CN1201782C - Medicine composition for treating mammary gland proliferation, and its prepn. method - Google Patents
Medicine composition for treating mammary gland proliferation, and its prepn. method Download PDFInfo
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- CN1201782C CN1201782C CNB021534586A CN02153458A CN1201782C CN 1201782 C CN1201782 C CN 1201782C CN B021534586 A CNB021534586 A CN B021534586A CN 02153458 A CN02153458 A CN 02153458A CN 1201782 C CN1201782 C CN 1201782C
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- 239000003814 drug Substances 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 title claims description 16
- 229940079593 drug Drugs 0.000 title claims description 11
- 210000005075 mammary gland Anatomy 0.000 title abstract description 12
- 230000035755 proliferation Effects 0.000 title 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 11
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- 241000207929 Scutellaria Species 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 16
- 241000522620 Scorpio Species 0.000 claims description 15
- 239000000706 filtrate Substances 0.000 claims description 15
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 239000009490 scorpio Substances 0.000 claims description 12
- 239000012141 concentrate Substances 0.000 claims description 10
- 230000006837 decompression Effects 0.000 claims description 10
- 241001250596 Pleione Species 0.000 claims description 7
- 239000006071 cream Substances 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 239000000796 flavoring agent Substances 0.000 claims description 5
- 235000019634 flavors Nutrition 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 238000004321 preservation Methods 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- 235000019640 taste Nutrition 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 4
- 239000008107 starch Substances 0.000 claims description 4
- 241001523579 Ostrea Species 0.000 claims description 3
- 239000000890 drug combination Substances 0.000 claims 2
- 229920001353 Dextrin Polymers 0.000 claims 1
- 239000004375 Dextrin Substances 0.000 claims 1
- 241001529739 Prunella <angiosperm> Species 0.000 claims 1
- 241001530126 Scrophularia Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 235000019425 dextrin Nutrition 0.000 claims 1
- 206010020718 hyperplasia Diseases 0.000 abstract description 5
- 244000161999 Acacia greggii Species 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 241000512259 Ascophyllum nodosum Species 0.000 abstract 1
- 241000481604 Bolbostemma Species 0.000 abstract 1
- 241000202726 Bupleurum Species 0.000 abstract 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 1
- 244000150195 Cyperus longus Species 0.000 abstract 1
- 235000018109 Cyperus longus Nutrition 0.000 abstract 1
- 244000075634 Cyperus rotundus Species 0.000 abstract 1
- 241000766380 Iphigenia Species 0.000 abstract 1
- 240000005001 Paeonia suffruticosa Species 0.000 abstract 1
- 235000003889 Paeonia suffruticosa Nutrition 0.000 abstract 1
- 241000218206 Ranunculus Species 0.000 abstract 1
- 244000081426 Ranunculus ficaria Species 0.000 abstract 1
- 235000002226 Ranunculus ficaria Nutrition 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 235000005010 Scirpus paludosus Nutrition 0.000 abstract 1
- 241000239226 Scorpiones Species 0.000 abstract 1
- 235000008326 Trichosanthes anguina Nutrition 0.000 abstract 1
- 244000078912 Trichosanthes cucumerina Species 0.000 abstract 1
- 235000004608 catclaw acacia Nutrition 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 235000005412 red sage Nutrition 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 229920002307 Dextran Polymers 0.000 description 4
- 206010020880 Hypertrophy Diseases 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 3
- 230000000202 analgesic effect Effects 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 210000002445 nipple Anatomy 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 239000000583 progesterone congener Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 210000002027 skeletal muscle Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 208000000114 Pain Threshold Diseases 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 230000002443 hepatoprotective effect Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 230000037040 pain threshold Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a medicine composition for treating the hyperplasia of mammary glands, which is characterized in that the medicine composition is prepared from (portions by weight) 42 to 126 portions of stir-fried bupleurum root, 42 to 126 portions stir-baked radix paeoniae alba, 32 to 96 portions of stir-fried nutgrass galingale rhizome, 42 to 126 portions of figwort root, 53 to 158 portions of kelp, 32 to 96 portions of snakegourd fruit, 53 to 158 portions of spica prunellae, 42 to 126 portions of oyster shell, 32 to 96 portions of Chinese angelica root, 42 to 126 portions of catclaw buttercup root, 32 to 96 portions of scutellaria root, 42 to 126 portions of red sage root, 21 to 63 portions of paniculate bolbostemma, 11 to 32 portions of Indian iphigenia bulb, 11 to 32 portions scorpion and 42 to 126 portions of tree peony bark. The present invention also discloses a preparation method of the medicine composition for treating the hyperplasia of mammary glands.
