CN1541172A - ALbumin in flexible polymeric container - Google Patents
ALbumin in flexible polymeric container Download PDFInfo
- Publication number
- CN1541172A CN1541172A CNA02809557XA CN02809557A CN1541172A CN 1541172 A CN1541172 A CN 1541172A CN A02809557X A CNA02809557X A CN A02809557XA CN 02809557 A CN02809557 A CN 02809557A CN 1541172 A CN1541172 A CN 1541172A
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- Prior art keywords
- albumin
- bag
- container
- sealing
- filling
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Links
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- 108010088751 Albumins Proteins 0.000 title claims abstract description 127
- 238000000034 method Methods 0.000 claims abstract description 58
- 239000000463 material Substances 0.000 claims abstract description 27
- 238000007789 sealing Methods 0.000 claims description 123
- 238000011049 filling Methods 0.000 claims description 115
- 229920005570 flexible polymer Polymers 0.000 claims description 56
- 238000000465 moulding Methods 0.000 claims description 54
- 238000012856 packing Methods 0.000 claims description 50
- 239000012530 fluid Substances 0.000 claims description 18
- 229920000642 polymer Polymers 0.000 claims description 16
- 230000000712 assembly Effects 0.000 claims description 15
- 238000000429 assembly Methods 0.000 claims description 15
- 229920000092 linear low density polyethylene Polymers 0.000 claims description 14
- 239000004707 linear low-density polyethylene Substances 0.000 claims description 14
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- 229920006254 polymer film Polymers 0.000 claims description 5
- 239000005033 polyvinylidene chloride Substances 0.000 claims description 5
- 229920001328 Polyvinylidene chloride Polymers 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000011144 upstream manufacturing Methods 0.000 claims description 4
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- 229920001778 nylon Polymers 0.000 claims description 2
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B39/00—Nozzles, funnels or guides for introducing articles or materials into containers or wrappers
- B65B39/04—Nozzles, funnels or guides for introducing articles or materials into containers or wrappers having air-escape, or air-withdrawal, passages
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B9/00—Enclosing successive articles, or quantities of material, e.g. liquids or semiliquids, in flat, folded, or tubular webs of flexible sheet material; Subdividing filled flexible tubes to form packages
- B65B9/06—Enclosing successive articles, or quantities of material, in a longitudinally-folded web, or in a web folded into a tube about the articles or quantities of material placed upon it
- B65B9/08—Enclosing successive articles, or quantities of material, in a longitudinally-folded web, or in a web folded into a tube about the articles or quantities of material placed upon it in a web folded and sealed transversely to form pockets which are subsequently filled and then closed by sealing
- B65B9/087—Enclosing successive articles, or quantities of material, in a longitudinally-folded web, or in a web folded into a tube about the articles or quantities of material placed upon it in a web folded and sealed transversely to form pockets which are subsequently filled and then closed by sealing the web advancing continuously
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1475—Inlet or outlet ports
Abstract
A flexible polymeric container for holding albumin. The container (12) is made of a sheet of flexible polymeric film (34) formed into a bag having a cavity enclosed by a first wall, an opposing second wall, and seals about a periphery of the first and second walls. The seals join an interior portion of the opposing first and second walls and create a fluid-tight chamber within the cavity of the container for storing a concentration of the albumin. A method of packaging the albumin protein into a flexible polymeric container is also provided. Therein a flexible polymeric material is converted into bags, the bags are filled with a quantity of albumin by a filler (44), and a seal area of the bags is sealed to enclose the albumin within the bag.
Description
Technical field
The present invention relates generally to protein pack in a kind of flexible polymer container, more specifically, relate in the gnotobasis of moulding filling sealing and packing machine the albumin batch package in the flexible polymer container.
Background of invention
Many peptide and protein that are used for pharmacy or other purposes are known, comprising: glycoprotein, lipoprotein, immunoglobulin (Ig), monoclonal antibody, enzyme, haemproteins, receptor protein and hormone.
One type in this cmpd is albumin.Albumin is a kind of sulphurous water soluble proteins, and it condenses when being heated, and is present in albumen, and breast is in blood and other animal and plant tissue and the secrete.Albumin perhaps helps rising patient's blood pressure usually as the vasodilator that helps to keep patient's blood pressure in the loss of blood process.
Protein, for example albumin is adsorbed by multiple artificial material, and described artificial material comprises the liquid container of being made by multiple polymers.Protein has caused reducing the protein content in the solution in the lip-deep absorption of man-made polymer.Through a process that is called sex change, some protein solution can be owing to the absorption on artificial surfaces affects adversely.Described sex change is such process, and promptly protein is not forever to be attracted on the polymer container, but protein molecule is attracted on the container earlier and is released again then.Described absorption and release can change the shape (that is, making its sex change) of molecule.Usually, when the sex change of the protein molecule in the protein soup, will lose its function and effectiveness.Therefore, up to the present, for fear of the risk of sex change, protein for example albumin is stored in the glass phial in order to using separately.Because the cost of producing, packing, case, transport and in the glass phial, store, cost and weight with the glass phial, and the glass phial be easy to break, therefore, wish to obtain for example albumin packing method of a kind of actv. more, cheap and the user-friendly and protein that can overcome above-mentioned shortcoming.
It is polymer pouches by the moulding of moulding filling sealing and packing machine that one type be used to packed the nonprotein pharmaceutical packing.Moulding filling sealing and packing machine is the typical machine that is used for packaging the product in flexible cell.Described moulding filling sealing and packing machine provides a kind of equipment, and this equipment is packed particular medication and many other products with a kind of cheapness and effective and efficient manner.
According to the requirement of FDA, traditionally, the particular medication that is packaged in the moulding filling sealed package is sterilized in a packing back autoclaving steps.Described packing back step comprises: the sealed package that will accommodate medicine places an autoclave, and described packing and content thereof are carried out the steam sterilizing or the heating of specified time, and up to reaching necessary temperature, this temperature is typically about 250 °F.This sterilisation step plays the bacterium killed in the packing and the effect of other pollutants, no matter they are on the internal layer of film or be present among the medicine itself.
But specific packaged medicine comprises for example albumin of specified protein, can not sterilize in such a way usually.This is that the needed heat of kill bacteria can destroy particular medication or make it invalid because in high-pressure sterilizing course.In addition, under the situation of albumin protein, described heat can make proteins coagulation.
For example during albumin, except the problem relevant with sterilization, also there is other problem in moulding filling sealed package at the packing specified protein.Particularly, traditional moulding filling sealed package machinery imports heat the specific region of the polymeric material of packing into, thereby forms sealing.If protein touches heat in seal process, protein may condense or take place the similar sex change that is taken place in the high-temperature sterilization process.In addition and since specified protein for example albumin be heat guard, all sealing areas must leave protein, so that polymeric material is heat sealed together.If the sealing before, have protein for example albumin be present in the sealing area, just may damage the leak free integraty.
