CN1491692A - Red medicine thin film coating tablet - Google Patents
Red medicine thin film coating tablet Download PDFInfo
- Publication number
- CN1491692A CN1491692A CNA031337848A CN03133784A CN1491692A CN 1491692 A CN1491692 A CN 1491692A CN A031337848 A CNA031337848 A CN A031337848A CN 03133784 A CN03133784 A CN 03133784A CN 1491692 A CN1491692 A CN 1491692A
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- CN
- China
- Prior art keywords
- film coating
- thin film
- red
- substrate
- flos carthami
- Prior art date
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- 239000003814 drug Substances 0.000 title claims abstract description 34
- 238000009501 film coating Methods 0.000 title claims description 38
- 239000010409 thin film Substances 0.000 title claims description 28
- 238000000576 coating method Methods 0.000 claims abstract description 30
- 239000011248 coating agent Substances 0.000 claims abstract description 24
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims abstract description 22
- 238000002360 preparation method Methods 0.000 claims abstract description 22
- 229920001353 Dextrin Polymers 0.000 claims abstract description 14
- 239000004375 Dextrin Substances 0.000 claims abstract description 14
- 235000019425 dextrin Nutrition 0.000 claims abstract description 14
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 9
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 9
- 239000000758 substrate Substances 0.000 claims description 34
- 239000000203 mixture Substances 0.000 claims description 25
- 241000628997 Flos Species 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 18
- 239000007888 film coating Substances 0.000 claims description 15
- 239000007921 spray Substances 0.000 claims description 15
- 238000001035 drying Methods 0.000 claims description 13
- 239000002671 adjuvant Substances 0.000 claims description 12
- 238000005516 engineering process Methods 0.000 claims description 12
- 239000008187 granular material Substances 0.000 claims description 12
- 241001489978 Eupolyphaga Species 0.000 claims description 8
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 8
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 8
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 8
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 8
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- -1 drying Substances 0.000 claims description 6
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims description 4
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 4
- 239000002002 slurry Substances 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 239000004925 Acrylic resin Substances 0.000 claims description 2
- 229920000178 Acrylic resin Polymers 0.000 claims description 2
- 241000736919 Pelodiscus sinensis Species 0.000 claims description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 235000011132 calcium sulphate Nutrition 0.000 claims 1
- 238000003860 storage Methods 0.000 abstract description 2
- 244000061520 Angelica archangelica Species 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 241000131329 Carabidae Species 0.000 abstract 1
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000005453 pelletization Methods 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 239000003826 tablet Substances 0.000 description 22
- 206010013786 Dry skin Diseases 0.000 description 4
- SQFDQLBYJKFDDO-UHFFFAOYSA-K merbromin Chemical compound [Na+].[Na+].C=12C=C(Br)C(=O)C=C2OC=2C([Hg]O)=C([O-])C(Br)=CC=2C=1C1=CC=CC=C1C([O-])=O SQFDQLBYJKFDDO-UHFFFAOYSA-K 0.000 description 4
- 229940008716 mercurochrome Drugs 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000005580 one pot reaction Methods 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The coated red medicine tablet is prepared with the medicinal material including notoginseng, Chuanxiong rhizome, white atractylodes rhizome, angelica, ground beetle and safflower; and supplementary material including avicel, calcium sulfate and dextrin. The preparation process includes crushing, pelletizing, tabletting and coating, and the coating includes preparing coating liquid, preheating base tablet and spraying. The medicine tablet has red coating, and the coating process is short and fast and produces less influence on the medicine components. The coated medicine tablet has raised humidity and heat resistance and longer storage life. The coated red medicine tablet has less sugar content and may be also taken by diabetics.
Description
Affiliated technical field
The present invention relates to a kind of medicine for the treatment of traumatic injury, relating in particular to the Chinese herbal medicine is the Chinese patent medicine Red medicine thin film coating tablet of feedstock production.
Background technology
Mercurochrome tablet is as the treatment promoting blood circulation and stopping pain, diseases such as traumatic injury, swelling and pain due to blood stasis, rheumatic numbness, be subjected to the favorable comment of extensive patients deeply, but mercurochrome tablet has been a coated tablet since dropping into production always, and used adjuvant such as Pulvis Talci, the sucrose etc. of sugar-coat packaging technique, not only increase patient's oral dose, and have the easy moisture absorption, mouldy, deliquescence, be difficult for problems such as storage and transport, complex process, especially be not suitable for diabetic to take.
Summary of the invention
Technical problem to be solved by this invention provides the preparation method of a kind of Red medicine thin film coating tablet and Red medicine thin film coating tablet, and it has solved the easy moisture absorption of red medicine coated tablet, has been difficult for problems such as preservation, complex process.
In order to solve the problems of the technologies described above, the present invention is achieved in that the mercurochrome tablet Film coated tablets, it comprises that following raw material is by weight being Radix Notoginseng: Rhizoma Chuanxiong: the Radix Angelicae Dahuricae: Radix Angelicae Sinensis: Eupolyphaga Seu Steleophaga: Flos Carthami=750: 175: 175: 175: 175: 175, wherein adding adjuvant on the basis of above-mentioned raw materials makes its hardness greater than 3.0kg, adjuvant comprises following composition, each composition of adjuvant is microcrystalline Cellulose with the ratio of Flos Carthami by weight: calcium sulfate: dextrin: Flos Carthami=(80-120): (20-40): (40-80): 175;
The preferred weight of above-mentioned adjuvant is microcrystalline Cellulose with the Flos Carthami ratio: calcium sulfate: dextrin: Flos Carthami=100: 30: 60: 175;
The preparation technology of Red medicine thin film coating tablet is as follows:
A. pulverize: get Flos Carthami or Flos Carthami and Eupolyphaga Seu Steleophaga by above-mentioned weight, with with the Flos Carthami weight ratio be starch or the dextrin paste producing slurry of (20-40): 175g, standby in 50-90 ℃ of bake drying then, again with Radix Notoginseng, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Trionyx sinensis Wiegmann worm mix homogeneously, powder becomes fine powder, medicated powder is made in sterilization;
B. granulate: in medicated powder, be blended into microcrystalline Cellulose by above-mentioned weight, calcium sulfate, dextrin, system granule, drying, granulate;
C, tabletting: use the scrobicula stamping, the substrate sheet heavily is the 0.25-0.5g/ sheet, and substrate promptly;
D, coating:
The first step: the preparation of coating solution, prepare earlier the ethanol water of coating solvent 70%-80% and put into agitator, behind the rotation motor, red film coating is desired mixture join gradually in the ethanol water, generally finished preparation process in two hours being not less than;
Second step: the preheating of substrate, substrate is poured in the jar, through 2-4 rev/min rotation at a slow speed, be heated to 30-50 ℃, finished in 10-50 minute;
The 3rd step: to the requirement of spray gun: between two spray guns 10-20 centimetre, the distance of spray gun and sheet bed is 10-30 centimetre.
The 4th step: coating process and prescription: substrate is put into pot spray, pot speed should be at 3-4 rev/min, in 20-40 minute, on substrate, form thin film, in the time of 35-70 minute, can it be 5-7 rev/min with the pot velocity modulation, injecting time should be in 4 hours and finishes, and is rotated further 5-10 minute drying after having sprayed, and obtains sheet and heavily is the Red medicine thin film coating tablet of 0.255-0.55g/ sheet.
The dosage form of Red medicine thin film coating tablet, specification are: the heavy 0.26g/ sheet of sheet, the outward appearance film coating is red.
The present invention has following advantage:
The art for coating time short, easy and simple to handle, rate of drying is fast, medicine is subjected to damp and hotly to influence lessly, has improved drug quality;
2. the weight increase generally only in 2%-10%, can reduce the consumption of Pulvis Talci and Icing Sugar in a large number, can keep former type, is convenient to swallow and transport, and saves packaging material, has reduced patient's dosage;
3. tablet can be made into abnormal shape, carves characters, and still can keep original labelling behind the coating, is convenient to identification;
4. medicine can reach moisture-resisting, heat-proof requirement behind film coating, can prolong and improve the life-span of product;
5. reduced the sugar content of mercurochrome tablet, the diabetes patient also can take.
Description of drawings
Fig. 1 is preparation technology's flow diagram of the present invention.
Fig. 2 is a coating process flow block diagram among the preparation technology of the present invention.
The specific embodiment
Embodiment one
The substrate of Red medicine thin film coating tablet of the present invention is made of by weight following raw material:
Radix Notoginseng 750g, Rhizoma Chuanxiong 175g, Radix Angelicae Dahuricae 175g,
Radix Angelicae Sinensis 175g, Eupolyphaga Seu Steleophaga, 175g, Flos Carthami 175g,
Add adjuvant and make its hardness greater than 3.0kg on the basis of above-mentioned raw materials, adjuvant can comprise following composition: cellulose 100g, calcium sulfate 30g, dextrin 60g.
Preparation technology of the present invention following (Fig. 1):
A. pulverize: get Flos Carthami 175g by above-mentioned weight, with 30g starch paste producing slurry, standby in 75 ℃ of bake dryings then, with Radix Notoginseng, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Eupolyphaga Seu Steleophaga mix homogeneously, powder becomes fine powder again, and medicated powder is made in sterilization then;
B. granulate: in above-mentioned 1655g medicated powder, be blended into microcrystalline Cellulose 100g, calcium sulfate 30g, dextrin 60g adds up to 190g; The system granule, drying, granulate;
C, tabletting: with the stamping of Φ 9mm scrobicula, the substrate of extrusion is the 0.25g/ sheet, and substrate promptly; The character of the substrate of Red medicine thin film coating tablet of the present invention is:
Faint yellow substrate, it is sweet little arduous to distinguish the flavor of;
Disintegration:＜30 minutes;
Hardness:＞3.0kg;
Tablet weight variation: 0.25g/ sheet ± 7%.
D, coating (Fig. 2):
The first step: the preparation of coating solution, with one pot of calculating of 50kg substrate, use red film coating to desire mixture 2.5kg, elder generation's preparation coating solvent i.e. 75% ethanol water is put into agitator, behind the rotation motor, with spoon red film coating is desired mixture and join gradually in the intermediary vortex of ethanol water, be convenient to scatter faster, it is " prompt color " powder that mixture is desired in the general preparation of finishing coating solution at two hours, wherein red film coating; It should be noted: should under agitation slowly add red film coating and desire mixture, otherwise cause desire mixture bulk easily, thereby prolong dissolution time;
Second step: the preheating of substrate, substrate is poured in the jar, through 3 rev/mins rotation at a slow speed, purpose is the wearing and tearing that reduce substrate, should be heated to 38 ℃, finishes the preheating of substrate in 30 minutes;
The 3rd step: to the requirement of spray gun, between two spray guns 15 centimetres, the distance of spray gun and sheet bed is 18 centimetres.
The 4th step: coating process and prescription, substrate to be put into pot spray, pot speed should be at 4 rev/mins, should be in 30 minutes, forming thin film on substrate, can be 6 rev/mins with the pot velocity modulation in the time of 50 minutes, and injecting time should be in 4 hours and finishes, be rotated further 8 minutes dryings after having sprayed, obtain Red medicine thin film coating tablet, dosage form, specification are: the heavy 0.26g/ sheet of sheet, and diameter is 90mm, outward appearance thin film bag is red, disintegration＜60 minute.
Embodiment two
The substrate of Red medicine thin film coating tablet of the present invention is made of by weight following raw material:
Radix Notoginseng 750g, Rhizoma Chuanxiong 175g, Radix Angelicae Dahuricae 175g,
Radix Angelicae Sinensis 175g, Eupolyphaga Seu Steleophaga, 175g, Flos Carthami 175g
Add adjuvant and make its hardness greater than 3.0kg on the basis of above-mentioned raw materials, adjuvant can be made of following composition, cellulose 100g, calcium sulfate 30g, dextrin 60g.
Preparation technology of the present invention is as follows:
A. pulverize: get Flos Carthami 175g, Eupolyphaga Seu Steleophaga 175g by above-mentioned weight, with 30g dextrin paste producing slurry, standby in 70 ℃ of bake dryings then, with Radix Notoginseng, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Angelicae Dahuricae mix homogeneously, powder becomes fine powder again, and medicated powder is made in sterilization then;
B. granulate: in above-mentioned 1655g medicated powder, be blended into microcrystalline Cellulose 100g, calcium sulfate 30g, dextrin 60g adds up to 190g; The system granule, drying, granulate;
C, tabletting: use the scrobicula stamping, substrate is the 0.5g/ sheet, and substrate promptly;
The character of Red medicine thin film coating tablet substrate of the present invention is:
Faint yellow substrate, it is sweet little arduous to distinguish the flavor of;
Disintegration:＜30 minutes;
Hardness:＞3.5kg;
Tablet weight variation: 0.5g/ sheet ± 7%.
D, coating:
The first step: the preparation of coating solution, with one pot of calculating of 50kg substrate, use red film coating to desire mixture 2.5kg, the ethanol water of preparation 75% is put into agitator earlier, behind the rotation motor, with spoon red film coating is desired mixture and join gradually in the intermediary vortex of ethanol water, be convenient to scatter faster, generally finished preparation process at two hours;
What note is: under agitation, slowly add red film coating and desire mixture, otherwise cause desire mixture bulk easily, thereby prolong dissolution time;
Second step: the preheating of substrate, substrate is poured in the jar, through 2 rev/mins rotation at a slow speed, purpose is to subtract 5 few wearing and tearing to substrate, is heated to 40 ℃, finishes in 40 minutes;
The 3rd step: to the requirement of spray gun, between two spray guns 10 centimetres, the distance of spray gun and sheet bed is 20 centimetres.
The 4th step: coating process and prescription, coating begins the step that be the technology most critical half an hour, and pot speed should be at 4 rev/mins, in 30 minutes, on substrate, form thin film, can be 5 rev/mins in the second half section with the pot velocity modulation during coating, and injecting time should be in 4 hours and finishes, and is rotated further 7 minutes dryings after having sprayed, obtain Red medicine thin film coating tablet, dosage form is: sheet is heavily for the 0.52g/ sheet, and the outward appearance film coating be a redness, disintegration＜60 minute.
Embodiment three
Embodiment one and embodiment two described red film coatings desire mixture " prompt color " powder can for acrylic resin (Eudragitl, s), hydroxypropyl emthylcellulose (HPMC), Polyethylene Glycol (PEG6000), polyvinylpyrrolidone (PVP), cellulose acetate-phthalate (CAP), Hydroxypropyl Methylcellulose Phathalate (HPMCP).
Embodiment four
The first step in embodiment one and embodiment two described d, the coating: the coating etoh solvent can also be water, methanol, isopropyl alcohol, chloroform, acetone, butanone, dichloromethane in the preparation of coating solution, and above solvent can be used alone, but also also mix together.
Claims (6)
1. Red medicine thin film coating tablet, it comprises that following raw material is by weight being Radix Notoginseng: Rhizoma Chuanxiong: the Radix Angelicae Dahuricae: Radix Angelicae Sinensis: Eupolyphaga Seu Steleophaga: Flos Carthami=750: 175: 175: 175: 175: 175, it is characterized in that adding on the basis of above-mentioned raw materials adjuvant makes its hardness greater than 3.0kg, adjuvant comprises following composition, ratio with Flos Carthami is microcrystalline Cellulose by weight: calcium sulfate: dextrin: Flos Carthami=(80-120): (20-40): (40-80): 175.
2. Red medicine thin film coating tablet according to claim 1 is characterized in that described adjuvant can comprise that following composition and Flos Carthami are microcrystalline Cellulose by weight: calcium sulfate: dextrin: Flos Carthami=100: 30: 60: 175.
3. the preparation technology of Red medicine thin film coating tablet, the preparation technology of Red medicine thin film coating tablet is as follows:
A. pulverize: get Flos Carthami or Flos Carthami and Eupolyphaga Seu Steleophaga by above-mentioned weight, with with the Flos Carthami weight ratio be (20-40): 175 starch or dextrin paste producing slurry, standby in 50-90 ℃ of bake drying then, again with Radix Notoginseng, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Trionyx sinensis Wiegmann worm mix homogeneously, powder becomes fine powder, medicated powder is made in sterilization;
B. granulate: in medicated powder, be blended into microcrystalline Cellulose, calcium sulfate, dextrin by above-mentioned weight; The system granule, drying, granulate;
C, tabletting: use the scrobicula stamping, the substrate sheet heavily is the 0.25-0.5g/ sheet, and substrate promptly;
D, coating:
The first step: the preparation of coating solution, prepare earlier the ethanol water of coating solvent 70%-80% and put into agitator, behind the rotation motor, red film coating is desired mixture join gradually in the ethanol water, finished preparation process in two hours being not less than;
Second step: the preheating of substrate, substrate is poured in the jar, through 2-4 rev/min rotation at a slow speed, be heated to 30-50 ℃, finished in 10-50 minute;
The 3rd step: to the requirement of spray gun: between two spray guns 10-20 centimetre, the distance of spray gun and sheet bed is 10-30 centimetre.