Description
The present invention relates to a kind of pharmaceutical composition for the treatment of cyclomastopathy and preparation method thereof.
Cyclomastopathy is with periodically disorder of hormone secretion or mammary gland tissue sensitivity increase relevant.Though the ununified at present classification therapy method of the traditional Chinese medical science, what it is generally acknowledged the cyclomastopathy morbidity is deficiency of kidney-QI at all, Chong and Ren channel disorder.Adopting methods such as dispersing the stagnated live-QI to relieve the stagnation of QI, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, the kidney invigorating accent dash in the treatment, or the single usefulness of a method, or the number method is share.We collection is soothing the liver, the nourishing the liver hepatoprotective, reduce phlegm, invigorate blood circulation, number method such as hard masses softening and resolving share, and catches the pathogenesis key of primary disease, is the good recipe for the treatment of cyclomastopathy.
The object of the invention is to provide a kind of pharmaceutical composition and preparation method thereof of the treatment cyclomastopathy that has no side effect of evident in efficacy, taking convenience.
Technical solution of the present invention is achieved in that
Bulk drugs as described below:
Process 32～96 parts of 42～126 parts of prepared RHIZOMA CYPERIs of 42～126 parts of Radix Paeoniae Alba (parched)s of Radix Bupleuri
32～96 parts of 53～158 parts of Fructus Trichosanthis of 42～126 parts of Thallus Laminariae (Thallus Eckloniae)s of Radix Scrophulariae
32～96 parts of 42～126 parts of Radix Angelicae Sinensis of 53～158 portions of Concha Ostreaes of Spica Prunellae
42～126 parts of 32～96 parts of Radix Salviae Miltiorrhizaes of 42～126 parts of Radix Scutellariaes of Radix Ranunculi Ternati
11～32 parts of 11～32 portions of Scorpios of 21～63 parts of Pseudobulbus Cremastrae Seu Pleioness of Rhizoma Bolbostematis
42～126 parts of Cortex Moutans
Get Rhizoma Cyperi, Scorpio, Cortex Moutan three flavors, be ground into fine powder, standby; Get Radix Bupleuri, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Salviae Miltiorrhizae, the Rhizoma Bolbostematis five tastes, add 40～80% alcohol reflux 2～3 times, each 1～3 hour, filter, filtrate decompression concentrates, and clear paste is standby; Other gets Radix Paeoniae Alba (parched), Thallus Laminariae (Thallus Eckloniae), Fructus Trichosanthis, Spica Prunellae, Concha Ostreae, Radix Ranunculi Ternati, Radix Scutellariae, Pseudobulbus Cremastrae Seu Pleiones, decocts with water 2～3 times, and 1～3 hour for the first time, 0.5～2 hour for the second time, filter, filtrate merges, and concentrating under reduced pressure, gained clear paste add ethanol to be made and contain the alcohol amount and reach 50%, cold preservation 12～48 hours filters, and filtrate decompression concentrates, add above-mentioned clear paste, and continue to be condensed into thick paste, drying under reduced pressure, dried cream powder is broken, is blended into Rhizoma Cyperi, Scorpio, Cortex Moutan fine powder, mixing, add starch, incapsulate, promptly.
Through laboratory observation, take pharmaceutical composition of the present invention in advance and make rat mammary gland model of hyperplasia hypertrophy situation obviously lighter, the hypertrophy of the nipple redness of gross examination of skeletal muscle, mammary gland increase and microexamination lobule, acinus and conduit, also obviously lighter, preventive effect is arranged; The rat mammary gland hypertrophy all there is the obvious treatment effect, each treatment group mammary gland swelling and dissect being seen cardinal principle classification and micro-classification all significantly is better than model group and therapeutical effect and is the dose-effect dependency; The mice hyperplasia of mammary gland model also had significantly alleviate effect, and can obviously dwindle the mice breast diameter.And analgesic activity is arranged.Influence and matched group difference to rat TSOD and CAT do not have clear meaning; Low to MDA than matched group, but no difference of science of statistics; Significantly increase GSH-Px is active.
Pharmaceutical composition of the present invention has dispersing the stagnated live-QI to relieve the stagnation of QI, eleminating phlegm and freeing channels, and effects such as promoting blood circulation and stopping pain can be used for become silted up cyclomastopathy due to the cohesion of stagnation of QI due to depression of the liver, expectorant, treatment of conditions such as distending pain of the breast.
