CN103285107A - Alcoholic hepatitis treatment Kazakh traditional drug composition and preparation method thereof - Google Patents
Alcoholic hepatitis treatment Kazakh traditional drug composition and preparation method thereof Download PDFInfo
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Abstract
The present invention discloses an alcoholic hepatitis treatment Kazakh traditional drug composition and a preparation method thereof, wherein a six-element theory of the traditional medicine theory basis "Kazakh Medicine Outline" is combined, the six-element theory comprises a "a le te tu gu er theory", a "hu wa ti" theory (ie., a qi, function and energy theory), a "su le" theory (ie., a body fluid theory), a "mu xie lie er" theory (ie., an organ theory), and the like, and the composition has effects of prevention and treatment of various common colds such as viral cold, wind cold type cold and the like. The preparation method comprises: selecting the traditional and commonly used medicinal plant Rhamnus Cathartica L fruit (ie., Xinjiang drug buckthorn fruit), raw milkvetch root and radix puerariae, carrying out water extraction and ethanol extraction, and uniformly mixing to prepare an oral preparation, wherein formulations comprise an decoction, pills, powders, granules, tablets and other oral formulations suitable for clinical alcoholic hepatitis prevention and treatment. The alcoholic hepatitis treatment Kazakh traditional drug composition particularly provides a good treatment effect for alcoholic hepatitis oral adjuvant therapy, and has characteristics of reasonable formula, convenient preparation, exact treatment effect, rapid effect, no stimulation, and no other toxic-side effects.
Description
Technical field
The present invention relates to treat Kazak conventional medicament compositions and its preparation method of alcoholic hepatitis.
Background technology
Kazak nationality traditional medicine theory has long history, in its very long history development procedure Kazak nationality my late grandfather and traditional medicine worker and among the people widely based on the hexa-atomic theory of the theoretical basis of Kazak's traditional medicine namely " A Lete dash forward Gu Er " study multiple disease pathogenesis and diagnosis and treatment method.Kazak's physician Wu Taiboyida cut be listed as my haab rein in (1388～?) in Christian era the 15th century show " Kazak's medical science outline " book namely from gas, function, energy namely recklessly watt theory, internal organs namely " wooden Xie Lieer " academic theory multiple disease is carried out pathological analysis and medical scheme, medicine diagnosis and treatment design.
Kazak nationality medicine tradition medicinal plants Bao Erhute fruit commonly used be Xinjiang Phamnus cathartica L. fruit, Radix Astragali, RADIX PUERARIAE be mainly rely on the internal organs theory namely " wooden Xie Lieer " treat dyscrasia, among the people main for oral administration by extracting the processing back, it mainly acts on is the treatment alcoholic hepatitis.
According to Kazak traditional medicine theory, alcoholic hepatitis has part etiology and pathology process relevant with the organ function imbalance, and its sign is different.
Alcoholic hepatitis is a kind of because the hepatic disease that long-term heavy drinking causes can bring out popularity hepatic necrosis even liver failure when seriously indulging in excessive drinking.This disease is one of common hepatic disease of China.The serious harm people health.Show that according to alcoholic liver disease Epidemiological study data the alcoholic hepatitis prevalence is about 6% in the adult colony.The ratio that alcoholic hepatitis accounts for the hepatopathy inpatient same period constantly rises, and has become a very important problem in China because of the hepatic injury due to the ethanol.Under the many realities of China wine common people, predict 10 years from now in, under the direct influence of alcoholic hepatitis disease, national economy is taken in will remarkable loss.Active prevention and treatment alcoholic hepatitis are extremely urgent.Alcoholic hepatitis not only is related to self health problem, more has to be related to how to improve our quality of life problem.
Alcohol factor is as the first influencing factor to pathologic liver for alcoholic hepatitis, impels reactive oxide to increase by oxidative stress, assembles and bring out liver fat.Under the effect of the relevant lipid peroxidation of oxidative stress and inflammatory cytokine, effect for the second time takes place in the hepatocyte that fat is become, and causes inflammation, necrosis and fibrosis.
There are some researches show that the tentative diagnosis main points of alcoholic hepatitis comprise having patient long-term, the heavy drinking history, occur ascites and except other reasons.To indivedual cases.Inquiry kinsfolk and partner confirm that its history of drinking history just can make a definite diagnosis.The serious symptom alcoholic hepatitis refers to that the performance of liver failure appears in the alcoholic hepatitis patient, as disturbances of blood coagulation, jaundice, hepatic encephalopathy, acute renal failure, upper gastrointestinal hemorrhage etc., often with endotoxemia.
