CN1491716A - Fingered citron particals for stomach ailment and its preparing method - Google Patents
Fingered citron particals for stomach ailment and its preparing method Download PDFInfo
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- CN1491716A CN1491716A CNA03157338XA CN03157338A CN1491716A CN 1491716 A CN1491716 A CN 1491716A CN A03157338X A CNA03157338X A CN A03157338XA CN 03157338 A CN03157338 A CN 03157338A CN 1491716 A CN1491716 A CN 1491716A
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- 240000007126 Citrus medica var. sarcodactylis Species 0.000 title abstract 4
- 238000000034 method Methods 0.000 title description 7
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- 239000008187 granular material Substances 0.000 claims abstract description 23
- 239000003814 drug Substances 0.000 claims abstract description 22
- 238000002360 preparation method Methods 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
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- 239000000047 product Substances 0.000 claims description 9
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- 238000001035 drying Methods 0.000 claims description 8
- 239000004615 ingredient Substances 0.000 claims description 8
- 239000002671 adjuvant Substances 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 5
- 235000011837 pasties Nutrition 0.000 claims description 5
- WHGYBXFWUBPSRW-UHFFFAOYSA-N Cycloheptaamylose Natural products O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO WHGYBXFWUBPSRW-UHFFFAOYSA-N 0.000 claims description 4
- 239000000796 flavoring agent Substances 0.000 claims description 4
- 235000019634 flavors Nutrition 0.000 claims description 4
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- 244000061520 Angelica archangelica Species 0.000 abstract 1
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- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 description 8
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- Medicines Containing Plant Substances (AREA)
Abstract
The fingered citron granule for stomach ailment is prepared with fingered citron, white peony root, angelica, bupleurum root, dried orange peel, white atractylodes rhizome and other five kinds of Chinese medicinal materials. The preparation process of the fingered citron granule for stomach ailment includes ethanol extraction of partial materials and concentration to obtain extractum, water vapor distillation of partial materials to obtain volatile oil, beta-cyclodextrin inclusion of the volatile oil, decoction of the medicine dregs after volatile oil extraction and other materials and concentration to obtain extractum, and mixing the extractum, the inclusion, sugar and dextrin to obtain the granule.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation prescription and preparation method thereof, particularly a kind of Fructus Citri Sarcodactylis stomach peace granule prescription and preparation method thereof.
Background technology
With Fructus Citri Sarcodactylis is that the Fructus Citri Sarcodactylis stomach peace granule of main effective ingredient has the effect of depressed liver-energy dispersing and QI regulating, invigorating the spleen and regulating the stomach.Cure mainly with stomachache, the side of body and expand, belch acid regurgitation etc. is the gastritis of primary symptom, the syndrome of incoordination between liver and stomach of chronic gastritis (shallow).Fructus Citri Sarcodactylis stomach peace granule therapy has been obtained obvious effects, and the prescription of this medicament and preparation technology can produce bigger influence to the quality and the curative effect of medicine.
Summary of the invention
The object of the present invention is to provide a kind of Fructus Citri Sarcodactylis stomach to pacify particulate preparation method, the Fructus Citri Sarcodactylis 'Weian ' is made graininess, be used to take after mixing it with water.Its effective ingredient can reach at utmost and keep.
Fructus Citri Sarcodactylis stomach of the present invention is pacified particulate prescription: the Radix Paeoniae Alba (stir-fry), Radix Angelicae Sinensis, Radix Bupleuri, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae (stir-fry), Radix Codonopsis, Rhizoma Cyperi, Fructus Citri Sarcodactylis, Cortex Magnoliae Officinalis, Fructus Amomi, Radix Glycyrrhizae.
