proteins 0.000 description 3
- 206010044565 Tremor Diseases 0.000 description 3
- 125000000539 amino acid group Chemical group 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000036783 anaphylactic response Effects 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 229910052802 copper Inorganic materials 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 3
- 229940092253 ovalbumin Drugs 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 230000008733 trauma Effects 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 229910052725 zinc Inorganic materials 0.000 description 3
- JGSARLDLIJGVTE-UHFFFAOYSA-N 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-UHFFFAOYSA-N 0.000 description 2
- FTOAOBMCPZCFFF-UHFFFAOYSA-N 5,5-diethylbarbituric acid Chemical compound CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 102000001554 Hemoglobins Human genes 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- 101710135785 Subtilisin-like protease Proteins 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000002607 hemopoietic effect Effects 0.000 description 2
- 239000000413 hydrolysate Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 239000007928 intraperitoneal injection Substances 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 229910052748 manganese Inorganic materials 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 108091008146 restriction endonucleases Proteins 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 239000008354 sodium chloride injection Substances 0.000 description 2
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 2
- 235000010262 sodium metabisulphite Nutrition 0.000 description 2
- 239000003549 soybean oil Substances 0.000 description 2
- 235000012424 soybean oil Nutrition 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 210000001541 thymus gland Anatomy 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 240000004859 Gamochaeta purpurea Species 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- QGMRQYFBGABWDR-UHFFFAOYSA-M Pentobarbital sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)[N-]C1=O QGMRQYFBGABWDR-UHFFFAOYSA-M 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000010165 autogamy Effects 0.000 description 1
- 229960002319 barbital Drugs 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 208000036654 deficiency anemia Diseases 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 210000003195 fascia Anatomy 0.000 description 1
- 210000001105 femoral artery Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000011902 gastrointestinal surgery Methods 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000000703 high-speed centrifugation Methods 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000001699 lower leg Anatomy 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 239000011785 micronutrient Substances 0.000 description 1
- 235000013369 micronutrients Nutrition 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 229960002275 pentobarbital sodium Drugs 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910052979 sodium sulfide Inorganic materials 0.000 description 1
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
Images
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
样品 Zn Cu Fe Mn Zn/Cu |
超滤前 18.13 1.04 71.36 5.29 17.4 |
超滤后 18.17 0.99 71.33 5.20 16.8 |
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100227435A CN1290574C (zh) | 2004-06-07 | 2004-06-07 | 阿胶注射液及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100227435A CN1290574C (zh) | 2004-06-07 | 2004-06-07 | 阿胶注射液及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1583162A true CN1583162A (zh) | 2005-02-23 |
CN1290574C CN1290574C (zh) | 2006-12-20 |
Family
ID=34600701
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100227435A Expired - Lifetime CN1290574C (zh) | 2004-06-07 | 2004-06-07 | 阿胶注射液及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1290574C (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100582214C (zh) * | 2007-01-05 | 2010-01-20 | 浙江省医学科学院 | 阿胶多肽酒及其生产方法 |
-
2004
- 2004-06-07 CN CNB2004100227435A patent/CN1290574C/zh not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100582214C (zh) * | 2007-01-05 | 2010-01-20 | 浙江省医学科学院 | 阿胶多肽酒及其生产方法 |
Also Published As
Publication number | Publication date |
---|---|
CN1290574C (zh) | 2006-12-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1976715A (zh) | 与腹部疾病有关的表位 | |
CN1165539A (zh) | 肽及蛋白质的修饰 | |
CN1898262A (zh) | Il-7融合蛋白 | |
CN1427725A (zh) | 酪蛋白衍生肽及其治疗用途 | |
CN1492040A (zh) | 单克隆人天然抗体 | |
CN1838965A (zh) | 用于癌症治疗的药品 | |
CN101080420A (zh) | 胸腺特异性蛋白质 | |
CN1678341A (zh) | 促红细胞生成素的应用 | |
CN1646564A (zh) | 修饰的因子ⅷ | |
CN1142186A (zh) | 用白介素-10激活外周血单核细胞的细胞溶解活性 | |
CN1079166A (zh) | 用白细胞介素-10抑制移植物抗宿主病 | |
CN1735428A (zh) | 伴侣蛋白10的免疫抑制作用 | |
CN1765932A (zh) | 一种胸腺素α1和干扰素的融合蛋白 | |
CN1626669A (zh) | 完全人源化抗体的制备 | |
CN1088095A (zh) | 预防或治疗癌症的抗癌组合物 | |
CN1583162A (zh) | 阿胶注射液及其制备方法 | |
CN1684979A (zh) | 糖基化的人干扰素α同种型 | |
CN1202127C (zh) | 癌症治疗中的免疫刺激剂细菌膜组分 | |
CN1691961A (zh) | 半胱氨酸蛋白酶抑制剂 | |
CN1217023A (zh) | 犬ob蛋白组合物和方法 | |
CN1879891A (zh) | 利用转基因灵芝表达人胰岛素降血糖的方法 | |
CN1665835A (zh) | 草花粉过敏原Phl p4 的 DNA 序列和用重组方法进行的制备 | |
CN1506375A (zh) | 具有广谱抗肿瘤作用的细菌蛋白天青蛋白及其用途和含有其的药物组合物 | |
CN1168739C (zh) | 水仙子糖肽及其用途 | |
CN1324580A (zh) | 一种含活性营养蛋白的保健食品及制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: CHONGQING LAIMEI PHARMACY CO., LTD. Free format text: FORMER OWNER: YAOYOU SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD., CHENDU CITY Effective date: 20080215 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20080215 Address after: No. 5, Rose Road, Nan'an District, Chongqing Patentee after: CHONGQING LUMMY PHARMACEUTICAL Co.,Ltd. Address before: No. 23, high shed Road, hi tech Zone, Sichuan, Chengdu Patentee before: CHENGDU PHARMMATE TECHNOLOGY Co.,Ltd. |
|
CX01 | Expiry of patent term |
Granted publication date: 20061220 |