CN111773330A

CN111773330A - Traditional Chinese medicine composition for treating Parkinson's disease and preparation method thereof

Info

Publication number: CN111773330A
Application number: CN202010553630.7A
Authority: CN
Inventors: 高筱雅; 崔美琪; 梁晓媚
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-06-17
Filing date: 2020-06-17
Publication date: 2020-10-16

Abstract

The invention discloses a traditional Chinese medicine composition for treating Parkinson's disease and a preparation method thereof, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 15-30 parts of tortoise plastron, 1-3 parts of pilose antler, 12-15 parts of sea cucumber, 20-50 parts of egg yolk, 12-24 parts of wine-processed angelica, 12-15 parts of white peony root, 12-15 parts of cistanche, 10-12 parts of American ginseng, 15-30 parts of astragalus, 12-20 parts of bighead atractylodes rhizome, 12-15 parts of poria, 6-10 parts of rhizoma pinellinae praeparata, 20-30 parts of bamboo juice, 12-15 parts of gastrodia elata, 10-15 parts of uncaria, 15-30 parts of oyster, 4-6 parts of schisandra chinensis, 8-10 parts of rhizoma acori graminei, 6-10 parts of polygala tenuifolia, 2-5 parts of scorpion, 1-3 parts of centipede, 3-6 parts of earthworm, 12-15 parts of pawpaw, 15-24 parts of radix puerariae and 10-15 parts of radix achyranth. The traditional Chinese medicine composition can improve the motor symptoms and non-motor symptoms of the Parkinson's disease, has no obvious toxic or side effect and the like, adopts the rule of nourishing brain, calming wind and relieving spasm and takes medicines according to symptoms to achieve the curative effect of effectively treating the Parkinson's disease; in addition, the monarch, minister, assistant and guide medicines in the compatibility can treat the Parkinson's disease in a multi-target and multi-level manner, have remarkable treatment effect, are suitable for long-term administration, and have good application prospect.

Description

Traditional Chinese medicine composition for treating Parkinson's disease and preparation method thereof

Technical Field

The invention relates to the technical field of medicines, in particular to a traditional Chinese medicine composition for treating Parkinson's disease and a preparation method thereof.

Background

Parkinson's Disease (PD) is the second most degenerative Disease of the nervous system, the annual incidence rate is about 362/10 ten thousands, and in 2005, Parkinson's Disease patients reach 200 thousands of people [1], which brings a heavy medical burden to the society. The typical pathological changes in parkinson's disease are the formation of lewy bodies within neurons and the progressive loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain, and thus, protection of dopaminergic neurons, reduction of dopaminergic neuron apoptosis and loss are fundamental means of delaying disease progression. However, current clinical treatment of parkinson's disease only improves symptoms and does not reduce neuronal apoptosis and loss.

Typical symptoms of Parkinson's disease are myotonia, bradykinesia, resting tremor, and non-motor symptoms such as olfactory loss, sleep disorders, constipation, depression, etc., and are sensitive to dopa preparations. The characteristic pathological changes are the formation of lewy bodies in neurons and the progressive loss of nigral dopaminergic neurons.

The Chinese medicine considers that the human body movement regulation function is closely related to the functions of kidney, liver, heart and brain. The substantia nigra neurons are the central nervous system, and when the essence of the substantia nigra neurons is nourished by kidney essence, kidney water is deficient, kidney essence is deficient, and brain and marrow are not nourished, the substantia nigra neurons gradually degenerate and reduce, denature and necrotize, and the corresponding parts of the midbrain naturally become light black. The substantia nigra neurons synthesize dopamine, as if the kidney essence transforms into blood, to nourish the liver meridian. The liver is nourished by blood, and has soft nature, if the degeneration of the substantia nigra neurons is reduced, the synthesized dopamine is also reduced, and the excess is the deficiency of kidney essence and the blood transformation failure of essence, so that the liver blood deficiency is less, the liver is used too strongly, and the liver is too loose and over-drained, the liver yang is excessive, and the liver wind moves inwards; in addition, the deficiency of the kidney fails to transform qi and promote diuresis, and the liver deficiency fails to dredge qi and causes phlegm-dampness accumulation and qi and blood stasis. Thereby forming pathological products of wind-phlegm-dampness-stasis, disturbing the upper-jiao clear, disturbing the brain collaterals and obstructing the channels, muscles and bones. Wind-phlegm-dampness-stasis can be disturbed, so abnormal deposition of protein in brain can be seen. The liver stores blood, mainly regulates and relieves diarrhea, has yin and soft body, uses yang and hard body, and is full of liver blood, so that meridians and bones can be nourished, thereby ensuring flexible limbs and movement; if the liver blood is deficient and the meridians and bones fail to nourish, it will be spasm and stiffness and inflexible. Liver governing wind, "all wind falling dizziness and falling dizziness all belong to liver", wind phlegm dampness stasis, cross-talk in channels and collaterals, and obstruction of muscles and bones to cause tremor of limbs, and spasm, rigidity and straightness.

