CN101244205A - Vein relaxing antihypelipidemic product based on reestablishment entatic state theory and preparation method - Google Patents

Abstract

The invention relates to a collateral-dredging and blood sugar reducing producut and preparation method based on inner steady reconstruction theory, comprising a compatibility of at least three, or six to ten, and at most 22 pieces of herbs of radix rehmanniae, radix asparagus, ginseng and other herbs; also comprising processed dark green tea and active ingredients; which is characterized in that the product is a new Chinese medicine or functional food for diabetes treatment or blood sugar reducing assistant remedy, and is made according to latest technique. The product has the advantages of obvious blood sugar reducing therapeutic effect as well as blood-fat reducing, blood pressure reducing, cardiovascular and cerebral diseases controlling function.

Description

A kind of vein relaxing antihypelipidemic product and preparation method based on reestablishment entatic state theory

Technical field:

The invention belongs to the Chinese medicine technical field.Especially relate to a kind of vein relaxing antihypelipidemic product and preparation method based on reestablishment entatic state theory.

Background technology:

The traditional Chinese medical science is called diabetes usually for " diabetes ", shows as mainly that thirsty, polydipsia, polyphagia can be eaten, features such as frequent micturition matter is sweet, the thin many diseases of body.Its pathogeny is summarised as " deficiency of YIN is scorching " more, and treatment is rule of treatment often from lung, spleen, kidney three dirty setting about with " blood circulation promoting and blood stasis dispelling, nourshing Yin and drynsessmoistening prescription ".But up to the present, TCM treatment of diabetes is no doubt abide by the law more, does not still have important breakthrough.According to I to Chinese medicine for many years institute must reach holographic network of human body and the drug molecule regulating networks viewpoint that I proposed in (seeing " Chinese medicine Leader, Hunan " 99-3 phase 10-11 page or leaf paper) paper in 99 years, with the body official key of Chinese medicine, internal organs are theoretical combines with the Chinese medicine genomics, recognize that the Chinese medicine drug molecule can be effectively carries out adjusting on the cellular level to the human body network; Have the combination gene material in the botanical herbs, it can repair and reproduce body damaged cells, organ.And the theory that reestablishment entatic state is only treatment and improves diabetics crowd basic outlet proposed in view of the above.

A large amount of pharmacological evaluation prove: Chinese medicine equilibrium between yin and yang, internal organs coordinate, classical theory and the modernized drug molecule network adjustment theory used of inside and outside, Xiang Jiwei up and down, and the dawn that has disclosed thorough healing diabetes in the offering.We have reason and evidence shows that we have found and continue combination gene material new, that exist already in the medicine upon the look; It can make the gene expression aspect biological organs cell regeneration between body biomolecule and realization of Chinese medicine drug molecule and the molecular network adjusting.The effective combination gene material of this Chinese medicine of treatment diabetes, the effect of its existing significant hypoglycemic activity, blood lipid regulation, blood pressure, metabolic function that again can overall regulation of body, and be to have realized the adjusting carbohydrate metabolism carried out from the cellular level; Make it to impel organismic internal environment that the variation of matter has taken place, the islet tissue that helps pathological changes recovers normal physiological function, and islet function is restarted; Promote and regulate the normal secretion of insulin, improve the sensitivity of receptor to insulin, the activity of enzyme is fundamentally regulated sugar, fat, proteinic metabolism behind the recovery receptor.Again activate the respond of adipose cell, accelerate the metabolic processes of glucose greatly insulin.Rather than the blood sugar reducing function as the Western medicine, only just stimulate or the excretory deficiency of supplementation with insulin.

It should be noted that, existing test shows, drug molecule is in the process of network adjustment, a more stem-winding phenomenon is to repair impaired islets of langerhans, pancreatic tissue cell to some extent, quicken infiltration and the attack of drug molecule in specific target organ target position, so that impaired gene repaired or regenerate, thereby regulate and recover islet function.

Simultaneously, it can resist radical damage, and enhancing body is removed the ability of oxygen-derived free radicals, thereby alleviates or stop the damage of radical pair beta Cell of islet, promotes the reparation and the regeneration of beta Cell of islet.Blood lipid regulation is unusual significantly for it, slow down atherosclerotic process, thereby significantly improve the disorders of lipid metabolism due to insulin relative deficiency and the lipid peroxidation, to significantly reduce surge because of the popular cardiovascular disease that causes of global diabetes, and reduce and reduce death and the disabled probability that diabetes and complication (as cardiovascular and cerebrovascular disease, obesity etc.) are caused, recover and improve diabetes patient's health level.