Specifically each the tcm components processing and preparing by following ratio forms:
170～210 parts of the Radix Paeoniae Albas (stir-fry)
170～210 parts of Radix Angelicae Sinensis
100～150 parts of Radix Bupleuri
170～210 parts of Pericarpium Citri Reticulataes
170～210 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry)
300～350 parts of Radix Codonopsis
170～210 parts of Rhizoma Cyperis
170～210 parts of Fructus Citri Sarcodactylis
110～150 parts of Cortex Magnoliae Officinalis
170～210 parts of Fructus Amomis
40～80 parts in Radix Glycyrrhizae
In the above-mentioned Chinese medicine of respectively distinguishing the flavor of, best formula combination is:
193 parts of the Radix Paeoniae Albas (stir-fry)
193 parts of Radix Angelicae Sinensis
130 parts of Radix Bupleuri
193 parts of Pericarpium Citri Reticulataes
193 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry)
323 parts of Radix Codonopsis
193 parts of Rhizoma Cyperis
193 parts of Fructus Citri Sarcodactylis
130 parts of Cortex Magnoliae Officinalis
193 parts of Fructus Amomis
66 parts in Radix Glycyrrhizae
Above-mentioned Fructus Citri Sarcodactylis stomach of the present invention is pacified particulate preparation method and be may further comprise the steps:
A: extract the Radix Paeoniae Alba, Cortex Magnoliae Officinalis effective ingredient: take the Radix Paeoniae Alba, Cortex Magnoliae Officinalis is ground into coarse powder, add 70% ethanol extraction 2 times, add for the first time 10 times of amounts, add for the second time 8 times of amounts, the each extraction 2 hours, merge extractive liquid,, concentrate and reclaim ethanol, obtain relative density and be 1.35～1.38 drug extract, standby;
B: Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Fructus Amomi, the Rhizoma Atractylodis Macrocephalae (stir-fry), Fructus Citri Sarcodactylis are extracted volatile oil with steam distillation: pulverizing medicinal materials is become coarse powder, add 5 times of water gagings, steam distillation extracted volatile oil 4 hours, got the cycloheptaamylose of 5 times of amounts of volatile oil, 20% ethanol that adds 2 times of cycloheptaamylose amounts, grind to form pasty state, add volatile oil, continue to grind 2 hours, get pastel, cold drying is pulverized, and obtains the volatile oil encapsulation object, and is standby; Extract the medical filtration behind the volatile oil, other usefulness of purchasing;
C: medicinal residues behind the extraction volatile oil and Radix Bupleuri, Radix Codonopsis, Radix Glycyrrhizae decoct secondary, the water that adds for the first time 12 times of amounts, the water that adds for the second time 8 times of amounts, the each decoction 2 hours, collecting decoction filters, filtrate merges with the medicinal liquid that extracts behind the volatile oil, and concentrating and obtaining density is 1.35～1.38 drug extract, standby;
D: the extractum that combining step a and c obtain, decompression or spray drying are pulverized, and obtain extract dry powder;
E: combining step d obtains the volatile oil encapsulation object dry powder that extract powder and step b obtain, and fully mixes, and the mixture that adds dextrin and sugar obtains this product as the adjuvant dry granulation.
Wherein, the ratio of sugar and dextrin is 1: 1 in the adjuvant that uses among this step e, and supplementary product consumption is drug extract powder and volatile oil encapsulation object total amount 1 times.
By the Fructus Citri Sarcodactylis stomach peace granule of method for preparing, made full use of the characteristic of the effective ingredient of the medical material of respectively distinguishing the flavor of, taked different extractions and processing method, kept content of effective to greatest extent.With the peoniflorin is index, adopt the HPLC method to measure the amount of the Radix Paeoniae Alba in this preparation, the result shows the amount that can accurately determine the peoniflorin in the preparation with this method mensuration, determine at last to contain the amount of the Radix Paeoniae Alba in peoniflorin in this preparation, Fructus Citri Sarcodactylis stomach peace granule specification is every bag of 8g, and per 8 its paeoniflorin contents of gram granule are no less than 7.4mg.
The specific embodiment
Embodiment 1:
Extract the Radix Paeoniae Alba, Cortex Magnoliae Officinalis effective ingredient: the Radix Paeoniae Alba 170 grams, Cortex Magnoliae Officinalis 110 grams are ground into coarse powder, add 70% ethanol for the first time and extract 2 hours for 2800 milliliters, reclaim extracting solution; Add 2300 milliliters of extractions of ethanol of 70% more once, the time is 2 hours, reclaims extracting solution; Merge extractive liquid,, concentrate and reclaim ethanol, obtain relative density and be 1.35～1.38 about 70 grams of drug extract, standby.
Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Fructus Amomi, the Rhizoma Atractylodis Macrocephalae (stir-fry), Fructus Citri Sarcodactylis is extracted volatile oil with steam distillation: with Radix Angelicae Sinensis 170 grams, Pericarpium Citri Reticulatae 170 grams, the Rhizoma Atractylodis Macrocephalae (stir-fry) 170 grams, Rhizoma Cyperi 170 grams, Fructus Citri Sarcodactylis 170 grams, Fructus Amomi 170 grams are ground into coarse powder, add 5100 milliliters in water, carry out steam distillation and extract volatile oil, extraction time is 4 hours, 6.6 milliliters of the distillates of collection volatile oil, take 33 gram cycloheptaamyloses, 20% ethanol that adds 66 milliliters, grind to form pasty state, add volatile oil again, continue to grind 2 hours, get about 100 grams of pastel, cold drying is pulverized, obtain about 35 grams of volatile oil encapsulation object, standby, filter distillate simultaneously, obtain medicinal residues and medicinal liquid respectively.
The medicinal residues that extract behind the volatile oil mix decoctions with Radix Bupleuri, Radix Codonopsis, Radix Glycyrrhizae: get Radix Bupleuri 100 grams, Radix Codonopsis 300 grams, Radix Glycyrrhizae 40 restrains and said extracted volatile oil after medicinal residues merging decoction secondary, add for the first time 18000 milliliters in water, add for the second time 12000 milliliters in water, the each decoction 2 hours, the medicinal liquid that collecting decoction filters, obtain with step b again merges and concentrates, obtain density and be 1.35～1.38 about 510 grams of drug extract, standby.
The extractum that combining step a and c obtain, drying under reduced pressure is pulverized, and obtains about 370 grams of extract dry powder;
Combining step d obtains extract powder and step b carries the volatile oil encapsulation object dry powder that obtains behind the oil, fully mixes, and what add dextrine powder 240 grams and sugar 240 grams carries out mixing granulation as adjuvant, obtains about 880 grams of product particle.
Embodiment 2:
Extract the Radix Paeoniae Alba, Cortex Magnoliae Officinalis effective ingredient: the Radix Paeoniae Alba 210 grams, Cortex Magnoliae Officinalis 150 grams are ground into coarse powder, add 70% ethanol for the first time and extract 2 hours for 3600 milliliters, reclaim extracting solution; Add 70% ethanol, 2900 grams again and extract once, the time is 2 hours, reclaims extracting solution; Merge extractive liquid,, concentrate and reclaim ethanol, obtain relative density and be 1.35～1.38 about 96 grams of drug extract, standby;
Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Fructus Amomi, the Rhizoma Atractylodis Macrocephalae (stir-fry), Fructus Citri Sarcodactylis is extracted volatile oil with steam distillation: with Radix Angelicae Sinensis 210 grams, Pericarpium Citri Reticulatae 210 grams, the Rhizoma Atractylodis Macrocephalae (stir-fry) 210 grams, Rhizoma Cyperi 210 grams, Fructus Citri Sarcodactylis 210 grams, Fructus Amomi 210 grams are ground into coarse powder, add 6300 milliliters in water, carry out steam distillation and extract volatile oil, extraction time is 4 hours, collect 8.2 milliliters of volatile oil, take 41 gram cycloheptaamyloses, add 82 milliliters 20% ethanol, grind to form pasty state, add volatile oil again, continue to grind 2 hours, get about 120 grams of pastel, cold drying is pulverized, obtain about 45 grams of volatile oil encapsulation object, standby, filter distillate simultaneously, obtain medicinal residues and medicinal liquid respectively.
The medicinal residues that extract behind the volatile oil mix decoctions with Radix Bupleuri, Radix Codonopsis, Radix Glycyrrhizae: get Radix Bupleuri 150 grams, Radix Codonopsis 350 grams, Radix Glycyrrhizae 80 restrains and said extracted volatile oil after medicinal residues merging decoction secondary, add for the first time 22000 milliliters in water, add for the second time 15000 milliliters in water, the each decoction 2 hours, collecting decoction filters, carry the medicinal liquid that obtains behind the oil with step b again merges and concentrates, obtain density and be 1.35～1.38 about 640 grams of drug extract, standby.
