CN101040985A - Chinese traditional medicine compound took orally for treating osteonecrosis - Google Patents

Abstract

The invention discloses an oral administration pharmaceutical composition for treating femoral head apoptosis, wherein the active constituents include the following raw material herbs (by weight portion): Chinese angelica root 12g, prepared rhizome of rehmannia 9g, dried rehmannia root 9g, red peony root 9g, rhizome of Sichuan lovage 9g, pulp of dogwood fruit 12g, monkshood 6g, Cinnamomum cassia 6g, psoralea fruit 9g, ginger ale 9g, Chinese yam 12g, epimeddium 9g, curculigo rhizome 4g and pubescent angelica root 12g. The medicament should be decocted in water for the oral dose.

Description

A kind of Chinese medicine composition of took orally for treating osteonecrosis

Technical field

The present invention relates to a kind of Chinese medicine composition of took orally for treating osteonecrosis, belong to the field of Chinese medicines.

Background technology

Femur head necrosis is that the vigor composition of phalanges comprises osteocyte, myeloid element and adipose cell death.Or ischemic necrosis of femoral head, thereby cause that the further ischemia of osteocyte, necrosis, bone trabecula rupture, a kind of pathological changes of collapse of the femoral head.World medical circle is familiar with this disease of femur head necrosis so far first, and femur head necrosis changes frequently-occurring disease, commonly encountered diseases into by rare disease.According to incompletely statistics, about 3,000 ten thousand people of this patient are suffered from the whole world at present, and China has 4,000,000 people approximately.

The common pathological manifestations of femur head necrosis is an ischemic femoral head, and relatively consistent theory of generally acknowledging is that blood supply is obstructed.The cause of disease is varied mainly contain following several: wound causes femur head necrosis, causes fracture of femoral neck, dislocation of hip joint, hip joint bruise etc. as external force collision.Wound is to cause the principal element of femur head necrosis.But whether traumatic Avascular Necrosis Of Femur Head takes place, range size, depends primarily on angiolysis degree and side and props up the circulation compensatory capacity.Clinical manifestation is that vestige fracture, head are subluxation, and lower limb muscles atrophy, limping, heavy burden pain increase the weight of etc.

Other causes the reason of femur head necrosis also much to cause femur head necrosis as medicine, wind, cold, the wet femur head necrosis that causes; Caused by liver and kidney deficiency causes femur head necrosis; Osteoporosis causes osteonecrosis; Myelodysplastisches causes osteonecrosis; Osteonecrosis after bone tuberculosis and osteonecrosis and the operation.

The clinical manifestation of femur head necrosis has: the cardinal symptom of femur head necrosis shows pain, and pain can be intermittence or persistence, the Ambulatory Activity postemphasis, and pain mostly is acupuncture sample, dull pain or the discomfort etc. of aching, ankylosis and limitation of activity.Squat down difficulty, can not stand for a long time.Walk lamely, because hip pain and collapse of the femoral head, or occur due to the hip joint subluxation late period.Intermittent claudication often appears in early days. abduction, outward turning or inward turning limitation of activity, and suffer from limb and can shorten, amyotrophy, even the subluxation sign is arranged.

The means of present treatment femur head necrosis have a lot: roughly be divided into following several: operating substitution therapy, treatment by Chinese herbs, electromagnetic curing, the treatment of intervention method ... in the face of so many treatment femur head necrosis method, general patient is difficult to tell and anyly actually is fit to oneself.If the patient has selected unsuitable Therapeutic Method, not only be difficult to rehabilitation, can cause also that sb.'s illness took a turn for the worse, this patient who has been hit on health and soul is made the matter worse.

Summary of the invention

The objective of the invention is to overcome the shortcoming that above-mentioned prior art exists, and a kind of Chinese medicine composition of took orally for treating osteonecrosis is provided, treatment femur head necrosis determined curative effect is difficult for recurrence.