Summary of the invention:

The present invention proposes the theory of rebuilding people's homeostasis, and further invented a kind of vein relaxing antihypelipidemic product and preparation method on this basis based on reestablishment entatic state theory.

What is meant by rebuilding the human body entatic state theory? rebuilding people's homeostasis is the important goal of whole biological study.It is based on a kind of breakthrough discovery on the comprehensive study basis of human genome, polysaccharide group, proteomics, metabolism group, first genomics research.Be meant that promptly we should at first establish a kind of like this theory: the traditional Chinese medical science focuses on treating both the principal and secondary aspects of a disease to the treatment of human diseases, and the purpose for the treatment of both the principal and secondary aspects of a disease is to rebuild people's homeostasis.Discover: human body is the product that nature is evolved, and is the ingredient of nature.Balance is not only the rule of nature, also is the rule of health.Therefore, human optimal health care pattern should be to keep keeping normal self-repairing capability on the equilibrated basis of human body integral.This is that one in the Chinese medicine development process innovated greatly, also is the exclusive feature of vein relaxing antihypelipidemic product.This is because we have at first established a brand-new viewpoint in the process of research: the imbalance of any function of human body, and all relevant with the variation of gene expression; And the change of same gene expression can cause different functional impairments and variation again.Functional disorder is not monistic and critical, but a kind of individuality----integral body----individual or whole----individuality-----whole change procedure.Existing research is verified, and human diseases or sub-health state are all directly or indirectly relevant with gene; And genomics has been formed a complete whole biological systems with polysaccharide group, proteomics, metabolism group, first genomics.Gene regulation has proved theoretical importance, the science of traditional Chinese medical science negative and positive adjusting.Being of vein relaxing antihypelipidemic product: reestablishment entatic state a big innovation.Promptly be that the biotechnology of theory of Chinese medical science and modern science forefront is organically combined, and apply in the research and development of new Chinese medicine and functional food and go.Reestablishment entatic state also is that the classical theory that on the basis that negative and positive are regulated negative and positive is regulated has been opened new page in the process that modernization strides forward.It illustrates that also the expression of mutant gene or the product function of gene can be modified, be regulated to the relevant composition of vein relaxing antihypelipidemic product, thereby obtains not only to have no side effect but also the health-care effect of no sequel.Here it is rebuilds people's homeostasis and is only the health care, alleviates the particularly final purpose place of the only way of delay property chronic disease such as diabetes, hypertension, high fat of blood etc. of human body sub-health status.

The basic ideas of treatment diabetes are that novelty of the present invention has formed active ingredient of Chinese herbs and diabetics played the important function of regulating the human body stable state, clear and definite adjusting, to rebuild the human body stable state be the principle that Chinese medicine is cured the basic outlet of diabetes, and then formed the plant gene composition that exists already in the Chinese medicine can be effectively to the human insulin secretion, and the viewpoint of the comprehensive targeting symmetry treatment that assimilation and the alienation of sugar imposed general equilibrium.

