CN1957972B - Composition in use for invigorating primordial energy, benefiting pubic region, preparation method and usage - Google Patents
Composition in use for invigorating primordial energy, benefiting pubic region, preparation method and usage Download PDFInfo
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- CN1957972B CN1957972B CN200510022013XA CN200510022013A CN1957972B CN 1957972 B CN1957972 B CN 1957972B CN 200510022013X A CN200510022013X A CN 200510022013XA CN 200510022013 A CN200510022013 A CN 200510022013A CN 1957972 B CN1957972 B CN 1957972B
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Abstract
A composition used as medicine or health-care food for nourishing vital energy and essence, improving immunity and anoxic tolerance, and relieving fatigue is prepared from rhodiola root, girald acanthopanax bark, nardostachys rhizome, saffron, and astragalus root. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of compositions that is used for invigorating primordial QI, benefiting pubic region, specifically, it is to be medicine or the health food that feedstock production forms by Chinese crude drug.
Background technology
Chinese medicine medicated wine, the application aspect Chinese nation's health care is of long standing and well established, has just put down in writing the example that medicated wine is cured the disease in Huangdi's Internal Classics.To medicated wine, promptly rise to medical skill and means from cooking culture by wine, medicated wine has been given full play to unique effect such as " Wine competent medicine tendency ", " wine helps the efficacy of a drug ".Modern medicine study confirms, the plurality of active ingredients of Chinese medicine all is soluble in the wine as alkaloid and its esters, glycoside, tannin, organic acid, volatilization wet goods, and some Chinese medicines are behind the steeping in wine bubble, and the easier stripping of effective ingredient can improve curative effect.Because wine has effects such as " warming intestines and stomach are driven wind and cold for promoting blood circulation, row medicine gesture ", so wine and medicine preparation can strengthen the efficacy of a drug, both can treat disease and prevent disease, can be used for auxiliary treatment after being ill again.The merit of all right medicine of chartreuse, the power of borrowing wine plays the strong and anti-ageing effect that lengthens one's life of tonify deficiency.According to the viewpoint of Traditional Chinese medical theory, vigour can be regarded the total output of people's vital movement as, regard as inherent, coexist the inside and outside up and down primordial QI of week row whole body with giving birth to." the five internal organs respectively have vigour, and six internal organs respectively have vigour; The extremity bones of the body collectively relies vigour with moving; Fur muscle relies vigour to fill; The clear key of face relies vigour with wise; Mental awareness relies vigour with gods." from the angle of theory of Chinese medical science, other method obstinate of various difficult miscellaneous diseases all can be started with from transferring invigorating primordial QI.
If be used for the drug main Chinese medicine of invigorating primordial QI, benefiting pubic region at present: as multiple medicine or Chinese medicine prescriptions such as Radix Ginseng, the Radix Astragali, Rhizoma Dioscoreaes.But not all medical material can be made medicated wine, at first to select raw material according to the needs of treatment, secondly according to effective ingredient self characteristics in the raw material, through a large amount of screening tests with the compatibility of determining raw material and usage, consumption, the selection of solvent and concentration.
Summary of the invention
Technical scheme of the present invention has provided a kind of compositions that is used for invigorating primordial QI, benefiting pubic region, and another technical scheme of the present invention also provides the preparation method and the purposes of said composition.
The invention provides a kind of compositions that is used for invigorating primordial QI, benefiting pubic region, it is to contain the preparation that is prepared from by the following weight proportion raw material:
100～125 parts of Radix Rhodiolaes, 40～50 parts of Cortex Acanthopanacis Giraldii, 5～10 parts of Radix Et Rhizoma Nardostachyos, 2.5～5 parts of Stigma Crocis, 75～90 parts of the Radixs Astragali.
Further, it is the preparation that is prepared from by the following weight proportion raw material:
100～125 parts of Radix Rhodiolaes, 40～50 parts of Cortex Acanthopanacis Giraldii, 5～10 parts of Radix Et Rhizoma Nardostachyos, 2.5～5 parts of Stigma Crocis, 75～90 parts of the Radixs Astragali;
Further, it is the preparation that is prepared from by the following weight proportion raw material:
100 parts of Radix Rhodiolaes, 50 parts of Cortex Acanthopanacis Giraldii, 5 parts of Radix Et Rhizoma Nardostachyos, 2.5 parts of Stigma Crocis, 75 parts of the Radixs Astragali.