Experimental example 1: the prevention administration is to the effect of cyclomastopathy
Get 50 of female rats, be divided into 5 groups at random, be respectively blank group, model control group, test high dose group, test low dose group and positive control drug group by body weight.Animal is surgical removal bilateral ovaries behind etherization in advance.Postoperative rose on the 4th day, and lumbar injection estrogen continuous 25 days, gave progestogen subsequently again and caused hyperplasia of mammary gland model every day.Make film simultaneously, what give oral various dose is subjected to reagent thing or control drug.Observe outgrowth incidence rate of animal's mammary gland and pathologic finding situation.The result, compare with model group, the preventative animal that gives this product extractum 1g crude drug/kg or 3g crude drug/kg in female, the progestogen of injection, the cyclomastopathy incidence rate all significantly reduces, the nipple redness of pathologic finding gross examination of skeletal muscle, mammary gland increases and the hypertrophy of microexamination lobule, acinus and conduit, also obviously lighter, show that pharmaceutical composition of the present invention has the effect of treatment cyclomastopathy.
Experimental example 2: to the therapeutical effect of blood stasis model due to the rabbit dextran
Healthy female rabbit, auricular vein are injected 10% dextran 5ml/kg, every day 2 times, and continuous 2 days, cause the blood stasis model, measure last and inject back 15 minutes animal blood viscosities.Same animal begins the extract powder 2g crude drug/kg or the 5g crude drug/kg of oral administration gavage pharmaceutical composition of the present invention after 1 week, continuous 5 days, dextran was injected in administration in the 4th and 5 day again after 30 minutes, and method is the same, measures back 15 minutes animal blood viscosities of injection.The result shows, pharmaceutical composition of the present invention has whole blood viscosity and the plasma viscosity effect of animal due to the remarkable reduction high molecular dextran.This results suggest pharmaceutical composition of the present invention has certain blood circulation-promoting functions.
Experimental example 3: analgesic activity
Adopt the hot-plate analgesic test, the result shows: but pharmaceutical composition of the present invention 0.5,1.5,3g crude drug/kg dosage equal significant prolongation mice response latency bitterly down, pain threshold all is significantly increased.
Embodiment 1:
Process Radix Bupleuri 84g Radix Paeoniae Alba (parched) 84g prepared RHIZOMA CYPERI 63g Radix Scrophulariae 84g
Thallus Laminariae (Thallus Eckloniae) 105g Fructus Trichosanthis 63g Spica Prunellae 105g Concha Ostreae 84g
Radix Angelicae Sinensis 63g Radix Ranunculi Ternati 84g Radix Scutellariae 63g Radix Salviae Miltiorrhizae 84g
Rhizoma Bolbostematis 42g Pseudobulbus Cremastrae Seu Pleiones 21g Scorpio 21g Cortex Moutan 84g
Get Rhizoma Cyperi, Scorpio, Cortex Moutan three flavors, be ground into fine powder, standby; Get Radix Bupleuri, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Salviae Miltiorrhizae, the Rhizoma Bolbostematis five tastes, add 60% alcohol reflux secondary, each 1.5 hours, filter, filtrate decompression concentrates, and clear paste is standby; Other gets and fries Radix Paeoniae Alba, Thallus Laminariae (Thallus Eckloniae), Fructus Trichosanthis, Spica Prunellae, Concha Ostreae, Radix Ranunculi Ternati, Radix Scutellariae, Pseudobulbus Cremastrae Seu Pleiones, decocts with water secondary, 1.5 hours for the first time, 1.0 hours for the second time, filter, filtrate merges, concentrating under reduced pressure, the gained clear paste adds ethanol to be made and contains alcohol amount and reach 50%, cold preservation 24 hours filters, and filtrate decompression concentrates, add above-mentioned clear paste, and continue to be condensed into thick paste, and drying under reduced pressure, dried cream powder is broken, be blended into Rhizoma Cyperi, Scorpio, Cortex Moutan fine powder, mixing adds starch to 400g, incapsulates, make 1000, promptly.
