CN1544056A - Oral medicine for treating ischemic necrosis of femoral head and its preparation - Google Patents
Oral medicine for treating ischemic necrosis of femoral head and its preparation Download PDFInfo
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- CN1544056A CN1544056A CNA2003101151867A CN200310115186A CN1544056A CN 1544056 A CN1544056 A CN 1544056A CN A2003101151867 A CNA2003101151867 A CN A2003101151867A CN 200310115186 A CN200310115186 A CN 200310115186A CN 1544056 A CN1544056 A CN 1544056A
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- 239000003814 drug Substances 0.000 title claims abstract description 36
- 208000007875 Femur Head Necrosis Diseases 0.000 title claims description 11
- 238000002360 preparation method Methods 0.000 title claims description 9
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 8
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 8
- 229940079593 drug Drugs 0.000 claims description 13
- 239000002994 raw material Substances 0.000 claims description 10
- 241001489978 Eupolyphaga Species 0.000 claims description 7
- 241000628997 Flos Species 0.000 claims description 7
- 239000009636 Huang Qi Substances 0.000 claims description 7
- 241001057584 Myrrha Species 0.000 claims description 7
- 239000009286 sanguis draxonis Substances 0.000 claims description 7
- 239000004615 ingredient Substances 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 abstract description 13
- 230000000694 effects Effects 0.000 abstract description 7
- 239000008280 blood Substances 0.000 abstract description 4
- 210000004369 blood Anatomy 0.000 abstract description 4
- 230000017531 blood circulation Effects 0.000 abstract description 3
- 210000003734 kidney Anatomy 0.000 abstract description 3
- 230000003213 activating effect Effects 0.000 abstract description 2
- 230000017074 necrotic cell death Effects 0.000 abstract description 2
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 235000021511 Cinnamomum cassia Nutrition 0.000 abstract 1
- 240000007311 Commiphora myrrha Species 0.000 abstract 1
- 235000006965 Commiphora myrrha Nutrition 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 241000123589 Dipsacus Species 0.000 abstract 1
- 241001116742 Drynaria Species 0.000 abstract 1
- 244000241838 Lycium barbarum Species 0.000 abstract 1
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 1
- 235000007265 Myrrhis odorata Nutrition 0.000 abstract 1
- 240000004824 Trimezia steyermarkii Species 0.000 abstract 1
- 229940107666 astragalus root Drugs 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 239000009136 dragon's blood Substances 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Inorganic materials O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 239000002023 wood Substances 0.000 abstract 1
- 210000003414 extremity Anatomy 0.000 description 4
- 229940126678 chinese medicines Drugs 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000005728 strengthening Methods 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 210000002391 femur head Anatomy 0.000 description 2
- 210000004394 hip joint Anatomy 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 230000001338 necrotic effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 208000007848 Alcoholism Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010017577 Gait disturbance Diseases 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 206010023204 Joint dislocation Diseases 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 210000001624 hip Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 206010043827 tibia fracture Diseases 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Abstract
The invention discloses a medicament to be taken orally for treating femoral head ischemic necrosis, which is prepared from pyrolusite, dragon's blood resin, notoginseng, wood louse, dipsacus root, drynaria, myrrh, safflower, matrimony vine, Cinnamomum cassia, Chinese angelica root, astragalus root and native copper. The medicament has the effects of activating blood circulation and removing stasis, kidney and bones tonifying, and vital energy and blood adjustment.
Description
Technical field
The present invention relates to a kind of endo-medicine for the treatment of ischemic necrosis of femoral head, specifically, be a kind of be the medicine that raw material is made with the Chinese crude drug, the invention still further relates to the preparation method of this medicine.
Background technology
In a single day femoral head is carrying maximum joint hip joint in human body, blood supply disorder takes place in the femoral head, will cause necrosis.Ischemic necrosis of femoral head is exactly owing to the non-traumatic reasons such as application with some drugs such as hormone such as hip wound such as dislocation of hip joint and bone fracture of tibia and some internal diseases such as pancreatitis, hematopathy, gout, alcoholism cause.Adopt conservative treatment to avoid bearing a heavy burden to the early stage patient doctor trained in Western medicine, middle and advanced stage adopts operative therapy as displacement artificial joint, Drilling, osteotomy etc., but the late result of these therapies is poor, because of not excising focus, painful big, the expense height brings spirit and very big wound economically to the patient.Though also there are some Chinese medicines can treat this disease at present, the bone gold ball of these Chinese medicines such as CN 1174078A, a kind of pharmaceutical composition for the treatment of femur head necrosis of the bone activating and muscle strengthening pill of CN 1218677A, CN 113892252A, the curative effect of these Chinese medicines is general.The inventor is exactly at improving treatment ischemic necrosis of femoral head curative effect, having developed another Chinese patent medicine, clinically through checking, finds that this medicine curative effect on treatment ischemic necrosis of femoral head osteopathia has certain breakthrough, thereby finishes the present invention.