Therefore, wish to obtain a kind of be used to pack specified protein easily and the method for saving cost, described specified protein comprises for example albuminised protein.
Summary of the invention
The invention provides a kind of flexible polymer container that is used for the enrichedmaterial of splendid attire peptide and/or protein.Described peptide and protein comprise: glycoprotein, lipoprotein, immunoglobulin (Ig), monoclonal antibody, enzyme, haemproteins, receptor protein and hormone.In addition, the invention provides a kind of method that is used for above-claimed cpd is packaged in a kind of flexible polymer container.Usually, described flexible polymer container comprise one by a slice flexible polymer film form the bag.This bag has a cavity, and this cavity is by a first wall second wall sealing relative with.This bag also has around the sealing of the periphery of described first and second walls, and sealing portion connects the described relative first wall and the inside of second wall, thereby forms a fluid annular seal space in the cavity of described container.A kind of enrichedmaterial of above-claimed cpd is stored in the described fluid tight chamber.In one embodiment, above-claimed cpd is an albumin.
According to an aspect of of the present present invention, the described flexible polymer container that is used for the water-soluble albuminised enrichedmaterial of splendid attire comprises: a slice flexible polymeric materials, described flexible polymeric materials at first is processed into a pipe by a former, and subsequently, this pipe is processed to a series of adjacent bags.Described bag has one first side element, along the one second side element that peripherally is sealed on the described first side element, and a cavity between the described first and second side element internals, a certain amount of water-soluble albumin enrichedmaterial is in the cavity of described bag.Subsequently, with the opening sealing of described bag, thereby form a fluid annular seal space.
According to another aspect of the present invention, described container has some peripheries, and wherein three described peripheries are heat sealed, and one of them described periphery comprises first wall or the first side element and relative second wall or the separated folding part of the second side element.
According to another aspect of the present invention, an annex is connected on the container, and adjoins described folding part, and this annex extends from the folding part of described shell of tank, and has a path that cooperates with the fluid tight chamber of described container.Described seal path extends in the cavity of described container, discharges from described fluid tight chamber to allow described albumin.One chevron can be positioned at a distance, opposite flank apart from described annex, and along described folding part, discharges from described container to help described albumin.
According to another aspect of the present invention, the periphery relative with the folding part of described container comprises one first sealing and one second sealing.This first and second sealing connects the described first and second relative walls.One hole and extends through the described first and second relative walls between described first sealing and second sealing.
According to another aspect of the present invention, described flexible polymer flaky material comprises a stratiform film, this laminar film has: a linear low density polyethylene skin, one barrier layer for gases, one polyamide sandwich layer, with a linear low density polyethylene internal layer, above-mentioned each layer is bonded together by a kind of polyurethane adhesive.
According to another aspect of the present invention, concentration is that 20% and 25% albumin is packaged in the described flexible polymer container.In addition, the volume of described flexible polymer container can be 50 milliliters or 100 milliliters.
According to another aspect of the present invention, a kind of method of packing albumin protein, comprise: a flexible polymer container is provided, this container has an opening that extends from the cavity of described polymer container, a certain amount of albumin enrichedmaterial in sterile solution is provided, under a pressure, albumin is packed in the cavity of described polymer container by described opening,, thereby described liquid albumin is remained in the fluid tight chamber of cavity of polymer container described opening sealing.
According to another aspect of the present invention, use a kind of rammer that albumin is packed in the described flexible cell.This rammer has an end, and this end has the first and second adjacent internal paths.The sectional area of described first internal path is greater than the sectional area of second internal path.Described second internal path and described first internal path are adjacent to extend to the outside of described end, by described second internal path albumin are distributed from described rammer.
According to another aspect of the present invention, the dividing range between described first and second internal paths is an exterior inside of described end, and described second internal path extends to the outside of described end.At the filling intercourse of bag, described albumin is maintained at the dividing range place between first and second internal paths.
According to another aspect of the present invention, an overcoat is positioned at the outside of the part of the described rammer adjacent with described end.Described overcoat prevents contacting between polymer container and the rammer.
According to another aspect of the present invention, described overcoat is coaxial with rammer.One air flue extends between described overcoat inside and described rammer outside.In addition, sterile air flows through described air flue and is discharged near the end of rammer and in the upstream of albumin outlet.
According to another aspect of the present invention, use moulding filling sealing and packing machine that albumin is packaged in a series of flexible polymer containers.Provide albumin and a kind of flexible polymeric materials of a certain amount of filtration, and described moulding filling sealing and packing machine is processed into a series of bags with described flexible polymeric materials.In described moulding filling sealing and packing machine, a certain amount of albumin packed in the described bag,, thereby the albumin of described amount is enclosed in the described bag by of the sealing area sealing of this wrapping machine with described bag.
According to another aspect of the present invention, the adjacent bag in a series of bags is joined together at first, and described bag is loaded into a certain amount of albumin continuously, and after each bag was loaded, each bag is separated to be opened.
According to another aspect of the present invention, described moulding filling sealing and packing machine has an aseptic area.Sterilized flexible polymeric materials is placed in the described aseptic area, and is formed bag in this aseptic area.In addition, the albumin that will filter in this aseptic area is packed in the described bag, and is sealed at bag described in the described aseptic area, thereby forms a fluid airtight container.
According to another aspect of the present invention, use following method in moulding filling sealing and packing machine, albumin to be packaged in a series of flexible polymer containers: in described moulding filling sealing and packing machine, to use a former that described flexible polymeric materials is processed into a pipe; In described moulding filling sealing and packing machine, described pipe is processed into a series of bags; In described moulding filling sealing and packing machine, a certain amount of albumin is packed in the described bag continuously; Utilize described wrapping machine that the sealing area of described bag is sealed, thereby the albumin of described amount is enclosed in the described bag.Can use a rammer that described bag is loaded, described albumin is discharged from rammer, and is discharged in the bag, and does not contact with the sealing area of the opening of described bag.
According to another aspect of the present invention, use following method that albumin is packaged in a kind of flexible polymer container: a kind of albuminised enrichedmaterial is provided; A kind of wrapping machine is provided, and this wrapping machine has a molding assembly, a filling assembly and a poted assemblies, and each in above-mentioned each assembly all is arranged in the inside gnotobasis of wrapping machine; A kind of flexible polymer film is provided; Use molding assembly that described flexible polymer film is formed elongated pipe; Use the part sealing of poted assemblies with described thin polymer film elongated tubular, sealed thin polymer film is defined and is of a size of the shape that has around the bag of the sealing area of its periphery, one cavity is in described bag and be between the described sealing area, and an opening extends to the outside of described bag from described cavity; Under pressure, by the filling assembly albumin is packed in the described bag, described filling assembly have one extend through the bag opening and enter the bag cavity in the filling pipe, and one and the overcoat of the outer, coaxial of described filling pipe, described filling pipe imports the periphery a distance of the inner opening apart from bag of bag with albumin, and described overcoat restriction filling pipe with bag between contact; Seal the opening of described bag, thereby albumin is remained in the cavity of described bag.
Therefore, store being used to of making albuminised flexible polymer container according to the present invention a kind of cheapness is provided, be easy to make, and actv. packing and method, it has been eliminated with existing and has been used to pack the albuminised packing defective relevant with method.
By the explanation of carrying out with reference to accompanying drawing hereinafter, other features and advantages of the present invention will become apparent.
Description of drawings
In order to understand the present invention, the present invention will be described by example below with reference to accompanying drawings:
Fig. 1 loads the cross sectional elevation of sealing and packing machine for the moulding of making a kind of flexible polymer container that is used for splendid attire albumin enrichedmaterial of the present invention;
Fig. 2 is a scheme drawing of making the method for the flexible polymer container that is used for splendid attire albumin enrichedmaterial of the present invention;
Fig. 3 is the anterior elevational view of the flexible polymer container of splendid attire albumin enrichedmaterial of the present invention;
Fig. 4 is the partial side view of flexible polymer container of the splendid attire albumin enrichedmaterial of Fig. 3;
Fig. 5 is the partial side view of filling assembly of the present invention;
Fig. 6 is the enlarged side view of a part of the filling assembly of Fig. 5;
Fig. 7 is the side cross-sectional view that is used for the overcoat of filling assembly of the present invention;
Fig. 8 is the end elevation of the overcoat of Fig. 7;
Fig. 9 is the schematic sectional view of an embodiment of film laminar texture of the present invention;
Figure 10 is the section drawing of the end of filling pipe of the present invention and overcoat.
The specific embodiment
The present invention allows multiple multi-form embodiment, shown in the drawings, and will should understand here to a preferred embodiment of the present invention will be described in detail, this specification sheets is considered to the example of principle of the present invention, rather than in order to limit the scope of the invention to the embodiment that is used to illustrate.
Determine that as mentioned the scope of this specification sheets comprises: to the particular medication cmpd of any kind, for example, the peptide and the protein that are used for medicine or other purposes are packed.Described cmpd is known, and comprises: glycoprotein, lipoprotein, immunoglobulin (Ig), monoclonal antibody, enzyme, haemproteins, receptor protein and hormone.Illustrative purposes for example, detailed description of the present invention concentrates on the packing of albumin in a flexible polymer container.
Be elaborated referring now to accompanying drawing 3, wherein show a flexible polymer container 12 of the present invention, this container is loaded with a kind of albumin enrichedmaterial.Described flexible polymer container 12 is preferably made by a kind of aseptic moulding filling sealing and packing machine 10 as shown in Figure 1, and adopts the method that schematically illustrates shown in Fig. 2.
Aseptic moulding filling sealing and packing machine 10 generally includes an expansion portion 14, one film sterilization portion 16, one film drying portion, 18, one idler rollers/dancer roll portion 20, one clamping drive roll assembly portion (not shown), one molding assembly portion 22,26, one filling assembly portions 30 of 24, one annex installation component portions of one fin-shaped poted assemblies portion, one end seal/cutting assembly portion 32, and a transport unit (not shown).These each in the assembly in expansion portion 14 downstreams all are comprised in the inside gnotobasis of aseptic moulding filling sealing and packing machine 10.
A function of each in each assembly of moulding filling sealing and packing machine 10 is: expansion portion 14 comprises a volume flexible polymer film 34, and it finally forms container; Described film sterilization portion 16 has a peroxide groove, is used for film 34 is sterilized; Described film drying portion 18 has a device, is used for from the film 34 dry and remove described peroxide; Described molding assembly portion 22 has a roll forming machine 36, is used for the rolling processing film is become pipe 38 final flexible cell or the bag 12 of forming of this pipe; Thereby described fin-shaped poted assemblies 24 forms longitudinal sealing portion 40 pipe 38 of moulding is sealed on pipe 38, sealing portion finally becomes the longitudinal sealing portion 40 on the flexible cell 12; Described annex installation component 26 is installed to annex 42 on the pipe 38; Described filling assembly 30 comprises a rammer 44, and this rammer is packed into described flexible cell 12 with a kind of material, and described material is water-soluble albuminised enrichedmaterial in this advantageous applications; And described end seal/cutting part 32 comprises cutting and sealing clamp 46, and it forms the end sealing 76,78 of flexible polymer container 12, so that albumin is enclosed in the described flexible polymer container 12.
In a preferred embodiment, be used for being packaged in the albumin or 20% human albumin of flexible polymer container 12, or 25% human albumin.In order to reach desired concn, to be typically albumin is mixed with sterilized water and stabilizer.In addition, before the albumin enrichedmaterial was packed, earlier it being pasteurized and it is stored in the mensuration volume was that temperature is about 2 ℃ to 8 ℃ in the big corrosion-resistant steel holding vessel (not shown) of about 500-600 litre.In packing not long ago, described albumin jar was taken out from cold storage environment, and allowed balance under packing place temperature (about 68).Importantly, need under the temperature that does not cause protein denaturation albumin to be processed, this temperature is lower than about 60 ℃.Yet, between 0 ℃ to 60 ℃, all be suitable, and more preferably between 20 ℃ to 45 ℃.In addition, processing temperature is 68 °F to 77 °F in one embodiment.In addition, when it entered wrapping machine 10, described albumin filtered through one 0.2 micron filters.
With in a preferred embodiment of the invention flexible polymer film 34 are a kind of linear low density polyethylene layer shape things.Find that this film with gas barrier is specially adapted to hold the solution of oxygen mutability, for example Jian Yan protein comprises albumin.Particularly, found that this film has reduced or eliminated the degenerative process before for example albumin places plastic container with protein.As shown in Figure 9, in a preferred embodiment, laminar film 34 has a linear low density polyethylene (LLDPE) outer 52, one barrier layer for gases 54, an one polyamide sandwich layer 56 and a linear low density polyethylene internal layer 58, above-mentioned layer is bonded together by polyurethane adhesive 60.More preferably, the material requirements of layered structure has following feature: a LLDPE layer (about 61 ± 10 μ m) 52, the bonding layer 60 of one polyurethane, one polyvinylidene chloride (PVDC) layer (about 19 ± 5 μ m) 54, the bonding layer 60 of one polyurethane, bonding layer 60 of one nylon layer (about 15 ± 5 μ m), 56, one polyurethane and LLDPE layer (about 61 ± 10 μ m) 52.The gross thickness of film is about 160 ± 25 μ m.In addition, described PVDC layer 54 is preferably made by Dow Chemical, and sales trademark is SARAN.This film is open in U.S. Pat 4629361.U.S. Pat 4629361 is endowed cessionary of the present invention, and be comprised in use herein for referencial use.Described film 34 is made by Fujimori, and commodity are called FTR-13F.
