CN103239562B - Traditional Kazak medicament composition for treating diabetes mellitus and preparation method of traditional Kazak medicament composition - Google Patents
Traditional Kazak medicament composition for treating diabetes mellitus and preparation method of traditional Kazak medicament composition Download PDFInfo
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Abstract
The invention discloses a traditional Kazak medicament composition for treating diabetes mellitus and a preparation method of the traditional Kazak medicament composition. According to the traditional Kazak medicament composition, six yuan theory, namely alta turor theory, gas, function and energy theory, namely huwati theory, body fluid theory, namely suhler theory, viscera theory, namely muxielieer theory and the like of introduction of Kazak nationality medicine of theoretical basis of traditional medicine are combined, and the traditional Kazak medicament composition has the main action of preventing and treating the diabetes mellitus. Balsam pear seed, ribes, mayberry, raspberry, elecampane, the fruit of Chinese wolfberry, helichrysum arenarium and plains coreopsis in the traditional common plants of Kazak medicine are selected as raw materials and subjected to water extraction and ethanol extraction to be uniformly mixed to prepare an oral preparation. The dosage forms comprise all of oral preparations, such as decoction, pills, powder, granules and the like suitable for clinically preventing and curing the diabetes mellitus. The traditional Kazak medicament composition especially has a good curative effect for oral adjuvant treatment of the diabetes mellitus and the like. The traditional Kazak medicament composition is reasonable in formula, convenient to prepare, definite in curative effect, quick in effectiveness, free of toxic and side effects of irritation and the like.
Description
Technical field
The present invention relates to a kind of Kazak conventional medicament compositions and its preparation method for the treatment of diabetes.
Background technology
Kazak nationality traditional medicine theory has long history, Kazak nationality my late grandfather and traditional medicine worker and among the peoplely study various diseases pathogenesis and diagnosis and treatment method based on the hexa-atomic theory of theoretical basis i.e. " A Lete dash forward Gu Er " of Kazak's traditional medicine widely in the history development procedure that it is very long.Kazak's physician Wu Taiboyida cut arrange my haab strangle (1388 ~?) in Christian era the 15th century show " Kazak's medical science outline " book and namely from gas, function, energy recklessly i.e. watt theory, internal organs i.e. " wooden Xie Lieer " academic theory, pathological analysis and medical scheme, medicine diagnosis and treatment design carried out to various diseases.
The conventional medicinal plants Semen Momordicae Charantiae of Kazak nationality medicine tradition, tea bit of a bridle, Fructus Rubi corchorifolii Immaturus, Fructus Rubi, Radix Inulae, Fructus Lycii, Helichrysum arenarium (Linn.) Moench., Herba Coreopsis tinctoria rely on internal organs theory i.e. " wooden Xie Lieer " to treat dyscrasia, among the people mainly through for oral administration after extraction process, its Main Function is treatment diabetes.
Theoretical according to Kazak traditional medicine, diabetes have part etiology and pathology process to lack of proper care relevant to organ function, and its sign is different.
Diabetes (Diabetes mellitus, DM) are a kind of metabolic disease groups increasing the multi-pathogenesis for feature with blood glucose, and it is classified as worldwide three disaster diseases by World Health Organization (WHO) together with tumor, cardiovascular and cerebrovascular disease.Within 2006, national disease prevention and control center publish data shows, China's more than 20 years old diabetics reaches 2,380 ten thousand people, has become the country that onset diabetes number is maximum.In predicting 10 years from now on, under the direct impact of the large disease of cardiovascular disease, apoplexy and diabetes three, the national economy of loss 5,580 hundred million dollars is taken in by China.Active prevention is extremely urgent with treatment diabetes.Diabetes are not only related to own health problem, more have to be related to how to improve our quality of life problem.
Diabetes are divided into two types clinically: type i diabetes, i.e. insulin-dependent, account for patient's 10%, and treatment relies on the exogenous insulin that gives and maintains.Another large class is type ii diabetes, i.e. insulin-independent, accounts for patients's 90%.
There are some researches show, in the metabolic disease group increasing the multi-pathogenesis for feature with blood glucose, there is microcirculation disturbance, cold arthromyodynia, carbuncle be stagnant in diabetes spp, and main manifestations is bodily tissue and acral pruritus, dizzy etc.After medicine treatment of suiting the medicine to the illness, slowing down with inflammation, blood microcirculation also has improvement in various degree.Can not only the misery of diabetes-alleviating patient, simultaneously in blood sugar lowering process, also may can have and reduce blood fat, blood pressure, improve the effect such as hemodynamics, microcirculation, effectively prevent diabetes and the generation of complication, improve the life quality of patient.
Use the medicine of national minorities, comprise Chinese medicine and pharmacy traditional theory, carry out organ function imbalance, the research of antibody mediated disease has long history, but due to the restriction of historical conditions, motherland's medical science does not carry out carefully clearly distinguishing to organ function disorders, fails the complete theoretical system of formation system.Along with the systemtheoretical introducing of doctor trained in Western medicine, and according to the principle of differentiation of tcm, just really progressively launch with Chinese medicine, the research that prevents and treats diabetes, start all kinds of organ function sexual maladjustment of systematic research disease, define the control organ function disease scientific research of the exclusive feature that is combined into Chinese and western medicine national medicine of China.
Application for Chinese herbal medicine in various organ function sexual maladjustment and antibody mediated diseases prevention and treatment is increasingly extensive; For many years, the drug research of China to control organ function sexual maladjustment disease has carried out a large amount of work, think and wherein may there is the various Chinese herbal medicine for improving organ function imbalance, the phylogenetic system of distribution is extensive, region, ecology are also varied, thus it is contemplated that, they also have various multi-form for the mechanism of action of control organ function disease, and this provides wide prospect just to research herbal control organ function dysfunctional disease medicine.
Research application Chinese medicine national medicine therapeutical effect compares to be paid attention to finding, with the research of development disease-resistant gene problem, to emphasize the relation of global configuration and gene expression.Comprising: balance organic conception and systems biology; The correspondence between man and universe and environmental genomics; Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs and pharmacogenomics; Treating the same disease with different methods, treating different diseases with the same therapeutic principle and pharmacogenetic; Etiology and tumor susceptibility gene; Strengthening vital QI to eliminate pathogenic factors and genomics are treated; The dependency of syndrome and genomics, protrinology.Strengthen taking gene expression as index simultaneously, with gene regulation change and functionalized modification for research direction, carry out the research of the multi-component too many levels of Chinese medicine compound, Mutiple Targets Accommodation, find the related gene that disease combines, set up " syndrome-gene expression profile ", be conducive to the essence of the 26S Proteasome Structure and Function disclosing TCM Syndrome.
The reason of organ function disorders and pathology are very complicated, and treatment should consider more problem.Since organ function imbalance multifactorly causes, so prevent and treat internal organs imbalance curative effect index and just can not only be confined to index in a certain respect, should widening roadbed, seek many-sided medicine.
Therefore, a kind of new treatment and the Chinese herb medicine prevented diabetes and production method thereof are just suggested.
Summary of the invention
The object of this invention is to provide a kind of Kazak conventional medicament compositions and its preparation method for the treatment of diabetes.
The object of the invention is to be achieved through the following technical solutions:
Chinese medicine of the present invention adopts following waste:
Water extraction: get Chinese crude drug
With the conventional medicinal herbs Semen Momordicae Charantiae of Kazak traditional national medicine, tea bit of a bridle, Fructus Rubi corchorifolii Immaturus, Fructus Rubi, Radix Inulae, Fructus Lycii, Helichrysum arenarium (Linn.) Moench., the multiple food such as Herba Coreopsis tinctoria, one or more of medicine dual-use materials, each 1 ~ 15 weight portion, be preferably each 5 ~ 10 weight portions, carry out water extraction 1 ~ 4 time: add water after above-mentioned material fragmentation by 3 ~ 20 of medical material weight times, heat to 90 ~ 105 DEG C, slow fire heating makes that maintenance is micro-boils, each water extraction 5 ~ 60 minutes, cross below 2mm sieve and get permeate, be preferably 150 ~ 500 μm of sieves, leave standstill and get supernatant in more than 5 hours, after being left standstill by water extraction gained permeate, gained supernatant concentration is dried to water content≤50%, obtain extracting solution, namely pharmaceutical composition of the present invention is obtained.
Amount of water after above-mentioned water extraction the 2nd time is that 2 ~ 10 times of Chinese crude drug weight are advisable.
Preferably first alcohol extraction is carried out: the ethanol being 80 ~ 95% by 3 ~ 10 times amount concentration of Chinese crude drug weight extracts 1 ~ 4 time at 60 ~ 90 DEG C of temperature before above-mentioned Chinese crude drug water extraction, each 15 ~ 45 minutes, obtain ethanol extract, cross below 2mm sieve and get permeate, be concentrated into the extract of dry matter content >=50%, and mix extract obtained to described extract and water extraction.
Medicine of the present invention effectively combine great Kazak's ancient medicine Wu Taiboyida cut arrange my haab strangle show the academic theory guidance that " wonderful work Ge Erlike Bayan " i.e. " Kazak's medical science outline " institute hexa-atomic theory of proposing is " A Lete dash forward Gu Er ", Wu Taiboyida cut arranges my haab and strangles and think the internal organs energy complete independently responsibility that has of first native endowments and function separately, and have morphosis unique separately, being got in touch with by mutual linking, is the human body component part continuing the day after tomorrow of life, and survive, health preserving creates conditions.This is that Kazak nationality doctor Sheng Wutaiboyida cut arranges my haab and strangles while the experience summing up forefathers and academic thought, oneself constantly observe in long-term medical practice widely, study, put into practice after the viewpoint that sums up and the concept to internal organs.The gas that the body maintaining body normal function has and playing the day after tomorrow and the exclusive gas of the internal organs facilitated.So, diabetes spp will play the exclusive gas of the internal organs facilitated the day after tomorrow, also be internal organs in " wooden Xie Lieer " meaning and internal organs theory and organ and " Su Leji " meaning and body fluid, " Hu Wati " anticipate various " A Lemasi wood " in i.e. gas, function etc., body anticipate namely transform, samsara, intercoordination between circulation, and human body shows the relation connected each other between 12 organs and built-in 12 internal organs outward.By actively excavating general character and the individual character of this prescription medicine, to improve the specific aim of this prescription to diabetes control, in conjunction with organic conception and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs the specializing in clinical treatment of traditional Chinese medical science national medicine, reach composition synergism and play the highest curative effect of medicine, strengthen human body body, tissue, organ self-repairing capability, patient person is recovered gradually, for above-mentioned organ function dysfunctional disease control, there is good curative effect, there is efficient, low toxicity, without Drug resistance and advantage applied widely, particularly diabetes type II is treated and there is good therapeutic effect.
Simultaneously, Chinese medicine of the present invention can make the multiple dosage form series such as granule, powder, pill, capsule, tablet, overcome decocting for Chinese herbal medicine in the past and use inconvenience and the wasting deficiency of some rare medicinal herbs, Raw material processing in prescription is accepted or rejected, not only be easy to effect, and can greatly facilitate patient to use.
Detailed description of the invention
Embodiment 1: get Kazak tradition food medicine resource Semen Momordicae Charantiae, tea bit of a bridle, Fructus Rubi corchorifolii Immaturus, Fructus Rubi, Radix Inulae, Fructus Lycii, Helichrysum arenarium (Linn.) Moench., one or more each 10 weight portions of the multiple materials such as Herba Coreopsis tinctoria, wherein vegetable material is broken into the bar section of below 1cm, granule, add water by 10 times of Chinese crude drug weight, heat to 98 DEG C of water extractions 30 minutes, cross 500 μm of sieves and get permeate, 5 times of water gagings will be added again 98 DEG C of water extractions 20 minutes in medicinal residues, cross 500 μm of sieves and get permeate, above-mentioned water extraction gained permeate is heated under 0.07Mpa negative pressure to boiling concentrate drying to water content≤70%, obtain extract, namely pharmaceutical composition of the present invention is obtained.
Embodiment 2: get Kazak tradition food medicine resource Semen Momordicae Charantiae, tea bit of a bridle, Fructus Rubi corchorifolii Immaturus, Fructus Rubi, Radix Inulae, Fructus Lycii, Helichrysum arenarium (Linn.) Moench., one or more each 30 weight portions of the multiple materials such as Herba Coreopsis tinctoria, wherein vegetable material is broken into the bar section of below 1cm, granule, by 10 times of above-mentioned Chinese crude drug gross weight measure concentration be 70% ethanol extract 30 minutes at 60 DEG C of temperature, cross 250 μm of sieves, obtain permeate, again by 5 times of above-mentioned Chinese crude drug gross weight measure concentration be 70% ethanol extract 2 hours at 60 DEG C of temperature, cross 250 μm of sieves, twice gained permeate is mixed also concentrate drying and obtains alcohol extract to dry matter content >=85%, by Chinese crude drug weight 10 times of Chinese medicine slag after above-mentioned alcohol extraction are added water, heat to 98 DEG C, water extraction twice, each 30 minutes, cross 150 μm and get permeate, by water extraction gained permeate concentrate drying to water content≤55%, obtain water extract, mix homogeneously with above-mentioned alcohol extract, namely obtain pharmaceutical composition of the present invention.
Embodiment 3: get Kazak tradition food medicine resource Semen Momordicae Charantiae, tea bit of a bridle, Fructus Rubi corchorifolii Immaturus, Fructus Rubi, Radix Inulae, Fructus Lycii, Helichrysum arenarium (Linn.) Moench., one or more each 15 weight portions of the multiple materials such as Herba Coreopsis tinctoria, wherein vegetable material is broken into the bar section of below 1cm, granule, the ethanol being 90% by 8 times amount of Chinese crude drug weight and 5 times amount concentration respectively at 85 DEG C of temperature extracts 1 time, each 25 minutes, extracting solution crosses 250 μm of sieves, gained permeate concentrate drying is obtained extract to dry matter content >=90%, Chinese medicine slag after above-mentioned alcohol extraction to be added water at 98 DEG C each water extraction once by 8 times and 5 times of Chinese crude drug weight respectively, keep 20 minutes first times, second time 15 minutes, 150 μm of sieves are crossed after each water extraction, by water extraction gained permeate concentrate drying to water content≤10%, obtain water extract, mix homogeneously with upper alcohol extraction is extract obtained, namely pharmaceutical composition of the present invention is obtained.
Embodiment 4: one or more each 10 weight portions getting the multiple materials such as Kazak tradition food medicine resource Semen Momordicae Charantiae, tea bit of a bridle, Fructus Rubi corchorifolii Immaturus, Fructus Rubi, Radix Inulae, Fructus Lycii, Helichrysum arenarium (Linn.) Moench., Herba Coreopsis tinctoria, wherein vegetable material is broken into bar section, the granule of below 1cm, the ethanol being 80% by 10 times amount concentration of Chinese crude drug weight extracts 30 minutes at 90 DEG C of temperature, cross 500 μm of sieves, gained permeate is concentrated into dry matter content >=87% and obtains extract; By the Chinese medicine slag after above-mentioned alcohol extraction respectively by 10 times, 5 times, the 5 times water extractions at 98 DEG C that add water of Chinese crude drug weight, 30 minutes first times, second and three times each 20 minutes, cross 75 μm sieve permeate concentrate drying to water content≤13%, obtain extract; With above-mentioned water extraction with alcohol extraction is extract obtained mixs homogeneously, obtain pharmaceutical composition of the present invention.
Embodiment 5: get Kazak tradition food medicine resource Semen Momordicae Charantiae, tea bit of a bridle, Fructus Rubi corchorifolii Immaturus, Fructus Rubi, Radix Inulae, Fructus Lycii, Helichrysum arenarium (Linn.) Moench., one or more each 30 weight portions of the multiple materials such as Herba Coreopsis tinctoria, wherein vegetable material is broken into the bar section of below 1cm, granule, press 7 times amount of Chinese crude drug weight respectively, 4 times amount, 4 times measure concentration be 68% ethanol respectively at 90 DEG C of temperature to extract 1 time, the time of each time is respectively 30 minutes, 15 minutes, 15 minutes, cross 250 μm of sieves, gained permeate is concentrated into dry matter content >=92% and obtains extract, by the Chinese medicine slag after above-mentioned alcohol extraction by 8 times of the Chinese crude drug weight water extractions 3 minutes of adding water at 98 DEG C, cross 150 μm of sieves, by gained permeate concentrate drying to water content≤50%, obtain extract, above-mentioned water extraction and the extract obtained mix homogeneously of alcohol extraction, namely pharmaceutical composition of the present invention is obtained.
Embodiment 6: one or more each 45 weight portions getting the multiple materials such as Kazak tradition food medicine resource Semen Momordicae Charantiae, tea bit of a bridle, Fructus Rubi corchorifolii Immaturus, Fructus Rubi, Radix Inulae, Fructus Lycii, Helichrysum arenarium (Linn.) Moench., Herba Coreopsis tinctoria, wherein vegetable material is broken into bar section, the granule of below 1cm, to add water each at 95 DEG C extraction 1 time by 10 times amount of Chinese crude drug weight, 7 times amount and 5 times amount, the time of each time is respectively 30 minutes, 20 minutes, 15 minutes, cross 180 μm of sieves, gained permeate is concentrated into water content≤15%, obtain water extract, namely obtain pharmaceutical composition of the present invention.
Embodiment 7 ~ 16: embodiment 7 ~ 16 is that embodiment 1 ~ 6 gained pharmaceutical composition is added appropriate distilled water, through making granule.
Embodiment 17 ~ 26: embodiment 17 ~ 26 is that embodiment 1 ~ 6 gained pharmaceutical composition is added appropriate distilled water, through making granule, makes capsule after made granule is filled into capsulae vacuus.
Embodiment 27 ~ 36: embodiment 27 ~ 36 is that embodiment 1 ~ 6 gained pharmaceutical composition is added appropriate distilled water, soluble starch, through making granule, requiring compacting according to tablet producton order afterwards, making tablet.
Embodiment 37 ~ 46: embodiment 37 ~ 46 is that embodiment 1 ~ 6 gained pharmaceutical composition is added appropriate refined honey and water, makes pill.
Embodiment 47 ~ 56: embodiment 47 ~ 56 is that embodiment 1 ~ 6 gained pharmaceutical composition is added appropriate distilled water, soluble starch, through making the granule of dimension order number, makes powder.
It is below the diagnosed SARS case that patient uses medicine of the present invention.
1, Lay, man, 50 years old, Kazak.Medical history: first visit on March 14 in 2010.Be " diabetes " through hospital diagnosis, do not take a turn for the better through treatment, produce complication.This medicine is taken five months, frank improvement through treatment.
2, Ka, female, 45 years old, Kazak, in October, 2011 was diagnosed as " diabetes ".Take this medicine July through treatment, sb.'s illness took a favorable turn for patient.
3, storehouse, man, 46 years old, Kazak, nineteen ninety diagnosis suffered from " diabetes ", and long-term taking Chinese medicine, Western medicine, effect is bad.Take this medicine June through treatment, sb.'s illness took a favorable turn for patient, do not recommit diabetes.
Claims (6)
1. treat a Kazak conventional medicament compositions for diabetes, it is characterized in that adopting following technique to prepare:
Get Semen Momordicae Charantiae, tea bit of a bridle, Fructus Rubi corchorifolii Immaturus, Fructus Rubi, Radix Inulae, Fructus Lycii, Helichrysum arenarium (Linn.) Moench., each 1 ~ 15 weight portion of Herba Coreopsis tinctoria, carry out water extraction 1 ~ 4 time: add water after above-mentioned material fragmentation by 3 ~ 20 of medical material weight times, heat to 90 ~ 105 DEG C, slow fire heating makes that maintenance is micro-boils, each water extraction 5 ~ 60 minutes, crosses below 2mm sieve and gets permeate, leave standstill and get supernatant in more than 5 hours, after being left standstill by water extraction gained permeate, gained supernatant concentration is dried to water content≤50%, obtains aqueous extract.
2. pharmaceutical composition according to claim 1, is characterized in that adopting following technique to prepare:
Get Semen Momordicae Charantiae, tea bit of a bridle, Fructus Rubi corchorifolii Immaturus, Fructus Rubi, Radix Inulae, Fructus Lycii, Helichrysum arenarium (Linn.) Moench., each 5 ~ 10 weight portions of Herba Coreopsis tinctoria, cross less than 150 ~ 500 μm sieves and get permeate.
3. treat a Kazak conventional medicament compositions for diabetes, it is characterized in that adopting following technique to prepare:
Get Semen Momordicae Charantiae, tea bit of a bridle, Fructus Rubi corchorifolii Immaturus, Fructus Rubi, Radix Inulae, Fructus Lycii, Helichrysum arenarium (Linn.) Moench., each 1 ~ 15 weight portion of Herba Coreopsis tinctoria, extract 1 ~ 4 time at 60-90 DEG C of temperature with the ethanol that the concentration of 3 ~ 10 times amount of medical material weight is 80%-95%, each 15 ~ 45 minutes, obtain ethanol extract, cross below 2mm sieve and get permeate, be concentrated into the extract of dry matter content >=50%, and described extract is mixed with claim 1 or 2 water extraction is extract obtained.
4. treat a Kazak conventional medicament compositions for diabetes, it is characterized in that adopting following technique to prepare:
The pharmaceutical composition of claim 1,2 or 3 is made granule, powder, pill, capsule or tablet.
5. according to the purposes of pharmaceutical composition in the medicine of preparation treatment diabetes of claim 1,2 or 3.
6. purposes according to claim 5, is characterized in that affiliated diabetes are type ii diabetes.
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| CN110279730B (en) * | 2019-07-23 | 2021-10-12 | 中国科学院西北高原生物研究所 | A Ribes glaciens extract and its application in preparing medicine for reducing postprandial blood sugar |
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| CN101024037A (en) * | 2007-04-09 | 2007-08-29 | 李水清 | Medicine for treating non-insulin-depending type diabetes |
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| 治疗糖尿病的红色晶珠——枸杞;周洪喜;《中华养生保健》;20011231(第1期);47 * |
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