The extractum that combining step a and c obtain, drying under reduced pressure is pulverized, and obtains extract dry powder 460 grams;
Combining step d obtains the volatile oil encapsulation object dry powder that extract powder and step b obtain, and fully mixes, and what add dextrine powder 300 grams and sugar 300 grams carries out mixing granulation as adjuvant, obtains about 1150 grams of product particle.
Embodiment 3:
Extract the Radix Paeoniae Alba, Cortex Magnoliae Officinalis effective ingredient: the Radix Paeoniae Alba 193 grams, Cortex Magnoliae Officinalis 130 grams are ground into coarse powder, add 70% ethanol for the first time and extract 2 hours for 3200 milliliters, reclaim extracting solution; Add 2500 milliliters of extractions of ethanol of 70% more once, the time is 2 hours, reclaims extracting solution; Merge extractive liquid,, concentrate and reclaim ethanol, obtain relative density and be 1.35～1.38 about 70 grams of drug extract, standby;
Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Fructus Amomi, the Rhizoma Atractylodis Macrocephalae (stir-fry), Fructus Citri Sarcodactylis is extracted volatile oil with steam distillation: with Radix Angelicae Sinensis 193 grams, Pericarpium Citri Reticulatae 193 grams, the Rhizoma Atractylodis Macrocephalae (stir-fry) 193 grams, Rhizoma Cyperi 193 grams, Fructus Citri Sarcodactylis 193 grams, Fructus Amomi 193 grams are ground into coarse powder, add 5800 milliliters in water, carry out steam distillation and extract volatile oil, extraction time is 4 hours, 7.5 milliliters of the distillates of collection volatile oil, take 37.5 gram cycloheptaamyloses, 20% ethanol that adds 75 milliliters, grind to form pasty state, add volatile oil again, continue to grind 2 hours, get about 110 grams of pastel, cold drying is pulverized, obtain about 40 grams of volatile oil encapsulation object, standby, filter distillate simultaneously, obtain medicinal residues and medicinal liquid respectively.
The medicinal residues that extract behind the volatile oil mix decoctions with Radix Bupleuri, Radix Codonopsis, Radix Glycyrrhizae: get Radix Bupleuri 130 grams, Radix Codonopsis 323 grams, Radix Glycyrrhizae 66 restrains and said extracted volatile oil after medicinal residues merging decoction secondary, add for the first time 20000 milliliters in water, add for the second time 13500 milliliters in water, the each decoction 2 hours, collecting decoction filters, carry the medicinal liquid that obtains behind the oil with step b again merges and concentrates, obtain density and be 1.35～1.38 about 580 grams of drug extract, standby.
The extractum that combining step a and c obtain, drying under reduced pressure is pulverized, and obtains extract dry powder 420 grams;
Combining step d obtains the volatile oil encapsulation object dry powder that extract powder and step b obtain, and fully mixes, and what add dextrine powder 270 grams and sugar 270 grams carries out mixing granulation as adjuvant, obtains about 1000 grams of product particle.
The invention described above obtains Fructus Citri Sarcodactylis stomach peace granule except reaching the general prescription of granule.Also active constituent content is measured research: be index with the peoniflorin, adopt the HPLC method to measure the amount of the Radix Paeoniae Alba in this preparation, the result shows the amount that can accurately determine the peoniflorin in the preparation with this method mensuration, determine at last to contain the amount of the Radix Paeoniae Alba in peoniflorin in this preparation, Fructus Citri Sarcodactylis stomach peace granule specification is every bag of 8g, and per 8 its paeoniflorin contents of gram finished particle are no less than 7.4mg.
Stability observing: 3 months reserved sample observing methods are measured the preliminarily stabilised of this preparation, and the result shows that this preparation was stable in 3 months, and its long-time stability await further observation.
Antiinflammatory action: the heavy dose of group of Fructus Citri Sarcodactylis stomach peace granule can significantly suppress the mice auricle swelling that caused by dimethylbenzene; The large, medium and small dosage group of Fructus Citri Sarcodactylis stomach peace granule swells to rat granuloma remarkable inhibitory action is arranged.
Analgesic activity: the pain threshold that the large, medium and small dosage group of Fructus Citri Sarcodactylis stomach peace granule can significant prolongation hot plate mice when administration 0.5h, middle dosage group can cause the analgesia incubation period of mice bitterly by significant prolongation acetic acid, and can significantly reduce mice turn round the body number of times, remarkable analgesic activity is arranged.
Effect to intestinal function: the heavy dose of group of Fructus Citri Sarcodactylis stomach peace granule can significantly improve mice charcoal end propelling rate, and can significantly promote in the contraction of body rabbit myenteron; Dosage group big or middle is absorbed with significant facilitation to the rat small intestine xylose.
Effect to gastric emptying: the big or middle dosage group of Fructus Citri Sarcodactylis stomach peace granule can significantly increase the gastric emptying ability of mice.
Effect to the gastritis rat model: the large, medium and small dosage group of Fructus Citri Sarcodactylis stomach peace granule can significantly reduce the gastric acidity and the gastric juice viscosity of gastritis rat model, and the heavy dose of group of peptic activity of stomach that can significantly reduce in the gastritis rat model gastric juice significantly increases the secretory volume of gastrin.
Acute toxicity test: Fructus Citri Sarcodactylis stomach peace granule mice maximum dosage-feeding is 240g/kg, is equivalent to 300 times of people's clinical application amount, illustrates that this product is the less medicine of acute toxicity.
Long term toxicity test: it is one month that the Fructus Citri Sarcodactylis stomach is pacified particulate clinical course of treatment, this experimental observation convalescent period of 3 months long term toxicity of rat continuous use and one month observe.After having observed the long-term gastric infusion of rat, the toxic reaction that the body whole body is produced and the degree of reversibility of reaction.The result shows, 3 months whole bodies of rat continuous use do not have the generation of poisoning, rats eating, movable normal, body weight slightly increases, hematology, serum biochemistry are learned relatively no significant difference (p＞0.05) of each index and organ coefficient and matched group, each medication group internal organs of histopathologic examination and matched group relatively there is no obvious pathomorphology and change, and illustrate that this product is the less medicine of long term toxicity.
Claims (5)
1. a Fructus Citri Sarcodactylis stomach is pacified granule, and it is characterized in that: by following Chinese herbal medicine is that raw material makes: the Radix Paeoniae Alba (stir-fry), Radix Angelicae Sinensis, Radix Bupleuri, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae (stir-fry), Radix Codonopsis, Rhizoma Cyperi, Fructus Citri Sarcodactylis, Cortex Magnoliae Officinalis, Fructus Amomi, Radix Glycyrrhizae.