Before using, the inside aseptic area of wrapping machine must be sterilized every day.Use is carried out above-mentioned sterilization by the hydrogen peroxide mist of the aseptic area of wrapping machine.
As shown in Figure 1, the volume of film 34 is arranged in the expansion portion 14 of wrapping machine 10.During use, described film 34 is transferred through hydrogen peroxide groove 16, thereby before the aseptic area that enters wrapping machine 10 film is sterilized.Described sterilization steps cleaning film net sheet, thus described film can be used to produce sterile product.The sterilization of film and purification are crucial in medical industry, when particularly drug products is packed in to injectable drug or intestines.When the product that is obtained is not in the end sterilized, that is, when wrapping machine was sterile packaging machine, this sterilization steps was crucial especially.Be cleaned at film, after cleaning or the sterilization, liquid and other residuum, for example chemosterilant or wetting agent for example are typically residual peroxide on film.Like this, just need remove described liquid and/or residuum from film 34.One air knife that is positioned at film drying portion 18 (thereby one blow over the thin-film network sheet will be positioned at the air-flow that the liquid on the film blows off) is used to remove liquid and other residuums from film 34 when film enters the aseptic area of wrapping machine.
In the aseptic area of wrapping machine 10, before entering molding assembly portion 22, described film 34 is through described dancer roll portion 20 and driven roller portion.Before entering molding assembly 22, described film 34 net sheets are flat basically, and have a first surface 62 and a second surface 64.When film entered molding assembly 22, described first surface 62 faced down and finally becomes the inside face of container 12, and when described film enters molding assembly 22, and described second surface 64 is towards last and finally become the outside face of container 12.
Shown in Fig. 3 and 4, described film 34 also has near a theoretical broken line that approximately is positioned at the line of centers of length of film 34 net sheets in addition.This theory broken line becomes a fold domain 67 of the first side element 66 or first wall and the second side element 68 or second wall of partitioned bottle 12.
One roll forming machine 36 is arranged in molding assembly portion 22.Described roll forming machine 36 assists to become basically flat polymeric thing material 34 net sheets to be processed into elongated and in a tubular form element 38 basically.Should be appreciated that described elongated tubular member 38 or pipe are not columnar usually, but ellipse as shown in Figure 4.With the zone of above-mentioned thin-film network sheet really phasing close, through after the molding assemblies 22, the first surface 62 of the described first side element 66 is relative with first side surface 62 of the second side element 68 at film 34.
In case tube element 38 forms, described tube element forms longitudinal sealing portion 40 in described fin-shaped poted assemblies portion 24, and in described annex installation component 26, an annex 42 is connected to described pipe 38.Concrete is, in described fold domain 67, annex 42 is installed to container 12 puts and extend out from described overcoat outward, and utilizes heating component that annex 42 is sealed on the fold domain 67 of container 12.Be typically, described annex sealer is being worked under about 415 to 450 temperature, and works under the pressure of about 70psig at about 55psig (pound/sq in), and any scope in above-mentioned definite scope all is acceptables.As shown in Figure 4, annex 42 has the seal path with pipe 38 internal communication.Specifically, described path extends in the inner chamber 82 of described container and forms fluid passage with described inner chamber 82, thereby allows albumin to emit from fluid tight chamber.Should be appreciated that in certain embodiments albumin can be injected in the inner chamber 82 of container 12 through described annex 42.
24 pairs of films 34 of described fin-shaped poted assemblies apply heat and pressure, thereby form longitudinal sealing portion 40 in the outer rim relative with fold domain 67 of pipe 38.Be typically, described fin-shaped poted assemblies is being worked under about 380 temperature and under the pressure from about 40psig to 80psig from about 350 °F, yet any scope in above-mentioned definite scope all is an acceptable.In the preferred embodiment of as shown in Figure 3 container 12, described longitudinal sealing portion 40 comprises one first longitudinal sealing portion 70 and one second longitudinal sealing portion 72.The first and second longitudinal sealing portions 70,72 link to each other with the first surface 62 of first wall 66, and relative with the first surface 62 of second wall 68.One hole 74 that typically is used to hang container molding 12 is formed between the first longitudinal sealing portion 70 and the second longitudinal sealing portion 72.Therefore, described hole 74 extends through the first and second relative walls 66,68.
Described leak free tube element 38 is sent to filling assembly 30 and end seal assembly 32 from fin-shaped poted assemblies 24.At described end seal assembly 32 places, described moulding filling sealing and packing machine 10 application of heat and pressure are processed into a series of bags 12 with described leak free pipe 38, are also referred to as container 12.Be typically, described end seal assembly is being worked under 375 to 405 temperature and under the pressure from 500psig to 850psig, yet any scope in above-mentioned definite scope all is an acceptable.Described leak free pipe 38 at first forms an end sealing 76, thereby the initial bag 12 that forms with a cavity 82, described cavity is positioned at first and second sidewalls 66 of container 12,68 and the end sealing 76 of container between, also form an opening 80, this opening extends to the outside of container 12 from the cavity 82 of container 12.Should be appreciated that described opening 80 extends into the center of pipe 38 from the cavity 82 of container 12 in moulding filling sealing manufacturing process.In case sealing of the described end 76 forms, by described opening 80 albumin is packed in the described bag 12, form top sealing 78 then, with described opening 80 sealings or sealing, so just formed the wherein albuminised fluid tight chamber 82 of splendid attire.In addition, in case sealing of the described end 76 forms, described thin polymer film 34 promptly is defined the shape that is of a size of open-bag 12, and have that (longitudinal sealing portion 34 is relative with fold domain 67 around its peripheral sealing area, end sealing 76 is connected with longitudinal sealing portion 40 with fold domain 67), have and be arranged in bag 12 and be in cavity 82 between described sealing area 40,76 and the fold domain 67.Like this, through overmolding filling sealed package process, the container 12 that is processed into has the sealing area on three of bag 12: top sealing 78, end sealing 76 and longitudinal sealing portion 40.Described longitudinal sealing portion 40 connects described top sealing 78 and sealings of the described end 76.In the preferred course of processing, use described end seal assembly 32, form first bag 12 the top sealing 78 and the end sealing 76 of the adjacent bag 12 in downstream simultaneously.Like this, since be form bag 12 tube element 38 part and owing to have the end sealing that uses same end seal assembly 32 to form, the adjacent bag 12 in a series of bags 12 is joined together at first.
Make container of the present invention and, be that described container 12 loads albumins in being used for as illustrated in fig. 1 and 2 by filling assemblies 30 that extend along pipe 38 for it loads the preferred embodiment of albuminised method.Described filling assembly 30 loads by the cavity 82 of 80 pairs of bags 12 of opening of the open-bag 12 of three of one-tenth in the course of processing.