Summary of the invention
Purpose of the present invention just provides a kind of endo-medicine for the treatment of ischemic necrosis of femoral head.
Another object of the present invention provides the preparation method of this medicine.
Medicine of the present invention is an effective ingredient of selecting for use following Chinese crude drug to make as raw material: pyrolusitum 15-10 weight portion, Sanguis Draxonis 7-11 weight portion, Radix Notoginseng 4-8 weight portion, Eupolyphaga Seu Steleophaga 7-11 weight portion, Radix Dipsaci 4-11 weight portion, Rhizoma Drynariae 4-11 weight portion, Myrrha 4-11 weight portion, Flos Carthami 4-11 weight portion, Fructus Lycii 4-11 weight portion, Radix Angelicae Sinensis 4-11 weight portion, Radix Astragali 4-11 weight portion and Pyritum 0.5-1.5 weight portion.
Wherein monarch drug is pyrolusitum and Sanguis Draxonis, ministerial drug is Eupolyphaga Seu Steleophaga and Radix Notoginseng, adjuvant drug is Radix Angelicae Sinensis, the Radix Astragali, and messenger drug is Rhizoma Drynariae, Radix Dipsaci, Pyritum, Fructus Lycii, Myrrha and Flos Carthami, and effect is blood circulation promoting and blood stasis dispelling, dredge the meridian passage, warming the meridian, accent the kidney invigorating liver spleen, the living marrow of bone strengthening and Regeneration and Repair.
If in above-mentioned raw materials, add guiding drug, can improve the performance of drug effect more, so in a preferred version of the present invention, add guiding drug, be preferably Cortex Cinnamomi, cinnamomic consumption is the 1-3 weight portion.
Preferred feedstock in the preparation of effective ingredient of the present invention is: pyrolusitum 10 weight portions, Sanguis Draxonis 9 weight portions, Radix Notoginseng 6 weight portions, Eupolyphaga Seu Steleophaga 9 weight portions, Radix Dipsaci 9 weight portions, Rhizoma Drynariae 9 weight portions, Myrrha 9 weight portions, Flos Carthami 9 weight portions, Fructus Lycii 9 weight portions, Radix Angelicae Sinensis 9 weight portions, the Radix Astragali 9 weight portions, Pyritum 1 weight portion and Cortex Cinnamomi 2 weight portions.
The preparation of effective ingredient of the present invention can be that the above-mentioned raw materials decocting is boiled, filters, concentrates and make, and also above-mentioned raw materials pulverize mixing can be made.The effective ingredient of medicine of the present invention can be made oral preparations such as various pharmaceutical dosage forms such as tablet, electuary, oral liquid with adjuvant commonly used pharmaceutically.
Medicine of the present invention has the effect of blood circulation promoting and blood stasis dispelling, invigorating the kidney and strengthening the bones, QI and blood adjusting.The medication of medicine of the present invention is each 5-9g, each 1 time sooner or later, fries in shallow oil soup and takes.Period in a medicine is given up alcohol, hormone medicine and significantly the motion.
Concrete embodiment
Embodiment 1
Take by weighing pyrolusitum 10g, Sanguis Draxonis 9g, Radix Notoginseng 6g, Eupolyphaga Seu Steleophaga 9g, Radix Dipsaci 9g, Rhizoma Drynariae 9g, Myrrha 9g, Flos Carthami 9g, Fructus Lycii 9g, Cortex Cinnamomi 2g, Radix Angelicae Sinensis 9g, Radix Astragali 9g and Pyritum 0.5-1.5g, decoct with water 2 times, each 0.5-1 hour, collecting decoction filters and concentrates the effective ingredient that obtains medicine of the present invention.
Embodiment 2
Take by weighing pyrolusitum 10g, Sanguis Draxonis 9g, Radix Notoginseng 6g, Eupolyphaga Seu Steleophaga 9g, Radix Dipsaci 9g, Rhizoma Drynariae 9g, Myrrha 9g, Flos Carthami 9g, Fructus Lycii 9g, Cortex Cinnamomi 2g, Radix Angelicae Sinensis 9g, Radix Astragali 9g and Pyritum 0.5-1.5g, difference pulverize, mix homogeneously.
Test example 1
Physical data: select patient's 300 examples of ischemic necrosis of femoral head, male 160 examples, women 140 examples, maximum 50 years old age, minimal ages 30 years old.
Therapeutic Method: medicine of the present invention is for oral administration, each 5-9g, and one day twice, be a course of treatment February, cooperates acupuncture treatment.
