CN1513347A - Application os glycerin tributyrate as feed additive - Google Patents

Application os glycerin tributyrate as feed additive Download PDF

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Publication number
CN1513347A
CN1513347A CNA031283683A CN03128368A CN1513347A CN 1513347 A CN1513347 A CN 1513347A CN A031283683 A CNA031283683 A CN A031283683A CN 03128368 A CN03128368 A CN 03128368A CN 1513347 A CN1513347 A CN 1513347A
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feed
application
tributyrin
feed addictive
feed additive
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CN1273036C (en
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侯永清
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Hubei Haohua Biotechnology Co ltd
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Abstract

An application of glyceride tributyrate as feed additive is disclosed, which features that said glyceride tributyrate can be substituted for antibiotics to prevent and treat the digestion disorder and diarrhea of delactated piglet. Its advantage is high effect on promoting growth and increasing the utilization rate of feed.

Description

Tributyrin is as the application of feed addictive
The present invention relates to the purposes of tributyrin, relate in particular to the purposes of feed additive field.
Intestines and stomach are in disorder behind the weaned piglet has a strong impact on growth in piglets with diarrhoea, has now become " bottleneck " of Swine Production.Need in the production practices to take effective measures and recover the intestines and stomach normal function, overcome the influence of ablactation stress, suppress the generation of grice diarrhoea.In order to solve " bottleneck " problem in this Swine Production, the researcher attempts using the regulation technology of the 26S Proteasome Structure and Function of enteron aisle.For keeping the normal morphology structure of intestinal mucosa behind the weaned piglet, can adopt some trophism or non-nutritive conditioning agent, as glutamine, n-butyric acie, nucleotides, polyamines etc.By using these additives, can promote function of intestinal canal, and then replace antibiotic that this meets and bans use of antibiotic trend in the feed as growth accelerator.
The research that the enteron aisle 26S Proteasome Structure and Function is regulated all is in the starting stage both at home and abroad, and the application study of some adjusting materials such as glutamine (Gln) is more deep, has obtained consistent result.Now illustrated the main energy sources material of glutamine as intestinal mucosa cells, essential by keeping intestinal tissue normal configuration and barrier function.Research for tributyrin at present mainly concentrates on medically, and the research on animal is less, and medical research shows that it has certain biological effect to people's sdenocarcinoma of stomach cell.
The molecular formula C of tributyrin 15H 26O 6, molecular weight 302.37; Structural formula:
The tributyrin generation n-butyric acie that is decomposed in vivo, its active ingredient that plays a role should be n-butyric acie.
Butyric acid is a kind of SCFA, has important biological action.SCFA be generally polysaccharide in the diet in colonic lumen by the product of bacterium glycolysis, mainly comprise acetate, propionic acid and butyric acid, wherein butyric acid is by the main energy source of preferential absorption as colon epithelial cell.Confirm that with in vitro test butyrate can suppress the hyperplasia of colon cancer cell in many bodies, promote its apoptosis and differentiation, it has the protective effect that promotes hyperplasia, suppresses apoptosis to normal enterocyte.Butyric acid is as the important nutrient of mucous membrane of colon, and its physiological action and application clinically come into one's own day by day.N-butyric acie adds the height that can increase intestinal villi in growing-finishing pigs diets.Since the antibiotics feed addictive begin forbidding, and these materials improve animal health and improve production performance by the method for biological therapy, belong to biological or " green " feed addictive category, therefore have a good application prospect.