Parkinson's disease is based on pathological changes in the kidney, liver, heart and brain, and its etiology is multiple. Congenital deficiency, acquired recuperation, environmental pollution and poisoning, emotional disorders regulating fire, which can lead to deficiency of essence and marrow, imbalance of yin and yang, wind-fire phlegm stasis, obstruction of brain collaterals. The brain collaterals failing to dredge the orifices cause the five viscera and six fu organs, limbs and bones, muscles and bones failing to nourish and wind phlegm dampness and blood stasis. Wind-phlegm stasis obstructing the meridians and collaterals may cause stiffness of the limbs, tremor, dizziness, and miliaria and aphonia, leading to this disease. The disease is characterized by deficiency of origin and excess, deficiency of essence and blood of liver and kidney, wind-fire, phlegm-dampness and blood stasis, obstruction of brain collaterals and orifices, and disharmony of muscles and bones. It has some similarities with the symptoms of tremor, aphonia and convulsion of traditional Chinese medicine. The deficiency of kidney essence is the origin of this disease, but kidney essence can generate yin and yang because kidney is the house of water and fire, so its pathogenesis is not exterior to yin and yang. Or yin and blood deficiency mainly accompanied by yang deficiency, and pathogenic heat transforming to form yin deficiency with stirring wind, phlegm fire with blood stasis heat, and obstruction of brain collaterals; or yang qi deficiency mainly accompanied by yin blood deficiency, and pathogenic cold transformation, resulting in spleen and kidney yang qi deficiency, phlegm-fluid retention and damp turbidity, blood stasis and brain collateral stagnation. For both yin and yang syndromes, the key pathogenesis is essence and blood deficiency, yang qi deficiency, brain and marrow attenuation, wind phlegm and dampness stasis, and obstruction of brain collaterals.

At present, compound levodopa preparations, dopa receptor agonists, COMT enzyme inhibitors, MAOB inhibitors, amantadine, cholinergic inhibitors and the like are mainly adopted for treating PD in western medicine, the medicines can only temporarily improve symptoms, but do not have disease modification effect, the disease course progress cannot be delayed, the curative effect of the medicines is progressively reduced along with the disease course progress, and complications and side effects caused by the medicines gradually appear. Because the pathological changes of the kidney, the liver, the heart and the brain are the basis of the Parkinson's disease, and the etiology is multivariate, the traditional Chinese medicine composition can treat the PD at multiple targets and multiple levels.

The above background disclosure is only for the purpose of assisting understanding of the inventive concept and technical solutions of the present invention, and does not necessarily belong to the prior art of the present patent application, and should not be used for evaluating the novelty and inventive step of the present application in the case that there is no clear evidence that the above content is disclosed at the filing date of the present patent application.

Disclosure of Invention

In view of the defects in the aspect of the current Parkinson disease treatment, the invention provides a traditional Chinese medicine composition for treating Parkinson disease and a preparation method thereof through long-term tests and clinical tests. The medicine has remarkable curative effect on PD, and has high safety and no toxic or side effect.

In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:

in a first aspect, the invention provides a traditional Chinese medicine composition for treating Parkinson's disease, which is prepared from the following raw material medicines in parts by weight: 15-30 parts of tortoise plastron, 1-3 parts of pilose antler, 12-15 parts of sea cucumber, 20-50 parts of egg yolk, 12-24 parts of wine-processed angelica, 12-15 parts of white peony root, 12-15 parts of cistanche, 10-12 parts of American ginseng, 15-30 parts of astragalus, 12-20 parts of bighead atractylodes rhizome, 12-15 parts of poria, 6-10 parts of rhizoma pinellinae praeparata, 20-30 parts of bamboo juice, 12-15 parts of gastrodia elata, 10-15 parts of uncaria, 15-30 parts of oyster, 4-6 parts of schisandra chinensis, 8-10 parts of rhizoma acori graminei, 6-10 parts of polygala tenuifolia, 2-5 parts of scorpion, 1-3 parts of centipede, 3-6 parts of earthworm, 12-15 parts of pawpaw, 15-24 parts of radix puerariae and 10-15 parts of radix achyranth.

Preferably, the pilose antler, the sea cucumber, the American ginseng, the scorpion, the centipede and the earthworm are powder medicines. The tortoise plastron and the oyster are decocted first. The egg yolk and the uncaria are used as the medicines for the next time.