Use the medicine of national minorities, comprise the Chinese medicine and pharmacy traditional theory, the research of carrying out organ function imbalance, body fluid disease has had long history, but because the restriction of historical conditions, motherland's medical science is not carried out careful clearly differentiation to the organ function disorders, fails to form the theoretical system of system complete.Along with the systemtheoretical introducing of doctor trained in Western medicine, and according to the principle of differentiation of tcm, just really progressively launch with Chinese medicine, the research that prevents and treats alcoholic hepatitis, beginning systematic research alcoholic hepatitis disease, formed China exclusive prevent and treat the scientific research of alcoholic hepatitis disease with what the Chinese and western medicine national medicine was combined into characteristics.
The alcoholic hepatitis diseases prevention and treatment are extensive day by day for the application of Chinese herbal medicine; For many years, China has carried out a large amount of work to the drug research of preventing and treating alcoholic hepatitis, think wherein may exist various for the Chinese herbal medicine that improves organ function imbalance, the phylogenetic system that distributes is extensive, region, ecology are also varied, thereby it is contemplated that they also have various multi-form for the mechanism of action of preventing and treating the organ function disease, this provides wide prospect just for research herbal control alcoholic hepatitis disease medicament.
Research application Chinese medicine national medicine therapeutical effect is relatively paid attention to finding and the research that develops the disease-resistant gene problem, emphasizes the relation of global configuration and gene expression.Comprising: balance organic conception and systems biology; The correspondence between man and universe and environmental genomics; Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs and pharmacogenomics; Treating the same disease with different methods, treating different diseases with the same therapeutic principle and medicine genetics; Etiology and tumor susceptibility gene; Strengthening vital QI to eliminate pathogenic factors and genomics treatment; The dependency of syndrome and genomics, protrinology.Strengthen simultaneously with gene expression is index, change and functionalized modification is research direction with gene regulation, carry out the research of the multi-component too many levels of Chinese medicine compound, the Accommodation of many target spots, seek the related gene of disease combination, set up " syndrome-gene expression profile ", be conducive to disclose the essence of the 26S Proteasome Structure and Function of the traditional Chinese medical science " card ".
The disease reason of alcoholic hepatitis and pathology are very complicated, and treatment should be considered more problem.Since multifactor the causing of organ function imbalance prevented and treated internal organs imbalance curative effect index so and just can not only be confined to index in a certain respect, should widen thinking, seek many-sided medicine.
Therefore, a kind of Kazak conventional medicament compositions and its preparation method of new treatment alcoholic hepatitis just are suggested.
Summary of the invention
The purpose of this invention is to provide Kazak conventional medicament compositions and its preparation method for the treatment of alcoholic hepatitis.
The objective of the invention is to be achieved through the following technical solutions:
Chinese medicine of the present invention adopts following raw material to produce:
Water is carried: get Chinese crude drug
Using medicinal plants material Bao Erhute fruit always with Kazak traditional national medicine is Xinjiang Phamnus cathartica L. fruit, Radix Astragali, one or more of multiple medical material such as RADIX PUERARIAE, each 1～15 weight portion, be preferably each 5～10 weight portion, carrying out water carries 1～4 time: will press 3～20 water extraordinarily of medical material weight after the above-mentioned material fragmentation, heat to 90～105 ℃, the slow fire heating makes and keeps little boiling, each water is carried 5～60 minutes, cross the following sieve of 2mm and get permeate, be preferably 150～500 μ m sieve, leave standstill more than 5 hours and get supernatant, water is carried the gained permeate to leave standstill back gained supernatant concentration and is dried to water content≤50%, get extracting solution, namely obtain pharmaceutical composition of the present invention.
It is that 2～10 times of Chinese crude drug weight are advisable that above-mentioned water is carried amount of water after the 2nd time.
Above-mentioned Chinese crude drug water preferably carries out alcohol extraction before proposing earlier: be that 80～95% ethanol extracts 1～4 time under 60～90 ℃ of temperature by 3～10 times of amount concentration of Chinese crude drug weight, each 15～45 minutes, get ethanol extract, cross the following sieve of 2mm and get permeate, be concentrated into the extract of dry matter content 〉=50%, and described extract and water are carried extract obtained the mixing.
Medicine of the present invention effectively in conjunction with great Kazak's ancient medicine Wu Taiboyida cut be listed as my haab rein in institute show " wonderful work Ge Erlike Bayan " namely " Kazak's medical science outline " hexa-atomic theory of carrying be the academic theory guidance of " A Lete dash forward Gu Er ", the Wu Taiboyida cut is listed as my haab and reins in and think that internal organs can independently finish responsibility and function that first native endowments separately have, and particular shape structure separately arranged, get in touch with the human body component part that creates conditions for the continuity day after tomorrow, existence, the health preserving of life by mutual linking.This is that Kazak nationality doctor Sheng Wutaiboyida cut is listed as my haab and reins in the experience and academic thought of summing up forefathers, the own viewpoint that sums up after constantly observing, study, put into practice in long-term medical practice widely and to the concept of internal organs.The exclusive gas of internal organs of keeping the total gas of the body of body normal function and the performance day after tomorrow and facilitating.So, alcoholic hepatitis belongs to the exclusive gas of internal organs that the acquired disposition effect is facilitated, also be that " wooden Xie Lieer " meaning is that internal organs and organ and " Su Leji " meaning in the internal organs theory is body fluid, " Hu Wati " various " A Lemasi wood " in i.e. gas, function etc., the body anticipate intercoordination between i.e. conversion, samsara, the circulation and the relation that connects each other between outer apparent 12 organs of human body and built-in 12 internal organs of anticipating.General character and individual character by positive this prescription medicine of excavation, to improve this prescription to the specific aim of alcoholic hepatitis control, organic conception and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs specializing in clinical treatment in conjunction with traditional Chinese medical science national medicine, reach the highest curative effect of composition synergism performance medicine, strengthen human body body, tissue, organ self-repairing capability, patient person is recovered gradually, has better curative effect for above-mentioned organ function dysfunctional disease control, have efficient, low toxicity, no Drug resistance and advantage applied widely, particularly treatment has better curative effect to alcoholic hepatitis.
Simultaneously, Chinese medicine of the present invention can be made multiple dosage form series such as granule, powder, pill, capsule, tablet, overcome decocting for Chinese herbal medicine in the past and used inconvenience and the wasting deficiency of some rare medicinal herbs, the processing of raw material in the prescription is accepted or rejected, not only be easy to effect, and can make things convenient for the patient to use greatly.
The specific embodiment
Embodiment 1: getting Kazak tradition herb resource Bao Erhute fruit is Xinjiang Phamnus cathartica L. fruit, Radix Astragali, each 10 weight portion of one or more of multiple medical material such as RADIX PUERARIAE, wherein vegetable material is broken into the following bar section of 1cm, granule, press 10 water extraordinarily of Chinese crude drug weight, heat to 98 ℃ of water and carry 30 minutes, cross 500 μ m sieve and get permeate, carry 20 minutes with adding 5 times of water gagings in the medicinal residues again at 98 ℃ of water, cross 500 μ m sieve and get permeate, with above-mentioned water carry the gained permeate under the 0.07Mpa negative pressure, heat to the boiling concentrate drying to water content≤70%, get extract, namely obtain pharmaceutical composition of the present invention.
Embodiment 2: getting Kazak tradition herb resource Bao Erhute fruit is Xinjiang Phamnus cathartica L. fruit, Radix Astragali, each 30 weight portion of one or more of multiple medical material such as RADIX PUERARIAE, wherein vegetable material is broken into the following bar section of 1cm, granule, measuring concentration by 10 times of above-mentioned Chinese crude drug gross weight is that 70% ethanol extracted 30 minutes under 60 ℃ of temperature, cross 250 μ m sieve, get permeate, measuring concentration by 5 times of above-mentioned Chinese crude drug gross weight again is that 70% ethanol extracted 2 hours under 60 ℃ of temperature, cross 250 μ m sieve, mixing twice gained permeate also, concentrate drying to dry matter content 〉=85% gets alcohol extract, Chinese medicine slag after the above-mentioned alcohol extraction is pressed 10 water extraordinarily of Chinese crude drug weight, heat to 98 ℃, water is carried twice, each 30 minutes, cross 150 μ m and get permeate, water is carried gained permeate concentrate drying to water content≤55%, get water extract; With above-mentioned alcohol extract mix homogeneously, namely obtain pharmaceutical composition of the present invention.
Embodiment 3: getting Kazak tradition herb resource Bao Erhute fruit is Xinjiang Phamnus cathartica L. fruit, Radix Astragali, each 15 weight portion of one or more of multiple medical material such as RADIX PUERARIAE, wherein vegetable material is broken into the following bar section of 1cm, granule, be that 90% ethanol respectively extracts 1 time under 85 ℃ of temperature by 8 times of amounts of Chinese crude drug weight and 5 times of amount concentration, each 25 minutes, extracting solution is crossed 250 μ m sieve, gained permeate concentrate drying to dry matter content 〉=90% is got extract, with the Chinese medicine slag after the above-mentioned alcohol extraction respectively by 8 times and 5 of Chinese crude drug weight extraordinarily water 98 ℃ down each water carry once, kept 20 minutes for the first time, 15 minutes for the second time, each water is carried the back and is crossed 150 μ m sieve, water is carried gained permeate concentrate drying to water content≤10%, get water extract, with the extract obtained mix homogeneously of last alcohol extraction, namely obtain pharmaceutical composition of the present invention.