Technical scheme of the present invention is: the Chinese medicine composition of this kind took orally for treating osteonecrosis, it is characterized in that, make the raw materials of effective components medicine and be: Radix Angelicae Sinensis 12 grams, Radix Rehmanniae Preparata 9 grams, the Radix Rehmanniae 9 grams, Radix Paeoniae Rubra 9 grams, Rhizoma Chuanxiong 9 grams, Fructus Corni 12 grams, Radix Aconiti Lateralis Preparata 6 grams, Cortex Cinnamomi 6 grams, Fructus Psoraleae 9 grams, hair Rhizoma Zingiberis Recens 9 grams, Rhizoma dioscoreae 12 grams, Herba Epimedii 9 grams, Rhizoma Curculiginis 4 grams and Radix Angelicae Pubescentis 12 grams by following weight.

Preparation and instructions of taking: receive all medicines in marmite, add water 500ml, fry in shallow oil to 300ml, divide 3 times decoction being taken warmly 1 dose of every day, be 1 course of treatment January.

Attention: treatment is early stage, and the adult lies in bed or holds up and turn the walking of not bearing a heavy burden, and child patient adopts traction to cooperate plaster fixation, braking, the walking of not bearing a heavy burden in 2 years.

Pharmacological action:

Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.

Radix Rehmanniae Preparata: nourishing YIN and supplementing blood, beneficial essence is filled out marrow.Be used for the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever.

The Radix Rehmanniae: clearing away heat and cooling blood, be used for the heat in blood poison and contain, hematemesis and epistaxis, macule is purple black, YIN nourishing and the production of body fluid promoting, interior-heat is quenched one's thirst.

Rhizoma dioscoreae: sweet in the mouth, warm in nature.QI invigorating arranged, be good for the stomach, the function of kidney tonifying, benefit strengthening spleen and lung.

Hair Rhizoma Zingiberis Recens: can be in order to wind, dissipating cold, blood circulation promoting.

Radix Paeoniae Rubra: bitter in the mouth, be slightly cold.Can remove or alleviate liver-heat.

Rhizoma Chuanxiong: acrid in the mouth, warm in nature.Invigorate blood circulation, dredge the blood network, support fresh blood, energy pain relieving, change silt.

Poria: sweet in the mouth, nontoxic, property are flat.Happy beneficial will, tranquilizing mind, diuresis, take good care of living body function, the nourishing spleen, dry, consumer edema.

Cortex Cinnamomi: sweet in the mouth and suffering, extremely hot in nature can highly fill blood, strengthen physical ability.

Fructus Corni: control soreness of waist and knee joint, dizzy, the deficiency of the liver cold and heat, the heart shakes scattered pulse.Liver and kidney tonifying: cure mainly deficiency of the liver and kindey, essence and blood loses empty, has a dizzy spell soreness of the waist and knees.

Radix Aconiti Lateralis Preparata: be used for fear of cold, cold extremities has the tonification kidney yang, the merit of cold relieving pain relieving.

Fructus Psoraleae: reinforcing the kidney and supporting YANG, warming spleen and stopping diarrha.Be used for kidney yang deficiency, frequent micturition, chills and pain of the waist and kness.

Radix Pseudostellariae: mend strengthening spleen and lung, supplementing QI for promoting the production of body fluid.

Herba Epimedii: wind-damp dispelling, kidney invigorating and YANG supporting is used for impotence due to deficiency of the kidney, weakness of the waist and knees.

Radix Angelicae Pubescentis: hot, bitter, tepor.Return kidney, urinary bladder channel.Expelling wind and removing dampness, numbness relieving and pain relieving.Be used for anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache.

Rhizoma Curculiginis: kidney-replenishing, bone and muscle strengthening, dispelling cold and dampness.Be used for that sexual impotence cold sperm, muscles and bones flaccidity are soft, the cold numbness of waist knee joint, yang deficiency is cold.

After the present invention made up said medicine, drug effect had synergism, had mediation blood network, the effect of strong muscles and bones, from inside to outside, treating both the principal and secondary aspects of a disease.Determined curative effect in the treatment of femur head necrosis, without any side effects.