Preferably, the traditional Chinese medicine composition for treating the Parkinson disease is prepared from the following raw material medicines in parts by weight: 24 parts of tortoise plastron, 1 part of pilose antler, 12 parts of sea cucumber, 30 parts of egg yolk, 12 parts of wine-processed Chinese angelica, 15 parts of white paeony root, 12 parts of desertliving cistanche, 12 parts of American ginseng, 15 parts of astragalus, 15 parts of largehead atractylodes rhizome, 12 parts of poria, 8 parts of rhizoma pinellinae praeparata, 30 parts of succus bambusae, 15 parts of tall gastrodia tuber, 10 parts of uncaria, 20 parts of oyster, 4 parts of schisandra chinensis, 8 parts of grassleaf sweelflag rhizome, 6 parts of thinleaf milkwort root-bark, 3 parts of scorpion, 2 parts of centipede, 6 parts of earthworm, 12 parts of pawpaw, 20 parts of.

Preferably, the traditional Chinese medicine composition for treating the Parkinson disease is prepared from the following raw material medicines in parts by weight: 28 parts of tortoise plastron, 2 parts of pilose antler, 12 parts of sea cucumber, 40 parts of egg yolk, 18 parts of wine-processed Chinese angelica, 12 parts of white paeony root, 13 parts of cistanche, 10 parts of American ginseng, 25 parts of astragalus, 18 parts of bighead atractylodes rhizome, 13 parts of poria, 9 parts of rhizoma pinellinae praeparata, 25 parts of succus bambusae, 12 parts of gastrodia elata, 13 parts of uncaria, 25 parts of oyster, 5 parts of schisandra chinensis, 10 parts of rhizoma acori graminei, 8 parts of polygala tenuifolia, 4 parts of scorpion, 3 parts of centipede, 4 parts of earthworm, 15 parts of pawpaw, 18 parts of radix puerariae and 15 parts.

Preferably, the traditional Chinese medicine composition for treating the Parkinson disease is prepared from the following raw material medicines in parts by weight: 20 parts of tortoise plastron, 1 part of pilose antler, 13 parts of sea cucumber, 50 parts of egg yolk, 22 parts of wine-processed Chinese angelica, 15 parts of white paeony root, 12 parts of desertliving cistanche, 12 parts of American ginseng, 20 parts of astragalus, 15 parts of largehead atractylodes rhizome, 15 parts of poria, 6 parts of rhizoma pinellinae praeparata, 20 parts of bamboo juice, 12 parts of tall gastrodia tuber, 15 parts of uncaria, 30 parts of oyster, 6 parts of schisandra chinensis, 8 parts of grassleaf sweelflag rhizome, 10 parts of thinleaf milkwort root-bark, 3 parts of scorpion, 2 parts of centipede, 6 parts of earthworm, 13 parts of pawpaw, 24 parts of kudzuvine.

In a second aspect, the invention also provides a preparation method of the traditional Chinese medicine composition for treating the Parkinson's disease, which is prepared by a water extraction and alcohol precipitation method and comprises the following specific steps: weighing the raw materials according to the proportion, adding water with the weight 6-10 times of that of the raw materials, decocting the first decocted medicine for 0.5-2 hours, adding other medicines except the later decocted medicine, decocting for 1-3 hours, adding the later decocted medicine, decocting for 0.5-1 hour, and filtering out medicine juice; adding water 6-10 times the weight of the raw materials, decocting for 0.5-2 hr, filtering to obtain filtrate, mixing the two filtrates, and concentrating; adding the powder preparation, mixing, adding 2-3 times of alcohol, stirring, precipitating overnight, collecting precipitate, washing with alcohol, removing alcohol, drying to obtain effective component precipitate; adding adjuvants, and making into pharmaceutically acceptable dosage forms.

Preferably, the pharmaceutically acceptable dosage forms include powders, decoctions, tablets, granules, capsules, powders, mixtures, pills, oral liquids, and injections.

In a third aspect, the invention provides another preparation method of a traditional Chinese medicine composition for treating Parkinson's disease, wherein the raw materials comprise, by weight, 24g of tortoise plastron (decocted first), 1g of pilose antler (stewed second), 10g of sea cucumber (stewed second), 0.5 egg yolk (taken after blending), 12g of Chinese angelica (prepared with wine), 15g of white paeony root, 12g of cistanche, 6g of ginseng (stewed second), 15g of astragalus membranaceus, 12g of bighead atractylodes rhizome, 12g of poria, 6g of rhizoma pinellinae praeparata, 30g of bamboo juice (taken with water), 10g of gastrodia elata (stewed second), 10g of uncaria (taken after dropping), 12g of oyster (decocted first), 4g of schisandra chinensis, 8g of rhizoma acori graminei, 6g of polygala tenuifolia, 3g of scorpion (swallowed in the end), 2g of centipede (removed in the head and feet, swallowed in the end), 6g of earthworm, 12g of pawpaw, 15g of kudzuvine root and; decocting by conventional method.

The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating Parkinson's disease. The traditional Chinese medicine composition accounts for 60-100% of the total mass of the medicine.

The invention is based on the following pharmacological implementations: according to the traditional Chinese medicine, PD moves in deficient wind, wind phlegm stasis is blocked, muscles and bones are used as main symptoms, muscle spasm and stiffness and paralysis are used as main symptoms, rhizoma gastrodiae is used for calming liver wind, arresting convulsion and relieving spasm, dispelling wind and dredging collaterals, scorpio, centipede and earthworm penetrate through tendons and bones, the wind toxin penetrating into the bones and the muscles is most intensely removed and shaved, the scorpio is pungent and flatly enters the liver, and has strong violent toxicity, which is good at calming wind and relieving spasm, attacking toxin and resolving masses, dredging collaterals and relieving pain, and the wind toxin penetrating into the bones and the muscles is removed and shaved, so that the traditional Chinese medicine can be used for treating spasm and convulsion caused by internal and external wind, and the centipede is pungent and warm and toxic, has good property and resolving masses, can reach the inside and outside, extinguish wind and relieve spasm, attack toxin, and has. Di Long is salty in flavor and cold in property and acts on clearing and activating the channels and collaterals, extinguishing wind and arresting convulsions, clearing heat and relieving asthma, and inducing diuresis and dispelling dampness. It is suitable for wind-phlegm-dampness-stasis obstructing the meridians. Homology of liver and kidney and interconversion of essence and blood. The Chinese angelica, the peony root and the twotooth achyranthes root combine the main medicines, treat both liver and kidney, supplement essence and blood, mutually transform the essence and blood of the liver and the kidney to replenish essence and tonify brain, nourish water and nourish tendons, nourish the blood and calm wind, soften liver and relax tendons, so the Chinese traditional medicine can relieve the symptoms of spasm and trembling of the tendons and vessels and is used for treating the root cause. Kidneys host true yin and true yang, solitary yin does not grow, solitary yang does not qi invigorate spleen, transport and resolve water dampness, and eliminate the source of phlegm to treat the root cause. The recipe is used together to eliminate phlegm from the liver and eliminate phlegm, and the recipe is used in treating both symptoms and root causes. The ginseng, the astragalus, the atractylodes and the tuckahoe are combined to strengthen the spleen and reduce phlegm, and the treatment of both manifestation and root cause of disease is performed to prevent phlegm-damp from internally misting and blocking the muscles and bones. The traditional Chinese medicine composition has the effects of tonifying yin, yang, qi, blood, essence and marrow, treating both wind-fire phlegm-dampness and blood stasis, regulating brain, marrow, spirit, muscles and bones, replenishing essence and nourishing brain, reducing phlegm and inducing resuscitation, calming wind and relieving convulsion, relaxing muscles and tendons and dredging collaterals, so the traditional Chinese medicine composition can be used for treating aphonia and miliaria convulsion and syncope caused by essence deficiency, marrow reduction, wind-phlegm stasis, brain and collaterals obstruction, spirit decline, muscles and bones malnutrition and channel spasm.

Compared with the prior art, the invention has the advantages and beneficial effects that:

1. the compatibility of the traditional Chinese medicine combination drug conforms to the principle of monarch, minister, assistant and guide of traditional Chinese medicines, has the advantages of good curative effect, capability of improving motor symptoms and non-motor symptoms of the Parkinson disease, no obvious toxic or side effect and the like, adopts the principle of tonifying brain, calming wind and relieving spasm, and takes medicines according to symptoms to achieve the curative effect of effectively treating the Parkinson disease; in addition, the monarch, minister, assistant and guide medicines in the compatibility can treat the Parkinson disease in a multi-target and multi-level manner, and the treatment effect is obvious.

2. The medicine provided by the invention is simple in preparation method, low in cost, suitable for long-term administration, safe and effective in preventing and treating the Parkinson's disease or the motor complications of the Parkinson's disease, and has a good application prospect.

Detailed Description

The present invention will be further described in detail with reference to specific examples and clinical trial results, but is not limited to the scope of the present invention.

Example 1

A traditional Chinese medicine composition for treating Parkinson's disease is prepared from the following raw material medicines by weight: 24g of tortoise plastron (decocted first), 1g of pilose antler (prepared powder), 12g of sea cucumber (prepared powder), 30g of egg yolk (added later), 12g of wine-processed Chinese angelica, 15g of white peony root, 12g of cistanche, 12g of American ginseng (prepared powder), 15g of astragalus, 15g of bighead atractylodes rhizome, 12g of poria, 8g of rhizoma pinellinae praeparata, 30g of bamboo juice, 15g of gastrodia elata, 10g of uncaria (added later), 20g of oyster (decocted first), 4g of schisandra chinensis, 8g of acorus gramineus, 6g of polygala tenuifolia, 3g of scorpion (prepared powder), 2g of centipede (removed head and prepared powder), 6g of earthworm (prepared powder), 12g of pawpaw, 20g of kudzuvine root and 10.

Example 2

A traditional Chinese medicine composition for treating Parkinson's disease is prepared from the following raw material medicines by weight: 28g of tortoise plastron (decocted first), 2g of pilose antler (prepared powder), 12g of sea cucumber (prepared powder), 40g of egg yolk (added later), 18g of wine-processed Chinese angelica, 12g of white peony root, 13g of cistanche, 10g of American ginseng (prepared powder), 15g of astragalus, 15g of bighead atractylodes rhizome, 12g of poria, 8g of rhizoma pinellinae praeparata, 30g of bamboo juice, 15g of gastrodia elata, 10g of uncaria (added later), 25g of oyster (decocted first), 5g of schisandra chinensis, 10g of rhizoma acori graminei, 8g of polygala tenuifolia, 4g of scorpion (prepared powder), 3g of centipede (removed head and prepared powder), 4g of earthworm (prepared powder), 15g of pawpaw, 18g of kudzuvine root and.

Example 3

A traditional Chinese medicine composition for treating Parkinson's disease is prepared from the following raw material medicines by weight: 20g of tortoise plastron (decocted first), 1g of pilose antler (prepared powder), 13g of sea cucumber (prepared powder), 50g of egg yolk (added later), 22g of wine-processed Chinese angelica, 15g of white peony root, 12g of cistanche, 12g of American ginseng (prepared powder), 20g of astragalus, 15g of bighead atractylodes rhizome, 15g of poria, 6g of rhizoma pinellinae praeparata, 20g of bamboo juice, 12g of gastrodia elata, 15g of uncaria (added later), 30g of oyster (decocted first), 6g of schisandra chinensis, 8g of rhizoma acori graminei, 10g of polygala tenuifolia, 3g of scorpion (prepared powder), 2g of centipede (removed head and prepared powder), 6g of earthworm (prepared powder), 13g of pawpaw, 24g of kudzuvine root and.

Example 4

A traditional Chinese medicine composition for treating Parkinson's disease is prepared from the following raw material medicines by weight: 18g of tortoise plastron (decocted first), 3g of pilose antler (prepared powder), 15g of sea cucumber (prepared powder), 40g of egg yolk (added later), 15g of wine-processed Chinese angelica, 13g of white peony root, 12g of cistanche, 12g of American ginseng (prepared powder), 28g of astragalus, 18g of bighead atractylodes rhizome, 12g of poria, 10g of rhizoma pinellinae praeparata, 25g of bamboo juice, 15g of gastrodia elata, 12g of uncaria (added later), 15g of oyster (decocted first), 5g of schisandra chinensis, 10g of rhizoma acori graminei, 8g of polygala tenuifolia, 4g of scorpion (prepared powder), 1g of centipede (removed head and prepared powder), 5g of earthworm (prepared powder), 15g of pawpaw, 20g of kudzuvine root and.

Example 5

A traditional Chinese medicine composition for treating Parkinson's disease is prepared from the following raw material medicines by weight: 25g of tortoise plastron (decocted first), 2g of pilose antler (prepared powder), 12g of sea cucumber (prepared powder), 50g of egg yolk (added later), 22g of wine-processed Chinese angelica, 15g of white peony root, 15g of cistanche, 10g of American ginseng (prepared powder), 20g of astragalus, 15g of bighead atractylodes rhizome, 15g of poria, 8g of rhizoma pinellinae praeparata, 28g of bamboo juice, 13g of gastrodia elata, 15g of uncaria (added later), 25g of oyster (decocted first), 5g of schisandra chinensis, 9g of rhizoma acori graminei, 7g of polygala tenuifolia, 3g of scorpion (prepared powder), 2g of centipede (removed head and prepared powder), 4g of earthworm (prepared powder), 12g of pawpaw, 24g of kudzuvine root and.

Example 6 preparation of granules and electuary of the Chinese medicinal composition of the invention

Weighing the raw materials of the traditional Chinese medicine composition in any one of embodiments 1-5 according to the proportion, adding water with the weight 6-10 times of that of the raw materials, decocting the first decocted medicine for 0.5-1 hour, adding other medicines except the later decocted medicine, decocting for 1-3 hours, finally adding the later decocted medicine, decocting for 0.5-1 hour, and filtering out the decoction; adding water 6-10 times the weight of the raw materials, decocting for 0.5-2 hr, filtering to obtain filtrate, mixing the two filtrates, and concentrating; adding the powder preparation, mixing, adding 2-3 times of ethanol, stirring, precipitating overnight, collecting precipitate, washing with 0.2-2 times of 95% ethanol for 3 times, removing ethanol, collecting precipitate as effective component, and drying; adding adjuvant, making into granule or granule, drying, and packaging.

Example 7 preparation of mixture, oral liquid, and ointment of the Chinese medicinal composition of the present invention

Weighing the raw materials of the traditional Chinese medicine composition in any one of embodiments 1-5 according to the proportion, adding water with the weight 6-10 times of that of the raw materials, decocting the first decocted medicine for 0.5-1 hour, adding other medicines except the later decocted medicine, decocting for 1-3 hours, finally adding the later decocted medicine, decocting for 0.5-1 hour, and filtering out the decoction; adding water 6-10 times the weight of the raw materials, decocting for 0.5-2 hr, filtering to obtain filtrate, mixing the two filtrates, and concentrating; adding the powder preparation, mixing, adding 2-3 times of ethanol, stirring, precipitating overnight, collecting precipitate, washing with 0.2-2 times of 95% ethanol for 3 times, removing ethanol, collecting precipitate as effective component, and drying; adding appropriate pharmaceutical adjuvants, and making into mixture, oral liquid, and unguent.

Example 8 tablets or capsules for preparing the Chinese medicinal composition of the present invention

Weighing the raw materials of the traditional Chinese medicine composition in any one of embodiments 1-5 according to the proportion, adding water with the weight 6-10 times of that of the raw materials, decocting the first decocted medicine for 0.5-1 hour, adding other medicines except the later decocted medicine, decocting for 1-3 hours, finally adding the later decocted medicine, decocting for 0.5-1 hour, and filtering out the decoction; adding water 6-10 times the weight of the raw materials, decocting for 0.5-2 hr, filtering to obtain filtrate, mixing the two filtrates, and concentrating; adding the powder preparation, mixing, adding 2-3 times of ethanol, stirring, precipitating overnight, collecting precipitate, washing with 0.2-2 times of 95% ethanol for 3 times, removing ethanol, collecting precipitate as effective component, and drying; adding adjuvant, granulating or tabletting, drying, grading or tabletting, and packaging. Adding pharmaceutical adjuvants, vacuum drying, pulverizing, granulating, and making into tablet or capsule. The prepared capsules are 0.5 g (60-80% of the traditional Chinese medicine composition, 20-40% of starch and the like as auxiliary materials) per capsule, 2-10 capsules are taken each time, and the taking effect is optimal in an empty stomach manner for 3-4 times per day.

Example 9

A Chinese medicinal composition for treating Parkinson disease is prepared by weighing raw materials (unit: g) carapax et Plastrum Testudinis 240; cornu Cervi Pantotrichum (stewed separately) 10; sea cucumber (stewed separately) 100; 5 egg yolk (taken after concocting); 120 parts of angelica sinensis processed with wine; 150 parts of white peony root; 120 of cistanche salsa; ginseng (simmered) 60; astragali radix 150; 120 of largehead atractylodes rhizome; poria 120; rhizoma Pinelliae Preparata 60; 300 of bamboo juice (taking with water); 100 parts of rhizoma gastrodiae (stewed in other soup); ramulus Uncariae cum uncis (rear lower) 100; 120 of oyster (decocted first); 40 parts of schisandra chinensis; 80 of grassleaved sweetflag rhizome; cortex et radix Polygalae 60; scorpio (administered as powder) 30; scolopendra (with its head and feet removed and its powder taken) 20; earthworm 60; 120 of pawpaw; 150 parts of kudzu roots; achyranthes bidentata 100. Decocting by conventional method.

Example 10

A Chinese medicinal composition for treating Parkinson disease is prepared by weighing raw materials (unit: g) carapax et Plastrum Testudinis (decocted first) 30; cornu Cervi Pantotrichum (stewed separately) 3; sea cucumber (stewed separately) 10; 1 egg yolk (taken after concocting); processing radix Angelicae sinensis 12 with wine; 15 parts of white peony root; cistanche deserticola 13; ginseng radix (stewed separately) 6; astragali radix 10; 12 of bighead atractylodes rhizome; poria 12; summer 6; 30 parts of bamboo juice (taking with water); rhizoma Gastrodiae (stewed separately) 10; ramulus Uncariae cum uncis (rear lower) 10; decocting Concha Ostreae (first) 12; 60 parts of schisandra chinensis; 8 of acorus gramineus; radix Polygalae 6; scorpio (administered as powder) 3; centipede (with the head and feet removed and the powder swallowed) 2; earthworm 6; 12, pawpaw; 15 parts of kudzu roots; achyranthes bidentata 10. Decocting by conventional method.

Example 11

A Chinese medicinal composition for treating Parkinson disease is prepared by weighing raw materials (unit: g) carapax et Plastrum Testudinis (decocted first) 24; cornu Cervi Pantotrichum (stewed separately) 1; sea cucumber (stewed separately) 10; 0.5 egg yolk (taken after concocting); processing radix Angelicae sinensis 12 with wine; 15 parts of white peony root; 12 of cistanche salsa; ginseng radix (stewed separately) 6; astragali radix 15; 12 of bighead atractylodes rhizome; poria 12; summer 6; 30 parts of bamboo juice (taking with water); rhizoma Gastrodiae (stewed separately) 10; ramulus Uncariae cum uncis (rear lower) 10; decocting Concha Ostreae (first) 12; fructus Schisandrae 4; 8 of acorus gramineus; radix Polygalae 6; scorpio (administered as powder) 3; centipede (with the head and feet removed and the powder swallowed) 2; earthworm 6; 12, pawpaw; 15 parts of kudzu roots; achyranthes bidentata 10. Decocting by conventional method.

Treatment effectiveness test of the Chinese medicinal composition

68 PD patients were selected and randomized into two groups. In the control group, 60-120 mg of compound carbidopa tablet (essence pharmaceutical group, Inc., batch No. 20140221, standard: 250 mg/tablet) and po and tid were administered, and the dosage was adjusted according to the patient's condition until satisfied. The experimental group took the traditional Chinese medicine composition of example 11 on the basis of taking the compound carbidopa, and the traditional Chinese medicine composition was decocted by the patient, and the amount of the decoction was 300 ml. One dose is taken every day, and the oral liquid is decocted with water and then is taken for 2 times. The treatment course of the two groups of patients is 3 months.

The clinical curative effect and safety of the two groups of patients are compared as shown in table 1, after treatment, the total effective rate of the experimental group is 91.18 percent and is obviously higher than 64.7 percent of the control group, and the difference has statistical significance P < 0.05. In addition, 1 patient in the experimental group is accompanied by nausea symptom, 2 patients are suffered from hyperkinesia and dizziness respectively, 1 patient in the control group is suffered from palpitation, 2 patients are suffered from constipation, and 3 patients are suffered from vomit, which indicates that the medicine safety of the experimental group is high.

Table 1: clinical efficacy and safety comparison of two groups of patients [ n (%) ]

Group of	Number of examples	Basic control	Is remarkably advanced	Progress of the technology	Without change	Deterioration of	Total effective
								Experimental group	34	18	8	5	2	1	31
Control group	34	7	4	11	7	5	22

The clinical test results show that the medicine provided by the invention has better clinical curative effect and provides a new treatment scheme for PD patients.

The foregoing is a further detailed description of the invention in connection with specific/preferred embodiments and it is not intended that the invention be limited to these specific embodiments. It will be apparent to those skilled in the art that various substitutions and modifications can be made to the described embodiments without departing from the spirit of the invention, and such substitutions and modifications are to be considered as within the scope of the invention.

Claims

1. A traditional Chinese medicine composition for treating Parkinson's disease is characterized in that: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 15-30 parts of tortoise plastron, 1-3 parts of pilose antler, 12-15 parts of sea cucumber, 20-50 parts of egg yolk, 12-24 parts of wine-processed angelica, 12-15 parts of white peony root, 12-15 parts of cistanche, 10-12 parts of American ginseng, 15-30 parts of astragalus, 12-20 parts of bighead atractylodes rhizome, 12-15 parts of poria, 6-10 parts of rhizoma pinellinae praeparata, 20-30 parts of bamboo juice, 12-15 parts of gastrodia elata, 10-15 parts of uncaria, 15-30 parts of oyster, 4-6 parts of schisandra chinensis, 8-10 parts of rhizoma acori graminei, 6-10 parts of polygala tenuifolia, 2-5 parts of scorpion, 1-3 parts of centipede, 3-6 parts of earthworm, 12-15 parts of pawpaw, 15-24 parts of radix puerariae and 10-15 parts of radix achyranth.

2. The traditional Chinese medicine composition for treating Parkinson's disease according to claim 1, which is characterized in that: the pilose antler, the sea cucumber, the American ginseng, the scorpion, the centipede and the earthworm are powder medicines; the tortoise plastron and the oyster are decocted firstly; the egg yolk and the uncaria are used as the medicines for the next time.

