CN1545923A - Natural beta-carotene microcapsule and preparation method thereof - Google Patents
Natural beta-carotene microcapsule and preparation method thereof Download PDFInfo
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- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 title claims abstract description 61
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 title claims abstract description 60
- 239000003094 microcapsule Substances 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 title abstract description 19
- 235000013734 beta-carotene Nutrition 0.000 title abstract description 19
- 239000011648 beta-carotene Substances 0.000 title abstract description 19
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- 239000003795 chemical substances by application Substances 0.000 claims description 10
- BGNXCDMCOKJUMV-UHFFFAOYSA-N Tert-Butylhydroquinone Chemical compound CC(C)(C)C1=CC(O)=CC=C1O BGNXCDMCOKJUMV-UHFFFAOYSA-N 0.000 claims description 8
- 239000008346 aqueous phase Substances 0.000 claims description 8
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- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 5
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical group [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 5
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- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
- 239000008101 lactose Substances 0.000 claims description 4
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 4
- 235000010234 sodium benzoate Nutrition 0.000 claims description 4
- 239000004299 sodium benzoate Substances 0.000 claims description 4
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- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 3
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- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 3
- 239000008103 glucose Substances 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
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- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 2
- 239000002285 corn oil Substances 0.000 claims description 2
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- 235000011175 beta-cyclodextrine Nutrition 0.000 abstract 1
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- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 235000005473 carotenes Nutrition 0.000 description 2
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- 150000001747 carotenoids Chemical class 0.000 description 2
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- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 2
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- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a natural beta-carotene microcapsule and a preparation method thereof, wherein the natural beta-carotene microcapsule is prepared from the following raw materials in parts by weight: 10-50 parts of natural beta-carotene oil solution, 2032 parts of modified starch, 5-18 parts of beta-cyclodextrin, 5-15 parts of maltodextrin, 0.8-2 parts of oil-phase emulsifier, 0.7-1.5 parts of water-phase emulsifier, 5-15 parts of dispersant, 0.5-1 part of preservative and 0.1-0.5 part of antioxidant; the content of beta-carotene in the microcapsule prepared by the method is high and can reach 10 percent; the product has strong antioxidant effect, good compactness, more uniform particles, strong extrusion resistance, high rehydration speed and high embedding efficiency, and the embedding efficiency is over 95 percent; and the process is simple, the operation and control are convenient, and the production cost is low.
Description
Technical field
The present invention relates to a kind of natural beta-carotin microcapsules and preparation method thereof.
Background technology
Natural beta-carotin is meant and utilizes a kind of carotenoid that nature biotechnology self physiology is synthetic and extract, main component is a beta carotene, also contain a spot of carotenoid, beta carotene is nontoxic, the nourishing food additive of FAO (Food and Agriculture Organization of the United Nation) (FAO) and the approval of food additives joint committee of The World Health Organization (WHO), belong to " A " class nutrition pigment, having good preventing " three C " is cancer, angiocardiopathy and cataract effect.Existing in the world at present 52 countries approval is used, and has obtained the approval of Food and Drug Administration (FDA), lists American Pharmacopeia in.
Natural beta-carotin has strong antioxidant action, can remove free radical and cancellation singlet oxygen in the human body effectively; The energy stimulating immune system, the immunocompetence of raising human body; Cancer-resisting, anti-senility; Weaken radiotherapy, chemotherapy and radiation to effects such as the infringement of body and angiocardiopathy preventings.Along with development of times, the application of natural beta-carotin also turns to nutraceutical, health products, medicine, cosmetics and feed five big fields from food color.
Natural beta-carotin is a fat-soluble pigment, dissolve in lipid and the non-polar solven, water insoluble, this specific character, limit beta carotene and can only be used for the painted of oil, fat and lipid food, and can not be applied to water base food, and its is stable very poor, is easy to be subjected to light, heat, air influence and oxidation Decomposition.Utilize microcapsules technology, the oil phase of dissolving beta carotene is spread at the aqueous phase of being made up of carbohydrate, antioxidant, emulsifying agent etc. with minimum diffuser, make emulsion homogeneous, stable, use spray-dired method again, emulsion is processed into dry water dispersible dry powder.