Filling assembly 30 in the preferred embodiment is shown in Fig. 5-8 and 10.As shown in the figure, described filling assembly 30 comprises a pressurization rammer 44, and this rammer 44 is coaxial and center on this filling and manage the overcoat 86 of 84 peripheries and form by a filling pipe 84 and one and this filling pipe 84.Be typically, this rammer 44 is worked under the solution line pressure from about 4psig to about 20psig, yet any range of pressure in above-mentioned definite scope all is an acceptable.In a preferred embodiment, described rammer 44 is worked under the solution line pressure from about 10psig to about 16psig, and better is to work under the solution line pressure from about 12psig to about 16psig.Determined range of pressure is intended to be used for to reduce the turbulent flow of when described pipe inserts container 12 albumin or other protein and splashes.As mentioned above, after end sealing 76 forms, make bag 12 fill albumin by described filling assembly 30, described top sealing 78 forms simultaneously with the end sealing 76 of next bag, and the next bag 12 of pipe 38 continues to be loaded, and constantly repeats said process.Like this, the adjacent bag 12 in a series of bag 12 is joined together at first, and is separated after the filling of subsequently each bag 12 and sealing then.
As shown in Figure 5, in a preferred embodiment, the rammer 44 of described filling assembly 30 is formed at the pipe 86 outside the pipe 84.It is 84 coaxial that described outer tube 86 and described filling are managed, and extend in the space of described filling pipe 84, one air flues 88 between the external diameter of the internal diameter of described outer tube 86 and described filling pipe 84.Sterilized air flows through described air flue, and is discharged near the end of described filling pipe 84 and in the upstream of filling pipe outlet 92.
In the preferred embodiment of as shown in Figure 5 filling pipe 84, described filling pipe 84 has a Venturi tube 85, this Venturi tube along its length direction from first diameter gradually chap to the second than major diameter.In addition, as shown in Figure 6, the end 90 of filling pipe 84 has one first internal path 94, and this path is coaxial with the second adjacent internal path 96.In a preferred embodiment of the invention, it is circular that the cross sectional shape of described first internal path 94 is generally, and have first internal diameter, and it is circular that the cross sectional shape of described second internal path 96 is generally, and have second internal diameter.The internal diameter of described first internal path 94 and the size of sectional area thereof are greater than the size of the internal diameter and the sectional area thereof of second internal path 96.One dividing range 98 couples together first internal path 94 and second internal path 96 on an exterior in-to-in position of the outlet 92 of rammer 44 ends 90.In a preferred embodiment, described dividing range comprises that one is positioned at the incline bench portion 98 between first and second internal paths 94,96, and the diameter of this stage portion sharply reduces from first internal path, 94 to second internal paths 96.In the work of described rammer, the dividing range 98 between first and second paths 94,96 provides an important function.Owing to carry out albuminised distribution from the outlet of second internal path 96 of rammer 44, therefore in the filling interrupt procedure, capillary force generation effect in the filling pipe, make and be deposited in first and second paths 94, the albumin at dividing range 98 places between 96 produces meniscus, rather than produces described meniscus at outlet 92 places of alternate path.Like this, even albumin is assigned with from rammer 44 by second internal path 96, in the filling interrupt procedure between the filling of the bag 12 that at every turn carries out continuously, albumin is maintained at inside and keeps certain distance with the outlet of described rammer 44, promptly be in first and second paths 94, on the dividing range 98 between 96, this structure has helped prevent the outlet migration of albumin from rammer widely.Any migration will make albumin be transferred on the outside of rammer and contact membrane 34.As mentioned above, albumin is a kind of heat guard.If described albumin is moved on the film, it may endanger the integraty of described top sealing area.Therefore, structure of the present invention provides a kind of device that is used to eliminate described shortcoming.In the test that the sealing integrity of container 12 of the present invention is carried out, splitting cruelly in the test assessment, 99.90% container molding 12 is higher than the minimum seal strength values of 20psi.
As mentioned above, overcoat 86 is coaxial with filling pipe 84, and around the periphery of described filling pipe, and extend in the space between the external diameter of the internal diameter of described outer tube 86 and described filling pipe 84 gas passage 88.In a preferred embodiment, the distal portion 100 of overcoat 86 is adapters that are installed on the described overcoat 86, and it is the part of described overcoat 86 that described distal portion 100 can be manufactured into, and does not destroy the expectation function of described overcoat 86.Shown in Fig. 7 and 8, the distal portion 100 of overcoat 86 has a chamfered end 104.Plurality of rows pore 102 is positioned near the described end of distal portion 100 of described overcoat 86.Described sterilized air is discharged from described deflation hole 102 through described air flue 88.Because the outlet of deflation hole 102 is positioned at chamfered end 104 places of described overcoat 86, therefore the glide path of sterile air around described from loading the periphery of the albuminised glide path that end is discharged from, therefore can not disturb albuminised flowing.This has just reduced the chance that sterile air makes the albumin generation turbulence effects that is assigned with.In addition, owing to the air flows route is in outside the albuminised liquid flow line, and, therefore, thereby make albumin contact the minimizing possibility that produces foam with air away from this liquid flow line.Be similar to the benefit that two internal diameter appeared by filling pipe 84, very useful by the mobile benefit that is appeared of sterile air.This structure has helped prevent albumin to splash and foam from the outlet generation of described rammer widely.This has just prevented the contacting of the part that will become the top sealing area of albumin and film, thereby also helps to form continuously stronger top sealing.
The size of first internal diameter 106 of the distal portion 100 of overcoat 86 is designed to be engaged on the overcoat 86, and is fixed to described outer putting by setscrew 110.The size of second internal diameter 108 of the distal portion 100 of overcoat 86 is designed between overcoat 86 and filling pipe 84 air flue 88 is set.As shown in Figure 7, an inclined-plane 112 is positioned at the end of second internal diameter 108, thereby has further reduced the internal diameter of overcoat 86.One relative inclined-plane 114 is positioned at the outside of the end of described overcoat 86.
As shown in figure 10, the external diameter of overcoat 86 is greater than the external diameter of filling pipe 84 outstanding overcoats 86.Usually during loading, assemblies 30 are loaded in pipe 38 contacts of film.Because the structure of above-mentioned determined filling pipe and overcoat, even the filling pipe 84 of filling assembly 30 extends through the opening 80 of bag in a section of filling process, and enter in the cavity 82 of bag, overcoat 86 is outside the part of described filling pipe 84, so only overcoat 86 can contact tubes 38, thereby have prevented the contact between polymer container and the filling pipe 84.Like this, the outlet 92 of described filling pipe 84 is positioned in a distance of the inwall that leaves described flexible polymer container 12.Like this, with the interior dividing range 98 of first and second internal paths and oppositely the position of the overcoat 86 that combines of chamfering 114 and size prevented that any albumin from moving to the outside of filling assembly 30, and prevent that it from contacting with the sealing area of managing 38 the top sealing 78 that finally becomes container molding.Because albumin is a heat guard, therefore, polymeric material is sealed for being heated, must guarantee that all sealing areas do not have protein.If had albumin to be present in the sealing area before sealing, the leak free integraty will be endangered.Like this, because above-mentioned determined structure, albumin is discharged from filling pipe 84, and is loaded into the bottom of bag 12, and does not contact the sealing area of the opening of the bag 12 that becomes top sealing 78 the most at last.
