CN1456193A - Natural sugar inhibiting elements - Google Patents

Abstract

A natural medicine "Ketangsu" for treating the diabetes and its complications is prepared from the natural plants through supercritical fluid extracting. Its advantages are high curative effect and no toxic by-effect.

Description

Natural ketangsu

The title of this invention is a natural ketangsu.

Natural ketangsu belongs to the high sharp technological achievement in modern Chinese medicine and the medical health care field.

Diabetes are one of big difficult disease of ten in world today's medical domain, are again the common frdquently encountered diseases of middle-aged and elderly people all over the world, and special sickness rate is higher in the serious developed country of aged tendency of population, and ill degree more very.Before 10 years, the number of patients of whole world diabetes only is the today after 3,000 ten thousand, 10 years, and the diabetics in the whole world has reached 200,000,000 more than, and increases day by day with the increasing of the economic development of various places and aged tendency of population.It is considered herein that the essence of diabetes is deficiency of YIN, but the deficiency of YIN hyperamization stasis of blood.The cyclic adenosine monophosphate that blood stasis can cause in the human plasma obviously raises, and the rising of cyclic adenosine monophosphate can affect the phosphorylation of glycogen apace, the enhancing of phosphorylation is the increased activity of phosphorylase, thereby the oxidation of glucose is obstructed, and then makes blood sugar increasing in the body.Blood sugar increasing stimulates B cell generation functional compensation again with feeding back, the growing amount of insulin is increased, so that form high pancreas homoatomic mass formed by blood stasis, hyperinsulinemia causes complicated diabetic complication again, form glycometabolic vicious cycle thus again and again, lure into the unconspicuous modern Chinese medicine diabetes of clinical symptoms such as rapid digestion of food and polyorexia, polydipsia, polyphagia, polyuria at last.

Microcirculation disturbance due to the blood stasis, both can make the gene mutation of Insulin receptor INSR and caused the defective of insulin, can make the gene mutation of insulin again and reduce the secretion of insulin amount, both can reduce the affinity of Insulin receptor INSR to insulin, the effect that makes insulin is obstructed and is formed the opposing of insulin, can reduce peripheral tissues again to the sensitivity of insulin and the biological effect of the insulin that weakened.Threaten human life and healthy diabetes, horrifying more than its number of patients, and complicated general complication is bound to arouse fear especially, can use yet there is not ideal medicine again, bring great misery not only for all patients, and bring heavy financial burden to family for society.Though it is various to treat the medicament categories of diabetes at present, can cure the drug research of diabetes in a short time, Shang Weijian has report.Therefore and the present invention similarly and can cure the new drug of diabetes in short-term, not seeing as yet both at home and abroad has use.

Succeeding in developing of natural ketangsu put forth effort on the screening of effective Chinese herbal medicine before this, through clinical practice in advance for many years, compatible combination is that existing prescription is formed, i.e. the Radix Astragali, Rhizoma Coptidis, Spica Prunellae, Radix Puerariae, Rhizoma Dioscoreae, Radix Rehmanniae Preparata, Rhizoma Polygonati, Cortex Magnoliae Officinalis, Fructus Schisandrae Chinensis, Rhizoma Zingiberis, Radix Paeoniae, Radix Panacis Quinquefolii.

Next is the research of natural ketangsu preparation method, for adapting to Chinese herbal medicine development of modernization strategy, producing of Chinese herbal medicine must International standardization, chemical constituent that should clear and definite Chinese herbal medicine, matter amount of having and controlled standard are arranged again, being far from it to adapt to world today's back to nature, yearns for green, relies on the trend of natural plant preventing and treating diseases.Therefore, the square medicine composition with having drafted adopts supercritical liquid extraction technique one by one separately, carries out the extraction of active chemical.The main active chemical that we are carried is blood sugar lowering element, puerarin, astragalus polysaccharides etc., and it is CO2 that solvent for use is extracted at the interface, the compound powder that the excipient of the effective ingredient of carrying is looked into for the medicine of carrying.

The 3rd is with basis and the clinical matched group of setting up, to carrying effective ingredient is natural blood sugar lowering element, carry out the basis of pharmacodynamics and the study on mechanism of clinical efficacy, the result proves, natural ketangsu one can improve the activity of hexokinase, aldolase and phosphofructokinase in the body effectively, promote the aerobic oxidation and the anerobic glycolysis of glucose, thereby reduce blood glucose and the glucose in urine that raises fast and significantly; Two can stop and eliminate the stimulation and the infringement of the radical pair B cell that vivo oxidation produces, thereby promote the reparation and the regeneration of islet cells; Three can regulate the gene expression and the generation of Insulin receptor INSR exactly, stop the sudden change of insulin receptor gene in the expression process, adjust the normal expression and the biological effect of Insulin receptor INSR; Four can suppress and reduce the activity and the content of cyclic adenosine monophosphate effectively, thereby from bringing into play blood sugar reducing function in fact; Five can strengthen Insulin receptor INSR effectively to the affinity of insulin and eliminate the opposing of insulin significantly; Six activity that can suppress the alditol reductase are effectively conciliate the nonenzymatic glycosylation effect of isolating protein, thereby fundamentally stop the generation and the development of diabetic complication, and to concurrent diabetic complication, the effect of removing burning wood away under the boiler are arranged also.

The 4th is behind the pharmacological action of having grasped natural ketangsu and mechanism of action, organize clinical case to set up contrast, conscientiously carry out clinical research, through tight clinical observation and relevant biochemistry detection, the result proves, but natural ketangsu is clearing away heat-fire, promoting the production of body fluid to quench thirst both, again can nourshing Yin and drynsessmoistening prescription, controlling nocturnal emission with astringent drugs reducing urination; But both blood circulation promoting and blood stasis dispelling, disappear that it is long-pending coagulate to loose, but activating QI cloth Tianjin again, the conditioning internal organs.Make being separated yearningly of quenching one's thirst, the famine of quenching one's thirst is filled, and the moon of quenching one's thirst is supported, the dry profit of quenching one's thirst, and the urine of quenching one's thirst is ended.

In sum, natural ketangsu is effective new drug of treatment diabetes, its existing tangible chemical constituent, but content and quality standard are arranged again, both can cure type 2 diabetes mellitus, type 1 diabetes can be cured again, diabetes complicated all kinds of complication can be treated effectively, simultaneously without any side effects again, meanwhile, have produce effects fast again, the original point of short treating period makes all diabeticss can obtain thorough rehabilitation in a short time.Yet this medicine had both adapted to the specification requirement of Chinese herbal medicine modern production, can comply with current whole world back to nature again, yearn for natural green, relied on the new historical trend of Chinese herbal medicine preventing and treating diseases.So this medicine is hopeful the strong main flow market that enters international medicine.

Claims (5)

1 natural ketangsu belongs to the High-Tech result in Chinese medicine and the medical health care field.This medicine is mainly with the Radix Astragali, Rhizoma Coptidis, Spica Prunellae, Radix Puerariae, Rhizoma Dioscoreae, Radix Rehmanniae Preparata, and Rhizoma Polygonati, Cortex Magnoliae Officinalis, Fructus Schisandrae Chinensis, Rhizoma Zingiberis, Radix Paeoniae, Radix Panacis Quinquefolii are raw material, the complex and the relevant excipient thereof of the effective ingredient that extracts through supercritical liquid extraction technique.After an amount of allotment of extract and excipient, natural ketangsu.This medicine not only can be cured diabetes in a short time, can effectively prevent and treat all kinds of diabetic complications again.

The 2 effective ingredient complex according to claims 1 is characterized in that the active chemical of this complex is blood sugar lowering element (Spica Prunellae is contained), puerarin, astragalus polysaccharides and astragalin etc. successively.

3 excipient according to claims 1 is characterized in that the essence of this excipient is the composite powder of the last medicinal residues of effective component extracting.

4 natural ketangsus according to claims 1, its functional character is, both can improve the activity of hexokinase in the body, aldolase, phosphofructokinase effectively, promote the aerobic oxidation and the anerobic glycolysis of glucose, thus blood sugar lowering and glucose in urine fast and significantly; The stimulation and the infringement of the radical pair islets of langerhans that vivo oxidation produces prevented and eliminated, the reparation and the regeneration of islet cells promoted; Can regulate the gene expression and the generation of Insulin receptor INSR exactly, prevent the normal expression and the biological effect of Insulin receptor INSR; Suppress and reduce the activity and the content of cyclic adenosine monophosphate, thereby from bringing into play blood sugar reducing function in fact; Suppress the activity of alditol reductase and conciliate the nonenzymatic glycosylation effect of isolating protein, thereby fundamentally stop the generation and the development of diabetic complication, and the diabetic complication to having taken place, therapeutical effect is significantly arranged.Simultaneously, can strengthen Insulin receptor INSR to the affinity of insulin and eliminate the opposing of insulin.

5 can effectively prevent and treat all kinds of complication of diabetes according to the described natural ketangsu of claims, its main functional character is, natural ketangsu not only can stop the generation and the development of diabetic complication, and all kinds of diabetic complications to concurrent have notable therapeutic effect.