CN106509902A - Lycopene-loaded nano-emulsion and preparation method thereof - Google Patents
Lycopene-loaded nano-emulsion and preparation method thereof Download PDFInfo
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- CN106509902A CN106509902A CN201611090099.4A CN201611090099A CN106509902A CN 106509902 A CN106509902 A CN 106509902A CN 201611090099 A CN201611090099 A CN 201611090099A CN 106509902 A CN106509902 A CN 106509902A
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- 235000012661 lycopene Nutrition 0.000 title claims abstract description 80
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 title claims abstract description 78
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 title claims abstract description 78
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 title claims abstract description 78
- 239000001751 lycopene Substances 0.000 title claims abstract description 78
- 229960004999 lycopene Drugs 0.000 title claims abstract description 78
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 title claims abstract description 78
- 239000007908 nanoemulsion Substances 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 41
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 11
- 239000000126 substance Substances 0.000 claims abstract description 5
- 239000012071 phase Substances 0.000 claims description 50
- 235000019198 oils Nutrition 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 13
- 239000008367 deionised water Substances 0.000 claims description 9
- 229910021641 deionized water Inorganic materials 0.000 claims description 9
- 230000001804 emulsifying effect Effects 0.000 claims description 9
- 238000004090 dissolution Methods 0.000 claims description 6
- 239000008346 aqueous phase Substances 0.000 claims description 4
- 102000011632 Caseins Human genes 0.000 claims description 2
- 108010076119 Caseins Proteins 0.000 claims description 2
- 102000008192 Lactoglobulins Human genes 0.000 claims description 2
- 108010060630 Lactoglobulins Proteins 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 238000011068 loading method Methods 0.000 claims description 2
- 229940080237 sodium caseinate Drugs 0.000 claims description 2
- 150000003626 triacylglycerols Chemical class 0.000 claims description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 2
- 239000003921 oil Substances 0.000 claims 4
- 229920002472 Starch Polymers 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 239000004006 olive oil Substances 0.000 claims 1
- 235000008390 olive oil Nutrition 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 abstract description 6
- 235000013305 food Nutrition 0.000 abstract description 6
- 239000002245 particle Substances 0.000 abstract description 4
- 239000013543 active substance Substances 0.000 abstract description 2
- 238000009826 distribution Methods 0.000 abstract description 2
- 230000004060 metabolic process Effects 0.000 abstract description 2
- 230000029142 excretion Effects 0.000 abstract 1
- 235000008935 nutritious Nutrition 0.000 abstract 1
- 230000014759 maintenance of location Effects 0.000 description 13
- 238000005516 engineering process Methods 0.000 description 12
- 238000000034 method Methods 0.000 description 11
- 229920000881 Modified starch Polymers 0.000 description 9
- 239000004368 Modified starch Substances 0.000 description 9
- 235000019426 modified starch Nutrition 0.000 description 9
- 239000000839 emulsion Substances 0.000 description 5
- 238000000354 decomposition reaction Methods 0.000 description 4
- 239000003094 microcapsule Substances 0.000 description 4
- 239000002539 nanocarrier Substances 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 241000227653 Lycopersicon Species 0.000 description 2
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 150000002664 lycopenes Chemical class 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 206010017943 Gastrointestinal conditions Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 231100000734 genotoxic potential Toxicity 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 235000019476 oil-water mixture Nutrition 0.000 description 1
- 235000020195 rice milk Nutrition 0.000 description 1
- 230000036299 sexual function Effects 0.000 description 1
- 230000005476 size effect Effects 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the technical field of preparation processes of functional nutritious food, and particularly relates to a nano-emulsion for relieving oxygenolysis of lycopene and a preparation method thereof. The nano-emulsion is composed of an oil phase and a water phase. The mass ratio of the oil phase to the water phase is 1:11 to 1:7. A macromolecular emulsifier is dissolved in water to serve as the water phase. The lycopene is dissolved in oily substances to serve as the oil phase. The lycopene-loaded nano-emulsion is prepared after the oil phase and the water phase are mixed, emulsified and dispersed. The nano-emulsion provided by the invention is loaded with the lycopene and has the characteristics of high safety performance, high load rate and the like, and the acting condition is mild; since the lycopene is a sensitive active substance, the load efficiency of the lycopene can be improved; and meanwhile, through the absorption, metabolism, distribution and excretion characteristics of lycopene-loaded nano-emulsion particles, the bioavailability of the lycopene-loaded nano-emulsion can be improved, and the lycopene-loaded nano-emulsion has broad market prospects.