This be because, I progressively recognize in scientific research for many years, the treatment of human diseases and rehabilitation course come down to that Chinese medicine genome compound is repaired the formed focus of the damaged gene of human body or the process of Organ Reconstruction.That is to say, the combination gene material that exists already in the Chinese medicine participated in the overall process human organ and even whole machine body health, damaged, repair, reproduce, healthy process.Body biomolecule and Chinese medicine drug molecule can be effectively carry out adjusting on the cellular level to the human body network, realize with the molecular network adjusting between gene expression aspect biological organs cell regeneration.Assortment of genes material in this Chinese medicine, I temporarily am called Chinese medicine gene group or human organ translation factor.It can rebuild people's homeostasis comprehensively, and human body environment top layer, middle level, deep layer stable state are rebuild.With regard to diabetics, it can make glycoprotein, lipid metabolism balance; Hormonal system and neural, immune system co-ordination; Insulin β cell function must send out performance normal, and gene is able to normal expression, and stable state reaches health value, and blood glucose, glucose in urine are replied normal, and related complication disappears gradually and even all.This meets the traditional Chinese medical science fully mainly is the theory of animal economy functional disorder about the generation of disease.What differentiation of tcm was emphasized is the harmony of animal economy function because the treatment by Chinese herbs disease is not to emphasize that medicine directly removes to resist single virulence factor, it focus on regulating the body function state, the performance body resistance against diseases.In this process, relate to molecule---a plurality of aspects, number of ways that cell---organ---is whole realizing from hereditary information to whole steady state function.For example, often from lung, spleen, kidney three dirty setting about, this is the summary that Chinese medicine enriched clinical experience in several thousand to TCM treatment of diabetes.The act spleen is an example, spleen transfer function if not normal, then will cause the defeated cloth of water paddy body fluid and utilize unbalance and metabolism disorder in the process, this is the basic of morbidity.The traditional Chinese medical science thinks that disease is this earlier, and the back is sick to be mark.With regard to diabetes, transferring the defeated cloth of water paddy body fluid that functional imbalance causes and utilizing unbalance, metabolism disorder in the process of spleen must cause hyperglycemia, glucosuria, and this be; The various complication of association thus again, as hyperlipemia etc., this is mark.Therefore, sugar peace specimen of last epoch of treatment furthermore.Studies have shown that in a large number of modern medicine and modern Chinese medicine pharmacy, insulin resistant (insulin can not combine well with receptor) is one of topmost paathogenic factor of diabetes; Diabetes with Hypertension and atherosclerosis have a common basis, and promptly insulin resistant and hyperinsulinemia may be the main approach of curing type ii diabetes so reduce insulin resistant.Epoch sugar is positioned on this and has also embodied its advantage on the one hand.

In addition, the also other tool clever thought of this researcher ground in prescription compatibility ANHUA HEI CHA and active component Eurotium cristatum (being commonly called as " JINHUA ") thereof, it can make blood glucose be controlled better.This is because no matter ANHUA HEI CHA and active component Eurotium cristatum thereof be and other drug matching, also or single use, existing correlation test shows that ANHUA HEI CHA and active component Eurotium cristatum thereof can make the defeated cloth of general metabolite promote the biopotency of insulin by increasing blood flow; By reducing whole blood viscosity, HP can make matter transportation sugar and insulin get over the raising of film (as muscle, adipose cell etc.) ability, and carbohydrate metabolism improves obviously, the lipid metabolism increased activity, and lipid is drained and is quickened, and blood fat effectively reduces.It is as my discovery when studying TPS, and this will be to seek the breakthrough that the efficacious prescriptions medicine is arranged.

Also must indicate out, we should pay attention to the trace element effect of Chinese medicine.Modern pharmacological research discloses, and the pathogeny of diabetes is the minimizing of insulin beta cell excreting insulin.And the beta cell surface is the film that is made of a large amount of multiple proteins, to protect and to keep the 26S Proteasome Structure and Function of cell.Body is when some trace element of famine, and as copper, chromium, zinc, potassium, particularly when lacking copper, the special albumen of a kind of GLUT-2 by name can synthesize deficiency, and it must have influence on secretion of insulin, promotes the generation of diabetes.This is because secretion of insulin is subjected to the adjusting of nervus centralis, and copper is the conduction mediator of nervus centralis, can affect the nerves and transmits and reduce secretion of insulin and cause or increase the weight of diabetes so lack copper.The epoch Chinese prescription of sugar peace contains trace element and vitamin Cs such as copper, chromium, zinc, vitamin B, can significantly improve insulin resistant, increase the sensitivity of Insulin receptor INSR, increase the utilization of glucose, and can improve the microcirculation of insulin, alleviate insulin β cellular edema, be beneficial to the recovery of islet function, thereby make blood glucose, glucose in urine obtain permanently effective control, and progressively return to normal.

Therefore, blood sugar lowering mechanism of the present invention and adjusting, reconstruction people homeostasis, regulate immunologic function, improve insulin and its receptors bind, and strengthen β emiocytosis insulin, the activity of enzyme behind the recovery receptor, fundamentally regulate sugar, fat, proteinic metabolism, the aspects such as ability of enhancing body removing oxygen-derived free radicals demonstrate its advantage, and this may be for Chinese medicine passes through the human body stable state, and the immunity of raising body is treated diabetes and opened up a new approach.