About the preparation method of beta carotene microcapsules, existing both at home and abroad multinomial patent disclosure.In the CN1151864A document, it is characterized in that adopting vegetable oil and organic solvent cyclohexane or chloroform to dissolve, and then heating remove organic solvent, make oil phase, make water, spray-dried again forming with gelatin etc.Its weak point is to have dissolvent residual in the product, influences quality, and has increased processing step, and as the wall material, its antioxidant effect is poor with gelatin; In the CN 1038220C document, it is characterized in that carrotene, emulsifying agent, hydrophilic colloid, dextrin, water are mixed by a certain percentage, behind the emulsification homogeneous, obtain the beta carotene particle through steps such as granulation, oven dry.Its weak point is that drying process is selected oven drying method for use, and the temperature height, the time is long, efficient is low, beta carotene loss is bigger; In the CN 1082890A document, it is characterized in that adopting the dissolution in low temperature beta carotene to make oil phase, mix the spray-dried microcapsule granule of making after the emulsification again and by the water that Arabic gum, emulsifying agent, stabilizing agent, essence etc. are formed.Its weak point is; the dissolution in low temperature beta carotene, though can protect beta carotene not to be damaged effectively, its solubility be very low; content beta-carotene can't be produced the beta carotene pulvis of high-load in the product of making between 0.1-1%.
Summary of the invention
Purpose of the present invention just for the shortcoming that overcomes above-mentioned prior art with not enough, provide a kind of simply, natural beta-carotin microcapsules and preparation method thereof efficiently.
The objective of the invention is to be achieved through the following technical solutions: natural beta-carotin microcapsules of the present invention are made by the raw material of following weight portion:
Natural beta-carotin oil solution 10-50 converted starch 20-32
Cycloheptaamylose 5-18 maltodextrin 5-15
Oil phase emulsifier 0.8-2 aqueous emulsifier phase 0.7-1.5
Dispersant 5-15 anticorrisive agent 0.5-1
Antioxidant 0.1-0.5.
Natural beta-carotin microcapsules of the present invention, make by the raw material of following weight portion:
Natural beta-carotin oil solution 20-40 converted starch 24-28
Cycloheptaamylose 10-15 maltodextrin 8-12
Oil phase emulsifier 1-1.5 aqueous emulsifier phase 0.8-1.2
Dispersant 9-12 anticorrisive agent 0.5-1
Antioxidant 0.1-0.5.
Natural beta-carotin microcapsules of the present invention, make by the raw material of following weight portion:
Natural beta-carotin oil solution 30 converted starches 26
Cycloheptaamylose 12 maltodextrins 10
Oil phase emulsifier 1.2 aqueous emulsifier phases 1
Dispersant 11 anticorrisive agents 0.8
Antioxidant 0.3.
Natural beta-carotin of the present invention is that described vegetable oil is corn oil, palm oil, salad oil or sunflower oil by the vegetable oil solution of the 5%--30% concentration of conventional zymotechnique production.
Oil phase emulsifier of the present invention is soybean lecithin or polysorbate60; Described aqueous emulsifier phase is sucrose fatty ester or Span.
Dispersant of the present invention is sucrose, glucose, maltose or lactose.
Anticorrisive agent of the present invention is potassium sorbate or Sodium Benzoate.
Antioxidant of the present invention is natural V
E, V
C, TBHQ or BHT.
The preparation method of natural beta-carotin microcapsules of the present invention:
1), the natural beta-carotin oil solution of 5-30%, add oil phase emulsifier, antioxidant after, oil bath is heated to 120--190 ℃, makes it dissolving, makes oil phase;
2), converted starch adds cold water, stir, abundant swelling, standing over night, heat next day to 40-70 ℃ standby;
3), above-mentioned cycloheptaamylose, maltodextrin, aqueous emulsifier phase, dispersant, anticorrisive agent are added water, stir, be heated to 50-80 ℃ standby;
4), with 2) and 3) mix, fully stir, make water;
5), oil phase is slowly joined aqueous phase, constant temperature carries out emulsification to 60-80 ℃ with mulser, and rotating speed is 2000-4000 rev/min, and the time is 10-30 minute;
6), emulsion is carried out homogeneous, pressure is 30-40kg/cm
2
7), above-mentioned emulsion is carried out spray-drying, the charging solid content is controlled at 20-35%, and inlet temperature 150-200 ℃, outlet temperature 70-90 ℃;
8), after above-mentioned steps, can obtain 40-80 order, free flowable natural beta-carotin microcapsule granule.
The present invention compared with prior art has the following advantages:
1), content beta-carotene height in the microcapsules, can reach 10%.
2), production technology adopts emulsify at a high speed, high-pressure homogeneous, low temperature mixed flow type atomizing drying, the compactness of product is better, particle is more even, anti-extruding is strong, rehydration speed is fast.
3), the present invention adopts the one-step method spray-drying, spraying granulation is once finished, and has reduced secondary pollution, has improved product quality, and the rate of drying height, the time is short, technical process is simple, convenient operation and control, production cost is lower.
4), to adopt converted starch be the wall material, product embedding efficiency height is more than 95%, core content can account for about 50% of microcapsules total amount, and the oxidation resistance of this kind converted starch is strong, and product is more stable, and external conditions such as light, heat, air are very little to its influence.Product normal temperature is exposed in the air, after two months, content beta-carotene 5% (see figure 1) that only descended; Used main wall material converted starch (representing with A) and other wall material embedding effect comparing data see Table 1 and Fig. 2, among Fig. 2 1234 and abcd correspondence table 1 in each data.
Table 1 different materials embedding effect relatively
Description of drawings
The graph of a relation of Fig. 1 carotene carotene content and resting period;
Fig. 2 different materials embedding effect contrast schematic diagram.
The specific embodiment
Embodiment 1
Put into 100g water in the container, under stirring, slowly add converted starch 20g, after fully stirring evenly, standing over night makes it dissolving.5% natural beta-carotin finish 40g, behind adding 2g soybean lecithin, the 0.2g TBHQ, oil bath is heated to 120 ℃, makes it dissolving, makes oil phase.Put into 300g water in the container, add maltodextrin 8g, cycloheptaamylose 16g, Span 1.5g, maltose 15g, Sodium Benzoate 0.5g, be heated with stirring to 80 ℃, standby converted starch solution is heated to 70 ℃, join in the above-mentioned solution, make water.Oil phase is joined aqueous phase, and constant temperature to 80 ℃ carries out emulsification with mulser, and rotating speed 4000 changes 20 minutes time.The liquid that emulsification is good carries out homogeneous, pressure 40kg/cm
2, the material process spray-drying behind the homogeneous, 195 ℃ of inlet temperatures, 75 ℃ of outlet temperatures can make 2.1% natural beta-carotin microcapsules.
Embodiment 2
Put into 200g water in the container, under stirring, slowly add converted starch 26g, after fully stirring evenly, standing over night makes it dissolving.20% natural beta-carotin finish 50g, behind adding 1g polysorbate60, the natural VC0.5g, oil bath is heated to 190 ℃, makes it dissolving, makes oil phase.Put into 200g water in the container, add maltodextrin 5g, cycloheptaamylose 6g, soybean lecithin 1g, lactose 8g, potassium sorbate 1g, be heated with stirring to 75 ℃, standby converted starch solution is heated to 50 ℃, joins in the above-mentioned solution, makes water.Oil phase is joined aqueous phase, and constant temperature to 75 ℃ carries out emulsification with mulser, and rotating speed 3000 changes 30 minutes time.The liquid that emulsification is good carries out homogeneous, pressure 40kg/cm
2, the material process spray-drying behind the homogeneous, 200 ℃ of inlet temperatures, 90 ℃ of outlet temperatures can make 10.05% natural beta-carotin microcapsules.
Embodiment 3
Put into 100g water in the container, under stirring, slowly add converted starch 20g, after fully stirring evenly, standing over night makes it dissolving.5% natural beta-carotin finish 10g, behind adding 0.8g soybean lecithin, the 0.1g TBHQ, oil bath is heated to 120 ℃, makes it dissolving, makes oil phase.Put into 300g water in the container, add maltodextrin 5g, cycloheptaamylose 5g, Span 0.7g, glucose 5g, Sodium Benzoate 0.5g, be heated with stirring to 50 ℃, standby converted starch solution is heated to 40 ℃, join in the above-mentioned solution, make water.Oil phase is joined aqueous phase, and constant temperature to 60 ℃ carries out emulsification with mulser, and rotating speed 2000 changes 10 minutes time.The liquid that emulsification is good carries out homogeneous, pressure 30kg/cm
2, the material process spray-drying behind the homogeneous, 150 ℃ of inlet temperatures, 70 ℃ of outlet temperatures can make 1.06% natural beta-carotin microcapsules.
Embodiment 4
Put into 200g water in the container, under stirring, slowly add converted starch 26g, after fully stirring evenly, standing over night makes it dissolving.20% natural beta-carotin finish 30g, behind adding 1.2g polysorbate60, the natural VC 0.3g, oil bath is heated to 160 ℃, makes it dissolving, makes oil phase.Put into 200g water in the container, add maltodextrin 10g, cycloheptaamylose 12g, sucrose fatty ester 1g, lactose 11g, potassium sorbate 0.8g, be heated with stirring to 65 ℃, standby converted starch solution is heated to 55 ℃, joins in the above-mentioned solution, makes water.Oil phase is joined aqueous phase, and constant temperature to 75 ℃ carries out emulsification with mulser, and rotating speed 3000 changes 20 minutes time.The liquid that emulsification is good carries out homogeneous, pressure 35kg/cm
2, the material process spray-drying behind the homogeneous, 180 ℃ of inlet temperatures, 80 ℃ of outlet temperatures can make 6.5% natural beta-carotin microcapsules.