Pharmaceutical composition of the present invention is to be active component with the primary crude drug of Radix Rhodiolae, Cortex Acanthopanacis Giraldii, Radix Et Rhizoma Nardostachyos, Stigma Croci, the Radix Astragali or extract, adds the preparation that acceptable accessories or complementary composition are prepared from.
Wherein, described Radix Rhodiolae is Crassulaceae Sedum Rhodiola crenulata (HOOK.f.etThoms) H.ohba root and rhizome; Described Cortex Acanthopanacis Giraldii is the skin of Araliaceae Acanthopanax Acanthopanaxgiraldii (Regel) Regel; Described Stigma Croci is the dry stigma of Iridaceae crocus Crocus sativus L.; The described Radix Astragali is the root and rhizome of pulse family Astragalus Astragalus membranaceus (Fisch.) Bunge; Described Radix Et Rhizoma Nardostachyos is the root and rhizome that Herba Patriniae section Radix Et Rhizoma Nardostachyos belongs to Nardostachys chinensis Batal.orN.jatamansi DC..Except above-mentioned material choice,, can select equal generic other raw medicinal material to replace according to those skilled in the art's general knowledge.
Wherein, described preparation is medicated wine, oral liquid, tablet, capsule, granule or powder.The number of degrees of described medicated wine are: 38 °～52 °, the number of degrees of medicated wine are the volume ratio of ethanol in the medicated wine (ethanol) and finished product medicated wine herein.
The present invention also provides this preparation of drug combination method, and it comprises the steps:
A, take by weighing raw material: 100～125 parts of Radix Rhodiolaes, 40～50 parts of Cortex Acanthopanacis Giraldii, 5～10 parts of Radix Et Rhizoma Nardostachyos, 2.5～5 parts of Stigma Crocis, 75～90 parts of the Radixs Astragali according to weight proportion;
B, get the raw material among the step a, water or concentration are the ethanol extraction of 60～65%v/v, filter, and filtrate concentrates, and add acceptable accessories or complementary composition and are prepared into preparation pharmaceutically commonly used.
Wherein, the preparation method of the medicated wine of medicine of the present invention comprises the steps:
A, take by weighing raw material: 100～125 parts of Radix Rhodiolaes, 40～50 parts of Cortex Acanthopanacis Giraldii, 5～10 parts of Radix Et Rhizoma Nardostachyos, 2.5～5 parts of Stigma Crocis, 75～90 parts of the Radixs Astragali according to weight proportion;
B, get the Chinese liquor that contains alcohol amount 60～65%v/v, the consumption of Chinese liquor is 50～60%w/w of raw material gross weight among the step a, soaks, and immersion is standby; Medicinal residues are measured the Chinese liquor liquid percolation of 60～65%v/v with containing alcohol, and the consumption of Chinese liquor is 40～50%w/w of raw material gross weight among the step a; Percolate and immersion are merged, the medicinal residues distilled water wash, cleaning mixture and percolate, immersion merge, and filter; Filtrate is left standstill, and adds the Ovum Gallus domesticus album precipitation, removes precipitation and promptly gets medicated wine.
Wherein, described Chinese liquor is the Chinese liquor that contains alcohol amount 60%.
The present invention also provides said composition to have the medicine of anoxia enduring, resisting fatigue, immunoregulation effect or the purposes in the health food in preparation.
Radix Rhodiolae is gone into the Liver and kidney warp in the raw material of medicine of the present invention or health food, and nourishing the kidney and liver, benefiting QI for activating blood circulation effect are arranged, and heavy dose can strong body; The Cortex Acanthopanacis Giraldii invigorating the liver and kidney, bone and muscle strengthening; The Stigma Croci blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body; Radix Astragali supplementing qi and invigorating vasculum, invigorating QI to consolidate the body surface resistance, diuresis poison holding.The Radix Et Rhizoma Nardostachyos regulating QI to relieve pain, relieving stagnation and activating the spleen.All medicines share, and play altogether and tonify Qi of the kidney, strong smart live body, resisting fatigue, the effect of defying age.