Description
Technical field
The invention belongs to functional nutrient food preparation processes technical field, and in particular to a kind of to alleviate protection lycopene
Nanoemulsions of oxidation Decomposition and preparation method thereof.
Background technology
Lycopene has the health care for improving function of human body and health level, but due to water insoluble, biological utilisation
The characteristic such as degree is low, very sensitive to environment and work flow and gastrointestinal conditions, it is difficult in being directly appended to food or by human body
Effectively absorb.
The technology of the not oxidized decomposition of energy effective protection lycopene at present is mainly microcapsule technology, i.e., by selecting conjunction
Target substance embedding is got up by suitable filmogen, plays a part of protection.For example, using sucrose plus gelatin or some other is multiple
The material that combines harmoniously prepares lycopene microcapsule by spray drying method, also has by building lycopene water inclusion, liposome, micro-
Newborn system and nanometer disperse system simultaneously obtain better effects, but these technologies are concentrated mainly in micron level.
Nano-carrier technology is development of the microcapsule technology to depth, nanoemulsions technology and simple emulsion（1~100 μ
m）Compare, have the advantages that much to can be used in food and beverage products system.First, small size effect specific to nanoemulsions
Should and skin effect, in addition to it can realize the protection to nutrient well, nano-carrier often shows higher stablizing
Property and more remarkable body absorption, controlled release and targeting sexual function, and then improve lycopene bioavailability；Secondly, nanometer
The particle diameter of level, the more preferable stable particle of energy prevent the emulsion caused because of aggregation or gravity from separating.And as particle diameter is less, receive
The light scattering ripple that rice milk liquid contains granule is weaker, therefore, emulsion is transparent or only slight cloudy state, is conducive to which in various foods
Addition in product, beverage systems.
Synthesis or semisynthetic little point even if some product technologies are deep into nano-scale on the market, used by its product
There is genotoxic potential in sub- emulsifying agent, and addition is big, inevitably brings hidden danger to food safety.
The content of the invention
The invention aims to overcome the shortcomings of existing microcapsule technology and other nano-carrier technologies and defect, carry
For a kind of nanoemulsions that can effectively slow down lycopene oxidation Decomposition, lycopene retention rate, the technical role condition is improved
Gently, technological process is easy, and Mechanization Level is high, provides basis for production application.
The purpose of the present invention is achieved by following technical proposals：
A kind of load lycopene nanoemulsions, by oil phase and water phase composition, profit phase mass ratio is 1:11-1:7.
Further, the oil-phase solution is three sour fat of medium chain triglyceride（MCT）, long-chain triglycerides (LCT), Fructus Canarii albi
One or more in oil, Oleum menthae and lycopene.
Further, the aqueous phase solution is made up of macromole emulsifying agent and deionized water.
Further, the macromole emulsifying agent be modified starch, sodium caseinate, the one kind or several in beta lactoglobulin
Kind.
Further, in water phase, macromole emulsifying agent mass fraction is 20% ~ 30 %.
It is a further object to provide a kind of preparation method of load lycopene nanoemulsions, concrete steps are such as
Under：
S1:By macromole emulsifying agent and deionized water mix homogeneously, as aqueous phase solution；
S2:By lycopene and oil phase substance mix homogeneously, ultrasonic dissolution under room temperature, used as oil-phase solution；
S3:Oil phase and water are mutually mixed in mass ratio, and the stirring and emulsifying at 30 ~ 70 DEG C；
S4:After S3 mixed liquors are disperseed at a high speed, under high pressure homogenizer, homogenizing obtains loading lycopene nanoemulsions.
Preferably, step S1 macromole emulsifying agent stirring and dissolving at 30 ~ 70 DEG C, then puts to being stirred at room temperature so as to fill
Divide aquation.
Preferably, the mass fraction of lycopene described in step S2 is 0.1-0.5%.
Preferably, filtration treatment is done after oil phase dissolving completely described in step S2.
Preferably, step S3 oil-water mixture is emulsified at 30 DEG C.
It is highly preferred that step S3 oil-water ratio is 1:11 is emulsified at 50 ~ 70 DEG C.
Preferably, the mixed liquor described in step S4 homogenizes load tomato red under 90 ~ 120Mpa Jing after high speed is disperseed
Plain nanoemulsions.