Embodiment 2:
Process Radix Bupleuri 100g Radix Paeoniae Alba (parched) 100g prepared RHIZOMA CYPERI 80g Radix Scrophulariae 100g
Thallus Laminariae (Thallus Eckloniae) 120g Fructus Trichosanthis 80g Spica Prunellae 120g Concha Ostreae 100g
Radix Angelicae Sinensis 80g Radix Ranunculi Ternati 100g Radix Scutellariae 80g Radix Salviae Miltiorrhizae 100g
Rhizoma Bolbostematis 50g Pseudobulbus Cremastrae Seu Pleiones 25g Scorpio 25g Cortex Moutan 100g
Get Rhizoma Cyperi, Scorpio, Cortex Moutan three flavors, be ground into fine powder, standby; Get Radix Bupleuri, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Salviae Miltiorrhizae, the Rhizoma Bolbostematis five tastes, add 60% alcohol reflux secondary, each 1.5 hours, filter, filtrate decompression concentrates, and clear paste is standby; Other gets Radix Paeoniae Alba (parched), Thallus Laminariae (Thallus Eckloniae), Fructus Trichosanthis, Spica Prunellae, Concha Ostreae, Radix Ranunculi Ternati, Radix Scutellariae, Pseudobulbus Cremastrae Seu Pleiones, decocts with water secondary, 1.5 hours for the first time, 1.0 hours for the second time, filter, filtrate merges, concentrating under reduced pressure, the gained clear paste adds ethanol to be made and contains alcohol amount and reach 50%, cold preservation 24 hours filters, and filtrate decompression concentrates, add above-mentioned clear paste, and continue to be condensed into thick paste, and drying under reduced pressure, dried cream powder is broken, be blended into Rhizoma Cyperi, Scorpio, Cortex Moutan fine powder, mixing adds starch to 400g, incapsulates, make 1000, promptly.
Claims (4)
1, a kind of pharmaceutical composition for the treatment of cyclomastopathy, it is characterized in that: this pharmaceutical composition is made by following bulk drugs:
Process 100 parts of 80 portions of Radix Scrophulariaes of 100 parts of prepared RHIZOMA CYPERIs of 100 parts of Radix Paeoniae Alba (parched)s of Radix Bupleuri
100 parts of 120 portions of Concha Ostreaes of 80 parts of Spica Prunellaes of 120 parts of Fructus Trichosanthis of Thallus Laminariae (Thallus Eckloniae)
100 parts of 80 parts of Radix Salviae Miltiorrhizaes of 100 parts of Radix Scutellariaes of 80 portions of Radix Ranunculi Ternatis of Radix Angelicae Sinensis
100 parts of 25 parts of Cortex Moutans of 25 portions of Scorpios of 50 parts of Pseudobulbus Cremastrae Seu Pleioness of Rhizoma Bolbostematis.
2, according to the described a kind of pharmaceutical composition for the treatment of cyclomastopathy of claim 1, it is characterized in that: this pharmaceutical composition is made by following bulk drugs:
Process 63 parts of 84 parts of prepared RHIZOMA CYPERIs of 84 parts of Radix Paeoniae Alba (parched)s of Radix Bupleuri
63 parts of 105 parts of Fructus Trichosanthis of 84 parts of Thallus Laminariae (Thallus Eckloniae)s of Radix Scrophulariae
63 parts of 84 parts of Radix Angelicae Sinensis of 105 portions of Concha Ostreaes of Spica Prunellae
84 parts of 63 parts of Radix Salviae Miltiorrhizaes of 84 parts of Radix Scutellariaes of Radix Ranunculi Ternati
21 parts of 21 portions of Scorpios of 42 parts of Pseudobulbus Cremastrae Seu Pleioness of Rhizoma Bolbostematis
84 parts of Cortex Moutans.
3, a kind of preparation of drug combination method for the treatment of cyclomastopathy as claimed in claim 1 or 2 is characterized in that this method is: gets Rhizoma Cyperi, Scorpio, Cortex Moutan three flavors, is ground into fine powder, and standby; Get Radix Bupleuri, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Salviae Miltiorrhizae, the Rhizoma Bolbostematis five tastes, add 40～80% alcohol reflux 2～3 times, each 1～3 hour, filter, filtrate decompression concentrates, and clear paste is standby; Other gets Radix Paeoniae Alba (parched), Thallus Laminariae (Thallus Eckloniae), Fructus Trichosanthis, Spica Prunellae, Concha Ostreae, Radix Ranunculi Ternati, Radix Scutellariae, Pseudobulbus Cremastrae Seu Pleiones, decocts with water 2～3 times, and 1～3 hour for the first time, 0.5～2 hour for the second time, filter, filtrate merges, and concentrating under reduced pressure, gained clear paste add ethanol to be made and contain the alcohol amount and reach 50%, cold preservation 12～48 hours filters, and filtrate decompression concentrates, add above-mentioned clear paste, and continue to be condensed into thick paste, drying under reduced pressure, dried cream powder is broken, is blended into Rhizoma Cyperi, Scorpio, Cortex Moutan fine powder, mixing, add adjuvant, incapsulate, promptly.