Embodiment 4: getting Kazak tradition herb resource Bao Erhute fruit is one or more each 10 weight portions of multiple medical materials such as Xinjiang Phamnus cathartica L. fruit, Radix Astragali, RADIX PUERARIAE, wherein vegetable material is broken into 1cm following bar section, granule, be that 80% ethanol extracted 30 minutes under 90 ℃ of temperature by 10 times of Chinese crude drug weight amount concentration, cross 500 μ m sieve, the gained permeate is concentrated into dry matter content 〉=87% gets extract; With the Chinese medicine slag after the above-mentioned alcohol extraction respectively by 10 times, 5 times, 5 of Chinese crude drug weight extraordinarily water carry at 98 ℃ of following water, 30 minutes for the first time, second and three time each 20 minutes, cross 75 μ m sieve permeate and concentrate drying to water content≤13%, get extract; Carry and the extract obtained mix homogeneously of alcohol extraction with above-mentioned water, namely get pharmaceutical composition of the present invention.
Embodiment 5: getting Kazak tradition herb resource Bao Erhute fruit is Xinjiang Phamnus cathartica L. fruit 30 weight portions, get Kazak tradition herb resource Radix Astragali, each 15 weight portion of one or more of multiple medical material such as RADIX PUERARIAE, wherein vegetable material is broken into the following bar section of 1cm, granule, press 7 times of amounts of Chinese crude drug weight respectively, 4 times of amounts, 4 times measure concentration is that 68% ethanol respectively extracts 1 time under 90 ℃ of temperature, the time of each time was respectively 30 minutes, 15 minutes, 15 minutes, cross 250 μ m sieve, the gained permeate is concentrated into dry matter content 〉=92% gets extract, with the Chinese medicine slag after the above-mentioned alcohol extraction by Chinese crude drug weight 8 extraordinarily water carry 3 minutes at 98 ℃ of following water, cross 150 μ m sieve, with gained permeate concentrate drying to water content≤50%, get extract, above-mentioned water is carried and the extract obtained mix homogeneously of alcohol extraction, namely obtains pharmaceutical composition of the present invention.
Embodiment 6: getting Kazak tradition herb resource Bao Erhute fruit is one or more each 45 weight portions of multiple medical materials such as Xinjiang Phamnus cathartica L. fruit, Radix Astragali, RADIX PUERARIAE, wherein vegetable material is broken into 1cm following bar section, granule, adding water by 10 times of amounts of Chinese crude drug weight, 7 times of amounts and 5 times of amounts respectively extracts under 95 ℃ 1 time, the time of each time was respectively 30 minutes, 20 minutes, 15 minutes, cross 180 μ m sieve, the gained permeate is concentrated into water content≤15%, get water extract, namely obtain pharmaceutical composition of the present invention.
Embodiment 7～16: embodiment 7～16th, and embodiment 1～6 gained pharmaceutical composition is added an amount of distilled water, make granule through granulation.
Embodiment 17～26: embodiment 17～26th, and embodiment 1～6 gained pharmaceutical composition is added an amount of distilled water, make granule through granulation, make capsule after made granule is filled into capsulae vacuus.
Embodiment 27～36: embodiment 27～36th, and embodiment 1～6 gained pharmaceutical composition is added an amount of distilled water, soluble starch, make granule through granulation, require compacting according to the tablet producton order afterwards, make tablet.
Embodiment 37～46: embodiment 37～46th, and embodiment 1～6 gained pharmaceutical composition is added an amount of refined honey and water, make pill.
Embodiment 47～56: embodiment 47～56th, and embodiment 1～6 gained pharmaceutical composition is added an amount of distilled water, soluble starch, make the granule of corresponding specification order number through granulation, make powder.
It below is the diagnosed SARS case that the patient uses medicine of the present invention.
1, restrains certain, man, 45 years old, Kazak.Medical history: first visit on March 14 in 2010.Be " alcoholic hepatitis " through hospital diagnosis, do not take a turn for the better through treatment, produce complication.Took this medicine three months through treatment, symptom takes a turn for the better.
2, Ah certain, the man, 55 years old, Kazak was diagnosed as " alcoholic hepatitis " in October, 2011.Took this medicine six months through treatment, sb.'s illness took a favorable turn.