Model case:

Case 1: Lee, man, 42 years old.Right hip traumatic injury 4 months, the unexpected pain of right recently hip, the oxycinesia of living is very.Look into: right femoral triangle district tenderness, right lower extremity longitudinal axis percussion pain, right lower extremity are receives deformity in the flexing, the prompting of X line: right hip femoral head bone density increases, and the circular transparent area of 1～2 square centimeter of size is arranged under the cartilaginous lamina, and it is flat that right hipbone head becomes.Diagnosis: fl head bland necrosis.Take the Chinese medicine composition of this kind took orally for treating osteonecrosis, after 5 weeks, receive arms sideward lift in can suitably doing, after 3 months, the prompting of X line: the bone transparent area dwindles.After 9 months, clinical symptoms disappears substantially, and the prompting of x line: right hip femoral head cartilage density is normal, and the transparent area complete obiteration is recovered under the cartilage, follows up a case by regular visits to half a year and does not see recurrence.

Case 2: Liu, the man, 36 years old, because of the excessive use prednisone, feel two weakness of the lower extremitiess gradually, two hip pain after 1 year, limitation of activity, the prompting of X line: the bilateral femoral head upper limb all has bone destruction to resemble, in various degree damaged of many places arranged, give 4 courses of treatment of traditional Chinese medicine composition for treating of this kind took orally for treating osteonecrosis, disease fades away, and does not have recurrence with controlling 5 years.

Case 3: Zhu, the man, 20 years old, because of central nervous system infection, take dexamethasone, prednisone after, the skelalgia difficulty in walking appears, walk lamely, the prompting of X line: bilateral femoral head has irregular big lucent area.Diagnosis: sick bilateral femoral head necrosis.Gave the top 3 months, the prompting of check X line: capsule becomes the district to be dwindled, and bone density increases.The Chinese medicine composition of taking this kind took orally for treating osteonecrosis is after 18 months, the prompting of X line: a full bone thigh density is even, the bone trabecula growth still can, resume work.

Case 4: Zeng, man, 43 years old.It is surplus that right hip pain 2 years appears in not clear inducement, is and progressively increases the weight of trend, and right limited hip motion is walked lamely.The prompting of X line: right femoral head density unevenness is even, becomes flat slightly, and the joint space narrows down slightly, diagnosis: right ischemic necrosis of femoral head.Give 100 doses of treatments of Chinese medicine composition of this kind took orally for treating osteonecrosis, check, right hip does not have pain, and mobility is normal, X line prompting: right femoral head density is more even, has flatly slightly, and the joint space takes a turn for the better.Obey 100 doses again, all diseases disappear, and right femoral head density is even, and the joint space is normal, and is flat not obvious.

The specific embodiment

Example one: a kind of Chinese medicine composition of took orally for treating osteonecrosis, make the raw materials of effective components medicine and be: Radix Angelicae Sinensis 12 grams, Radix Rehmanniae Preparata 9 grams, the Radix Rehmanniae 9 grams, Radix Paeoniae Rubra 9 grams, Rhizoma Chuanxiong 9 grams, Fructus Corni 12 grams, Radix Aconiti Lateralis Preparata 6 grams, Cortex Cinnamomi 6 grams, Fructus Psoraleae 9 grams, hair Rhizoma Zingiberis Recens 9 grams, Rhizoma dioscoreae 12 grams, Herba Epimedii 9 grams, Rhizoma Curculiginis 4 grams and Radix Angelicae Pubescentis 12 grams by following weight.

Preparation and instructions of taking: receive all medicines in marmite, add water 500ml, fry in shallow oil to 300ml, divide 3 times decoction being taken warmly 1 dose of every day, be 1 course of treatment January.

Claims (1)

1, a kind of Chinese medicine composition of took orally for treating osteonecrosis, it is characterized in that, make the raw materials of effective components medicine and be: Radix Angelicae Sinensis 12 grams, Radix Rehmanniae Preparata 9 grams, the Radix Rehmanniae 9 grams, Radix Paeoniae Rubra 9 grams, Rhizoma Chuanxiong 9 grams, Fructus Corni 12 grams, Radix Aconiti Lateralis Preparata 6 grams, Cortex Cinnamomi 6 grams, Fructus Psoraleae 9 grams, hair Rhizoma Zingiberis Recens 9 grams, Rhizoma dioscoreae 12 grams, Herba Epimedii 9 grams, Rhizoma Curculiginis 4 grams and Radix Angelicae Pubescentis 12 grams by following weight.