4, according to the described a kind of preparation of drug combination method for the treatment of cyclomastopathy of claim 3, it is characterized in that this method is: get Rhizoma Cyperi, Scorpio, Cortex Moutan three flavors, be ground into fine powder, standby; Get Radix Bupleuri, Radix Angelicae Sinensis, Radix Scrophulariae, Radix Salviae Miltiorrhizae, the Rhizoma Bolbostematis five tastes, add 60% alcohol reflux secondary, each 1.5 hours, filter, filtrate decompression concentrates, and clear paste is standby; Other gets Radix Paeoniae Alba (parched), Thallus Laminariae (Thallus Eckloniae), Fructus Trichosanthis, Spica Prunellae, Concha Ostreae, Radix Ranunculi Ternati, Radix Scutellariae, Pseudobulbus Cremastrae Seu Pleiones, decocts with water secondary, and 1.5 hours for the first time, 1.0 hours for the second time, filter, filtrate merges, and concentrating under reduced pressure, gained clear paste add ethanol to be made and contain the alcohol amount and reach 50%, cold preservation 24 hours filters, and filtrate decompression concentrates, add above-mentioned clear paste, and continue to be condensed into thick paste, drying under reduced pressure, dried cream powder is broken, is blended into Rhizoma Cyperi, Scorpio, Cortex Moutan fine powder, mixing, add starch or dextrin, incapsulate, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021534586A CN1201782C (en) | 2002-11-29 | 2002-11-29 | Medicine composition for treating mammary gland proliferation, and its prepn. method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021534586A CN1201782C (en) | 2002-11-29 | 2002-11-29 | Medicine composition for treating mammary gland proliferation, and its prepn. method |
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| Publication Number | Publication Date |
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| CN1418683A CN1418683A (en) | 2003-05-21 |
| CN1201782C true CN1201782C (en) | 2005-05-18 |
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| Application Number | Title | Priority Date | Filing Date |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100369626C (en) * | 2006-04-04 | 2008-02-20 | 聂秀英 | Traditional Chinese medicine capsule for treating mammary gland diseases |
| CN100396326C (en) * | 2006-04-05 | 2008-06-25 | 山东中医药大学附属医院 | Mastoproliferation treating medicine and its preparing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100358493C (en) * | 2004-03-17 | 2008-01-02 | 咸阳步长医药科技发展有限公司 | Chinese medica preparation for curing hyperplasia of mammary glands and preparation method |
| CN100420480C (en) * | 2004-06-01 | 2008-09-24 | 闫丽娟 | Pillows for mastosis, e.g., hyperplasia, tumours and other diseases |
| CN1299736C (en) * | 2004-07-26 | 2007-02-14 | 耿新生 | Chinese medicine capsule for treating hyperplasia of mammary glands and its producing method |
| CN100352483C (en) * | 2005-04-28 | 2007-12-05 | 李建柱 | Externally applied medicine for treating mammary glands hyperplasia and preventing mammary cancer |
| CN100350888C (en) * | 2005-09-21 | 2007-11-28 | 灵宝市商业医院 | Thermotherapy bag for treating galactophore hyperplasia |
| CN101244177B (en) * | 2008-03-21 | 2010-06-23 | 朱霞 | Rupisan medicine and preparation thereof |
| CN102178896B (en) * | 2011-04-28 | 2012-09-05 | 时红霞 | Traditional Chinese medicine composition for treating breast hyperplasia and preparation method of composition |
| CN102319362B (en) * | 2011-09-23 | 2013-04-10 | 陕西步长高新制药有限公司 | Traditional Chinese medicine preparation for treating hyperplasia of mammary glands and preparation method thereof |
| CN102319361B (en) * | 2011-09-23 | 2013-06-12 | 陕西步长高新制药有限公司 | Traditional Chinese medicine preparation for treating hyperplasia of mammary glands and preparation method thereof |
| CN102319360B (en) * | 2011-09-23 | 2013-07-17 | 陕西步长高新制药有限公司 | Traditional Chinese medicine composition used for treating mammary gland hyperplasia, and preparation method thereof |
| CN103142852A (en) * | 2011-11-01 | 2013-06-12 | 邓永峰 | Pharmaceutical composition for treating breast hyperplasia and method for preparing same |
-
2002
- 2002-11-29 CN CNB021534586A patent/CN1201782C/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100369626C (en) * | 2006-04-04 | 2008-02-20 | 聂秀英 | Traditional Chinese medicine capsule for treating mammary gland diseases |
| CN100396326C (en) * | 2006-04-05 | 2008-06-25 | 山东中医药大学附属医院 | Mastoproliferation treating medicine and its preparing method |
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| Publication number | Publication date |
|---|---|
| CN1418683A (en) | 2003-05-21 |
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