Tributyrin is the low carbon chain fatty glyceride simultaneously, and the higher carbon chain fatty acid triglyceride absorbs fast, as feed addictive, can significantly promote growth of animals or poultry, improve feed efficiency.
The purpose of this invention is to provide a kind of feed addictive.
Technical problem to be solved by this invention provides the new purposes of tributyrin, i.e. new application in feed addictive.
The technical solution adopted for the present invention to solve the technical problems.Tributyrin meets molecular formula C as the application of feed addictive 15H 26O 6, molecular weight 302.37; Structural formula:
Figure A0312836800041
The using method of tributyrin of the present invention, similar with the feed addictive of other kinds, can directly this product be added in the feed; Or this product and adsorbent be mixed and made into pre-mixing agent; The forms such as premix, concentrate feed that also can be mixed and made into other feed addictive or feedstuff are used.The consumption of tributyrin of the present invention according to feed gross weight meter, is 0.1%~2.0%, preferably 0.5%~1.0%.
Tributyrin of the present invention is as the application of feed addictive, and application comprises nonruminants such as pig, fowl; Ruminant such as ox, sheep; Aquatic livestocks such as plant-eating animal such as horse, rabbit and shrimp, crab.
The advantage that the present invention had is:
1. tributyrin is the short-chain fat acid glyceride, and catabolite is butyric acid and glycerine in the body, and is without any side effects to animal body.
2. tributyrin can significantly promote growth of animal, improve food utilization efficiency as the application of feed addictive.
3. tributyrin can be prevented and treated post-weaning diarrhea in piglet as the application of feed addictive, avoids using antibiotic residue in the pork that antibiotic causes.
4. replace antibiotic as growth accelerator, eliminate antibiotic residual in animal product, the nuisanceless animal product of production high-quality.
Below in conjunction with embodiment the present invention is further described.
Example 1: carry out the weanling pig test with tributyrin.48 weanling pigs are divided into two groups, three repetitions of every component (hurdle), 8 on every hurdle.Piglet source, age in days, body weight are approaching. the sex unanimity.Two groups of basal diet unanimities, test group is added 0.5% tributyrin, and control group does not add the sweet firm ester of three butyric acid.The result is as follows:
Add the influence of tributyrin to the weanling pig growth performance
The control group test group
Daily gain ADG (g/d) 537.4 a612 b
Material anharmonic ratio F/G 1.46 a1.27 b
Diarrhea rate (%) 16.0 a9.5 b
Annotate: the female different persons of colleague's shoulder marking-up represent significant difference (p<0.05).
The result shows, uses the sweet pool ester of three butyric acid of the present invention, and the piglet daily gain improves 13.88%; The material anharmonic ratio reduces by 13.01%; Diarrhea rate reduces by 40.6%.
Example 2: carry out the feeding of broiler test with tributyrin.With 320 of a collection of Ai Weiyin meat chicks that hatches, be divided into two groups, four repetitions of every component (hurdle), 40 on every hurdle.Two groups of basal diet unanimities, test group is added 0.5% tributyrin, and control group does not add tributyrin.The result is as follows:
Add tributyrin to the growth of meat chicken Effect on Performance
The control group test group
Daily gain ADG (g/d) 47.6 a52.4 b
Daily ingestion amount ADFI (g/d) 101.4 102.2
Material anharmonic ratio F/G 2.13 a1.95 b
Annotate: the female different persons of colleague's shoulder marking-up represent significant difference (p<0.05).
The result shows, uses tributyrin of the present invention, and the fryer daily gain improves 10.08%; The material anharmonic ratio reduces by 8.45%.