2. Fructus Citri Sarcodactylis stomach peace granule according to claim 1, it is characterized in that: the ratio of each Chinese medicine of distinguishing the flavor of is:
170～210 parts of the Radix Paeoniae Albas (stir-fry)
170～210 parts of Radix Angelicae Sinensis
100～150 parts of Radix Bupleuri
170～210 parts of Pericarpium Citri Reticulataes
170～210 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry)
300～350 parts of Radix Codonopsis
170～210 parts of Rhizoma Cyperis
170～210 parts of Fructus Citri Sarcodactylis
110～150 parts of Cortex Magnoliae Officinalis
170～210 parts of Fructus Amomis
40～80 parts in Radix Glycyrrhizae
3. Fructus Citri Sarcodactylis stomach peace granule according to claim 2, it is characterized in that: the ratio of each Chinese medicine of distinguishing the flavor of is:
193 parts of the Radix Paeoniae Albas (stir-fry)
193 parts of Radix Angelicae Sinensis
130 parts of Radix Bupleuri
193 parts of Pericarpium Citri Reticulataes
193 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry)
323 parts of Radix Codonopsis
193 parts of Rhizoma Cyperis
193 parts of Fructus Citri Sarcodactylis
130 parts of Cortex Magnoliae Officinalis
193 parts of Fructus Amomis
66 parts in Radix Glycyrrhizae
4. a claim 1,2 or 3 described Fructus Citri Sarcodactylis stomaches are pacified particulate preparation method, it is characterized in that may further comprise the steps:
A: extract the Radix Paeoniae Alba, Cortex Magnoliae Officinalis effective ingredient: take the Radix Paeoniae Alba, Cortex Magnoliae Officinalis is ground into coarse powder, add 70% ethanol extraction 2 times, add for the first time 10 times of amounts, add for the second time 8 times of amounts, the each extraction 2 hours, merge extractive liquid,, concentrate and reclaim ethanol, obtain relative density and be 1.35～1.38 drug extract, standby;
B: Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Fructus Amomi, the Rhizoma Atractylodis Macrocephalae (stir-fry), Fructus Citri Sarcodactylis are extracted volatile oil with steam distillation: pulverizing medicinal materials is become coarse powder, add 5 times of water gagings, steam distillation extracted volatile oil 4 hours, got the cycloheptaamylose of 5 times of amounts of volatile oil, 20% ethanol that adds 2 times of cycloheptaamylose amounts, grind to form pasty state, add volatile oil, continue to grind 2 hours, get pastel, cold drying is pulverized, and obtains the volatile oil encapsulation object, and is standby; Extract the medical filtration behind the volatile oil, other usefulness of purchasing;
C: medicinal residues behind the extraction volatile oil and Radix Bupleuri, Radix Codonopsis, Radix Glycyrrhizae decoct secondary, the water that adds for the first time 12 times of amounts, the water that adds for the second time 8 times of amounts, the each decoction 2 hours, collecting decoction filters, filtrate merges with the medicinal liquid that extracts behind the volatile oil, and concentrating and obtaining density is 1.35～1.38 drug extract, standby;
D: the extractum that combining step a and c obtain, decompression or spray drying are pulverized, and obtain extract dry powder;
E: combining step d obtains the volatile oil encapsulation object dry powder that extract powder and step b obtain, and fully mixes, and the mixture that adds dextrin and sugar obtains this product as the adjuvant dry granulation.
5. Fructus Citri Sarcodactylis stomach according to claim 4 is pacified particulate preparation method, it is characterized in that: the ratio of sugar and dextrin is 1: 1 in the adjuvant that uses among this step e, and supplementary product consumption is drug extract powder and volatile oil encapsulation object total amount 1 times.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181451B (en) * | 2007-11-21 | 2010-06-09 | 宋敏 | Chinese medicine prescription orally taken for curing chronic atrophic gastritis |
| CN101244248B (en) * | 2008-02-02 | 2010-08-04 | 孟德芹 | Method of preparing traditional Chinese medicine for treating chronic superficial gastritis |
| CN104383422A (en) * | 2014-12-09 | 2015-03-04 | 中国人民解放军第五医院 | Chinese patent medicine for treating chronic gastritis and preparation method thereof |
| CN105267864A (en) * | 2015-10-16 | 2016-01-27 | 施君平 | Traditional Chinese medicine preparation for treating chronic gastritis and method for preparing traditional Chinese medicine preparation |
-
2003
- 2003-09-18 CN CN 03157338 patent/CN1218741C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181451B (en) * | 2007-11-21 | 2010-06-09 | 宋敏 | Chinese medicine prescription orally taken for curing chronic atrophic gastritis |
| CN101244248B (en) * | 2008-02-02 | 2010-08-04 | 孟德芹 | Method of preparing traditional Chinese medicine for treating chronic superficial gastritis |
| CN104383422A (en) * | 2014-12-09 | 2015-03-04 | 中国人民解放军第五医院 | Chinese patent medicine for treating chronic gastritis and preparation method thereof |
| CN105267864A (en) * | 2015-10-16 | 2016-01-27 | 施君平 | Traditional Chinese medicine preparation for treating chronic gastritis and method for preparing traditional Chinese medicine preparation |
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| Publication number | Publication date |
|---|---|
| CN1218741C (en) | 2005-09-14 |
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