The 4th step: coating process and prescription: substrate is put into pot spray, pot speed should be at 3-4 rev/min, in 20-40 minute, on substrate, form thin film, in the time of 35-70 minute, can it be 5-7 rev/min with the pot velocity modulation, injecting time should be in 4 hours and finishes, and is rotated further 5-10 minute drying after having sprayed, and obtains sheet and heavily is the Red medicine thin film coating tablet of 0.255-0.55g/ sheet.
4. Red medicine thin film coating tablet according to claim 1 and 2 is characterized in that the dosage form of described Red medicine thin film coating tablet, specification are: the heavy 0.26g/ sheet of sheet, outward appearance film coating are for red.
5. the preparation technology of Red medicine thin film coating tablet according to claim 3, it is characterized in that described red film coating desire mixture can for acrylic resin (Eudragitl, s), hydroxypropyl emthylcellulose (HPMC), Polyethylene Glycol (PEG6000), polyvinylpyrrolidone (PVP), cellulose acetate-phthalate (CAP), Hydroxypropyl Methylcellulose Phathalate (HPMCP).
6. the preparation technology of Red medicine thin film coating tablet according to claim 3 is characterized in that described coating solvent can also be water, methanol, isopropyl alcohol, chloroform, acetone, butanone, dichloromethane, and above solvent can be used alone, but also also mix together.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031337848A CN100551359C (en) | 2003-07-24 | 2003-07-24 | Red medicine thin film coating tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031337848A CN100551359C (en) | 2003-07-24 | 2003-07-24 | Red medicine thin film coating tablet |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1491692A true CN1491692A (en) | 2004-04-28 |
| CN100551359C CN100551359C (en) | 2009-10-21 |
Family
ID=34239907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031337848A Expired - Lifetime CN100551359C (en) | 2003-07-24 | 2003-07-24 | Red medicine thin film coating tablet |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100551359C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2895744A1 (en) * | 2006-01-05 | 2007-07-06 | Viviane Lab Soc Par Actions Si | Use of a film forming composition comprising a plasticizer for (film)coating a tablet containing plant powder |
| CN1332686C (en) * | 2005-09-29 | 2007-08-22 | 沈阳中药制药有限公司 | Chinese medicine for treating tractures and preparation for making plaster thereof |
| CN102106784A (en) * | 2009-12-28 | 2011-06-29 | 郑州豫密药业股份有限公司 | Method for coating Chinese medicine pill by film |
| GB2595441A (en) * | 2020-04-23 | 2021-12-01 | Wang Lulin | Bone-strengthening pill (BSP) as a dietary supplement to improve blood circulation and strengthen bone and muscle |
-
2003
- 2003-07-24 CN CNB031337848A patent/CN100551359C/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1332686C (en) * | 2005-09-29 | 2007-08-22 | 沈阳中药制药有限公司 | Chinese medicine for treating tractures and preparation for making plaster thereof |
| FR2895744A1 (en) * | 2006-01-05 | 2007-07-06 | Viviane Lab Soc Par Actions Si | Use of a film forming composition comprising a plasticizer for (film)coating a tablet containing plant powder |
| CN102106784A (en) * | 2009-12-28 | 2011-06-29 | 郑州豫密药业股份有限公司 | Method for coating Chinese medicine pill by film |
| GB2595441A (en) * | 2020-04-23 | 2021-12-01 | Wang Lulin | Bone-strengthening pill (BSP) as a dietary supplement to improve blood circulation and strengthen bone and muscle |
| GB2595441B (en) * | 2020-04-23 | 2022-08-10 | Wang Lulin | Bone-Strengthening Pill (BSP) as a Dietary Supplement to Improve Blood Circulation and Strengthen Bone and Muscle |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100551359C (en) | 2009-10-21 |
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