CN108030063A - A kind of preparation method of the beta carotene microcapsules of high carrying capacity high bioavilability - Google Patents
A kind of preparation method of the beta carotene microcapsules of high carrying capacity high bioavilability Download PDFInfo
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- CN108030063A CN108030063A CN201711369959.2A CN201711369959A CN108030063A CN 108030063 A CN108030063 A CN 108030063A CN 201711369959 A CN201711369959 A CN 201711369959A CN 108030063 A CN108030063 A CN 108030063A
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- oil
- beta carotene
- carrying capacity
- microcapsules
- oil phase
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- 239000003094 microcapsule Substances 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 title claims description 46
- 235000013734 beta-carotene Nutrition 0.000 title claims description 46
- 239000011648 beta-carotene Substances 0.000 title claims description 46
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 title claims description 46
- 229960002747 betacarotene Drugs 0.000 title claims description 46
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 title claims description 46
- 239000000463 material Substances 0.000 claims abstract description 19
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 14
- 238000001694 spray drying Methods 0.000 claims abstract description 10
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 7
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 7
- 238000010438 heat treatment Methods 0.000 claims abstract description 7
- 229940046009 vitamin E Drugs 0.000 claims abstract description 7
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 7
- 239000011709 vitamin E Substances 0.000 claims abstract description 7
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 5
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 5
- 235000006708 antioxidants Nutrition 0.000 claims abstract description 5
- 230000001079 digestive effect Effects 0.000 claims abstract description 5
- 238000004945 emulsification Methods 0.000 claims abstract description 5
- 239000000155 melt Substances 0.000 claims abstract description 5
- 239000012053 oil suspension Substances 0.000 claims abstract description 5
- 150000003626 triacylglycerols Chemical class 0.000 claims abstract description 5
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims abstract description 4
- 238000003181 co-melting Methods 0.000 claims abstract description 4
- 239000003623 enhancer Substances 0.000 claims abstract description 4
- 238000010008 shearing Methods 0.000 claims abstract 2
- 239000003921 oil Substances 0.000 claims description 38
- 235000019198 oils Nutrition 0.000 claims description 38
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- 229930006000 Sucrose Natural products 0.000 claims description 8
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 8
- 239000005720 sucrose Substances 0.000 claims description 8
- 229920002472 Starch Polymers 0.000 claims description 7
- KCYQMQGPYWZZNJ-BQYQJAHWSA-N hydron;2-[(e)-oct-1-enyl]butanedioate Chemical compound CCCCCC\C=C\C(C(O)=O)CC(O)=O KCYQMQGPYWZZNJ-BQYQJAHWSA-N 0.000 claims description 7
- 239000008107 starch Substances 0.000 claims description 7
- 235000019698 starch Nutrition 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 4
- 230000000996 additive effect Effects 0.000 claims description 4
- 235000010323 ascorbic acid Nutrition 0.000 claims description 4
- 239000011668 ascorbic acid Substances 0.000 claims description 4
- 229960005070 ascorbic acid Drugs 0.000 claims description 4
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 claims description 4
- 230000029087 digestion Effects 0.000 claims description 4
- 235000010352 sodium erythorbate Nutrition 0.000 claims description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
- 239000001110 calcium chloride Substances 0.000 claims description 3
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 3
- 239000006210 lotion Substances 0.000 claims description 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 3
- 235000019483 Peanut oil Nutrition 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 235000013927 calcium gluconate Nutrition 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000002285 corn oil Substances 0.000 claims description 2
- 235000005687 corn oil Nutrition 0.000 claims description 2
- 239000000312 peanut oil Substances 0.000 claims description 2
- 239000003549 soybean oil Substances 0.000 claims description 2
- 235000012424 soybean oil Nutrition 0.000 claims description 2
- CIWBSHSKHKDKBQ-DUZGATOHSA-N D-isoascorbic acid Chemical compound OC[C@@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-DUZGATOHSA-N 0.000 claims 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims 2
- 239000000263 2,3-dihydroxypropyl (Z)-octadec-9-enoate Substances 0.000 claims 1
- RZRNAYUHWVFMIP-GDCKJWNLSA-N 3-oleoyl-sn-glycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-GDCKJWNLSA-N 0.000 claims 1
- 240000007594 Oryza sativa Species 0.000 claims 1
- 235000007164 Oryza sativa Nutrition 0.000 claims 1
- 235000019482 Palm oil Nutrition 0.000 claims 1
- 235000019484 Rapeseed oil Nutrition 0.000 claims 1
- 235000019498 Walnut oil Nutrition 0.000 claims 1
- 229960003563 calcium carbonate Drugs 0.000 claims 1