The invention has the advantages that：
Nanoemulsions proposed by the invention load lycopene, with security performance is high and the features such as high load factor, nanometer
Emulsion technology compares other technologies, and action condition is gentle, and lycopene belongs to sensitive active substance, and this can improve tomato red
The load efficiency of element, while load absorption of the nanoemulsions granule of lycopene in human body, metabolism, distribution and the spy for draining
Point can improve its bioavailability again, with larger market prospect.
Description of the drawings
Fig. 1 is impact of the different oil-water ratios to lycopene retention rate.
Fig. 2 is impact of the different emulsifying temperatures to lycopene retention rate.
Fig. 3 is impact of the Different treatments to lycopene retention rate.
Specific embodiment
The present invention, but embodiment is further illustrated below in conjunction with Figure of description and specific embodiment not to the present invention
Limit in any form.Unless stated otherwise, the method and apparatus that the present invention is adopted is for the art conventional reagent, method
And equipment.Unless stated otherwise, following examples material therefor is commercial.
Embodiment 1 investigates impact of the different oil-water ratios to lycopene retention rate
Group 1：A kind of load lycopene nanoemulsions, by oil phase and water phase composition, profit phase mass ratio is 1:11, the oil phase
It is made up of MCT and lycopene, the water is made up of modified starch and deionized water.
Group 2：A kind of load lycopene nanoemulsions, by oil phase and water phase composition, profit phase mass ratio is 1:9, it is described
Oil phase is made up of MCT and lycopene, and the water is made up of modified starch and deionized water.
Group 3：A kind of load lycopene nanoemulsions, by oil phase and water phase composition, profit phase mass ratio is 1:7, it is described
Oil phase is made up of MCT and lycopene, and the water is made up of modified starch and deionized water.
A kind of preparation method of load lycopene nanoemulsions, comprises the following steps that：
S1. configuration quality concentration for 20 ~ 30% modified starch solution, then the stirring and dissolving at 30 ~ 70 DEG C put to room temperature and stir
Mix so as to abundant aquation, as water phase；
S2. configuration quality concentration is 0.1 ~ 0.5 %（w/w）Lycopene oil, ultrasonic dissolution under room temperature, after its dissolving completely
Filter, as oil phase；
S3. oil phase and water are mutually mixed in mass ratio, and the stirring and emulsifying at 30 ~ 70 DEG C；
S4. after mixed liquor disperses at a high speed, under 110 Mpa, homogenizing is finally loaded lycopene nanoemulsions 3 times.
Prepare according to as above method, after preserving one month, the reservation of three groups of lycopenes is determined by UV absorption method
Rate, test result are as shown in Figure 1.Experimental data shows, when profit phase mass ratio is 1:When 11, lycopene retention rate highest.
Embodiment 2 investigates impact of the different emulsifying temperatures to lycopene retention rate
A kind of load lycopene nanoemulsions, are made up of oil phase and aqueous, and profit phase mass ratio is 1:11, the oil phase by
MCT and lycopene composition, the water are made up of modified starch and deionized water.
Group 4：A kind of preparation method of load lycopene nanoemulsions, comprises the following steps that：
S1. configuration quality concentration for 20 ~ 30% modified starch solution, then the stirring and dissolving at 30 ~ 70 DEG C put to room temperature and stir
Mix so as to abundant aquation, as water phase；
S2. configuration quality concentration for 0.1 ~ 0.5% lycopene oil, ultrasonic dissolution under room temperature filtered after its dissolving completely,
As oil phase；
S3. by oil phase and water phase in mass ratio 1:11 mixing, and the stirring and emulsifying at 30 DEG C；
S4. after mixed liquor disperses at a high speed, under 110 Mpa, homogenizing is finally loaded lycopene nanoemulsions 3 times.
Group 5：With group 4, difference is that emulsifying temperature is 50 DEG C in step S3 to preparation method.
Group 6：With group 4, difference is that emulsifying temperature is 70 DEG C in step S3 to preparation method.
Prepare according to as above method, after preserving one month, the reservation of three groups of lycopenes is determined by UV absorption method
Rate, as a result as shown in Figure 2.Test data shows, with the rising of temperature, in emulsion, the retention rate of lycopene has one to carry
The process for rising, changes unobvious after 50 DEG C.