Medicine of the present invention or health food have anoxia enduring, resisting fatigue, immunoregulatory effect, and especially Zhi Bei medicated wine taste is good to eat mellow, and effect is remarkable, and other preparation is easy to carry, for the public provides a kind of new selection.
Obviously, according to foregoing of the present invention,,, can also make modification, replacement or the change of other various ways not breaking away under the above-mentioned basic fundamental thought of the present invention prerequisite according to the ordinary skill knowledge and the customary means of this area.The compatibility that is raw material prescription of the present invention because of one of purpose of the present invention is used, therefore under the prerequisite that does not break away from basic fundamental thought of the present invention, can prepare the regular dosage form pharmaceutically commonly used except that medicated wine, as the multiple dosage form of capsule, tablet, granule, powder, mixture, syrup or the like.
The specific embodiment of form is described in further detail foregoing of the present invention again by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
The specific embodiment
The preparation of embodiment 1 medicine medicated wine of the present invention
Get it filled material Radix Rhodiolae 100kg, Radix Et Rhizoma Nardostachyos 5kg, Stigma Croci 2.5kg, Radix Astragali 75kg, Cortex Acanthopanacis Giraldii 50kg pulverize, and soak about 2～3 weeks with 60 ° of raw material Chinese liquor 60kg, and immersion device preservation in addition is preceding liquid.Medicinal residues merge with 60 ° of raw material Chinese liquor 40kg percolation, filter liquid and preceding liquid.Medicinal residues are with a certain amount of distilled water wash, and washing liquid and preceding liquid merge.Medicinal residues are put in the centrifuge and are dried, and centrifugal medicinal liquid merges with preceding liquid, filters, left standstill, clarify 1～2 month, be precipitant with fresh albumen, utilize protein and tannin in wine, fully to react, 1～2 week of stand at low temperature, remove precipitate finished product.
Make finished product and below 0 ℃ low-temperature precipitation is being arranged; Be fallow liquid, clarification, transparent is put for a long time and is allowed small amount of precipitate; Distinguish the flavor of little puckery, be with sweet.
Medicated wine of the present invention can be used as medicine and uses, and also can be used as health food and uses.
The preparation of embodiment 2 medicinal granules of the present invention
A, take by weighing Radix Rhodiolae 100kg, Cortex Acanthopanacis Giraldii 45kg, Radix Et Rhizoma Nardostachyos 5kg, Stigma Croci 3kg, Radix Astragali 75kg by the prescription proportioning;
B, above-mentioned raw materials extract with the soak with ethanol of concentration 70～75% respectively, and soak filters, and is condensed into extractum;
C, the extractum mixing of getting step b gained add adjuvant, stir, and form through granulation, granulate, oven drying at low temperature, packing, sterilization, quality inspection, packing.
The preparation of embodiment 3 medicinal tablets of the present invention
A, take by weighing Radix Rhodiolae 125kg, Cortex Acanthopanacis Giraldii 50kg, Radix Et Rhizoma Nardostachyos 10kg, Stigma Croci 5kg, Radix Astragali 90kg;
B, above-mentioned raw materials extract with the soak with ethanol of concentration 70～75% respectively, and soak filters, and is condensed into extractum;
C, the extractum mixing of getting step b gained add adjuvant, stir, through granulation, granulate, tabletting promptly.
The preparation of embodiment 4 medicine capsules of the present invention
A, take by weighing Radix Rhodiolae 100kg, Cortex Acanthopanacis Giraldii 40kg, Radix Et Rhizoma Nardostachyos 5kg, Stigma Croci 2.5kg, Radix Astragali 75kg;
B, above-mentioned raw materials extract with the soak with ethanol of concentration about 75% respectively, and soak filters, and is condensed into extractum;
C, the extractum mixing of getting step b gained add adjuvant, stir, through granulation, granulate, promptly encapsulated.
