CN1528355A - Chinese medicine comp osition for treating spondylodynia - Google Patents
Chinese medicine comp osition for treating spondylodynia Download PDFInfo
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- CN1528355A CN1528355A CNA031340563A CN03134056A CN1528355A CN 1528355 A CN1528355 A CN 1528355A CN A031340563 A CNA031340563 A CN A031340563A CN 03134056 A CN03134056 A CN 03134056A CN 1528355 A CN1528355 A CN 1528355A
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- agkistrodon
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- myrrha
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Abstract
The present invention relates to a Chinese medicine composition for external application for curing spondylopathy with obvious therapeutic effect free from any side effect. Said Chinese medicine composition is made up by using five Chinese medicinal materials of krait/agkistrodon, scorpion, centipede, frankincense and myrrh.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of vertebrae disease.
Background technology
Vertebra comprises: cervical vertebra, thoracic vertebra, lumbar vertebra, sacral and caudal vertebra.Be to connect by a kind of cushion that is shaped as disk between the above-mentioned vertebra diaphysis, supporting physical activity thus, and this cushion be intervertebral disc, its main effect is to bear pressure, and the buffering concussion also makes the vertebra activity freely.Just because of the important function of intervertebral disc, so, in case the intervertebral disc dislocation will influence the activity of limbs, we can say that disc disease is the main forms of vertebrae disease.And the main cause that this disease produces is to bear external pressure for a long time, and health is caught a cold, due to reason such as muscle spasm, aging and bony spur and other disease.
Mainly treat according to tcm therapy treatment disc disease by massage and oral medicine etc.Its treatment mechanism mainly is that dredging the meridian reaches therapeutic purposes with invigorating blood circulation.The main function of nervous system that adjusts of massage can not thoroughly cure disc disease; And oral Chinese medicine has various different formulations, and as " Chinese medicine preparation of treatment prolapse of lumbar intervertebral disc " of CN1065132C bulletin, this patent has mainly selected for use Radix Ginseng Rubra, Radix Notoginseng, Flos Carthami, eupolyphage sece steleophaga, Moschus, Resina Draconis, Myrrha, Olibanum 8 flavor raw material of Chinese medicine formulated.As seen, treating this kind disease has the plurality of Chinese combination formula, and the purpose of treatment also mainly is logical regulating menstruation arteries and veins, blood circulation promoting and blood stasis dispelling.Above-mentioned Chinese medicine preparation mostly is tens flavors or nearly tens Chinese medicines constitute, and the proportioning of its Chinese medicine component is also relatively complicated to be prepared with being difficult to.But, to the pharmaceutical composition of thorough treatment disc disease, particularly application compress now also among exploring.
Technical scheme
Task of the present invention provides a kind of Chinese medicine composition of curing vertebrae disease by simple formulation.
The Chinese medicine composition of treatment vertebrae disease proposed by the invention is made of Agkistrodon, Scorpio, Scolopendra, Olibanum, Myrrha.According to putting down in writing in the Compendium of Material Medica: the Agkistrodon abnormal smells from the patient is sweet, and is salty, and temperature is poisonous, can treat diseases such as arthralgia, spasm of muscles and vessels; Scolopendra abnormal smells from the patient suffering, temperature, poisonous, cure mainly various poisonings; The Scorpio abnormal smells from the patient is sweet, hot, and is flat, poisonous, cures mainly all urticarias, apoplexy and hemiplegia, spasm of hands and feet etc.; Olibanum abnormal smells from the patient tepor, nontoxic, the main air noxious water is swollen, goes bad odor to remove oxious gas, and addiction is treated the poison of itching; The Myrrha bitter in the mouth, flat, nontoxic, cure mainly the removing blood stasis pain, treat the incised wound flogging injury, diseases such as all malignant boil anal fistula.
The weight ratio of this Chinese medicine composition each component is an Agkistrodon: Scorpio: Scolopendra: Olibanum: Myrrha=1: 0.8-1.2: 0.4-0.6: 0.3-0.5: 0.5-0.7.
The optimum weight proportioning of this Chinese medicine composition each component is: Agkistrodon: Scorpio: Scolopendra: Olibanum: Myrrha=1: 0.8-1: 0.5-0.6: 0.3-0.5: 0.5-0.6.
Chinese medicine composition proposed by the invention is through showing with clinical research that to Cavia porcellus and the experiment of SD rat animal this Chinese medicine composition has tangible analgesia, antiinflammatory reaches the therapeutical effect to soft tissue injury.In the skin allergy experiment, it is three groups that 30 Cavia porcelluss are divided into, and one group for adopting the present invention; Two groups are adopted the plaster substrate group; Three groups of positive matched groups (adopting the 2.4-dinitrochlorobenzene to dissolve in plaster substrate with 1% sensitization concentration), experiment show that Cavia porcellus does not have irritated phenomenon (referring to table 1) takes place.In addition, also 80 SD rats have been carried out secular toxicity test with Chinese medicine composition proposed by the invention, be about to rat and be divided into 4 groups (referring to table 2) by weight, every day, administration was respectively 0.25g/Kg, 0.5g/Kg, 1.0g/Kg, change dressings every day once, successive administration 90 days shows all in range of normal value through blood biochemical indicator continuous monitoring result, learns by statistics and handles no significant difference between each group.And there is no drug-induced overt toxicity pathological change (referring to table 2) through the rat pathological examination is also demonstrated Rats Organs and Tissues.Utilize Chinese medicine composition proposed by the invention through to long-term heavy dose of use of animal simultaneously, hemogram, blood biochemical, pathology detection be there is no obvious change, do not see obvious toxic-side effects.
Chinese medicine composition proposed by the invention suffers from lumbago and/or sciatica to 492 examples, and the cervical vertebra pain patient carries out clinical treatment.In treatment, external application every day said composition portion, one month is a course of treatment, treats 2-3 the course of treatment.In late result observation, drug withdrawal 1 year and allergy and toxic and side effects do not occur after statistics shows that total effective rate reaches more than 93%.
Table 1 the present invention is to the skin allergy experiment of Cavia porcellus
| Group | The example number | Sensitization rate (%) | The average response value | |||
| 6 hours | 24 hours | 48 hours | 72 hours | |||
| Of the present invention group | ????10 | ????0 | ????0 | ????0 | ????0 | ????0 |
| Plaster base value group | ????10 | ????0 | ????0 | ????0 | ????0 | ????0 |
| Positive controls | ????10 | ????100 | ????1 | ????0.96 | ????0.72 | ????0 |
The influence that table 2 the present invention causes rat long term toxicity internal organs (X ± S)
| Internal organs | Date | Matched group | Small dose group | Middle dosage group | Heavy dose of group |
| The heart | ?D60 | ??0.49±0.03 | ???0.45±0.05 | ???0.46±0.05 | ???0.47±0.06 |
| ?D82 | ??0.48±0.04 | ???0.38±0.03 | ???0.42±0.06 | ???0.43±0.05 | |
| Liver | ?D60 | ???3.8±0.3 | ????3.5±0.3 | ????3.5±0.3 | ????3.5±0.3 |
| ?D82 | ???3.5±0.4 | ????3.9±0.3 | ????3.3±0.5 | ????3.6±0.4 | |
| Spleen | ?D60 | ?0.289±0.04 | ??0.282±0.07 | ??0.284±0.05 | ??0.270±0.04 |
| ?D82 | ?0.264±0.11 | ??0.289±0.03 | ??0.238±0.04 | ??0.253±0.06 | |
| Lung | ?D60 | ??0.94±0.26 | ???0.80±0.49 | ???0.58±0.09 | ???0.59±0.12 |
| ?D82 | ??0.65±0.31 | ???0.58±0.08 | ???0.58±0.09 | ???0.58±0.07 | |
| Kidney | ?D60 | ??0.99±0.99 | ???0.85±0.05 | ???0.43±0.06 | ???0.45±0.06 |
| ?D82 | ??0.34±0.09 | ???0.75±0.06 | ???0.75±0.06 | ???0.74±0.05 | |
| The adrenal gland | ?D60 | ?0.033±0.01 | ??0.029±0.01 | ??0.025±0.01 | ??0.028±0.01 |
| ?D82 | ?0.033±0.01 | ??0.032±0.01 | ??0.029±0.01 | ??0.030±0.01 | |
| Brain | ?D60 | ??0.69±0.11 | ???0.68±0.12 | ???0.62±0.16 | ???0.65±0.13 |
| ?D82 | ??0.66±0.09 | ???0.65±0.14 | ???0.56±0.12 | ???0.63±0.11 | |
| Testis | ?D60 | ??1.42±0.15 | ???1.38±0.14 | ???1.45±0.15 | ???1.40±0.12 |
| ?D82 | ??1.43±0.15 | ???1.32±0.15 | ???1.29±0.07 | ???1.31±0.09 | |
| The uterus | ?D60 | ??0.46±0.13 | ???0.42±0.05 | ???0.38±0.08 | ???0.39±0.09 |
| ?D82 | ??0.46±0.08 | ???0.40±0.08 | ???0.35±0.04 | ???0.35±0.07 |
The specific embodiment:
Embodiment 1: get Agkistrodon 100 grams, Scorpio 80 grams, Scolopendra 60 grams, Olibanum 50 grams, Myrrha 60 grams, it is even that said medicine is pulverized the back remix separately, and be divided into 350 parts after making paste, and each administration portion spreads on the affected part outward.
Embodiment 2: get Agkistrodon 100 gram, Scorpio 100 grams, Scolopendra 50 grams, Olibanum 40 grams, Myrrha 70 grams, be divided into 350 parts after making paste as stated above, usage is the same.
Embodiment 3: get Agkistrodon 100 gram, Scorpio 110 grams, Scolopendra 60 grams, Olibanum 30 grams, Myrrha 50 grams, be divided into 350 parts after making paste as stated above, usage is the same.
Claims (3)
1, a kind of Chinese medicine composition for the treatment of vertebrae disease, it is characterized in that: said composition is made of Agkistrodon, Scorpio, Scolopendra, Olibanum, Myrrha.
2, Chinese medicine composition according to claim 1 is characterized in that: the weight ratio of this Chinese medicine composition each component is an Agkistrodon: Scorpio: Scolopendra: Olibanum: Myrrha=1: 0.8-1.2: 0.4-0.6: 0.3-0.5: 0.5-0.7.
3, Chinese medicine composition according to claim 1 is characterized in that: the optimum weight proportioning of this Chinese medicine composition each component is: Agkistrodon: Scorpio: Scolopendra: Olibanum: Myrrha=1: 0.8-1: 0.5-0.6: 0.3-0.5: 0.5-0.6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031340563A CN1233373C (en) | 2003-09-25 | 2003-09-25 | Chinese medicine comp osition for treating spondylodynia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031340563A CN1233373C (en) | 2003-09-25 | 2003-09-25 | Chinese medicine comp osition for treating spondylodynia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1528355A true CN1528355A (en) | 2004-09-15 |
| CN1233373C CN1233373C (en) | 2005-12-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031340563A Expired - Fee Related CN1233373C (en) | 2003-09-25 | 2003-09-25 | Chinese medicine comp osition for treating spondylodynia |
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| Country | Link |
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| CN (1) | CN1233373C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101288758B (en) * | 2008-06-06 | 2012-02-08 | 马新民 | Analgesic medicine |
| CN102727601A (en) * | 2011-04-12 | 2012-10-17 | 罗伟雄 | External patch for treating prolapse of lumbar intervertebral disc |
-
2003
- 2003-09-25 CN CNB031340563A patent/CN1233373C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101288758B (en) * | 2008-06-06 | 2012-02-08 | 马新民 | Analgesic medicine |
| CN102727601A (en) * | 2011-04-12 | 2012-10-17 | 罗伟雄 | External patch for treating prolapse of lumbar intervertebral disc |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1233373C (en) | 2005-12-28 |
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