CN1568370A - 用d－氨基酸氧化酶和d－天冬氨酸氧化酶拮抗剂治疗中枢神经系统障碍 - Google Patents

用d－氨基酸氧化酶和d－天冬氨酸氧化酶拮抗剂治疗中枢神经系统障碍 Download PDF

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CN1568370A
CN1568370A CNA028066650A CN02806665A CN1568370A CN 1568370 A CN1568370 A CN 1568370A CN A028066650 A CNA028066650 A CN A028066650A CN 02806665 A CN02806665 A CN 02806665A CN 1568370 A CN1568370 A CN 1568370A
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amino
acid
alkyl
oxidase
group
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D·科恩
I·丘马科夫
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Merck Biodevelopment SAS
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Genset SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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CNA028066650A 2001-01-16 2002-01-15 用d－氨基酸氧化酶和d－天冬氨酸氧化酶拮抗剂治疗中枢神经系统障碍 Pending CN1568370A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US26188301P 2001-01-16 2001-01-16
US60/261,883 2001-01-16
US30544501P 2001-07-13 2001-07-13
US60/305,445 2001-07-13
US34521101P 2001-10-22 2001-10-22
US60/345,211 2001-10-22
US33388101P 2001-11-19 2001-11-19
US60/333,881 2001-11-19

Publications (1)

Publication Number Publication Date
CN1568370A true CN1568370A (zh) 2005-01-19

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CNA028066650A Pending CN1568370A (zh) 2001-01-16 2002-01-15 用d－氨基酸氧化酶和d－天冬氨酸氧化酶拮抗剂治疗中枢神经系统障碍

Country Status (11)

Country Link
EP (1) EP1412515A2 (es)
JP (1) JP2004537275A (es)
KR (1) KR20030066813A (es)
CN (1) CN1568370A (es)
AU (1) AU2002247939B2 (es)
BR (1) BR0206495A (es)
CA (1) CA2433866A1 (es)
EA (1) EA006654B1 (es)
IL (1) IL156865A0 (es)
MX (1) MXPA03006321A (es)
WO (1) WO2002066672A2 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108504752A (zh) * 2018-06-26 2018-09-07 华中农业大学 一种与母猪繁殖性状关联的分子标记及应用
CN111909907A (zh) * 2020-07-08 2020-11-10 浙江工业大学 天冬氨酸氧化酶突变体、工程菌及其在氧化-还原偶联制备精草铵膦中的应用

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CA2446136C (en) 2001-05-03 2011-07-05 Galileo Pharmaceuticals, Inc. Pyruvate derivatives
WO2003070743A1 (en) * 2002-02-20 2003-08-28 Ribozyme Pharmaceuticals, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF G72 AND D-AMINO ACID OXIDASE (DAAO) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
EP1291015A1 (en) 2001-09-10 2003-03-12 Lunamed AG Dosage forms having prolonged active ingredient release
US20030162825A1 (en) * 2001-11-09 2003-08-28 Sepracor Inc. D-amino acid oxidase inhibitors for learning and memory
WO2003047558A2 (en) * 2001-12-03 2003-06-12 Genset S.A. Treatment of cns disorders using d-amino acid oxidase and d-aspartate oxidase inhibitors
IL162481A0 (en) * 2001-12-12 2005-11-20 Genset Sa Method and use of determining genotype
GB0223424D0 (en) * 2002-10-09 2002-11-13 Imp College Innovations Ltd Disease-associated gene
JP2007517056A (ja) 2003-12-29 2007-06-28 セプラコア インコーポレーテッド ピロール及びピラゾールｄａａｏ阻害剤
JP5367377B2 (ja) * 2006-01-09 2013-12-11 オクラホマ メディカル リサーチ ファウンデーション 炎症性疾患治療のためのランチオニン関連化合物
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
GB2456390A (en) * 2008-01-15 2009-07-22 Glaxo Group Ltd Bipolar disorder treatments
EP3006023B1 (en) 2009-01-20 2019-06-26 Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center Sorbic acid and derivatives thereof to enhance the activity of a neuropharmaceutical
JP4462382B1 (ja) * 2009-04-23 2010-05-12 学校法人北里研究所 Ｄ−アスパラギン酸オキシダーゼおよびｄ−アミノ酸オキシダーゼに対する新規阻害剤
WO2012135119A1 (en) * 2011-03-25 2012-10-04 Genomind, Llc Biomarker-based detection and treatment of neurodegenerative depression
CA2866392C (en) 2012-03-30 2023-10-24 Washington University Methods for modulating tau expression for reducing seizure and modifying a neurodegenerative syndrome
TWI772856B (zh) 2013-07-19 2022-08-01 美商百健Ｍａ公司 用於調節τ蛋白表現之組合物
KR102338171B1 (ko) 2016-06-13 2021-12-09 신유알엑스 인터내셔널 (타이완) 코포레이션 벤조산리튬의 공-결정 및 그의 용도
ES2936094T3 (es) 2016-06-13 2023-03-14 Syneurx Int Taiwan Corp Cocristales de benzoato de sodio y usos de los mismos
US11369579B2 (en) 2016-10-24 2022-06-28 Syneurx International (Taiwan) Corp. Polymorphic forms of sodium benzoate and uses thereof
US10336679B2 (en) 2016-10-24 2019-07-02 Syneurx International (Taiwan) Corp. Polymorphic forms of sodium benzoate and uses thereof
US10098861B1 (en) 2017-10-24 2018-10-16 Syneurx International (Taiwan) Corp. Pharmaceutical composition comprising sodium benzoate compound and clozapine, and uses thereof

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Publication number Priority date Publication date Assignee Title
US5668117A (en) * 1991-02-22 1997-09-16 Shapiro; Howard K. Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments
AU778868B2 (en) * 1999-03-30 2004-12-23 Serono Genetics Institute S.A. Schizophrenia associated genes, proteins and biallelic markers
WO2001009118A2 (en) * 1999-07-29 2001-02-08 Patrick T Prendergast Dithiolthione compounds for the treatment of neurological disorders and for memory enhancement
AU2001247474A1 (en) * 2000-03-16 2001-09-24 The Mclean Hospital Corporation Compounds for the treatment of psychiatric or substance abuse disorders

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108504752A (zh) * 2018-06-26 2018-09-07 华中农业大学 一种与母猪繁殖性状关联的分子标记及应用
CN108504752B (zh) * 2018-06-26 2021-05-11 华中农业大学 一种与母猪繁殖性状关联的分子标记及应用
CN111909907A (zh) * 2020-07-08 2020-11-10 浙江工业大学 天冬氨酸氧化酶突变体、工程菌及其在氧化-还原偶联制备精草铵膦中的应用
CN111909907B (zh) * 2020-07-08 2022-05-24 浙江工业大学 天冬氨酸氧化酶突变体、工程菌及其在氧化-还原偶联制备精草铵膦中的应用

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WO2002066672A3 (en) 2004-02-26
CA2433866A1 (en) 2002-08-29
IL156865A0 (en) 2004-02-08
EP1412515A2 (en) 2004-04-28
EA006654B1 (ru) 2006-02-24
EA200300807A1 (ru) 2004-08-26
BR0206495A (pt) 2006-01-24
JP2004537275A (ja) 2004-12-16
KR20030066813A (ko) 2003-08-09
AU2002247939B9 (en) 2002-09-04
MXPA03006321A (es) 2003-10-06
AU2002247939B2 (en) 2007-01-25
WO2002066672A2 (en) 2002-08-29

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