3, cling to certain, the man, 49 years old, the Mongols, the nineteen ninety diagnosis suffers from " alcoholic hepatitis ", and in taking, Western medicine preparation, effect is bad throughout the year.Took this medicine four months through treatment, sb.'s illness took a favorable turn.
Claims (9)
1. treat Kazak conventional medicament compositions and its preparation method of alcoholic hepatitis, it is characterized in that containing at least following technical process:
Water is carried: getting the Bao Erhute fruit is Xinjiang Phamnus cathartica L. fruit, Radix Astragali, one or more of multiple medical material such as RADIX PUERARIAE, each 1～15 weight portion, be preferably each 5～10 weight portion, carrying out water carries 1～4 time: will press 3～20 water extraordinarily of medical material weight after the above-mentioned material fragmentation, heat to 90～105 ℃, the slow fire heating makes and keeps little boiling, each water is carried 5～60 minutes, cross the following sieve of 2mm and get permeate, be preferably 150～500 μ m sieve, leave standstill more than 5 hours and get supernatant, water is carried the gained permeate leave standstill back gained supernatant concentration and be dried to water content≤50%, get aqueous extract (filtrate).
2. treat Kazak conventional medicament compositions and its preparation method of alcoholic hepatitis, it is characterized in that:
Alcohol extraction: getting the Bao Erhute fruit is one or more 1～15 weight portions of multiple medical materials such as Xinjiang Phamnus cathartica L. fruit, Radix Astragali, RADIX PUERARIAE, carry out 80% to 95% soak with ethanol or heating extraction 1～4 time: with above-mentioned Chinese crude drug be crushed to behind 1～5 centimetre of segment by Chinese crude drug weight 3～30 extraordinarily concentration be the ethanol of 80%-95%, the each immersion 1～7 day, cross the following sieve of 2mm or silk, filter cloth is got permeate, gets ethanol extract (filtrate).
3. according to Kazak conventional medicament compositions and its preparation method of claim 1 or 2 described treatment alcoholic hepatitis, it is characterized in that: the Chinese crude drug water when described water is carried carries out alcohol extraction in advance earlier: getting concentration by 3～10 times of Chinese crude drug weight is that 60～90% ethanol extracts 1～3 time down at 60～90 ℃, each 15～45 minutes, get extracting solution, be concentrated into dry matter content 〉=80% and get extract.
4. according to Kazak conventional medicament compositions and its preparation method of claim 1 or 2 or 3 described treatment alcoholic hepatitis, it is characterized in that: described water extract and ethanol extract carry out assembly according to a certain percentage, get mixed extract.
5. according to Kazak conventional medicament compositions and its preparation method of claim 1 or 2 or 3 or 4 described treatment alcoholic hepatitis, it is characterized in that: described water extract and ethanol extract carry out assembly according to a certain percentage, get mixed extract, continue behind the mix homogeneously to endure to pasty state, get pharmaceutical composition.
6. treat Kazak conventional medicament compositions and its preparation method of alcoholic hepatitis, it is characterized in that: described compositions is oral preparations.
7. Kazak conventional medicament compositions and its preparation method for the treatment of alcoholic hepatitis is characterized in that: its dosage form comprises the common oral preparations of clinical use such as pill, powder, capsule, tablet, granule.
8. treat Kazak conventional medicament compositions and its preparation method of alcoholic hepatitis, it is characterized in that: its purposes is mainly as medication auxiliary treatment alcoholic hepatitis for oral administration.
9. Kazak conventional medicament compositions and its preparation method for the treatment of alcoholic hepatitis is characterized in that: produce according to each described method of claim 1～5.
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| CN107951030A (en) * | 2017-12-04 | 2018-04-24 | 浙江农林大学 | A kind of compound granule with Antialcoholic liver-protecting and preparation method thereof |
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| KR20020011038A (en) * | 2000-07-31 | 2002-02-07 | 차순옥 | The liver genealogy patient using health support food of manufacture method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106177009A (en) * | 2016-08-26 | 2016-12-07 | 阿斯亚·拜山伯 | The Bao Erhute process for producing granula for the treatment of alcoholic liver disease is applied with it |
| CN107951030A (en) * | 2017-12-04 | 2018-04-24 | 浙江农林大学 | A kind of compound granule with Antialcoholic liver-protecting and preparation method thereof |
| CN107951030B (en) * | 2017-12-04 | 2021-01-01 | 浙江农林大学 | Compound granule with functions of dispelling effects of alcohol and protecting liver and preparation method thereof |
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Application publication date: 20130911 |