Claims (2)

1, a kind of purposes of organic compound is characterized in that: tributyrin is as the application of feed addictive, and application comprises nonruminants such as pig, fowl; Ruminant such as ox, sheep; Aquatic livestocks such as plant-eating animal such as horse, rabbit and shrimp, crab.
2, tributyrin according to claim 1 is characterized in that as the application of feed addictive: using method be addition according to feed gross weight meter, be 0.1%~2.0%, directly this product is added in the feed; Or this product and adsorbent be mixed and made into pre-mixing agent; Also can be mixed and made into forms such as premix, the concentrate feed aquatic livestocks such as plant-eating animals such as ruminants such as nonruminant, cattle and sheep, horse rabbits such as pig fowl and shrimp crab of feeding with other feed addictive or feedstuff.
CNB031283683A 2003-07-24 2003-07-24 Application os glycerin tributyrate as feed additive Expired - Lifetime CN1273036C (en)

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Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102178062A (en) * 2011-05-17 2011-09-14 张婷丽 Application of glyceroltriacetate as feed acidating agent
CN102204633A (en) * 2011-05-17 2011-10-05 张婷丽 Application of glyceryl tripropionate as feed acidifier
CN102204634A (en) * 2011-05-17 2011-10-05 张婷丽 Application of triformic acid glyceride as feed acidifier
CN103082094A (en) * 2013-01-31 2013-05-08 武汉工业学院 Application of butyrin lactate as feed additive
CN103082095A (en) * 2013-01-31 2013-05-08 武汉工业学院 Application of triglyceryl lactate as feed acidifier
CN103392928A (en) * 2013-07-11 2013-11-20 浙江恒兴饲料有限公司 High-efficiency expanded compound feed for dace and preparation method thereof
CN103598447A (en) * 2013-10-16 2014-02-26 哈尔滨大北农牧业科技有限公司 Non-antibiotic sucking pig milk replacer and preparation method
CN105029089A (en) * 2015-08-26 2015-11-11 青岛大信饲料有限公司 Combination feed for preventing PMWS (postweaning multisystemic wasting syndrome)
CN105166415A (en) * 2015-10-09 2015-12-23 武汉轻工大学 Different-chain-length fat composition for improving pig growth and intestinal health and application thereof
CN105639191A (en) * 2015-12-31 2016-06-08 西南大学 Feed additive for protecting intestinal health of hybrid snakehead fish and preparation method of feed additive
CN105724781A (en) * 2016-02-23 2016-07-06 广州英赛特生物技术有限公司 Feed composition and application thereof to preparation of animal feed additive
CN106212933A (en) * 2016-07-25 2016-12-14 山东省农业科学院畜牧兽医研究所 A kind of feed additive for preventing and treating piglet diarrhea and using method thereof
CN106260737A (en) * 2016-07-22 2017-01-04 天津市晨辉饲料有限公司 A kind of high-grade shrimp mixed feed and preparation method thereof
CN106260588A (en) * 2016-08-11 2017-01-04 天津市晨辉饲料有限公司 Mixed mixed feed for breeding shrimps and preparation method thereof
CN106509439A (en) * 2016-11-16 2017-03-22 山西大禹生物工程股份有限公司 Feed additive replacingantibiotics for preventing weaned piggies from suffering from diarrhoea
CN106551187A (en) * 2016-11-24 2017-04-05 佛山市南海东方澳龙制药有限公司 Improve additive, the feed of prawn anti allergic reaction
CN107373094A (en) * 2017-07-14 2017-11-24 浙江汇能生物股份有限公司 A kind of synthesis of tributyrin and the application in feed
CN107647104A (en) * 2017-08-21 2018-02-02 山东中牧饲料科技有限公司 A kind of preparation method for the function fat products for improving weak pigle growth performance
CN107836577A (en) * 2017-12-18 2018-03-27 安徽科技学院 One kind adult mutton sheep daily ration additive and its application method
CN108208341A (en) * 2017-12-29 2018-06-29 湖北浩华生物技术有限公司 Purposes, feed addictive and feed of the fat or oil composition on pig feed additive for fowls is prepared
CN110179010A (en) * 2019-06-27 2019-08-30 南京农业大学 It is a kind of for improving the premixed feed and its preparation method and application of laying hen intestinal health
CN111149944A (en) * 2020-01-15 2020-05-15 四川农业大学 Premix and feed for improving reproductive capacity of broiler breeder and application of premix and feed
CN112369516A (en) * 2020-11-26 2021-02-19 咸宁市农业科学院 Feed for weaning black goats and application
CN113303406A (en) * 2021-04-09 2021-08-27 西藏自治区农牧科学院畜牧兽医研究所 Sow feed formula suitable for healthy growth of piglets and sow feeding method
CN114041542A (en) * 2021-12-08 2022-02-15 成都大帝汉克生物科技有限公司 Feed additive for promoting piglet gastrointestinal health and preparation method thereof
CN115736108A (en) * 2022-11-02 2023-03-07 江苏奥迈生物科技有限公司 Composite medium-chain fatty acid feed additive and preparation method and application thereof

