CN1513849B - 甘露醇和山梨醇衍生物 - Google Patents

甘露醇和山梨醇衍生物 Download PDF

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Publication number
CN1513849B
CN1513849B CN200310123130.6A CN200310123130A CN1513849B CN 1513849 B CN1513849 B CN 1513849B CN 200310123130 A CN200310123130 A CN 200310123130A CN 1513849 B CN1513849 B CN 1513849B
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CN
China
Prior art keywords
oligomeric compounds
compound
group
marker
solid phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200310123130.6A
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English (en)
Chinese (zh)
Other versions
CN1513849A (zh
Inventor
F·伯格曼
H·冯德埃尔茨
C·赛德尔
K·温德尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F HOFFMANN LAMANCHE AG
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F HOFFMANN LAMANCHE AG
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Priority claimed from EP02028714A external-priority patent/EP1431297A1/en
Application filed by F HOFFMANN LAMANCHE AG filed Critical F HOFFMANN LAMANCHE AG
Publication of CN1513849A publication Critical patent/CN1513849A/zh
Application granted granted Critical
Publication of CN1513849B publication Critical patent/CN1513849B/zh
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Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CN200310123130.6A 2002-12-20 2003-12-19 甘露醇和山梨醇衍生物 Expired - Fee Related CN1513849B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP02028714.0 2002-12-20
EP02028714A EP1431297A1 (en) 2002-12-20 2002-12-20 Mannitol and glucitol derivatives
US44021203P 2003-01-15 2003-01-15
US60/440212 2003-01-15
EP03001215.7 2003-01-20
EP03001215 2003-01-20

Publications (2)

Publication Number Publication Date
CN1513849A CN1513849A (zh) 2004-07-21
CN1513849B true CN1513849B (zh) 2013-03-27

Family

ID=32600614

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200310123130.6A Expired - Fee Related CN1513849B (zh) 2002-12-20 2003-12-19 甘露醇和山梨醇衍生物

Country Status (8)

Country Link
EP (1) EP1431298B1 (ja)
JP (1) JP4169689B2 (ja)
CN (1) CN1513849B (ja)
AT (1) ATE319699T1 (ja)
CA (1) CA2453382C (ja)
DE (1) DE60303865T2 (ja)
ES (1) ES2260569T3 (ja)
HK (1) HK1066222A1 (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010060599A1 (en) 2008-11-27 2010-06-03 Roche Diagnostics Gmbh Directed synthesis of oligophosphoramidate stereoisomers
RU2573915C2 (ru) 2009-09-16 2016-01-27 Дженентек, Инк. Содержащие суперспираль и/или привязку белковые комплексы и их применение
AR080793A1 (es) 2010-03-26 2012-05-09 Roche Glycart Ag Anticuerpos biespecificos
CN103384681B (zh) 2010-12-23 2018-05-18 霍夫曼-拉罗奇有限公司 结合剂
ES2605493T3 (es) 2010-12-23 2017-03-14 F. Hoffmann-La Roche Ag Detección de un polipéptido modificado post-traduccionalmente mediante un agente ligante bivalente
EP2655413B1 (en) 2010-12-23 2019-01-16 F.Hoffmann-La Roche Ag Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
JP6486686B2 (ja) 2012-02-10 2019-03-20 ジェネンテック， インコーポレイテッド 単鎖抗体及び他のヘテロ多量体
CA2871882A1 (en) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof
CN104395339A (zh) 2012-06-27 2015-03-04 弗·哈夫曼-拉罗切有限公司 用于选择并产生含有至少两种不同结合实体的定制高度选择性和多特异性靶向实体的方法及其用途
JP6721590B2 (ja) 2014-12-03 2020-07-15 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 多重特異性抗体
WO2018013999A1 (en) 2016-07-15 2018-01-18 Am Chemicals Llc Non-nucleosidic solid supports and phosphoramidite building blocks for oligonucleotide synthesis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3384595A (en) * 1994-08-17 1996-03-07 Stichting Rega Vzw Sequence-specific binding oligomers for nucleic acids and their use in antisense strategies
DE10044373A1 (de) * 2000-09-08 2002-03-21 Roche Diagnostics Gmbh Neues Reagenz zur Markierung von Nukleinsäuren

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
N. PRAVDIC ET AL..Catalytic hydrogenation of some 2-acetamidoaldosederivatives.CROATICA CHEMICA ACTA45.1973,45343-356. *

Also Published As

Publication number Publication date
JP4169689B2 (ja) 2008-10-22
ATE319699T1 (de) 2006-03-15
DE60303865T2 (de) 2006-09-21
CN1513849A (zh) 2004-07-21
DE60303865D1 (de) 2006-05-04
CA2453382A1 (en) 2004-06-20
HK1066222A1 (en) 2005-03-18
CA2453382C (en) 2009-04-07
EP1431298A1 (en) 2004-06-23
JP2004203878A (ja) 2004-07-22
EP1431298B1 (en) 2006-03-08
ES2260569T3 (es) 2006-11-01

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