Though specific embodiment is illustrated and illustrates, thinkable multiple change under the situation of not obvious disengaging spirit of the present invention, and protection domain is only limited by the scope of appending claims.
Claims (48)
1. method of packing albumin protein may further comprise the steps:
One flexible polymer container is provided, and this container has an opening that extends from the cavity of described polymer container;
A certain amount of albumin enrichedmaterial in sterile solution is provided;
Under solution line pressure, albumin is packed in the cavity of described polymer container by the opening the described container from about 4 pounds/sq in to about 20 pounds/sq in;
With the sealing of described opening, thereby described liquid albumin is remained in the fluid tight chamber of cavity of polymer container.
2. before the method for claim 1, wherein in being loaded into the cavity of described container, described albumin is maintained at about under 68 the temperature.
3. the method for claim 1, wherein under solution line pressure, described albumin is packed in the described cavity of described flexible polymer container from about 12 pounds/sq in to about 16 pounds/sq in.
4. the method for claim 1, wherein, described flexible polymer container is in the gnotobasis of moulding filling sealing and packing machine, wherein said albumin is loaded in the cavity of the flexible polymer container in the gnotobasis that is in moulding filling sealing and packing machine, and the opening of wherein said container is sealed in the gnotobasis of moulding filling sealing and packing machine.
5. the method for claim 1, further may further comprise the steps, promptly, provide one to have terminal rammer, this end has the first and second adjacent internal paths, and described first internal path has the sectional area bigger than second internal path, wherein, described second internal path and first internal path are adjacent to extend to the outside of described end, and wherein, albumin is assigned with from rammer by described second internal path.
6. the method for claim 1, further may further comprise the steps, promptly, provide one to have terminal rammer, this end has the first and second coaxial internal paths, the internal diameter size of described first internal path is designed to the internal diameter size greater than described second internal path, wherein, dividing range between described first and second internal paths is an exterior inside of described end, wherein second internal path extends to the outside of described end, and wherein albumin is discharged described rammer by described second internal path.
7. the method for claim 1 further may further comprise the steps, and, provides an overcoat that is, and this overcoat is positioned at the outside of a part of the end of contiguous rammer, and this overcoat prevents the contact between described polymer container and the rammer.
8. the method for claim 1, wherein albuminised concentration is 20%.
9. the method for claim 1, wherein albuminised concentration is 25%.
10. the method for claim 1, the capacity of wherein said flexible polymer container is 50ml.
11. the method for claim 1, the capacity of wherein said flexible polymer container are 100ml.
12. the method for claim 1, further may further comprise the steps, promptly, a kind of flexible polymer container is provided, and this container comprises a stratiform film, and this laminar film has: a linear low density polyethylene skin, one barrier layer for gases, an one polyamide sandwich layer and a linear low density polyethylene internal layer, above-mentioned each layer is bonded together by a kind of polyurethane adhesive.
13. one kind is packaged in method in a series of flexible polymer containers with albumin protein, may further comprise the steps:
A certain amount of filtered albumin is provided;
A kind of flexible polymeric materials is provided;
A kind of moulding filling sealing and packing machine is provided, in this moulding filling sealing and packing machine, described flexible polymeric materials is processed into a series of bags;
In described moulding filling sealing and packing machine, a certain amount of albumin packed in the described bag;
Utilize described wrapping machine that the sealing area of described bag is sealed, thereby the albumin of described amount is enclosed in the described bag.
14. method as claimed in claim 13, wherein, the adjacent bag in a series of bag is joined together at first, and after each bag is filled separated opening.
15. method as claimed in claim 14 further may further comprise the steps, and, has a roll forming machine in described moulding filling sealing and packing machine that is.
16. method as claimed in claim 15 further may further comprise the steps, that is, utilize described roll forming machine that described flexible polymeric materials is formed a pipe, and described pipe is formed a series of adjacent bags.
17. method as claimed in claim 13, wherein, described bag is filled the albumin of described amount continuously.
18. method as claimed in claim 13 further may further comprise the steps, that is, described bag outer rim is sealed, so that the albumin of described amount is enclosed in the described bag.
19. method as claimed in claim 13, further may further comprise the steps, promptly, a kind of flexible polymer container is provided, and this container comprises a stratiform film, and this laminar film has: a linear low density polyethylene skin, one barrier layer for gases, an one polyamide sandwich layer and a linear low density polyethylene internal layer, above-mentioned each layer is bonded together by a kind of polyurethane adhesive.
20. method as claimed in claim 13, wherein, described moulding filling sealing and packing machine has an aseptic area, wherein a kind of flexible polymeric materials of having sterilized is placed in the described aseptic area, the wherein said flexible polymeric materials of having sterilized is processed to a series of adjacent bags in described aseptic area, wherein in described aseptic area, albumin packed into continuously in the described bag, and wherein in described aseptic area, thereby described bag is sealed continuously and is formed a kind of fluid containment vessel.
21. method as claimed in claim 13, further may further comprise the steps, promptly, the one repetition rammer with an end is provided, this end has the first and second coaxial internal paths, the sectional area of described first internal path is greater than the sectional area of second internal path, dividing range between wherein said first and second internal paths is an exterior inside of described end, wherein said second internal path extends to the outside of described end, wherein albumin is discharged described rammer by described second internal path, and wherein at the filling intercourse, albumin is maintained at the dividing range place between first and second internal paths.
22. method as claimed in claim 21 further may further comprise the steps, and, provides an overcoat that is, this overcoat is positioned at outside the part of end of adjacent rammer, and this overcoat limits the contact between described polymer container and the rammer.
23. method as claimed in claim 21, further may further comprise the steps, promptly, one overcoat coaxial with rammer is provided, one air flue that between the outside of the inside of described overcoat and described rammer, extends, wherein said overcoat limits the contact between described polymer container and the described rammer, and the sterile air described air flue of flowing through wherein, and is discharged near the upstream of albumin outlet and the end at rammer.
24. method as claimed in claim 13 further may further comprise the steps, that is, by one 0.2 micron filters described albumin is filtered.
25. one kind is packaged in method in a series of flexible polymer containers with albumin protein, may further comprise the steps:
A certain amount of filtered albumin is provided;
A kind of flexible polymeric materials is provided;
A kind of moulding filling sealing and packing machine is provided, in this moulding filling sealing and packing machine, uses a former that described flexible polymeric materials is processed into a pipe;
In described moulding filling sealing and packing machine, described pipe is processed into a series of bags;
In described moulding filling sealing and packing machine, the opening in described bag is packed a certain amount of albumin in the described bag; And
Utilize described wrapping machine that the sealing area of the opening of described bag is sealed, thereby the albumin of described amount is enclosed in the described bag.
