CN1493318A - Chinese medicine for treating diabetes - Google Patents
Chinese medicine for treating diabetes Download PDFInfo
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- CN1493318A CN1493318A CNA021463743A CN02146374A CN1493318A CN 1493318 A CN1493318 A CN 1493318A CN A021463743 A CNA021463743 A CN A021463743A CN 02146374 A CN02146374 A CN 02146374A CN 1493318 A CN1493318 A CN 1493318A
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- chinese medicine
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- rhizoma
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Abstract
A Chinese medicine for treating diabetes is prepared from 11 Chinese-medicinal materials including astragalus root, yam, dried ginger, American ginseng, etc through supercritical fluid extracting, and proportionally mixing with excipient. Its advantages are broad spectrum, high curative effect, quickly taking its effect, and no toxic by-effect.
Description
Technical field:
The present invention relates to the Chinese medicine preparation technique, particularly a kind of Chinese medicine for the treatment of diabetes.
Background technology:
Threaten human life and healthy diabetes at present, horrifying more than its number of patients, and complicated general complication is bound to arouse fear especially, can use yet there is not ideal medicine again, bring great misery not only for all patients, and bring heavy financial burden to family for society.Though it is various to treat the medicament categories of diabetes at present, can cure the drug research of diabetes in a short time, do not appear in the newspapers as yet, cure the new drug of diabetes in a short time, at home and abroad there is no use.
Summary of the invention:
The purpose of this invention is to provide and a kind ofly can cure diabetes in a short time, can effectively prevent and treat the pure Chinese medicinal preparation of all kinds of diabetic complications again.
The technical scheme that realizes this goal of the invention is: this medicine is a raw material with the Radix Astragali, Rhizoma Coptidis, Spica Prunellae, Radix Puerariae, Rhizoma Dioscoreae, Radix Rehmanniae Preparata, Rhizoma Polygonati, Cortex Magnoliae Officinalis, Fructus Schisandrae Chinensis, Rhizoma Zingiberis, Radix Paeoniae, the Radix Panacis Quinquefolii of equivalent, extract complex and the relevant excipient thereof contain effective composition through supercritical liquid extraction technique, with this complex and excipient by 1: 3 weight ratio allotment afterwards the Chinese medicine of treatment diabetes of the present invention.
It is considered herein that the essence of diabetes is deficiency of YIN, but the deficiency of YIN hyperamization stasis of blood.The cyclic adenosine monophosphate that blood stasis can cause in the human plasma obviously raises, and the rising of cyclic adenosine monophosphate can affect the phosphorylation of glycogen apace, the enhancing of phosphorylation is the increased activity of phosphorylase, thereby the oxidation of glucose is obstructed, and then makes blood sugar increasing in the body.Blood sugar increasing stimulates beta Cell of islet generation functional compensation again with feeding back, the insulin growing amount is increased, so that form hyperinsulinemia, hyperinsulinemia is printed and distributed complicated diabetic complication again, form glycometabolic vicious cycle thus again and again, lure into not star's modern Chinese medicine diabetes of clinical symptoms such as rapid digestion of food and polyorexia, polydipsia, polyphagia, polyuria at last.
Microcirculation disturbance due to the blood stasis, both can make the gene mutation of Insulin receptor INSR and caused the defective of insulin, can make the gene mutation of insulin again and reduce the secretion of insulin amount, both can reduce the affinity of Insulin receptor INSR to insulin, the effect that makes insulin is obstructed and is formed the opposing of insulin, can reduce peripheral tissues again to the sensitivity of insulin and the biological effect of the insulin that weakened.
The present invention is directed to the pathological characters of above-mentioned diabetes and complication thereof, at first put forth effort on the screening of effective Chinese herbal medicine, through first clinical trial phase for many years, having proposed with the Radix Astragali, Rhizoma Coptidis, Spica Prunellae, Radix Puerariae, Rhizoma Dioscoreae, Radix Rehmanniae Preparata, Rhizoma Polygonati, Cortex Magnoliae Officinalis, Fructus Schisandrae Chinensis, Rhizoma Zingiberis, Radix Paeoniae, Radix Panacis Quinquefolii is the compatible combination of raw material.Secondly, by Chinese herbal medicine produce must International standardization requirement, the square medicine composition with having drafted adopts supercritical liquid extraction technique one by one separately, carries out the extraction of active chemical.Its active chemical of the complex that contains effective composition that the present invention carried is blood sugar lowering element, puerarin, astragalus polysaccharides, astragalin successively, and its weight ratio is 4: 3: 1: 2, and it is CO that solvent for use is extracted at the interface
2The excipient of the effective ingredient that the present invention carried is the composite powder that extracts last medicinal residues behind the complex contain effective composition.
By to the basis of the pharmacodynamics of effective ingredient in the technical solution of the present invention and the Its Mechanisms of clinical efficacy, the result proves, the activity that Chinese medicine one of the present invention can improve hexokinase, aldolase and phosphofructokinase in the body effectively promotes the aerobic oxidation and the anerobic glycolysis of glucose, thereby reduces blood glucose and the glucose in urine that raises fast and significantly; Two can stop and eliminate the stimulation and the infringement of the radical pair beta Cell of islet that vivo oxidation produces, thereby promote the reparation and the regeneration of islet cells; Three can regulate the gene expression and the generation of Insulin receptor INSR exactly, stop the sudden change of gene in the expression process of Insulin receptor INSR, adjust the normal expression and the biological effect of Insulin receptor INSR; Four can suppress and reduce the activity and the content of cyclic adenosine monophosphate effectively, thereby from bringing into play blood sugar reducing function in fact; Five can strengthen Insulin receptor INSR effectively to the affinity of insulin and eliminate the opposing of insulin significantly; Six can suppress the active nonenzymatic glycosylation effect of conciliating isolating protein in alditol reductase top effectively, thereby fundamentally stop the generation and the development of diabetic complication, and to concurrent diabetic complication, the effect of removing burning wood away under the boiler are arranged also.
