CN1047947C - Ointment for bone tuberculosis and its preparation technology - Google Patents

Abstract

The present invention provides ointment for bone tuberculosis and a preparation technology thereof. The ointment is prepared by that 14 kinds of traditional Chinese medicines are pulverized, sieved and ground into orange red powder which is then matched with medical vaselin and honey. The present invention uses the method of external treatment for internal diseases and synchronous treatment of internal and external treatment to treat bone tuberculosis diseases; when matched with Chinese herbal medicines for oral taking, the ointment can nourish Yin, tonify the kidney and resist phthisis; bone strengthening is the foundation of detoxication and stasis removal to remove phthisis. The ointment for bone tuberculosis has the functions of warming humidity, breaking through hysteresis for decondensation, killing bacteria, resisting phthisis, activating blood circulation to dissipate blood stasis, easing joint movement, and promoting the growth of new bones. Thus, the internal and external treatment can relieve operation pains for patients and has no toxic or side effect caused by medicines for resisting phthisis.

Description

Ointment for bone tuberculosis and preparation technology thereof

The present invention relates to the Chinese drug preparation technique in a kind of medical domain, particularly a kind of ointment for bone tuberculosis and preparation technology thereof are a kind of medicine for the treatment of bone tuberculosis.

Bone tuberculosis claims bone tuberculosis again, is intractable difficult and complicated illness clinically, and at present, though the Chinese and western drugs and the method for some treatment bone tuberculosis are arranged, how not good clinical efficacy is.Along with the reach of science, the continuous appearance of various antitubercular agents, to leap really of the treatment of tuberculosis of bone and joint, but because of this disease is a chronic disease, part patient is with the tuberculosis at other position, in case morbidity is difficult to very fast healing.The doctor trained in Western medicine routine treatment has two kinds both at home and abroad, the one, conventional tuberculosis therapy, early stage effectively, but most patient entered when making a definite diagnosis in, late period, the osteoarthrosis focus is destroyed serious, because local coagulation of QI-blood is obstructed, the microcirculation serious hindrance is so effectively antituberculotics is difficult to reach affected area by circulation, so most patient's curative effect is very poor, the tuberculosis Western medicine is all big to liver, kidney, stomach, intestinal and neural toxic and side effects, so that the part patient is difficult to adhere to medication on schedule.The 2nd, operative treatment, this therapy not only patient is expensive high, makes general family be difficult to payment, and painful big, and dangerous big, success rate is low, the relapse rate height, and be difficult to radical cure, now a lot of experts and scholars think that this operation belongs to destructive operation, does not generally advocate operation.

Chinese patent CN1082419A discloses a kind of medicine powder for tuberculosis of bone and joints, and it is to be used to take orally, though certain curative effect is arranged clinically, most humans is all feared continuation and taken medicine for a long time, and child's difficulty especially of taking medicine is so bring many inconvenience to treatment.

The objective of the invention is a kind of ointment for bone tuberculosis and the preparation technology thereof that develop at above deficiency, it adopts inner disease outer treat, inside and outside the legislation of ruling together, the treatment bone tuberculosis, cooperate Chinese herbal medicine for oral administration can YIN nourishing, the kidney invigorating, anti-consumptive disease, the congenital foundation is mended in the bone strengthening training, and detoxification and removing stasis is to remove the consumptive disease heresy.Ointment for bone tuberculosis have " warming for eliminaring cold-damp, broken stagnate to separate coagulate, the anti-consumptive disease that sterilizes, blood circulation promoting and blood stasis dispelling, easing joint movement, the function of short new bone growth, internal and external application can make patient exempt the hardship of operation and because of the toxic and side effects due to the antituberculosis drugs thing like this.

The present invention is achieved in that

The prescription of ointment for bone tuberculosis is (by weight):

Herba Ephedrae 10-15g Semen Sinapis Albae 15-25g Venenum Bufonis 10-15g

Speckle insect destructive of the roots of seedlings 10-15g Scolopendra 15-30g Scorpio 20-30g

Olibanum 30-40g Myrrha 50-60g Sanguis Draxonis 40-50g

Galla Chinensis 50-60g Radix Scutellariae 15-20g Rhizoma Coptidis 15-20g

Cortex Phellodendri 20-30g Radix Notoginseng 20-30g

The present invention can be achieved in that also the preparation technology of ointment for bone tuberculosis is: at first assorts by the prescription weighing,

The first step, by formulation weight Venenum Bufonis, Sanguis Draxonis, Radix Notoginseng singly being ground respectively to 80 order fine powders is that A expects;

Second step, by formulation weight grind altogether after with Olibanum, Myrrha, mixing to 60 order fine powders be the B material;

The 3rd step, by formulation weight Herba Ephedrae, Semen Sinapis Albae, Galla Chinensis, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri are mixed the back and pulverize, sieve is got 60 order coarse powder 30g, and it is the C material that clout is crushed to 80 order fine powders again;

The 4th goes on foot, and pulverizing after by formulation weight 60 order coarse powder 30g in the speckle insect destructive of the roots of seedlings, Scolopendra, Scorpio and the C material being mixed is that 80 order fine powders are the D material again;

In the 5th step, the Sanguis Draxonis 80 order fine powders of getting in the A material place in the mortar, and Venenum Bufonis, Radix Notoginseng 80 order fine powders and D material, B in expecting with A successively expect facing-up successively, stir evenly, and cross 80 mesh sieves and promptly get orange red powder.

In the 6th step, with orange red powder, medical ventolin and Mel stir in 4: 1.5: 1.5 ratio, are the ointment for bone tuberculosis of preparation.

The present invention can also be achieved in that the using method of ointment for bone tuberculosis is, ointment for bone tuberculosis is spread on the osteoarthrosis, thickness is 1cm, apply lid with the beeswax silk fabric, fixing the getting final product of reuse scarf bandage (white plain cloth) wrapping, keep uniform temperature, 6-7 day changes dressings once, and 30 days is a course of treatment.

Good effect of the present invention is:

1, therapy of the present invention is easy, and painful little, pure Chinese medicinal preparation has no side effect, and the misery that it had both avoided patient to take medicine for a long time, have an injection or perform the operation makes medicine absorb through lesions position by local penetration, can be at 24 hours endosmosisly goes into osseous tissue, plays a role.

2, in the 500 routine cases, clinical recovery 433 examples account for 86.6%, and 48 examples that take a turn for the better account for 9.6%, and invalid 19 examples account for 38%, and total effective rate is 96.29%.

3, the present invention all has bacteriostasis to human-like and Mycobacterium tuberculosis var.bovis, causes swollen or granuloma induced by implantation of cotton pellets forms to the chemistry of mice, rat, and certain inhibitory action is all arranged, and through testing further proof, ointment for bone tuberculosis has analgesia, antiphlogistic effects preferably.

4, ointment for bone tuberculosis has no side effect through clinical use, the anxious poison of skin, and chronic toxicity test does not have overt toxicity to skin and human body, the non-stimulated and allergic phenomena to normal skin.

5, ointment for bone tuberculosis through external (90 days) to rat general activity, outward appearance, diet, the rat hemogram, the section of hepatic and renal function and liver, the heart, spleen, brain, stomach, intestinal main organs and medication local organization all has no adverse effects.

Function of the present invention is a warming for eliminaring cold-damp, the removing blood stasis collateral dredging, and anti-consumptive disease sterilization, blood stasis dispersing and fresh blood promoting, short new bone growth improves function of joint.It is used for various tuberculosis of bone and joint, mixed infection disease, lymphoid tuberculosis, bone tuberculosis, tuberculosis of skin, skin film tuberculosis, pleuritis.

Prescription pharmacology of the present invention is according to being: Herba Ephedrae, Semen Sinapis Albae are the main medicine of YANGHE TANG, are monarch in order to warming the meridian blood stasis dispelling and battalion's collateral dredging, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri bitter cold pathogenic fire reducing, and dry temperature detoxifcation is minister; Radix Notoginseng, XUEJIE SAN blood blood stasis removing, reducing swelling and alleviating pain, Scorpio, Scolopendra are expellingged wind and relieving convulsion, and detoxicating and resolving stagnation of pathogens is adjuvant drug altogether; Speckle insect destructive of the roots of seedlings treating the poisonous disease with poisonous drugs, specially the master walks lower orifices, loses thing under the erosion; The Venenum Bufonis topical anesthesia, anti-inflammatory analgetic is for making, and all medicines share, and bring out the best in each other, and play the warming the meridian blood stasis dispelling altogether, and putrefaction removing is held back skin ulcer, the merit of removing toxic substances and promoting tissue regeneration, reducing swelling and alleviating pain.

With specific embodiment technical characterictic of the present invention is described below.

Embodiment 1:

Herba Ephedrae 10g Semen Sinapis Albae 15g Venenum Bufonis 10g speckle insect destructive of the roots of seedlings 10g Scolopendra 15g

Scorpio 20g Olibanum 30g Myrrha 50g Sanguis Draxonis 40g Galla Chinensis 50g

Radix Scutellariae 15g Rhizoma Coptidis 15g Cortex Phellodendri 20g Radix Notoginseng 20g

The preparation technology of this prescription is:

The first step is with Venenum Bufonis 10g, Sanguis Draxonis 40g, Radix Notoginseng 20g, to develop 80 order fine powders respectively be the A material;

Second step was that B expects with grinding altogether after Olibanum 30g, Myrrha 50g, the mixing to 60 order fine powders;

The 3rd step, Herba Ephedrae 10g, Semen Sinapis Albae 15g, Galla Chinensis 50g, Radix Scutellariae 15g, Rhizoma Coptidis 15g, Cortex Phellodendri 20g are mixed the back pulverize, sieve is got 60 order coarse powder 30g, and it is the C material that clout is crushed to 80 order fine powders again;

The 4th goes on foot, and pulverizing after 60 order coarse powder 30g in speckle insect destructive of the roots of seedlings 10g, Scolopendra 15g, Scorpio 20g and the C material are mixed is that 80 order fine powders are the D material again;

The 5th step placed the Sanguis Draxonis 80 order fine powder 40g in the A material in the mortar, and 80 order fine powder Venenum Bufonis 10g, Radix Notoginseng 20g and D material, B in expecting with A successively expect facing-up successively, stir evenly, and cross 80 mesh sieves and promptly get the orange red powder of 320g;

In the 6th step, with the orange red powder of 320g, 120g medical ventolin and 120g Mel stir, and are the ointment for bone tuberculosis of preparation.

Embodiment 2:

Herba Ephedrae 15g Semen Sinapis Albae 20g Venenum Bufonis 13g speckle insect destructive of the roots of seedlings 13g Scolopendra 25g

Scorpio 30g Olibanum 40g Myrrha 50g Sanguis Draxonis 45g Galla Chinensis 50g

Radix Scutellariae 18g Rhizoma Coptidis 18g Cortex Phellodendri 25g Radix Notoginseng 30g

The prescription of embodiment 2 is weighed,, can make ointment for bone tuberculosis by above-mentioned preparation technology's processing.

Exemplify several model cases below:

1, Yang Mianfang, woman 54 years old, because of suffer from thoracic vertebra, tuberculosis of spine is invalid through province, the how tame hospitalize in city, after cause complete paraplegia, gatism, after adopt external application bone tuberculosis ointment to treat for 12 times, lower limb pain sensation functional rehabilitation, defecation is normal, obtains clinical cure.The physical health over back 9 years of healing, working properly, no any discomfort.

2, the virtuous woman of Wang Wei, 9 years old, the student, because of wound causes waist tuberculosis, back mistaken diagnosis is rheumatism and neuralgia, with a large amount of hormones the state of an illness is constantly increased the weight of, after making a definite diagnosis, regular anti-consumptive disease two months is not felt any better through the multi-treatment state of an illness, causes immaturity paraplegia.External application bone tuberculosis ointment is adopted 4 times in the back, patient oneself can stand up in bed, and lower limb function recovers, and diet is often become a full member, 10 bone tuberculosis ointment of external application, the patient is the handrail cane not, and oneself walks out the ward, and 11 bone tuberculosis ointment of external application reach clinical cure, appear the strong shape of body, physically well develop, through following up a case by regular visits at present just in university's reading, no any discomfort.

Claims (2)

1, a kind of external application medical ointment for the treatment of bone tuberculosis, the each component weight proportion that it is characterized in that preparing this ointment is as follows:

Herba Ephedrae 10-15g Semen Sinapis Albae 15-25g Venenum Bufonis 10-15g

Speckle insect destructive of the roots of seedlings 10-15g Scolopendra 15-30g Scorpio 20-30g

Olibanum 30-40g Myrrha 50-60g Sanguis Draxonis 40-50g

Galla Chinensis 50-60g Radix Scutellariae 15-20g Rhizoma Coptidis 15-20g

Cortex Phellodendri 20-30g Radix Notoginseng 20-30g

2, the preparation technology of claim 1 external application medical ointment is characterized in that: at first assorts by the prescription weighing,

The first step, by prescription Venenum Bufonis, Sanguis Draxonis, Radix Notoginseng being ground respectively to 80 order fine powders is that A expects;

Second step was that B expects by prescription with grinding altogether after Olibanum, Myrrha, the mixing to 60 order fine powders;

The 3rd step, by formulation weight Herba Ephedrae, Semen Sinapis Albae, Galla Chinensis, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri are mixed the back and pulverize, sieve is got 60 order coarse powder 30g, and it is the C material that clout is crushed to 80 order fine powders again;

The 4th goes on foot, and pulverizing after by formulation weight 60 order coarse powder 30g in the speckle insect destructive of the roots of seedlings, Scolopendra, Scorpio and the C material being mixed is that 80 order fine powders are the D material again;

In the 5th step, the Sanguis Draxonis 80 order fine powders of getting in the A material place in the mortar, and Venenum Bufonis, Radix Notoginseng 80 order fine powders and D material, B in expecting with A successively expect facing-up successively, stir evenly, and cross 80 mesh sieves and promptly get orange red powder;

In the 6th step, with orange red powder, medical ventolin and Mel stir in 4: 1.5: 1.5 ratio, are the ointment for bone tuberculosis of preparation.