26. method as claimed in claim 25, wherein, described bag is filled the albumin of described amount continuously.
27. method as claimed in claim 25 further may further comprise the steps, that is, rammer with under the situation that the sealing area of the opening of bag contacts is not being discharged albumin from this rammer, and in the described bag of packing into.
28. one kind is packaged into method in a kind of flexible polymer container with albumin, may further comprise the steps:
A kind of albumin enrichedmaterial is provided;
A kind of wrapping machine is provided, and this wrapping machine has a filling assembly and a poted assemblies, and described filling and poted assemblies are arranged in the inside gnotobasis of described wrapping machine;
A kind of aseptic flexible polymer container is provided, and this container has an opening that extends in the cavity;
By the filling assembly in the aseptic area that is in described wrapping machine, under pressure, albumin packed in the described container, described filling assembly has a filling pipe outlet, this outlet is positioned on the position of a wall certain distance of described flexible polymer container, the outlet of this filling pipe imports albumin in the cavity of container far-end of opening periphery of described container, and at the filling intercourse, described filling pipe remains on albumin on the position of this filling pipe outlet certain distance of this filling pipe middle distance;
The opening of the described container of sealing in the aseptic area of wrapping machine, thus albumin is remained in the described cavity of this container.
29. method as claimed in claim 28 further may further comprise the steps, and, provides an overcoat that is, this overcoat is positioned at outside the part of filling assembly, and this overcoat limits the contact between described polymer container and the filling assembly.
30. one kind is packaged in method in a kind of flexible polymer container with albumin, may further comprise the steps:
A kind of albuminised enrichedmaterial is provided;
A kind of wrapping machine is provided, and this wrapping machine has a molding assembly, a filling assembly and a poted assemblies, and each in above-mentioned each assembly all is arranged in the inside gnotobasis of wrapping machine;
A kind of flexible polymer film is provided;
Use molding assembly that described flexible polymer film is formed elongated pipe;
Use the part sealing of poted assemblies with described thin polymer film elongated tubular, sealed thin polymer film is defined and is of a size of the shape that has around the bag of the sealing area of its periphery, one cavity is in described bag and be between the described sealing area, and an opening extends to the outside of described bag from described cavity;
Under a solution line pressure, by the filling assembly albumin is packed in the described bag, described filling assembly have one extend through the bag opening and enter the bag cavity in the filling pipe, and one with the coaxial overcoat of described filling pipe, described filling pipe imports the periphery a distance of the inner opening apart from bag of bag with albumin, and described overcoat restriction filling pipe with bag between contact;
Seal the opening of described bag, thereby albumin is remained in the cavity of described bag.
31. method as claimed in claim 30, wherein, described sealing area is set at around the whole periphery of bag, but except the opening part.
32. method as claimed in claim 30 further may further comprise the steps, and, described pipe is processed into some adjacent bags that is.
33. method as claimed in claim 32 further may further comprise the steps, and, seals at least three sides of described bag that is.
34. method as claimed in claim 32 further may further comprise the steps, that is, and and in the described bag of continuously albumin of described amount being packed into.
35. method as claimed in claim 34 further may further comprise the steps, and, seals the opening of described bag continuously that is.
36. method as claimed in claim 30, wherein said filling step comprises: a rammer with an end is provided, this end has the first and second coaxial internal paths, the sectional area of described first internal path is greater than the sectional area of second internal path, dividing range between wherein said first and second internal paths is an exterior inside of described end, wherein said second internal path extends to the outside of described end, wherein albumin is discharged described rammer by described second internal path, and wherein at the filling intercourse, albumin is maintained at the dividing range place between first and second internal paths.
37. a flexible polymer container that is used for the water-soluble albumin enrichedmaterial of splendid attire comprises:
One by a slice flexible polymeric materials make the bag, described flexible polymeric materials at first is processed into a pipe by a former, subsequently, be processed to a series of adjacent bags in the aseptic area of this pipe in moulding filling sealing and packing machine, this bag has one first side element, along the one second side element that peripherally is sealed on the described first side element, and a cavity between the described first and second side element internals, wherein, in the aseptic area of described moulding filling sealing and packing machine, use after a rammer packs albumin in the cavity of adjacent bag by an opening of described bag continuously, a certain amount of water-soluble albumin enrichedmaterial just is in the cavity of described bag, subsequently, opening with described bag in the aseptic area of described moulding filling sealing and packing machine seals, thereby forms a fluid annular seal space.
38. flexible polymer container as claimed in claim 37, wherein, described flexible polymer flaky material comprises a stratiform film, this laminar film has: a linear low density polyethylene skin, one barrier layer for gases, an one polyamide sandwich layer and a linear low density polyethylene internal layer, above-mentioned each layer is bonded together by a kind of polyurethane adhesive.
39. flexible polymer container as claimed in claim 38, wherein, described barrier layer for gases is a polyvinylidene chloride.
40. flexible polymer container as claimed in claim 37, wherein, described polyamide sandwich layer is a nylon.
41. flexible polymer container as claimed in claim 38, wherein, described barrier layer for gases is made of SARAN.
42. one kind is equipped with albuminised flexible polymer container, comprises:
The shell of making by a kind of flexible polymer flaky material, described material comprises a stratiform film, this laminar film has: a linear low density polyethylene skin that uses first side of an a kind of polyurethane adhesive and a polyvinylidene chloride layer to be bonded together, second side of the described polyvinylidene chloride layer that is bonded together with first side of SARAN layer, use second side of the SARAN layer that an a kind of polyurethane adhesive and a linear low density polyethylene internal layer be bonded together, described shell has periphery at this shell and is heat sealed together one first side and a second side surface opposite, and the cavity between described first and second sides, this cavity formation one wherein stores a kind of fluid tight chamber of albuminised enrichedmaterial, wherein, one annex extends out from described shell, this annex has the seal path in the cavity that extends into described container, thereby allows described albumin to be discharged from described fluid tight chamber.
43. one kind is used for the albuminised container of splendid attire, comprise: a bag that forms by a slice flexible polymer film, this bag has by a first wall, the one second relative wall, and sealing osed top one cavity that centers on the periphery of described first and second walls, described sealing connects the inside of described first and second walls relatively, and in the cavity of described container, form a fluid annular seal space, wherein, a kind of albumin enrichedmaterial and the stabilizer that mix with aseptic aqueous solution are stored in the described fluid tight chamber.
44. container as claimed in claim 43, wherein, described bag has some peripheries, and wherein three described peripheries are heat sealed, and one of them described periphery comprises first wall and the separated folding part of the second relative wall.