Curative effect judging standard:
Recovery from illness: patient's limbs pain disappears, and limb functional recover is normal, and sitting crouches, stands, walks does not have limping, and X-ray film, CT sheet show that femur head aseptic environment necrotic area sequestrum absorbs, new fresh and alive bone reparation, and bone fibres, bone texture, bone trabecula recover normal configuration.
Progressive: patient's limbs pain alleviates, limb functional recover is normal substantially, sits the minimizing of walking lamely of crouching, stand, walk, and X-ray film, CT sheet show existing absorption of femur head aseptic environment necrotic area sequestrum, new fresh and alive bone begins to repair, and bone fibres, bone texture, bone trabecula are recovering normal configuration.
Invalid: patient's symptom variation is little.
Conclusion: treating various types of ischemic necrosis of femoral head osteopathia cure rates is 75%, progress 20%, and total effective rate is 95%, invalid 5%.
Claims (5)
1. an endo-medicine for the treatment of ischemic necrosis of femoral head is characterized in that it is an effective ingredient of selecting for use following Chinese crude drug to make as raw material: pyrolusitum 15-10 weight portion, Sanguis Draxonis 7-11 weight portion, Radix Notoginseng 4-8 weight portion, Eupolyphaga Seu Steleophaga 7-11 weight portion, Radix Dipsaci 4-11 weight portion, Rhizoma Drynariae 4-11 weight portion, Myrrha 4-11 weight portion, Flos Carthami 4-11 weight portion, Fructus Lycii 4-11 weight portion, Radix Angelicae Sinensis 4-11 weight portion, Radix Astragali 4-11 weight portion and Pyritum 0.5-1.5 weight portion.
2. according to the described endo-medicine of claim 1, also add Cortex Cinnamomi 1-3 weight portion in the raw material wherein.
3. according to the described endo-medicine of claim 2, raw material consumption wherein is: pyrolusitum 10 weight portions, Sanguis Draxonis 9 weight portions, Radix Notoginseng 6 weight portions, Eupolyphaga Seu Steleophaga 9 weight portions, Radix Dipsaci 9 weight portions, Rhizoma Drynariae 9 weight portions, Myrrha 9 weight portions, Flos Carthami 9 weight portions, Fructus Lycii 9 weight portions, Cortex Cinnamomi 2 weight portions, Radix Angelicae Sinensis 9 weight portions, the Radix Astragali 9 weight portions and Pyritum 1 weight portion.
4. the preparation method of any one the described endo-medicine among the claim 1-3, it comprises boils the above-mentioned raw materials decocting, filters, concentrates and obtain medicinal liquid.
5. the preparation method of any one described endo-medicine among the claim 1-3, it is to grind into above-mentioned raw materials into powder powder, mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101151867A CN1284579C (en) | 2003-11-26 | 2003-11-26 | Oral medicine for treating ischemic necrosis of femoral head and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101151867A CN1284579C (en) | 2003-11-26 | 2003-11-26 | Oral medicine for treating ischemic necrosis of femoral head and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1544056A true CN1544056A (en) | 2004-11-10 |
| CN1284579C CN1284579C (en) | 2006-11-15 |
Family
ID=34337273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2003101151867A Expired - Lifetime CN1284579C (en) | 2003-11-26 | 2003-11-26 | Oral medicine for treating ischemic necrosis of femoral head and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1284579C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1318080C (en) * | 2005-04-01 | 2007-05-30 | 郭永昌 | Medicine used for treating osteonecrosis, femur ischemic osteonecrosis |
| CN106668515A (en) * | 2015-11-04 | 2017-05-17 | 哈尔滨圣吉药业股份有限公司 | Pyrolusite detumescence and granulation promotion medicinal granules and preparation method thereof |
| EP3903798A1 (en) * | 2020-04-27 | 2021-11-03 | Lulin Wang | Bone-strengthening pill (bsp) as a dietary supplement to improve blood circulation and strengthen bone and muscle |
-
2003
- 2003-11-26 CN CNB2003101151867A patent/CN1284579C/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1318080C (en) * | 2005-04-01 | 2007-05-30 | 郭永昌 | Medicine used for treating osteonecrosis, femur ischemic osteonecrosis |
| CN106668515A (en) * | 2015-11-04 | 2017-05-17 | 哈尔滨圣吉药业股份有限公司 | Pyrolusite detumescence and granulation promotion medicinal granules and preparation method thereof |
| EP3903798A1 (en) * | 2020-04-27 | 2021-11-03 | Lulin Wang | Bone-strengthening pill (bsp) as a dietary supplement to improve blood circulation and strengthen bone and muscle |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1284579C (en) | 2006-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20061115 |