CN1284579C - Oral medicine for treating ischemic necrosis of femoral head and its preparation - Google Patents
Oral medicine for treating ischemic necrosis of femoral head and its preparation Download PDFInfo
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- CN1284579C CN1284579C CNB2003101151867A CN200310115186A CN1284579C CN 1284579 C CN1284579 C CN 1284579C CN B2003101151867 A CNB2003101151867 A CN B2003101151867A CN 200310115186 A CN200310115186 A CN 200310115186A CN 1284579 C CN1284579 C CN 1284579C
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- medicine
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- femoral head
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- 239000003814 drug Substances 0.000 title claims abstract description 40
- 208000007875 Femur Head Necrosis Diseases 0.000 title claims description 11
- 238000002360 preparation method Methods 0.000 title claims description 8
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 8
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims description 10
- 241000628997 Flos Species 0.000 claims description 7
- 239000009636 Huang Qi Substances 0.000 claims description 7
- 239000009286 sanguis draxonis Substances 0.000 claims description 7
- 241001057584 Myrrha Species 0.000 claims description 6
- 241001489978 Eupolyphaga Species 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 abstract description 13
- 230000000694 effects Effects 0.000 abstract description 7
- 239000008280 blood Substances 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 5
- 238000005728 strengthening Methods 0.000 abstract description 4
- 230000017531 blood circulation Effects 0.000 abstract description 3
- 210000003734 kidney Anatomy 0.000 abstract description 3
- 206010028851 Necrosis Diseases 0.000 abstract description 2
- 230000017074 necrotic cell death Effects 0.000 abstract description 2
- 230000000302 ischemic effect Effects 0.000 abstract 2
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 241001061264 Astragalus Species 0.000 abstract 1
- 241000131329 Carabidae Species 0.000 abstract 1
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 abstract 1
- 240000007311 Commiphora myrrha Species 0.000 abstract 1
- 235000006965 Commiphora myrrha Nutrition 0.000 abstract 1
- 241001116742 Drynaria Species 0.000 abstract 1
- 244000241872 Lycium chinense Species 0.000 abstract 1
- 235000015468 Lycium chinense Nutrition 0.000 abstract 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 abstract 1
- 235000007265 Myrrhis odorata Nutrition 0.000 abstract 1
- 206010031264 Osteonecrosis Diseases 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
- 235000017803 cinnamon Nutrition 0.000 abstract 1
- 229910052748 manganese Inorganic materials 0.000 abstract 1
- 239000011572 manganese Substances 0.000 abstract 1
- 210000004233 talus Anatomy 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 15
- 210000003414 extremity Anatomy 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 206010017577 Gait disturbance Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 229940126678 chinese medicines Drugs 0.000 description 2
- 210000002391 femur head Anatomy 0.000 description 2
- 210000004394 hip joint Anatomy 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000001338 necrotic effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 208000007848 Alcoholism Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 206010023204 Joint dislocation Diseases 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002436 femur neck Anatomy 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 210000001624 hip Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses an orally taken medicine for treating ischemic femoral head necrosis, which is prepared by using manganese black, sanguis draconis, notoginseng, ground beetles, radix dipsaci from Sichuan of China, drynaria, myrrh, safflowers, Chinese wolfberries, cinnamon, Chinese angelica roots, astragalus roots and pyritum. The medicine has the efficacies of blood circulation activation, blood stasis dissipation, kidney invigoration, bone strengthening, and qi and blood regulation. The cure rate of the medicine for treating various types of ischemic femoral head necrosis bone diseases is verified by clinic curative effect to be 75%, the improvement rate is 20%, and the total effective rate is 95%.
Description
Technical field
The present invention relates to a kind of endo-medicine for the treatment of ischemic necrosis of femoral head, specifically, be a kind of be the medicine that raw material is made with the Chinese crude drug, the invention still further relates to the preparation method of this medicine.
Background technology
Femoral head is carrying maximum joint hip joint in human body, in a single day blood supply disorder takes place in the femoral head, will cause necrosis, ischemic necrosis of femoral head is exactly owing to the non-traumatic reasons such as application with some drugs such as hormone such as hip wound figure dislocation of hip joint and fracture of femoral neck and some internal diseases such as pancreatitis, hematopathy, gout, alcoholism cause.Adopt conservative treatment to avoid bearing a heavy burden to the early stage patient doctor trained in Western medicine, middle and advanced stage adopts operative therapy as displacement artificial joint, Drilling, osteotomy etc., but the late result of these therapies is poor, because of not excising focus, painful big, the expense height brings spirit and very big wound economically to the patient.This disease of Chinese traditional treatment has oral medicine that medicine for external use is also arranged, at present more existing Chinese medicines for oral administration are treated this disease, the bone gold ball of these medicines such as CN1174078A, a kind of drug regimen for the treatment of femur head necrosis of the bone activating and muscle strengthening pill of CN1218677A, CN113892252A, but the curative effect of these Chinese medicines is general.The inventor is exactly at improving treatment ischemic necrosis of femoral head curative effect, having developed another Chinese patent medicine, clinically through checking, finds that this medicine curative effect on treatment ischemic necrosis of femoral head osteopathia has certain breakthrough, thereby finishes the present invention.