The preparation of embodiment 5 medicine medicated wine of the present invention
Get it filled material Radix Rhodiolae 100kg, Radix Et Rhizoma Nardostachyos 5kg, Stigma Croci 2.5kg, Radix Astragali 75kg, Cortex Acanthopanacis Giraldii 50kg, Radix Codonopsis 25kg, Fructus Lycii 25kg pulverize, and soak about 2～3 weeks with 60 ° of raw material Chinese liquor 60kg, and immersion device preservation in addition is preceding liquid.Medicinal residues merge with 60 ° of raw material Chinese liquor 40kg percolation, filter liquid and preceding liquid.Medicinal residues are with a certain amount of distilled water wash, and washing liquid and preceding liquid merge.Medicinal residues are put in the centrifuge and are dried, and centrifugal medicinal liquid merges with preceding liquid, filters, left standstill, clarify 1～2 month, be precipitant with fresh albumen, utilize protein and tannin in wine, fully to react, 1～2 week of stand at low temperature, remove precipitate finished product.
Make finished product and below 0 ℃ low-temperature precipitation is being arranged; Be fallow liquid, clarification, transparent is put for a long time and is allowed small amount of precipitate; Distinguish the flavor of little puckery, be with sweet.
The quality control standard of embodiment 6 medicated wine of the present invention
Below be the medicated wine that embodiment 1 prepares to be carried out quality standard detect:
The organoleptic indicator should meet the regulation of table 1
Table 1 organoleptic indicator
| Project | Index |
| Outward appearance | Yellowish-brown liquid, clarification, transparent is put for a long time and is allowed small amount of precipitate |
| Project | Index |
| Abnormal smells from the patient, flavour | Have inherent abnormal smells from the patient and flavour, distinguish the flavor of little puckery, be with sweet |
Physical and chemical index should meet the regulation of table 2, and (physical and chemical index is pressed the prescriptive procedure of GB5009.12, GB/T394.2, GB/T6682, GB/T5009.2, GB/T5009.48, GB/T12396 and is measured.)
Table 2 medicated wine physical and chemical index of the present invention is measured
Conclusion: the product alcohol concentration is 52 °, 45 °, 38 ° three kinds; Low-temperature precipitation below 0 ℃; Be fallow liquid, clarification, transparent is put for a long time and is allowed small amount of precipitate; Distinguish the flavor of little puckery, be with sweet.
Below use the beneficial effect of the pharmacodynamics evidence present composition.
The immunoregulation effect test of test example 1 medicine of the present invention or health food
Placing 60 ℃ of water-baths to be evaporated to alcohol concentration the medicated wine of embodiment 1 preparation is to be for experiment below 10%.
Test result such as following table 3, table 4:
Table 3 Turnover of Mouse Peritoneal Macrophages is engulfed the chicken red blood cell result of the test
Compare with the blank group,
*P＜0.01,
△P＜0.05
The inductive mouse spleen lymphocyte conversion test of table 4 ConA result
Compare with the blank group,
*P＜0.01
Result of the test shows that under this experimental condition, medicated wine of the present invention can improve the mice serum hemolysin level, improves the phagocytic activity of macrophage, promotes splenocyte to transform, and has immunoregulation effect.
The anoxia enduring and the anti-fatigue test of test example 2 medicines of the present invention or health food
The hypoxia endurance test result confirms that medicated wine of the present invention has very significantly resisting oxygen lack P＜0.01.Resisting fatigue experiment confirm, white mice be through swimming with a load attached to the body, surveys serum urea nitrogen (BuN) content regulating liver-QI and weigh in the hand former and lactic acid content, analyze by statistics, two with matched group than P＜0.01.Illustrate that medicated wine of the present invention has obvious anoxia enduring and antifatigue effect.
Above-mentioned two efficacy test explanation medicine of the present invention has anoxia enduring, resisting fatigue, immunoregulatory effect, and clear efficacy, for the public provides a kind of new selection.
Claims (8)
1. compositions that is used for invigorating primordial QI, benefiting pubic region, it is characterized in that: it is the preparation that is prepared from by the following weight proportion raw material:
100～125 parts of Radix Rhodiolaes, 40～50 parts of Cortex Acanthopanacis Giraldii, 5～10 parts of Radix Et Rhizoma Nardostachyos, 2.5～5 parts of Stigma Crocis, 75～90 parts of the Radixs Astragali.