- 229960002713 calcium chloride Drugs 0.000 claims 1
- 239000004227 calcium gluconate Substances 0.000 claims 1
- 229960004494 calcium gluconate Drugs 0.000 claims 1
- 229940095672 calcium sulfate Drugs 0.000 claims 1
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims 1
- 239000000944 linseed oil Substances 0.000 claims 1
- 235000021388 linseed oil Nutrition 0.000 claims 1
- RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 claims 1
- 239000004006 olive oil Substances 0.000 claims 1
- 235000008390 olive oil Nutrition 0.000 claims 1
- 239000002540 palm oil Substances 0.000 claims 1
- 235000009566 rice Nutrition 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 235000020238 sunflower seed Nutrition 0.000 claims 1
- 239000008170 walnut oil Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 239000000047 product Substances 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 8
- 239000000843 powder Substances 0.000 description 8
- 235000021466 carotenoid Nutrition 0.000 description 7
- 150000001747 carotenoids Chemical class 0.000 description 7
- 239000013078 crystal Substances 0.000 description 6
- 238000002844 melting Methods 0.000 description 6
- 230000008018 melting Effects 0.000 description 6
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000004519 grease Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005265 energy consumption Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000008601 oleoresin Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 229960003471 retinol Drugs 0.000 description 2
- 235000020944 retinol Nutrition 0.000 description 2
- 239000011607 retinol Substances 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001502 supplementing effect Effects 0.000 description 2
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 2
- PVNIQBQSYATKKL-UHFFFAOYSA-N tripalmitin Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 description 2
- 108090000371 Esterases Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- -1 breast Change Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 235000019621 digestibility Nutrition 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 150000002634 lipophilic molecules Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000012173 sealing wax Substances 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000037351 starvation Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 229960001947 tripalmitin Drugs 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/015—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
A kind of preparation method of high carrying capacity bata-carotene microcapsules, it is characterised in that：It is oil phase that bata-carotene, monoglyceride, triglycerides and vitamin E shearing that mass ratio is 5 20: 15: 60 80: 15, which are mixed, under the flow velocity of 0.01 1000L/min, by the coil heat exchanger of 140 250 DEG C of oil bath heatings, by the heat exchange area for controlling heat exchanger, control heating time is less than 5min, into oil suspension, bata-carotene melts completely, co-melting oil phase is added in the wall material solution that with the addition of antioxidant and digestive enhancers, clipped, emulsification, homogeneous and spray drying, obtain the bata-carotene microcapsules of high carrying capacity.Advantages of the present invention is：The high carrying capacity bata-carotene microcapsules of controllable preparation, easy to operate, equipment is easy to get, and can continuously mass produce, and the addition of organic solvent-free and residual, product stability is higher, can simply room temperature be kept in dark place, product has high bioavilability.
Description
Technical field
The present invention relates to hydrophobicity, oxidizable and low bioavilability class material microcapsules preparation, specifically one
Kind can high carrying capacity embedding liposoluble substance and the bag of starvation and the microencapsulation for improving such material bioavilability
Method is buried, belongs to food additives field.
Background technology
Carotenoid is a kind of liposoluble substance being widely present in nature, and wherein beta carotene is most representative,
It is the important and safe vitamin a source of human body.One molecule beta carotene can be converted into two molecule retinol (remaining in theory
Carotenoid is 1：1), but the report of World Health Organization's early stage shows that the beta carotene of six molecules can just have in human body
Effect is converted into the retinol of a molecule, or even has scientist to improve this effective ratio to 12 in recent years：1.This is because β-
This quasi-molecule of carrotene in human body there is extremely low biology can give rate and biological transformation ratio.Meanwhile β-the Hu Luo of natural form
Bu Su, it is most of to be present in reference state in fruits and vegetables, cause its release and utilization rate upon intake low.Therefore, if energy
Biology profit can be improved to the formulation product of the beta carotene of rate while dosage is reduced by developing a high biology
With rate, problem above can be solved well.
Numerous studies show that the existence form and its particle diameter of beta carotene can be very big to rate influence on its biology.
CN101016259A disclose it is a kind of the beta carotene in saturation good solvent dichloromethane is added in the form of spraying it is non-good
In etoh solvent, final beta carotene is separated out with 2 μm or so of crystal, and the crystal after filtering is added in protective colloid, breast
Change, beta carotene microcapsules have been made in spray drying.Existing document also reports, the beta carotene crystal form of different-grain diameter distribution
Bioavilability difference between scattered microcapsules is greatly (tend to vary with the reduction of crystal particle diameter and raise).But by average grain diameter
When being reduced to 300nm or so, the support of powerful equipment is generally required, energy consumption is big and easily loses core, and as particle diameter will
The further reduction asked, for energy consumption into the growth of geometry level, this development is clearly unsustainable.Present invention employs melting
The form embedding of beta carotene, rather than the state of crystal form, this can effectively improve the biological utilisation of core in microcapsules
Degree.The biology of beta carotene can give rate also related to the grease in system.If not oil-containing in microcapsules, even if particle diameter is very low,
It is also required to eat after the meal, with the digestion of grease in food, increases the absorption of beta carotene.
Beta carotene microcapsules with industrial application value should also be with certain carrying capacity.First, high carrying capacity is prepared
Beta carotene microcapsules reduce the costs of manufacturing and transportation that unit core is consumed.Secondly, the beta carotene of high carrying capacity is micro-
Capsule product of relatively low carrying capacity in certain addition content reduces the additive amount of coating material, this is to keeping finished product food
Quality have great help.Again, when supplementing beta carotene, effective dosages of microcapsules can also great quilt
Reduce.As pigment, in use, while industrial general being contemplated to be is keeping product stability, carrying capacity is the bigger the better；
As nutritional supplement in use, needing to keep the ratio of certain carotenoid and triglyceride oil (to avoid the need for eating
After the defects of supplementing), improving its biology can be to rate.And solubility of the beta carotene in most solvents is very low, in plant
0.3% is generally below in oil.The biology of obtained microcapsules can be to rate very when if carotenoid is only dispersed in oil
Low (being probably that the carotenoid of this state have impact on the digestion of grease).If carotenoid is only dissolved in oil,
The carrying capacity of microcapsules can be subject to strong influence (generally below 0.1%).Based on problem above, we develop a species Hu trailing plants
The microcapsule product of Bu Su and the co-melting state of triglycerides.It can also maintain higher biology can be to rate while certain carrying capacity is kept.
Storage-stable, general requirement two should also be had the characteristics that by being capable of the beta carotene microcapsules of large-scale promotion
Room temperature lucifuge storage in year, the degradation rate of core are less than 10%.Traditional way is to try to improve the thickness of wall material and fine and close journey
Degree, or addition antioxidant, also or are granulated to improve the progress of the means such as powder specific-surface area detection and sealing wax.It is of the invention then be base
Between different wall material molecules, the characteristic such as different proportion, co-melting, phase separation, preparing the high wall material of compactness extent, (wall material is put down
Equal gap is less than oxygen molecule Van der Waals diameter) microcapsules technology.This technology later stage can be additionally used in volatility core (such as essence
Oil) embedding, the volatilization and oxygen molecule for preventing such core permeate destruction to core, have and be widely applied very much prospect.
The content of the invention
The present invention is to overcome above-mentioned prior art defect, there is provided a kind of high carrying capacity and can be kept compared with high bioavilability
Fat-soluble small molecule microencapsulation technology, meanwhile, wall material proportioning provide it is a kind of prevent core aoxidize technology.
1) beta carotene crystal and edible triglycerides, glycerin monostearate and vitamin E are uniformly mixed, used
High speed shear is uniformly dispersed is less than 10 μm to average grain diameter, and the beta carotene oil suspension of 4%-30% is made.
2) coil heat exchanger by foregoing oil suspension with certain flow rate by 180 DEG C of oil bath heatings, is changed by adjusting coil pipe
The mode of hot area controls heating time less than 5min until the beta carotene in oil suspension melts completely, and formation black melts
Oleoresin.
3) above-mentioned melting oleoresin is added to molten by gelatinization, octenyl succinic acid starch and sucrose mixing after cooling
In liquid, to shear, emulsification, homogeneous, forms stable beta carotene lotion, adds the sodium ascorbate and calcium chloride of certain content,
And adjust lotion pH to 3-4.
4) above-mentioned emulsion is spray-dried, obtain high carrying capacity stabilization high biology can give rate beta carotene it is micro-
Capsule.
The beta carotene could alternatively be other carotenoid or other lipophilic molecules, change setting steps 2) oil bath
Temperature is higher than insoluble 10 DEG C or so of core fusing point.Oil phase can also be replaced with to volatile core (such as essential oil), prevent core
Volatilization or oxygen infiltration.
The present invention core be with the beta carotene of molten state under the emulsification of the wall material solution of special ratios, be aided with and disappear
Change accelerating agent, by spray drying, obtain the beta carotene microcapsules of high carrying capacity.Under the method beta carotene microcapsules due to
Wall material free volume is extremely low, so that stability is high；Beta carotene heating time is extremely short, avoids the loss and side reaction of core
Generation；The beta carotene of molten state is aided with digestive enhancers, and the biology that can effectively improve core can be to rate；The addition of sucrose
Also effectively improve the instant capacity of powder.
Finally, beneficial effects of the present invention are：Controllable high carrying capacity beta carotene microcapsules, easy to operate, equipment is easy
, can continuously mass produce, the addition of organic solvent-free and residual, product stability is higher, can simply room temperature be kept in dark place,
There is product high biology can give rate.
Embodiment
In order to make the foregoing objectives, features and advantages of the present invention clearer and more comprehensible, below by the specific of the present invention
Embodiment is described in detail.
Many details are elaborated in the following description to facilitate a thorough understanding of the present invention, still the present invention can be with
Implemented using other different from other manner described here, those skilled in the art can be without prejudice to intension of the present invention
In the case of do similar popularization, therefore the present invention is from the limitation of following public specific embodiment.
Embodiment 1
Beta carotene 5g, vitamin E 5g, glycerin monostearate 2g, corn oil 88g are taken, it is for oil phase to stir evenly；
Octenyl succinic acid starch 80g is taken, sucrose 150g is molten with 550g water, being gelatinized through 80 DEG C of 10 min of water-bath, postcooling to room temperature
It is spare, it is for water phase；Above-mentioned oil phase had into internal diameter 12mm, outside diameter with the flow of 100mL/min by 180 DEG C of oil baths
Black molten condition is presented in 14mm, the coil heat exchanger of the coil pipe of pipe range 1000mm, efflux, and melting oil phase is imported into water phase
In, 5min is sheared through 18000r/min, adds 5g ascorbic acid, 1g calcium gluconates, it is 3.35 to adjust pH, in 100MPa homogeneous
4 times, through 170 DEG C of inlet air, 70 DEG C of spray drying of outlet air, obtain microscapsule powder.Room temperature sealing is kept in dark place.
Embodiment 2
Beta carotene 20g, vitamin E 5g, tripalmitin 5g, peanut oil 70g are taken, it is for oil phase to stir evenly；
Octenyl succinic acid starch 80g is taken, sucrose 160g is molten with 550g water, being gelatinized through 80 DEG C of water-bath 10min, and postcooling is standby to room temperature
With being for water phase；Above-mentioned oil phase is had into internal diameter 12mm, outside diameter 14mm with the flow of 1000mL/min by 180 DEG C of oil baths,
Black molten condition is presented in the coil heat exchanger of the coil pipe of pipe range 10000mm, efflux, and melting oil phase is imported into water phase,
5min is sheared through 18000r/min, adds 6.5g arabo-ascorbic acids, 5g calcium nitrate, it is 3.35 to adjust pH, is surpassed under the conditions of 100W
Sound emulsifies 20min, through 180 DEG C of inlet air, and 70 DEG C of spray drying of outlet air, obtain microscapsule powder.Room temperature sealing is kept in dark place.
Embodiment 3
Beta carotene 10g, vitamin E 5g, olein 3g, soybean oil 87g are taken, it is for oil phase to stir evenly；Take
Octenyl succinic acid starch 80g, sucrose 120g are molten with 550g water, being gelatinized through 80 DEG C of water-bath 10min, and postcooling is standby to room temperature
With being for water phase；Above-mentioned oil phase is had into internal diameter 12mm, outside diameter 14mm with the flow of 1000mL/min by 200 DEG C of oil baths,
Black molten condition is presented in the coil heat exchanger of the coil pipe of pipe range 10000mm, efflux, and melting oil phase is imported into water phase,
5min is sheared through 18000r/min, adds 7g ascorbic acid, 5g calcium carbonate powders, it is 3.85 to adjust pH, is surpassed under the conditions of 100W
Sound emulsifies 20min, through 160 DEG C of inlet air, and 70 DEG C of spray drying of outlet air, obtain microscapsule powder.Room temperature sealing is kept in dark place.