Summary of the invention
Purpose of the present invention just provides a kind of endo-medicine for the treatment of ischemic necrosis of femoral head.
Another object of the present invention provides the preparation method of this medicine.
The following Chinese crude drug of choice of drug of the present invention is made raw material and is made: pyrolusitum 15-10 weight portion, Sanguis Draxonis 4-11 weight portion, Radix Notoginseng 4-8 weight portion, Eupolyphaga Seu Steleophaga 4-11 weight portion, Radix Dipsaci 4-11 weight portion, Rhizoma Drynariae 4-11 weight portion, Myrrha 4-11 weight portion, Flos Carthami 4-11 weight portion, Fructus Lycii 4-11 weight portion, Radix Angelicae Sinensis 4-11 weight portion, Radix Astragali 4-11 weight portion and Pyritum 0.5-1.5 weight portion.
Wherein monarch drug is pyrolusitum and Sanguis Draxonis, ministerial drug is whole worm of soil and Radix Notoginseng, adjuvant drug is Radix Angelicae Sinensis, the Radix Astragali, and messenger drug is Rhizoma Drynariae, Radix Dipsaci, Pyritum, Fructus Lycii and Flos Carthami, and effect blood circulation promoting and blood stasis dispelling, dredge the meridian passage, warming the meridian, accent the kidney invigorating liver spleen, bone strengthening are given birth to amiable Regeneration and Repair.
If in above-mentioned raw materials, add guiding drug, can improve the performance of drug effect more, so add guiding drug in the preferred version of the present invention, be preferably Cortex Cinnamomi, cinnamomic consumption is the 1-3 weight portion.
The preferred feedstock consumption is: pyrolusitum 10 weight portions, Sanguis Draxonis 9 weight portions, Radix Notoginseng 6 weight portions, Eupolyphaga Seu Steleophaga 9 weight portions, Radix Dipsaci 9 weight portions, Rhizoma Drynariae 9 weight portions, Myrrha 9 weight portions, Flos Carthami 9 weight portions, Fructus Lycii 9 weight portions, Cortex Cinnamomi 2 weight portions, Radix Angelicae Sinensis 9 weight portions, the Radix Astragali 9 weight portions and Pyritum 1 weight portion.
The preparation of medicine of the present invention can be that above raw water is decocted, filters, concentrates and make, and also above-mentioned raw materials pulverize mixing can be made.Medicine of the present invention can be made oral preparations such as various pharmaceutical dosage forms such as tablet, electuary, oral liquid with adjuvant commonly used pharmaceutically.
Medicine of the present invention has the effect of blood circulation promoting and blood stasis dispelling, invigorating the kidney and strengthening the bones, QI and blood adjusting.The medication of medicine of the present invention is each 5-9g, individual 1 time sooner or later, fries in shallow oil soup and takes.Period in a medicine is given up alcohol, hormone medicine and significantly the motion.
Concrete embodiment
Embodiment 1
Take by weighing the raw material of following consumption: pyrolusitum 10g, Sanguis Draxonis 9g, Radix Notoginseng 6g, Eupolyphaga Seu Steleophaga 9g, Radix Dipsaci 9g, Rhizoma Drynariae 9g, Myrrha 9g, Flos Carthami 9g, Fructus Lycii 9g, Cortex Cinnamomi 2g, Radix Angelicae Sinensis 9g, Radix Astragali 9g and Pyritum 0.5-1.5g.Decoct with water 2 times, each 0.5-1.0 hour, collecting decoction filtered and the concentrated medicinal liquid that obtains.
Embodiment 2
Take by weighing the raw material of following consumption: pyrolusitum 10g, Sanguis Draxonis 9g, Radix Notoginseng 6g, soil whole worm 9g, Radix Dipsaci 9g, Rhizoma Drynariae 9g, Myrrha 9g, Flos Carthami 9g, Fructus Lycii 9g, Cortex Cinnamomi 2g, Radix Angelicae Sinensis 9g, Radix Astragali 9g and Pyritum 0.5-1.5g.The difference pulverize, mix homogeneously.