Embodiment 3 investigates impact of the Different treatments to lycopene retention rate
Group 7：A kind of load lycopene nanoemulsions, are made up of oil-phase solution and aqueous phase solution, and profit phase mass ratio is 1:11,
The oil phase is made up of MCT and lycopene, and the water is made up of modified starch and deionized water.
A kind of preparation method of load lycopene nanoemulsions, comprises the following steps that：
S1. configuration quality concentration for 20 ~ 30% modified starch solution, then the stirring and dissolving at 30 ~ 70 DEG C put to room temperature and stir
Mix so as to abundant aquation, as water phase；
S2. configuration quality concentration for 0.1 ~ 0.5% lycopene oil, ultrasonic dissolution under room temperature filtered after its dissolving completely,
As oil phase；
S3. oil phase and water are mutually mixed in mass ratio, and the stirring and emulsifying at 50 DEG C；
S4. after mixed liquor disperses at a high speed, under 110Mpa, homogenizing is finally loaded lycopene nanoemulsions 3 times.
Load lycopene nanoemulsions are prepared by as above method, is placed under room temperature, week about by UV absorption
Method determines lycopene retention rate.
Matched group 1：Configuration quality concentration is 0.1% lycopene oil, ultrasonic dissolution under room temperature, after filtration at room temperature
Place, its light absorption value was surveyed every 1 week.Oil phase substance used is MCT.
As a result as shown in Figure 3, test data shows, organizes the lycopene of 7 Jing nanoemulsions load in storage one month
Retention rate still has 75.6 % afterwards, and the lycopene content that contrast groups 1 are directly dissolved in oil phase the 2nd week has been just 0 in storage.It is real
Test result to show, the lycopene good stability of Jing nanoemulsions load can effectively be alleviated lycopene oxidation Decomposition, and compare
The lycopene of oil phase substance is directly dissolved in, retention time is long, retention rate is high.
Embodiment described above only expresses the several embodiments of the present invention, and its description is more concrete and detailed, but and
Therefore the restriction to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that for one of ordinary skill in the art
For, without departing from the inventive concept of the premise, some deformations and improvement can also be made, these belong to the guarantor of the present invention
Shield scope.Therefore, the protection domain of patent of the present invention should be defined by claims.
Claims (10)
1. a kind of to load lycopene nanoemulsions, it is characterised in that by oil phase and water phase composition, profit phase mass ratio is 1:
11-1:7。
2. lycopene nanoemulsions are loaded according to claim 1, it is characterised in that the oil-phase solution is medium chain triglyceride
Three sour fat（MCT）, long-chain triglycerides (LCT), olive oil, one or more and lycopene in Oleum menthae.
3. lycopene nanoemulsions are loaded according to claim 1, it is characterised in that the aqueous phase solution is by macromole breast
Agent and deionized water composition.
4. lycopene nanoemulsions are loaded according to claim 3, it is characterised in that the macromole emulsifying agent is degeneration
One or more in starch, sodium caseinate, beta lactoglobulin.
5. lycopene nanoemulsions are loaded according to claim 4, it is characterised in that macromole emulsifying agent quality in water phase
Fraction is 20% ~ 30 %.
6. it is a kind of load lycopene nanoemulsions preparation method, it is characterised in that step is as follows：
S1:By macromole emulsifying agent and deionized water mix homogeneously, as water phase；
S2:By lycopene and oil phase substance mix homogeneously, ultrasonic dissolution under room temperature, used as oil phase；
S3:Oil phase and water are mutually mixed in mass ratio, and the stirring and emulsifying at 30 ~ 70 DEG C；
S4:After S3 mixed liquors are disperseed at a high speed, under high pressure homogenizer, homogenizing obtains loading lycopene nanoemulsions.
7. the preparation method of lycopene nanoemulsions is loaded according to claim 6, it is characterised in that macromole emulsifying agent
Stirring and dissolving is wanted, is put to being stirred at room temperature afterwards so as to abundant aquation.
8. the preparation method of lycopene nanoemulsions is loaded according to claim 6, it is characterised in that the lycopene
Mass fraction be 0.1-0.5%.
9. the preparation method of lycopene nanoemulsions is loaded according to claim 6, it is characterised in that oil-water ratio 1:11
Mixed liquor is emulsified at 50 ~ 70 DEG C.
10. the preparation method of lycopene nanoemulsions is loaded according to any one of claim 6-9, it is characterised in that mixed
Close liquid and homogenize load lycopene nanoemulsions Jing after high speed is disperseed under 90 ~ 120 Mpa.
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| CN201611090099.4A CN106509902A (en) | 2016-12-01 | 2016-12-01 | Lycopene-loaded nano-emulsion and preparation method thereof |
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| CN201611090099.4A CN106509902A (en) | 2016-12-01 | 2016-12-01 | Lycopene-loaded nano-emulsion and preparation method thereof |
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| CN106509902A true CN106509902A (en) | 2017-03-22 |
Family
ID=58354100
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| CN201611090099.4A Pending CN106509902A (en) | 2016-12-01 | 2016-12-01 | Lycopene-loaded nano-emulsion and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108634169A (en) * | 2018-05-14 | 2018-10-12 | 上海交通大学 | A kind of preparation method of lutein nanometer lotion |
| CN109122905A (en) * | 2018-09-12 | 2019-01-04 | 江南大学 | A kind of preparation method and sea-buckthorn oil nano emulsions of sea-buckthorn oil nano emulsions |
| CN109601999A (en) * | 2018-11-01 | 2019-04-12 | 华南农业大学 | A kind of lycopene nanometer powder and preparation method thereof |
| CN110800952A (en) * | 2019-12-12 | 2020-02-18 | 西北农林科技大学 | Method for improving bioavailability of lycopene in tomato juice |
| CN112056558A (en) * | 2020-09-21 | 2020-12-11 | 华南农业大学 | Oil-in-water carotene microemulsion and preparation method thereof |
| CN112708956A (en) * | 2021-01-08 | 2021-04-27 | 安徽大学 | Composite nanofiber loaded with lycopene based on electrostatic spinning, and preparation method and application thereof |
| CN115844015A (en) * | 2022-12-06 | 2023-03-28 | 南昌大学 | Lycopene oil, lycopene preparation and application thereof |
| CN116508996A (en) * | 2023-05-23 | 2023-08-01 | 华南理工大学 | Carotenoid emulsion and preparation method and application thereof |
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| WO2012168189A1 (en) * | 2011-06-06 | 2012-12-13 | Chr. Hansen A/S | Carotenoid coloring composition |
| CN102892414A (en) * | 2010-05-18 | 2013-01-23 | 富士胶片株式会社 | Carotenoid-containing composition and production method therefor |
| CN104661739A (en) * | 2012-09-28 | 2015-05-27 | 富士胶片株式会社 | Lycopene-containing oil-in-water emulsion composition and production method therefor |
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| CN102892414A (en) * | 2010-05-18 | 2013-01-23 | 富士胶片株式会社 | Carotenoid-containing composition and production method therefor |
| WO2012168189A1 (en) * | 2011-06-06 | 2012-12-13 | Chr. Hansen A/S | Carotenoid coloring composition |
| CN104661739A (en) * | 2012-09-28 | 2015-05-27 | 富士胶片株式会社 | Lycopene-containing oil-in-water emulsion composition and production method therefor |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108634169A (en) * | 2018-05-14 | 2018-10-12 | 上海交通大学 | A kind of preparation method of lutein nanometer lotion |
| CN109122905A (en) * | 2018-09-12 | 2019-01-04 | 江南大学 | A kind of preparation method and sea-buckthorn oil nano emulsions of sea-buckthorn oil nano emulsions |
| CN109601999A (en) * | 2018-11-01 | 2019-04-12 | 华南农业大学 | A kind of lycopene nanometer powder and preparation method thereof |
| CN110800952A (en) * | 2019-12-12 | 2020-02-18 | 西北农林科技大学 | Method for improving bioavailability of lycopene in tomato juice |
| CN112056558A (en) * | 2020-09-21 | 2020-12-11 | 华南农业大学 | Oil-in-water carotene microemulsion and preparation method thereof |
| CN112708956A (en) * | 2021-01-08 | 2021-04-27 | 安徽大学 | Composite nanofiber loaded with lycopene based on electrostatic spinning, and preparation method and application thereof |
| CN112708956B (en) * | 2021-01-08 | 2022-11-18 | 安徽大学 | Composite nanofiber loaded with lycopene based on electrostatic spinning, and preparation method and application thereof |
| CN115844015A (en) * | 2022-12-06 | 2023-03-28 | 南昌大学 | Lycopene oil, lycopene preparation and application thereof |
| CN116508996A (en) * | 2023-05-23 | 2023-08-01 | 华南理工大学 | Carotenoid emulsion and preparation method and application thereof |
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