3. The traditional Chinese medicine composition for treating Parkinson's disease according to claim 2, which is characterized in that: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 24 parts of tortoise plastron, 1 part of pilose antler, 12 parts of sea cucumber, 30 parts of egg yolk, 12 parts of wine-processed Chinese angelica, 15 parts of white paeony root, 12 parts of desertliving cistanche, 12 parts of American ginseng, 15 parts of astragalus, 15 parts of largehead atractylodes rhizome, 12 parts of poria, 8 parts of rhizoma pinellinae praeparata, 30 parts of succus bambusae, 15 parts of tall gastrodia tuber, 10 parts of uncaria, 20 parts of oyster, 4 parts of schisandra chinensis, 8 parts of grassleaf sweelflag rhizome, 6 parts of thinleaf milkwort root-bark, 3 parts of scorpion, 2 parts of centipede, 6 parts of earthworm, 12 parts of pawpaw, 20 parts of.

4. The traditional Chinese medicine composition for treating Parkinson's disease according to claim 2, which is characterized in that: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 28 parts of tortoise plastron, 2 parts of pilose antler, 12 parts of sea cucumber, 40 parts of egg yolk, 18 parts of wine-processed Chinese angelica, 12 parts of white paeony root, 13 parts of cistanche, 10 parts of American ginseng, 25 parts of astragalus, 18 parts of bighead atractylodes rhizome, 13 parts of poria, 9 parts of rhizoma pinellinae praeparata, 25 parts of succus bambusae, 12 parts of gastrodia elata, 13 parts of uncaria, 25 parts of oyster, 5 parts of schisandra chinensis, 10 parts of rhizoma acori graminei, 8 parts of polygala tenuifolia, 4 parts of scorpion, 3 parts of centipede, 4 parts of earthworm, 15 parts of pawpaw, 18 parts of radix puerariae and 15 parts.

5. The traditional Chinese medicine composition for treating Parkinson's disease according to claim 2, which is characterized in that: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 20 parts of tortoise plastron, 1 part of pilose antler, 13 parts of sea cucumber, 50 parts of egg yolk, 22 parts of wine-processed Chinese angelica, 15 parts of white paeony root, 12 parts of desertliving cistanche, 12 parts of American ginseng, 20 parts of astragalus, 15 parts of largehead atractylodes rhizome, 15 parts of poria, 6 parts of rhizoma pinellinae praeparata, 20 parts of bamboo juice, 12 parts of tall gastrodia tuber, 15 parts of uncaria, 30 parts of oyster, 6 parts of schisandra chinensis, 8 parts of grassleaf sweelflag rhizome, 10 parts of thinleaf milkwort root-bark, 3 parts of scorpion, 2 parts of centipede, 6 parts of earthworm, 13 parts of pawpaw, 24 parts of kudzuvine.

6. The preparation method of the traditional Chinese medicine composition for treating Parkinson's disease according to the claims 2-5, is characterized in that: weighing the raw materials according to the proportion, adding water with the weight 6-10 times of that of the raw materials, decocting the first decocted medicine for 0.5-2 hours, adding other medicines except the later decocted medicine, decocting for 1-3 hours, adding the later decocted medicine, decocting for 0.5-1 hour, and filtering out medicine juice; adding water 6-10 times the weight of the raw materials, decocting for 0.5-2 hr, filtering to obtain filtrate, mixing the two filtrates, and concentrating; adding the powder preparation, mixing, adding 2-3 times of alcohol, stirring, precipitating overnight, collecting precipitate, washing with alcohol, removing alcohol, drying to obtain effective component precipitate; adding adjuvants, and making into pharmaceutically acceptable dosage forms.

7. The preparation method of the traditional Chinese medicine composition for treating Parkinson's disease according to claim 6, which is characterized in that: the pharmaceutically acceptable dosage forms comprise powder, decoction, tablet, granule, capsule, powder, mixture, pill, oral liquid, and injection.

8. A preparation method of a traditional Chinese medicine composition for treating Parkinson's disease is characterized by comprising the following steps: weighing 24g of tortoise plastron (decocted first), 1g of pilose antler (stewed second), 10g of sea cucumber (stewed second), 0.5 egg yolk (taken after mixing), 12g of Chinese angelica processed with wine, 15g of white paeony root, 12g of cistanche, 6g of ginseng (stewed second), 15g of astragalus membranaceus, 12g of bighead atractylodes rhizome, 12g of poria cocos, 6g of rhizoma pinellinae praeparata, 30g of bamboo juice (taken with water), 10g of gastrodia elata (stewed second), 10g of uncaria (taken later), 12g of oyster (decocted first), 4g of schisandra chinensis, 8g of acorus gramineus, 6g of polygala tenuifolia, 3g of scorpion (swallowed in the end), 2g of centipede (swallowed in the end), 6g of earthworm, 12g of pawpaw, 15g of kudzuvine root and 10g of achyranthes bidentata; decocting by conventional method.

9. Use of a Chinese medicinal composition according to any one of claims 1-8 in the manufacture of a medicament for the treatment of parkinson's disease.