Simultaneously, the inventor thinks that also three-hypers disease etc. have special sign to change at its physiological structure.Rebuild people's homeostasis, just must recognize, the essence of human body, gas, god are commander's hats.Especially the elevating movement of sub-health population mechanism of qi be human body carry out metabolism, earn a bare living active basic, the not normal generation that then causes disease of ascending or descending movement of vital Qi." element asks six little purports big opinion " said: " it is strong always that non-discrepancy then is difficult growth, and non-lifting then is difficult the growthization collection "; " the useless then refreshing machineization of coming in and going out is gone out, and lifting ceases the then upright lonely danger of gas "; " ascending, descending, exiting and entering, no device does not have ".Zhou Xuehai " reading to cure random notes " says: " lifting person, the road that lining gas and lining gas circle round also, the road that gas and exogenous QI intersect in the discrepancy person is also." in human body, with regard to the meridians of the internal organs of phase the exterior and the interior, dirty liter then internal organs falls, hand channel rises then foot channel and falls.With regard to the five internal organs, between the five internal organs be cardiopulmonary last, should fall; The Liver and kidney infra should rise; Taste are arranged in Jiao, about leading to, and one rise and one drop, it is the hinge of ascending or descending movement of vital Qi motion.And each internal organs itself comprises two aspects of lifting, and lung master element falls and so has a surname's one side again; Heart governing blood and vessels rises and supports gods in face, has the one side that rises; But heart-yang must descend again and hand over kidney in water.The kidney master hides main again improving inspiration by invigorating kidney-QI, and right kidney yin must rise with Ji heart-yang or the like again.With regard to the cause of disease, Li Dongyuan " Treatise on the spleen and stomach " medium cloud: " dropping and can not rise for a long time, is the autumn and winter are arranged and not have spring and summer, be growth with the gas that sinks into to die and kill, and all kinds of diseases and ailments all rise, or liter does not fall for a long time, also disease here." this be because, vital organs of the human body mechanism of qi is unobstructed to be the basic assurance of body health, in case that the QI and blood operation will take place in mechanism of qi retardance is out-of-sequence, the pathological change of body fluid spreading obstacle and non-hibernating eggs kind illness.With regard to medical diagnosis on disease, rise not as good as how empty, that falls is too late how real, and it is too then real partially to rise, and void partially descends too then.Sick on a left side, its right side does not rise, and sick its left side does not fall on the right side, and is sick last, must descend obstructedly, and sick infra person must not go up and declare.The obstructed pathological changes that is associated of all the five internal organs, harmonizing the functional activities of vital QI all are most important treatment measures.So with regard to medication, the property of medicine of all medicines should be classified as " lifting " two words, " all property of medicine, non-liter promptly falls, maybe can rise and can fall, or rise fall more few, rise not invariably not fall be not property persons such as Xuan Tong ", visible lifting two words are group medicine generally.

This shows that sub-health population and three-hypers disease person are ill, to blame mechanism of qi obstructed as head, and uncomfortable then ought the increasing of mechanism of qi fallen, and lifting is orderly, can fail cloth, removing blood stasis, nourishing.Therefore, when the problems referred to above occurring, important problem at first is to rebuild people's homeostasis and can deals with problems.

Simultaneously, network one thing, essential.The theory of Chinese medical science cloud: though diabetes has the branch of upper, middle and lower three types of diabetes, the dryness of the lung, gastric heat, suffer from a deficiency of the kidney not, can both cause the cloudy damage of gas.So Ye Tianshi points out in " Linzheng Zhinan Yi three types of diabetes ", " three types of diabetes one card though the branch of upper, middle and lower is arranged, is not got over yin deficiency yang hyperactivity in fact, and Tianjin is dried up hot excessive ".The dryness of the lung, gastric heat, suffer from a deficiency of the kidney, just then cause deficiency of kidney-YIN, then can cause deficiency of both YIN and YANG for a long time.Kidney is the mother of liver, deficiency of kidney-YIN, and liver is lost and nourishes, and then becomes the deficient card of Liver and kidney.The kidney generating marrow and dominating bone, liver governing tendons is a source of endurance, and Liver and kidney is deficient, and muscles and bones mistake is supported, and so visible wasting and atrophy of muscle, flaccidity is soft unable.The diabetes interior-heat caused by deficiency of YIN, the bright liquid in consumption Tianjin can cause blood stasis.In addition, deficiency of YIN affecting YANG, deficiency of both YIN and YANG, insufficiency of YANG bringing about cold syndrome coagulates, and also can cause blood stasis.So Tang Rongchuan says in " treatise on blood trouble is sent out yearningly " piece of writing: " blood stasis sends out the person thirsty, and with the life of body fluid, its root is for kidney water ... blood stasis, then gas is the blood resistance, must not rise, water Tianjin is because of can not be with cloth on the gas ", be with yearningly.In addition, the traditional Chinese medical science is also thought, " pathogen usually intruding into collateral in protracted disease ", " blood is gone in prolonged illness ", " the kidney usually involved in chronic disease " are the change of disease rules of traditional disease, quench one's thirst with the passing of time, must consume impairment of QI the moon, obstruction of collaterals by blood stasis.So the present invention is a prerequisite with the reestablishment entatic state, with supplementing QI and nourishing YIN, liver and kidney tonifying, the disperse blood stasis and dredge collateral treating both the principal and secondary aspects of a disease is its innovation part, fundamental difference is a fresh and alive illustration in the Therapeutic Method of diabetes routine in fact.

Therefore, a kind of vein relaxing antihypelipidemic product and preparation method based on reestablishment entatic state theory of the present invention have provided the method and the excess syndrome example of solution treating diabetes and health care with brand-new theory and visual angle, and significant effect have been arranged.Simultaneously, it not only has significant glucose-lowering treatment effect and has blood fat reducing, blood pressure lowering simultaneously concurrently, control cardiovascular and cerebrovascular disease integrated function.

In view of the above, a kind of vein relaxing antihypelipidemic product and preparation method based on reestablishment entatic state theory of the present invention also proposed and the corresponding to prescription of the present invention, preparation method and embodiment when having set forth above-mentioned theory complete.

The specific embodiment:

A kind of vein relaxing antihypelipidemic product and preparation method based on reestablishment entatic state theory is characterized in that being made up of following material component and weight proportion: 5～45 parts of Radix Salviae Miltiorrhizaes, 5～45 parts of Radix Puerariaes, 5～30 parts of Radix Trichosanthis, 5～30 parts of Herba Dendrobiis, 5～60 parts of Radix Rehmanniae, 5～30 parts of Radix Ophiopogonis, 5～30 parts of Radix Asparagis, 5～25 parts of Semen Ginkgoes, 5～25 parts of LIANZIXU, 5～30 parts of Radix Ginsengs, 5～30 parts of Fructus Schisandrae Chinensis, 5～30 parts of Ootheca Mantidiss, 5～30 parts of Semen Cuscutae, 5～30 parts of Fructus Psoraleaes, 5～30 parts of Fructus Corni, 5～30 parts of Radix Panacis Quinquefoliis, 5～30 parts of the Radixs Polygoni Multiflori, 5～80 parts of the Radixs Astragali, 5～25 parts of Rhizoma Dioscoreaes, 5～25 parts of Fructus Ligustri Lucidi, 5～25 parts of Fructus Rosae Laevigatae, 3～20 parts of Semen Litchis, 1～10 part of Radix Glycyrrhizae Preparata.

Radix Panacis Quinquefolii, Radix Asparagi and Radix Ophiopogonis, Herba Dendrobii, Radix Rehmanniae, Rhizoma Dioscoreae, Fructus Ligustri Lucidi enriching yin and nourishing kidney in the side; Radix Puerariae, Radix Trichosanthis, Herba Dendrobii, Radix Rehmanniae promote the production of body fluid and moisturize; Semen Ginkgo, Ootheca Mantidis, Fructus Schisandrae Chinensis, LIANZIXU, Fructus Rosae Laevigatae convergence vital essence; Semen Cuscutae, Fructus Psoraleae, the Radix Astragali, Radix Ginseng warming YANG and invigorating QI.The Radix Salviae Miltiorrhizae hardship, be slightly cold.GUIXIN, Liver Channel.The effect that has stasis-dispelling and pain-killing, invigorates blood circulation and clear away heart-fire.Sweet, the little hardship of Semen Litchi, temperature.Return liver, kidney channel.Promoting QI to circulate and dispersing the agglomeration of the pathogens, cold relieving pain relieving.Comprehensive above-mentioned each property of medicine energy, we be its characteristics with the product of the fire of warming and recuperating the gate of life, astringent or styptic treatment for spontaneous sweating kidney essense again outside yin nourishing clearing away dryness, supplementing QI for promoting the production of body fluid, nourishing kidney, applied to xerostomia have a liking for drink, down have excessive turbid as fat, the glycosuria patient of obstinate disease, curative effect is infallible.

Optimization formula of the present invention is: it can form prescription of the present invention by at least 3 flavor as many as 10 flavors or 22 extremely whole flavors.

A kind of vein relaxing antihypelipidemic product and preparation method based on reestablishment entatic state theory, its feature also have been also to comprise in the product the exclusive ANHUA HEI CHA of China and the active component Eurotium cristatum (being commonly called as JINHUA) of ANHUA HEI CHA.

Simultaneously, when making various product forms, in above-mentioned Chinese herbal medicine, can also add one or more pharmaceutically acceptable carriers.Described carrier comprises diluent, excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, absorption carrier, lubricant of pharmaceutical field routine etc.; Can also add flavouring agent, sweeting agent etc. in case of necessity.

Health food of the present invention can be made the product of various ways such as capsule, tablet, granule, medicinal tea, powder, powder, oral liquid, drop pill, foot bath water preparation, patch, spray.The new drug of above-mentioned various dosage forms or health food all can be according to the conventional method preparations of pharmaceutical field.

Another prominent features of a kind of vein relaxing antihypelipidemic product based on reestablishment entatic state theory of the present invention be its main effective ingredient be in various trace elements such as polysaccharide, total glycosides, protein, flavonoid and copper, ferrum, zinc, potassium and necessary 24 seed amino acids of human body more than at least 6 kinds to 24 kinds.

Preparation method and embodiment: above-mentioned described formula material is optimized Radix Rehmanniae, Radix Asparagi, Radix Ginseng 3 flavors at first, and 6～10 flavors that perhaps optimize based on Radix Rehmanniae, Radix Asparagi, Radix Ginseng are optimization formula of the present invention.Get wherein at least 3 kinds then to 6～10 flavor or whole raw material extracting in waters.Extract and divide secondary to carry out, add 10～12 times of amounts of water for the first time, extraction time is 2 hours; For the second time add 6～8 times of amounts of water, extraction time is 1 hour.Two liquid merge, and leave standstill 12～24 hours, get supernatant, are evaporated to the thick paste of relative density 1.25～1.40 (50 ℃), and dry back is standby.

The tender flavor agent and 3～15 weight portion adjuvants that add 1～5 part of weight portion in the dried powder with extract, described adjuvant are microcrystalline Cellulose or dextrin, beta-schardinger dextrin-, HP-β-CD, DM-β-CD, α-CD, starch etc.

With above-mentioned Chinese herbal medicine powder mince, after extract and the auxiliary materials and mixing, the preparation soft material is granulated, drying is filled into the capsule that content is 0.25～0.5g, is finished product of the present invention.Packing, sterilizing, warehouse-in.

Through clinical confirmation, a kind of vein relaxing antihypelipidemic product based on reestablishment entatic state theory of the present invention has significant blood sugar decreasing effect.It not only has significant glucose-lowering treatment effect and has blood fat reducing, blood pressure lowering simultaneously concurrently, control cardiovascular and cerebrovascular disease integrated function.

Above embodiment, to every those skilled in the art or the personnel relevant with this area may cause with association, expansion, mode such as contrast change, extend, situation in the analogy protection domain of the present invention all can be considered and occupies of the present invention.The above embodiments are only just given an example or proof to of the present invention.It can carry out the association or the expansion of wide in range property on this basis, and it also can carry out unconfined according to duplicating and recreating based on this.A kind of vein relaxing antihypelipidemic product and preparation method based on reestablishment entatic state theory of the present invention advocates or makes to have protection equally to the principle, method, the technology that do not surmount category of the present invention, that is to say that it all belongs to protection scope of the present invention.

Claims (7)

1, a kind of vein relaxing antihypelipidemic product and preparation method based on reestablishment entatic state theory, it is characterized in that providing a kind of and can really embody the Chinese medicine synthesis treatment, mechanism is clear, target spot is clear and definite, effect obviously, a kind of vein relaxing antihypelipidemic product and the preparation method that have no side effect substantially based on reestablishment entatic state theory.