2. the compositions that is used for invigorating primordial QI, benefiting pubic region according to claim 1 is characterized in that: it is the preparation that is prepared from by the following weight proportion raw material:
100 parts of Radix Rhodiolaes, 50 parts of Cortex Acanthopanacis Giraldii, 5 parts of Radix Et Rhizoma Nardostachyos, 2.5 parts of Stigma Crocis, 75 parts of the Radixs Astragali.
3. the compositions that is used for invigorating primordial QI, benefiting pubic region according to claim 1 and 2, it is characterized in that: it is to be active component with the primary crude drug of Radix Rhodiolae, Cortex Acanthopanacis Giraldii, Radix Et Rhizoma Nardostachyos, Stigma Croci, the Radix Astragali or extract, adds the preparation that acceptable accessories or complementary composition are prepared from.
4. the compositions that is used for invigorating primordial QI, benefiting pubic region according to claim 3 is characterized in that: described preparation is medicated wine, oral liquid, tablet, capsule, granule or powder.
5. the compositions that is used for invigorating primordial QI, benefiting pubic region according to claim 4 is characterized in that: the number of degrees of described medicated wine are: 38 °～52 °.
6. one kind prepares the described method for compositions that is used for invigorating primordial QI, benefiting pubic region of claim 1, it is characterized in that: described preparation is that the number of degrees are 38 °～52 ° medicated wine, and the preparation method of medicated wine comprises the steps:
A, take by weighing raw material: 100～125 parts of Radix Rhodiolaes, 40～50 parts of Cortex Acanthopanacis Giraldii, 5～10 parts of Radix Et Rhizoma Nardostachyos, 2.5～5 parts of Stigma Crocis, 75～90 parts of the Radixs Astragali according to weight proportion;
B, get the Chinese liquor that contains alcohol amount 60～65%v/v, the consumption of Chinese liquor is 50～60%w/w of raw material gross weight among the step a, soaks, and immersion is standby; Medicinal residues are measured the Chinese liquor liquid percolation of 60～65%v/v with containing alcohol, and the consumption of Chinese liquor is 40～50%w/w of raw material gross weight among the step a; Percolate and immersion are merged, the medicinal residues distilled water wash, cleaning mixture and percolate, immersion merge, and filter; Filtrate is left standstill, and adds the Ovum Gallus domesticus album precipitation, removes precipitation and promptly gets medicated wine.
7. one kind prepares the described method for compositions that is used for invigorating primordial QI, benefiting pubic region of claim 1, and it comprises the steps:
A, take by weighing raw material: 100～125 parts of Radix Rhodiolaes, 40～50 parts of Cortex Acanthopanacis Giraldii, 5～10 parts of Radix Et Rhizoma Nardostachyos, 2.5～5 parts of Stigma Crocis, 75～90 parts of the Radixs Astragali according to weight proportion;
B, get the raw material among the step a, water or concentration are the ethanol extraction of 60～65%v/v, filter, and filtrate concentrates, and add acceptable accessories or complementary composition and are prepared into preparation pharmaceutically commonly used.
8. each described compositions of claim 1～5 has the medicine of anoxia enduring, resisting fatigue, immunoregulation effect or the purposes in the health food in preparation.
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Cited By (1)
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| CN103919845B (en) * | 2014-05-07 | 2017-06-16 | 南京中医药大学 | A kind of pharmaceutical composition for improving anoxia endurance and its preparation method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102349941A (en) * | 2011-10-19 | 2012-02-15 | 石家庄藏诺生物科技有限公司 | Traditional Chinese medicine composition for relieving fatigue and improving anoxia endurance and preparation method thereof |
| CN103656225A (en) * | 2012-09-12 | 2014-03-26 | 李汭洺 | Healthcare and rehabilitation medicinal liquor and preparation method thereof |
| CN103484280A (en) * | 2013-08-23 | 2014-01-01 | 朱奕 | Anti-aging multi-flavor beverage and preparation method thereof |
| CN104623219A (en) * | 2015-03-04 | 2015-05-20 | 苏州市天灵中药饮片有限公司 | Traditional-Chinese-medicine extracting liquid for relieving physical fatigue and preparation method thereof |
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| CN103919845B (en) * | 2014-05-07 | 2017-06-16 | 南京中医药大学 | A kind of pharmaceutical composition for improving anoxia endurance and its preparation method and application |
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