Test example 1
Physical data: select patient's 300 examples of ischemic necrosis of femoral head, male 160 examples, women 140 examples, maximum 50 years old age, minimal ages 30 years old.
Therapeutic Method: medicine of the present invention is for oral administration, each 5-9g, and twice, 3 month on the one is a course of treatment, cooperates acupuncture treatment.
Curative effect judging standard:
Recovery from illness: patient's limbs pain disappears, and limb functional recover is normal, and sitting crouches, stands, walks does not have limping, and X-ray film, CT sheet show that femur head aseptic environment necrotic area sequestrum absorbs, new fresh and alive bone reparation, and bone fibres, bone texture, bone trabecula recover normal configuration.
Progressive: patient's limbs pain alleviates, limb functional recover is normal substantially, and sitting crouches, stands, walks does not have limping, and X-ray film, CT sheet show that femur head aseptic environment necrotic area sequestrum absorbs, new fresh and alive bone reparation, bone fibres, bone texture, bone trabecula are recovering normal configuration.
Invalid: patient's symptom variation is little.
Conclusion: treating various types of Avascular Necrosis Of Femur Head osteopathia cure rates is 75%, progress 20%, and total effective rate is 95%, invalid 5%.
Claims (5)
1. endo-medicine for the treatment of ischemic necrosis of femoral head is characterized in that the raw material of making this effective ingredient is:
Pyrolusitum 15-10 weight portion, Sanguis Draxonis 7-11 weight portion, Radix Notoginseng 4-8 weight portion, Eupolyphaga Seu Steleophaga 7-11 weight portion, Radix Dipsaci 4-11 weight portion, Rhizoma Drynariae 4-11 weight portion, Myrrha 4-11 weight portion, Flos Carthami 4-11 weight portion, Fructus Lycii 4-11 weight portion, Radix Angelicae Sinensis 4-11 weight portion, Radix Astragali 4-11 weight portion and Pyritum 0.5-1.5 weight portion.
2. according to the described endo-medicine of claim 1, it is characterized by and also add Cortex Cinnamomi 1-3 weight portion in the raw material.
3. according to the described endo-medicine of claim 2, it is characterized by raw material and be: pyrolusitum 10 weight portions, Sanguis Draxonis 9 weight portions, Radix Notoginseng 6 weight portions, Eupolyphaga Seu Steleophaga 9 weight portions, Radix Dipsaci 9 weight portions, Rhizoma Drynariae 9 weight portions, Myrrha 9 weight portions, Flos Carthami 9 weight portions, Fructus Lycii 9 weight portions, Cortex Cinnamomi 2 weight portions, Radix Angelicae Sinensis 9 weight portions, the Radix Astragali 9 weight portions and Pyritum 1 weight portion.
4. the preparation method of each described endo-medicine among the claim 1-3 is characterized in that described raw water is decocted, and filters, and concentrates to obtain.
5. the preparation method of each described endo-medicine among the claim 1-3 is characterized in that described raw material is pulverized, and mixing obtains.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101151867A CN1284579C (en) | 2003-11-26 | 2003-11-26 | Oral medicine for treating ischemic necrosis of femoral head and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101151867A CN1284579C (en) | 2003-11-26 | 2003-11-26 | Oral medicine for treating ischemic necrosis of femoral head and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1544056A CN1544056A (en) | 2004-11-10 |
| CN1284579C true CN1284579C (en) | 2006-11-15 |
Family
ID=34337273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2003101151867A Expired - Lifetime CN1284579C (en) | 2003-11-26 | 2003-11-26 | Oral medicine for treating ischemic necrosis of femoral head and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1284579C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1318080C (en) * | 2005-04-01 | 2007-05-30 | 郭永昌 | Medicine used for treating osteonecrosis, femur ischemic osteonecrosis |
| CN106668515A (en) * | 2015-11-04 | 2017-05-17 | 哈尔滨圣吉药业股份有限公司 | Pyrolusite detumescence and granulation promotion medicinal granules and preparation method thereof |
| EP3903798A1 (en) * | 2020-04-27 | 2021-11-03 | Lulin Wang | Bone-strengthening pill (bsp) as a dietary supplement to improve blood circulation and strengthen bone and muscle |
-
2003
- 2003-11-26 CN CNB2003101151867A patent/CN1284579C/en not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| CN1544056A (en) | 2004-11-10 |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20061115 |
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| CX01 | Expiry of patent term |