2, a kind of vein relaxing antihypelipidemic product and preparation method based on reestablishment entatic state theory according to claim 1 is characterized in that its prescription is made up of the extract of Radix Salviae Miltiorrhizae, Radix Puerariae, Radix Trichosanthis, Herba Dendrobii, Radix Rehmanniae, Radix Ophiopogonis, Radix Asparagi, Semen Ginkgo, LIANZIXU, Radix Ginseng, Fructus Schisandrae Chinensis, Ootheca Mantidis, Semen Cuscutae, Fructus Psoraleae, Fructus Corni, Radix Panacis Quinquefolii, the Radix Polygoni Multiflori, the Radix Astragali, Rhizoma Dioscoreae, Fructus Ligustri Lucidi, Fructus Rosae Laevigatae, Semen Litchi, Radix Glycyrrhizae Preparata etc.These plants contain the biotin material and are meant its active component, and it can be polysaccharide, flavone, still contain the Saponin class simultaneously.

3, a kind of vein relaxing antihypelipidemic product and preparation method according to claim 1 based on reestablishment entatic state theory, it is characterized in that the active component in the product of the present invention, hyperglycemia population has been played the important function of regulating or rebuilding the human body stable state, clear and definite adjusting, rebuilding the human body stable state is the principle that Chinese medicine is cured the basic outlet of diabetics crowd, and then formed the plant gene composition that exists already in the Chinese medicine can be effectively to the secretion and the drainage of harmful substance in the hyperglycemia population human body, and the viewpoint of the comprehensive targeting symmetry treatment that assimilation and the alienation of sugar imposed general equilibrium.It not only has significant glucose-lowering treatment effect and has blood fat reducing, blood pressure lowering simultaneously concurrently, control cardiovascular and cerebrovascular disease integrated function.

4, a kind of vein relaxing antihypelipidemic product and preparation method based on reestablishment entatic state theory according to claim 1 is characterized in that prescription of the present invention most preferably Radix Rehmanniae, Radix Asparagi, Radix Ginseng 3 flavors.Also comprised and contained Radix Rehmanniae, Radix Asparagi, Radix Ginseng 3 flavors to other 6～10 optimization formula combination of distinguishing the flavor of.

5, a kind of vein relaxing antihypelipidemic product and preparation method according to claim 1 based on reestablishment entatic state theory, it is characterized in that preparation method of the present invention is that above-mentioned described formula material is optimized Radix Rehmanniae, Radix Asparagi, Radix Ginseng 3 flavors at first, 6～10 flavors that perhaps optimize based on Radix Rehmanniae, Radix Asparagi, Radix Ginseng are optimization formula of the present invention.Get wherein at least 3 kinds then to 6～10 flavor or whole raw material extracting in waters.Extract and divide secondary to carry out, add 10～12 times of amounts of water for the first time, extraction time is 2 hours; For the second time add 6～8 times of amounts of water, extraction time is 1 hour.Two liquid merge, and leave standstill 12～24 hours, get supernatant, are evaporated to the thick paste of relative density 1.25～1.40 (50 ℃), and dry back is standby.

The tender flavor agent and 3～15 weight portion adjuvants that add 1～5 part of weight portion in the dried powder with extract, described adjuvant are microcrystalline Cellulose or dextrin, beta-schardinger dextrin-, HP-β-CD, DM-β-CD, α-CD, starch etc.

With above-mentioned Chinese herbal medicine powder mince, after extract and the auxiliary materials and mixing, the preparation soft material is granulated, drying is filled into the capsule that content is 0.25～0.5g, is finished product of the present invention.Packing, sterilizing, warehouse-in.

6, a kind of vein relaxing antihypelipidemic product and preparation method based on reestablishment entatic state theory according to claim 1, its feature also have been also to comprise in the product the exclusive ANHUA HEI CHA of China and the active component Eurotium cristatum (being commonly called as JINHUA) of ANHUA HEI CHA.

7, a kind of vein relaxing antihypelipidemic product and preparation method based on reestablishment entatic state theory according to claim 1 is characterized in that the present invention can make the product of various ways such as capsule, tablet, medicinal tea, granule, powder, powder, oral liquid, drop pill, foot bath water preparation, patch, spray.