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102178062A (en) * 2011-05-17 2011-09-14 张婷丽 Application of glyceroltriacetate as feed acidating agent
CN102204633A (en) * 2011-05-17 2011-10-05 张婷丽 Application of glyceryl tripropionate as feed acidifier
CN102204634A (en) * 2011-05-17 2011-10-05 张婷丽 Application of triformic acid glyceride as feed acidifier
CN103082094A (en) * 2013-01-31 2013-05-08 武汉工业学院 Application of butyrin lactate as feed additive
CN103082095A (en) * 2013-01-31 2013-05-08 武汉工业学院 Application of triglyceryl lactate as feed acidifier
CN103392928A (en) * 2013-07-11 2013-11-20 浙江恒兴饲料有限公司 High-efficiency expanded compound feed for dace and preparation method thereof
CN103598447A (en) * 2013-10-16 2014-02-26 哈尔滨大北农牧业科技有限公司 Non-antibiotic sucking pig milk replacer and preparation method
CN105029089A (en) * 2015-08-26 2015-11-11 青岛大信饲料有限公司 Combination feed for preventing PMWS (postweaning multisystemic wasting syndrome)
CN105166415A (en) * 2015-10-09 2015-12-23 武汉轻工大学 Different-chain-length fat composition for improving pig growth and intestinal health and application thereof
CN105639191A (en) * 2015-12-31 2016-06-08 西南大学 Feed additive for protecting intestinal health of hybrid snakehead fish and preparation method of feed additive
CN105639191B (en) * 2015-12-31 2019-08-30 西南大学 A kind of feed addictive and preparation method thereof for protecting hybridized snakehead fish intestinal health
CN105724781A (en) * 2016-02-23 2016-07-06 广州英赛特生物技术有限公司 Feed composition and application thereof to preparation of animal feed additive
CN106260737A (en) * 2016-07-22 2017-01-04 天津市晨辉饲料有限公司 A kind of high-grade shrimp mixed feed and preparation method thereof
CN106212933A (en) * 2016-07-25 2016-12-14 山东省农业科学院畜牧兽医研究所 A kind of feed additive for preventing and treating piglet diarrhea and using method thereof
CN106260588A (en) * 2016-08-11 2017-01-04 天津市晨辉饲料有限公司 Mixed mixed feed for breeding shrimps and preparation method thereof
CN106509439A (en) * 2016-11-16 2017-03-22 山西大禹生物工程股份有限公司 Feed additive replacingantibiotics for preventing weaned piggies from suffering from diarrhoea
CN106551187A (en) * 2016-11-24 2017-04-05 佛山市南海东方澳龙制药有限公司 Improve additive, the feed of prawn anti allergic reaction
CN107373094A (en) * 2017-07-14 2017-11-24 浙江汇能生物股份有限公司 A kind of synthesis of tributyrin and the application in feed
CN107647104A (en) * 2017-08-21 2018-02-02 山东中牧饲料科技有限公司 A kind of preparation method for the function fat products for improving weak pigle growth performance
CN107836577A (en) * 2017-12-18 2018-03-27 安徽科技学院 One kind adult mutton sheep daily ration additive and its application method
CN108208341A (en) * 2017-12-29 2018-06-29 湖北浩华生物技术有限公司 Purposes, feed addictive and feed of the fat or oil composition on pig feed additive for fowls is prepared
CN108208341B (en) * 2017-12-29 2021-11-30 湖北浩华生物技术有限公司 Application of grease composition in preparation of pig and poultry feed additive, feed additive and feed
CN110179010A (en) * 2019-06-27 2019-08-30 南京农业大学 It is a kind of for improving the premixed feed and its preparation method and application of laying hen intestinal health
CN111149944A (en) * 2020-01-15 2020-05-15 四川农业大学 Premix and feed for improving reproductive capacity of broiler breeder and application of premix and feed
CN112369516A (en) * 2020-11-26 2021-02-19 咸宁市农业科学院 Feed for weaning black goats and application
CN113303406A (en) * 2021-04-09 2021-08-27 西藏自治区农牧科学院畜牧兽医研究所 Sow feed formula suitable for healthy growth of piglets and sow feeding method
CN114041542A (en) * 2021-12-08 2022-02-15 成都大帝汉克生物科技有限公司 Feed additive for promoting piglet gastrointestinal health and preparation method thereof
CN115736108A (en) * 2022-11-02 2023-03-07 江苏奥迈生物科技有限公司 Composite medium-chain fatty acid feed additive and preparation method and application thereof

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