Embodiment 5
Put into 200g water in the container, under stirring, slowly add converted starch 32g, after fully stirring evenly, standing over night makes it dissolving.30% natural beta-carotin finish 47g, behind adding 2g polysorbate60, the natural VE 0.5g, oil bath is heated to 190 ℃, makes it dissolving, makes oil phase.Put into 200g water in the container, add maltodextrin 15g, cycloheptaamylose 18g, sucrose fatty ester 1.5g, sucrose 15g, potassium sorbate 1g, be heated with stirring to 80 ℃, standby converted starch solution is heated to 70 ℃, joins in the above-mentioned solution, makes water.Oil phase is joined aqueous phase, and constant temperature to 80 ℃ carries out emulsification with mulser, and rotating speed 4000 changes 30 minutes time.The liquid that emulsification is good carries out homogeneous, pressure 40kg/cm
2, the material process spray-drying behind the homogeneous, 200 ℃ of inlet temperatures, 90 ℃ of outlet temperatures can make 10.7% natural beta-carotin microcapsules.
Claims (9)
1, a kind of natural beta-carotin microcapsules is characterized in that being made by the raw material of following weight portion:
Natural beta-carotin oil solution 10-50 converted starch 20-32
Cycloheptaamylose 5-18 maltodextrin 5-15
Oil phase emulsifier 0.8-2 aqueous emulsifier phase 0.7-1.5
Dispersant 5-15 anticorrisive agent 0.5-1
Antioxidant 0.1-0.5.
2, natural beta-carotin microcapsules according to claim 1 is characterized in that being made by the raw material of following weight portion:
Natural beta-carotin oil solution 20-40 converted starch 24-28
Cycloheptaamylose 10-15 maltodextrin 8-12
Oil phase emulsifier 1-1.5 aqueous emulsifier phase 0.8-1.2
Dispersant 9-12 anticorrisive agent 0.5-1
Antioxidant 0.1-0.5.
3, natural beta-carotin microcapsules according to claim 1 is characterized in that being made by the raw material of following weight portion:
Natural beta-carotin oil solution 30 converted starches 26
Cycloheptaamylose 12 maltodextrins 10
Oil phase emulsifier 1.2 aqueous emulsifier phases 1
Dispersant 11 anticorrisive agents 0.8
Antioxidant 0.3.
4, natural beta-carotin microcapsules according to claim 1, it is characterized in that: described natural beta-carotin oil solution is that described vegetable oil is corn oil, palm oil, salad oil or sunflower oil by the vegetable oil solution of the 5%--30% concentration of fermentation method production.
5, natural beta-carotin microcapsules according to claim 1 is characterized in that: described oil phase emulsifier is soybean lecithin or polysorbate60; Described aqueous emulsifier phase is sucrose fatty ester or Span.
6, natural beta-carotin microcapsules according to claim 1 is characterized in that: described dispersant is sucrose, glucose, maltose or lactose.
7, natural beta-carotin microcapsules according to claim 1 is characterized in that: described anticorrisive agent is potassium sorbate or Sodium Benzoate.
8, natural beta-carotin microcapsules according to claim 1 is characterized in that: described antioxidant is natural V
E, V
C, TBHQ or BHT.
9, the preparation method of the described natural beta-carotin microcapsules of claim 1 is characterized in that may further comprise the steps:
1), the natural beta-carotin oil solution of 5-30%, add oil phase emulsifier, antioxidant after, oil bath is heated to 120--190 ℃, makes it dissolving, makes oil phase;
2), converted starch adds cold water, stir, abundant swelling, standing over night, heat next day to 40-70 ℃ standby;
3), above-mentioned cycloheptaamylose, maltodextrin, aqueous emulsifier phase, dispersant, anticorrisive agent are added water, stir, be heated to 50-80 ℃ standby;
4), with 2) and 3) mix, fully stir, make water;
5), oil phase is slowly joined aqueous phase, constant temperature carries out emulsification to 60-80 ℃ with mulser, and rotating speed is 2000-4000 rev/min, and the time is 10-30 minute;
6), emulsion is carried out homogeneous, pressure is 30-40kg/cm
2
7), above-mentioned emulsion is carried out spray-drying, the charging solid content is controlled at 20-35%, and inlet temperature 150-200 ℃, outlet temperature 70-90 ℃;
8), after above-mentioned steps, can obtain 40-80 order, free flowable natural beta-carotin microcapsule granule.
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