Embodiment 4
Beta carotene 5g is taken, vitamin E 5g, olein 1 g, grape-kernel oil 89g, it is for oil phase to stir evenly；
Octenyl succinic acid starch 80g is taken, sucrose 100g is molten with 550g water, being gelatinized through 80 DEG C of water-bath 10min, and postcooling is standby to room temperature
With being for water phase；Above-mentioned oil phase is had into internal diameter 12mm, outside diameter 14mm with the flow of 1000mL/min by 200 DEG C of oil baths,
Black molten condition is presented in the coil heat exchanger of the coil pipe of pipe range 10000mm, efflux, and melting oil phase is imported into water phase,
5min is sheared through 18000r/min, adds 5g sodium isoascorbates, 1g calcium chloride powder, it is 3.75 to adjust pH, in 100W conditions
Lower ultrasonic emulsification 20min, through 160 DEG C of inlet air, 70 DEG C of spray drying of outlet air, obtain microscapsule powder.Room temperature sealing is kept in dark place.
Experimental result shows, by adjusting oil phase formula, wall material solution ratio, can obtain under the conditions of room temperature lucifuge can be with
The beta carotene microcapsule product of storage-stable, by controlling addition of the beta carotene in oil phase, is aided with high-temperature instantaneous and melts
Melt technology, can at utmost preserve the retention rate of beta carotene in process, and improve its load in microcapsules whereby
Amount.In vitro digestion can excite the work of esterase the results show that addition by calcium ion in wall material in the small intestine stage
Property, the digestibility and digestible degree of triglyceride material are improved, and it is aided with addition of the monoglyceride material in oil phase, increase β-
Micellization degree of the carrotene in the small intestine stage, rate can be given by improving biology.
Beta carotene is melted in triglycerides by the present invention, by controlling its additive amount to control final carrying capacity, addition dimension
Raw element E, with spray drying technology is emulsified, is embedded to slow down its loss in storage, by controlling wall material to match, is prepared into
The minimum microcapsule structure of free volume, the very big storage phase that must extend beta carotene under normal temperature condition.And by single sweet
The addition of Ester and calcium ion, excites the activity of digestive ferment and improves the micellization efficiency of fat-soluble small molecule, improve most
The biology of finished product can give rate.It is its work that its high carrying capacity characteristic, long-term room-temperature stability and high biology, which can give a variety of features such as rate,
The prospect of the application of industry gives enough guarantees.
It should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention and it is unrestricted, although with reference to preferable
The present invention is described in detail in embodiment, it will be understood by those of ordinary skill in the art that, can be to the technology of the present invention
Scheme technical scheme is modified or replaced equivalently, without departing from the spirit and scope of technical solution of the present invention, it should all cover in this hair
Among bright right.
Claims (6)
- A kind of 1. preparation method of high carrying capacity beta carotene microcapsules, it is characterised in that：It is 5-20 by mass ratio：1-5：60- 80：It is oil phase that beta carotene, monoglyceride, triglycerides and the vitamin E shearing of 1-5, which mixes, in the stream of 0.01-1000L/min Under speed, by the coil heat exchanger of 140-250 DEG C of oil bath heating, by controlling the heat exchange area of heat exchanger, heating time is controlled Less than 5min, into oil suspension, beta carotene melts completely, and co-melting oil phase, which is added to, with the addition of antioxidant and digestion promotion In the wall material solution of agent, clipped, emulsification, homogeneous and spray drying, obtain the beta carotene microcapsules of high carrying capacity.
- 2. monoglyceride according to claim 1 is glycerin monostearate, glyceryl monooleate or their mixture；Institute The triglyceride material stated is corn oil, soybean oil, Rice oil, peanut oil, grape-kernel oil, olive oil, palm oil, sunflower seeds Oil, walnut oil, linseed oil, rapeseed oil or their mixture.
- 3. wall material solution according to claim 1, consisting of octenyl succinic acid starch and sucrose, ratio is oil phase： Octenyl succinic acid starch：Sucrose=0.8-1:1:1-2.
- 4. antioxidant according to claim 1 is ascorbic acid, arabo-ascorbic acid, ascorbic acid are received, arabo-ascorbic acid Sodium or their mixture.Its additive amount is oil phase：Antioxidant=20：1-1.5.
- A kind of 5. preparation method of high carrying capacity beta carotene microcapsules, it is characterised in that spray drying before by lotion pH adjust to Between 3-4.
- 6. digestive enhancers according to claim 1 for calcium chloride, calcium carbonate, calcium gluconate, calcium sulfate, calcium nitrate or Their mixture.Its additive amount is oil phase：Digestive enhancers=2：0.001-10.
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Application publication date: 20180515 |