45. container as claimed in claim 44, wherein, an annex is connected on the container, and adjoins described folding part, and this annex has a path that cooperates with the fluid tight chamber of described container.
46. container as claimed in claim 44, wherein, the periphery relative with described folding part comprises one first longitudinal sealing portion and one second longitudinal sealing portion, the described first and second longitudinal sealing portions connect the described first and second relative walls, and wherein, one hole is between the described first longitudinal sealing portion and the second longitudinal sealing portion, and this hole extends through the described first and second relative walls.
47. container as claimed in claim 45 also comprises at least one chevron sealing in described folding part.
48. container as claimed in claim 45 also comprises the chevron sealing in the folding part on the opposite flank of described annex.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/804,047 US20020124526A1 (en) | 2001-03-12 | 2001-03-12 | Albumin in a flexible polymeric container |
| US09/804,047 | 2001-03-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1541172A true CN1541172A (en) | 2004-10-27 |
| CN1245310C CN1245310C (en) | 2006-03-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB02809557XA Expired - Lifetime CN1245310C (en) | 2001-03-12 | 2002-03-12 | ALbumin in flexible polymeric container |
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| US (1) | US20020124526A1 (en) |
| EP (1) | EP1368238B1 (en) |
| JP (2) | JP4636782B2 (en) |
| CN (1) | CN1245310C (en) |
| AU (2) | AU2002254196B2 (en) |
| BR (2) | BRPI0208033B1 (en) |
| CA (1) | CA2440444C (en) |
| CZ (1) | CZ304107B6 (en) |
| DK (1) | DK1368238T3 (en) |
| ES (1) | ES2492890T3 (en) |
| HU (1) | HU228558B1 (en) |
| MX (1) | MXPA03008320A (en) |
| NZ (1) | NZ528791A (en) |
| PL (1) | PL226183B1 (en) |
| RU (1) | RU2287462C2 (en) |
| SK (1) | SK287656B6 (en) |
| WO (1) | WO2002072429A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102131486A (en) * | 2008-07-09 | 2011-07-20 | 泰尔茂株式会社 | Medication-containing container |
| CN103316388A (en) * | 2012-03-19 | 2013-09-25 | 董东生 | Integrated transfusion container communicated through puncture |
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-
2001
- 2001-03-12 US US09/804,047 patent/US20020124526A1/en not_active Abandoned
-
2002
- 2002-03-12 ES ES02723415.2T patent/ES2492890T3/en not_active Expired - Lifetime
- 2002-03-12 PL PL364663A patent/PL226183B1/en unknown
- 2002-03-12 WO PCT/US2002/007581 patent/WO2002072429A1/en active Application Filing
- 2002-03-12 NZ NZ528791A patent/NZ528791A/en not_active IP Right Cessation
- 2002-03-12 CN CNB02809557XA patent/CN1245310C/en not_active Expired - Lifetime
- 2002-03-12 JP JP2002571361A patent/JP4636782B2/en not_active Expired - Lifetime
- 2002-03-12 MX MXPA03008320A patent/MXPA03008320A/en active IP Right Grant
- 2002-03-12 EP EP02723415.2A patent/EP1368238B1/en not_active Expired - Lifetime
- 2002-03-12 HU HU0303414A patent/HU228558B1/en not_active IP Right Cessation
- 2002-03-12 DK DK02723415.2T patent/DK1368238T3/en active
- 2002-03-12 BR BRPI0208033A patent/BRPI0208033B1/en unknown
- 2002-03-12 CA CA2440444A patent/CA2440444C/en not_active Expired - Lifetime
- 2002-03-12 BR BR0208033-8A patent/BR0208033A/en active IP Right Grant
- 2002-03-12 SK SK1270-2003A patent/SK287656B6/en not_active IP Right Cessation
- 2002-03-12 CZ CZ20032779A patent/CZ304107B6/en not_active IP Right Cessation
- 2002-03-12 AU AU2002254196A patent/AU2002254196B2/en not_active Expired
- 2002-03-12 RU RU2003130086/12A patent/RU2287462C2/en not_active IP Right Cessation
-
2007
- 2007-07-05 AU AU2007203131A patent/AU2007203131B2/en not_active Expired
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2008
- 2008-07-18 JP JP2008187938A patent/JP2008273631A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102131486A (en) * | 2008-07-09 | 2011-07-20 | 泰尔茂株式会社 | Medication-containing container |
| CN102131486B (en) * | 2008-07-09 | 2013-06-05 | 泰尔茂株式会社 | Medication-containing container |
| CN103316388A (en) * | 2012-03-19 | 2013-09-25 | 董东生 | Integrated transfusion container communicated through puncture |
| CN103316388B (en) * | 2012-03-19 | 2016-03-30 | 北京万生人和科技有限公司 | The integrated infusion container be communicated with by puncture |
Also Published As
| Publication number | Publication date |
|---|---|
| JP4636782B2 (en) | 2011-02-23 |
| PL364663A1 (en) | 2004-12-13 |
| NZ528791A (en) | 2005-10-28 |
| HUP0303414A2 (en) | 2004-03-01 |
| AU2002254196B2 (en) | 2007-08-23 |
| CN1245310C (en) | 2006-03-15 |
| AU2007203131B2 (en) | 2009-11-26 |
| CZ20032779A3 (en) | 2004-08-18 |
| US20020124526A1 (en) | 2002-09-12 |
| BR0208033A (en) | 2004-02-25 |
| WO2002072429A1 (en) | 2002-09-19 |
| EP1368238B1 (en) | 2014-05-07 |
| WO2002072429A9 (en) | 2002-12-19 |
| AU2007203131A1 (en) | 2007-07-26 |
| CA2440444A1 (en) | 2002-09-19 |
| PL226183B1 (en) | 2017-06-30 |
| BRPI0208033B1 (en) | 2018-11-21 |
| SK287656B6 (en) | 2011-05-06 |
| JP2004532059A (en) | 2004-10-21 |
| MXPA03008320A (en) | 2003-12-11 |
| ES2492890T3 (en) | 2014-09-10 |
| CZ304107B6 (en) | 2013-10-30 |
| HUP0303414A3 (en) | 2006-03-28 |
| SK12702003A3 (en) | 2004-06-08 |
| RU2287462C2 (en) | 2006-11-20 |
| DK1368238T3 (en) | 2014-06-23 |
| CA2440444C (en) | 2010-02-23 |
| HU228558B1 (en) | 2013-03-28 |
| RU2003130086A (en) | 2005-02-27 |
| JP2008273631A (en) | 2008-11-13 |
| EP1368238A1 (en) | 2003-12-10 |
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Effective date of registration: 20160708 Address after: Illinois State Patentee after: Hundred deep company Patentee after: Hundred deep limited liability company Address before: Illinois State Patentee before: Baxter International Inc. Patentee before: Baxter Healthcare SA |
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