Behind the pharmacological action of having grasped Chinese medicine of the present invention and mechanism of action, organize clinical application research.From July in May, 1996 to calendar year 2001, observe 135 routine I, type ii diabetes case altogether, all be the outpatient, course of disease 3-12 is divided into treatment at random and organizes 76 examples, matched group 59 examples, matched group I type insulin injection, the oral diabetes pill of II type.The result shows: treatment group 60 examples of fully recovering, effective 16 examples, invalid 0 example; Matched group 0 example of fully recovering, effective 10 examples, invalid 49 examples.Through to the research of above-mentioned clinical data and relevant biochemistry detection, the result shows: Chinese medicine of the present invention gets final product clearing away heat-fire, promoting the production of body fluid to quench thirst, again can nourshing Yin and drynsessmoistening prescription, controlling nocturnal emission with astringent drugs reducing urination; Get final product blood circulation promoting and blood stasis dispelling, disappear that it is long-pending coagulate to loose, but activating QI cloth Tianjin, conditioning internal organs again.Make being separated yearningly of quenching one's thirst, the famine of quenching one's thirst is filled, and the moon of quenching one's thirst is supported, the dry profit of quenching one's thirst, and the urine of quenching one's thirst is ended.
Chinese medicine of the present invention is compared with existing medicine, can cure type ii diabetes, can cure type i diabetes again, also can treat diabetes complicated all kinds of complication effectively, be pure Chinese medicinal preparation and without any side effects because of medicine of the present invention simultaneously, meanwhile, have produce effects fast again, the original point of short treating period makes all diabeticss can obtain thorough rehabilitation in a short time.
The specific embodiment:
Provide specific embodiment of the present invention below.Its raw material of the Chinese medicine of the said treatment diabetes of this embodiment is formed: the Radix Astragali, Rhizoma Coptidis, Spica Prunellae, Radix Puerariae, Rhizoma Dioscoreae, Radix Rehmanniae Preparata, Rhizoma Polygonati, Cortex Magnoliae Officinalis, Fructus Schisandrae Chinensis, Rhizoma Zingiberis, Radix Paeoniae, each 300g of Radix Panacis Quinquefolii, the heavy 3600g of total raw material, extract complex and the relevant excipient thereof that contains effective composition through supercritical liquid extraction technique, the weight ratio of this complex and excipient is 1: 3, be complex 450g, relevant excipient 1350g.In the present embodiment, the effective ingredient that complex contains is blood sugar lowering element, puerarin, astragalus polysaccharides, astragalin successively, and its weight ratio is 4: 3: 1: 2, i.e. and plain 180g, puerarin 135g of blood sugar lowering, astragalus polysaccharides 45g, astragalin 90g; Excipient is the composite powder that extracts last medicinal residues behind the complex contain effective composition.Promptly get the Chinese medicine that the present invention treats diabetes after above-mentioned complex and relevant excipient thereof allocated.
Claims (3)
1, a kind of Chinese medicine for the treatment of diabetes, this medicine is a raw material with the Radix Astragali, Rhizoma Coptidis, Spica Prunellae, Radix Puerariae, Rhizoma Dioscoreae, Radix Rehmanniae Preparata, Rhizoma Polygonati, Cortex Magnoliae Officinalis, Fructus Schisandrae Chinensis, Rhizoma Zingiberis, Radix Paeoniae, the Radix Panacis Quinquefolii of equivalent, extract complex and the relevant excipient thereof that contains effective composition through supercritical liquid extraction technique, this complex and excipient are allocated by 1: 3 weight ratio.
2, the Chinese medicine of treatment diabetes according to claim 1 is characterized in that the effective ingredient that this complex contains is blood sugar lowering element, puerarin, astragalus polysaccharides, astragalin successively, and its weight ratio is 4: 3: 1: 2.
3, the Chinese medicine of treatment diabetes according to claim 1 is characterized in that this excipient is the composite powder that extracts last medicinal residues behind the complex contain effective composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA021463743A CN1493318A (en) | 2002-10-30 | 2002-10-30 | Chinese medicine for treating diabetes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA021463743A CN1493318A (en) | 2002-10-30 | 2002-10-30 | Chinese medicine for treating diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1493318A true CN1493318A (en) | 2004-05-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA021463743A Pending CN1493318A (en) | 2002-10-30 | 2002-10-30 | Chinese medicine for treating diabetes |
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| CN (1) | CN1493318A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101259261B (en) * | 2008-04-10 | 2010-06-02 | 刘勇 | Diabetes treating traditional Chinese medicine |
| CN103976433A (en) * | 2014-04-17 | 2014-08-13 | 五河县鲲鹏食品饮料有限公司 | Magnolia officinalis blood sugar-reduction health beverage and preparation method thereof |
-
2002
- 2002-10-30 CN CNA021463743A patent/CN1493318A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101259261B (en) * | 2008-04-10 | 2010-06-02 | 刘勇 | Diabetes treating traditional Chinese medicine |
| CN103976433A (en) * | 2014-04-17 | 2014-08-13 | 五河县鲲鹏食品饮料有限公司 | Magnolia officinalis blood sugar-reduction health beverage and preparation method thereof |
| CN103976433B (en) * | 2014-04-17 | 2015-10-28 | 五河县鲲鹏食品饮料有限公司 | A kind of bark of official magnolia blood sugar reducing health beverage and preparation method thereof |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |