CN1473605A - Medicine for reieving methal stress and promoting intelligence growth and producing method - Google Patents
Medicine for reieving methal stress and promoting intelligence growth and producing method Download PDFInfo
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- CN1473605A CN1473605A CNA031355641A CN03135564A CN1473605A CN 1473605 A CN1473605 A CN 1473605A CN A031355641 A CNA031355641 A CN A031355641A CN 03135564 A CN03135564 A CN 03135564A CN 1473605 A CN1473605 A CN 1473605A
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- rhizoma
- carapax
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- schisandrae chinensis
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Abstract
The Chinese medicine for relieving mental stress and promoting intelligence growth is produced with ginseng, astragalus root, tortoise shell, grassleaved sweetflag rhizome, galangal fruit, polygala root and other four kinds of Chinese medicinal materials. The production process includes weighing, crushing, diacolation, decoction, concentration, letting stand to take the supernatant, pH value regulation, sterilizing, packing and other steps. The Chinese medicine has obvious curative effect on insomnia, dreaminess, poor memory, dizziness, asthenia and other symptoms of neurasthenia.
Description
The present invention relates to neurasthenic medicine of a kind of treatment and manufacture method, relate in particular to a kind of pure Chinese medicine mind calming nootropic drug and manufacture method.
With the quickening pace of modern life, the increase of intellectual activity, strengthened the burden of brain virtually, the disease that the temporary imbalance of cerebral cortex function (excited and inhibition) is caused, clinically with the neurasthenia symptom of tired weak, the hypomnesis of insomnia and dreamful sleep, forgetful vexed, dizzy, body, lassitude etc., as Chinese patent 97108327 disclosed " nutritive liquid for nourishing brain and promoting intelligence growth ", with Chinese medicine and marine organism extract is primary raw material, and its raw material sources difficulty, complex process, flow process be more, increased cost.
The object of the present invention is to provide that a kind of raw material sources are wide, cost is low, the manufacture method of the simple pure Chinese medicine mind calming nootropic drug of technology and various ways thereof.
In order to achieve the above object, the present invention adopts following technical proposal:
Its main component comprises by ratio of weight and the number of copies: Radix Ginseng 1-3 Radix Astragali 2-15 Carapax Et Plastrum Testudinis 2-6 Rhizoma Acori Graminei 1-4 Fructus Alpiniae Oxyphyllae 1-3 Radix Polygalae 1-4 Fructus Schisandrae Chinensis 2-10 Radix Et Rhizoma Nardostachyos 1-5 Rhizoma Polygonati Odorati 2-10 Radix Aucklandiae 1-4.
For better effect, its main component comprises by ratio of weight and the number of copies: Radix Ginseng 1-2 Radix Astragali 3-10 Carapax Et Plastrum Testudinis 3-4 Rhizoma Acori Graminei 1-3 Fructus Alpiniae Oxyphyllae 1-2 Radix Polygalae 1-3 Fructus Schisandrae Chinensis 3-8 Radix Et Rhizoma Nardostachyos 1-3 Rhizoma Polygonati Odorati 3-8 Radix Aucklandiae 1-3.
Best main component comprises by ratio of weight and the number of copies:
Radix Ginseng 2 Radixs Astragali 8 Carapax Et Plastrum Testudiniss 4 Rhizoma Acori Graminei 3 Fructus Alpiniae Oxyphyllae 2
Radix Polygalae 3 Fructus Schisandrae Chinensis 6 Radix Et Rhizoma Nardostachyos 3 Rhizoma Polygonati Odorati 6 Radix Aucklandiae 3.
Mind calming nootropic drug oral liquid manufacture method is:
After a, the weighing, the Radix Ginseng powder is broken into coarse powder, carries out percolation, be condensed into thick paste with ethanol; Its medicinal residues and the Radix Astragali, Rhizoma Polygonati Odorati, Radix Polygalae decoct with water, and merge decoction liquor;
B, Carapax Et Plastrum Testudinis decoct with water, and collecting decoction is concentrated into an amount of;
C, Rhizoma Acori Graminei, Fructus Schisandrae Chinensis, Fructus Alpiniae Oxyphyllae, the Radix Aucklandiae, Radix Et Rhizoma Nardostachyos add water and carry volatile oil, and its medicinal residues decoct with water again, merge decoction liquor;
D, merge above-mentioned a, c item decoction liquor, be concentrated in right amount, add and get supernatant after ethanol leaves standstill, reclaim ethanol, concentrate; Add adjuvants such as Radix Ginseng thick paste, Carapax Et Plastrum Testudinis concentrated solution, volatile oil and sucrose, essence, sorbic acid, tween 80, add water to be adjusted to total amount, and regulate pH value, sterilization, fill oral solutions.
Mind calming nootropic drug capsule manufacture method is:
After a, the weighing, Radix Ginseng, the Radix Astragali, Rhizoma Polygonati Odorati powder are broken into fine powder, cross 100 mesh sieves;
B, Rhizoma Acori Graminei, Fructus Schisandrae Chinensis, Fructus Alpiniae Oxyphyllae, the Radix Aucklandiae, Radix Et Rhizoma Nardostachyos add water and carry volatile oil, and its medicinal residues and Carapax Et Plastrum Testudinis, Radix Polygalae decoct with water, and filter, and collecting decoction is condensed into thick paste;
C, fine powder mix with thick paste, granulate, and granule is packed into Capsules with capsule filling machine, capsule.
Only need with the compacting of medicine tablet machine in flakes the granule in c step, tablet.
The present invention is in strict accordance with traditional Chinese medicine theory according to name sides in ancient times " hole holy pillow in red " and " reading ball ", in conjunction with national famous Chinese medicine expert clinical experience for many years, going through tens of experiment screenings adds to simplify and cuts out prescription again, the pure Chinese medicinal preparation that adopts the modern pharmaceutical Technology to develop by national three kind new medicine requirements, the contained active component of each medicine:
1. Radix Ginseng: property is flat, sweet in the mouth, little hardship.Strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, and calms the nerves.Contain 29 kinds of saponin components, as ginsenoside-R
0,-Ra
1,-Ra
3,-Rb
1, malonyl ginsenoside M-Rb
1, M-Rd, arasaponin-R
1,-R
4, Radix Panacis Quinquefolii Saponin-R
1Deng; Also contain multiple proteins, enzyme composition, polypeptide class chemical constituent such as peptide, neuropeptide, class glucagon-like peptide-1, ginseng polysaccharide, and several amino acids such as aspartic acid, threonine, glutamic acid, glycine, valine.
2. the Radix Astragali: contain multiple compositions such as monosaccharide, polysaccharide, Saponin, flavone, aminoacid, trace element, protein, riboflavin, folic acid, Citrin, organic acid, coumaric acid, cupreol, daucosterol, lupeol, choline, betanin.
3. Carapax Et Plastrum Testudinis: cold nature, salty in the mouth, sweet.Nourishing YIN for suppressing the hyperactive YANG, replenishing kidney and strengthening bone, the reinforcing the heart of nourishing blood.Contain 17 seed amino acids, comprising 7 kinds of essential amino acids such as lysine, threonine, valine, methionine, leucine, isoleucine, phenylalanine; The trace element that also contains multiple needed by human such as calcium, zinc, ferrum, aluminum.
4. Rhizoma Acori Graminei: warm in nature, acrid in the mouth is eliminated phlegm for resuscitation, Fructus Alpiniae Oxyphyllae the chest stuffiness relieving, the detoxifcation of drying.Contain volatile oil 0.11～0.42%, wherein main component is a beta-Asarone 63.2～81.2%, and secondly asaricin 8.8～13.7% is caryophyllene etc.
5. Radix Polygalae: cold in nature, bitter in the mouth, suffering, the calmness of calming the nerves, relieving cough and resolving phlegm, detoxifcation, relieving palpitation spasmolytic, the peace of avoiding evil spirits dream, Yang strengthening and life essence tonifying, nourishing the liver to improve visual acuity.Contain 7 kinds of triterpenoid compound, comprise senega-saponin A, B, C, D, E, F and G, content is respectively 0.52%, 0.77%, 1.07%, 0.29%, 0.28%, 0.94%, 0.11%; Also contain polygalite, N-acetyl-D-amino glucose, glucose, fructose, Radix Polygalae alkali etc.
6. Fructus Schisandrae Chinensis: warm in nature, sour in the mouth, salty, the nourishing kidney of astringing the lung, arresting seminal emission antidiarrheal, the arresting sweating that promotes the production of body fluid can the maintenance motive, adjusts central nervous system and cardiovascular system, contain total lignans 18.1～19.2%, comprising schizandrin, schisandrol, deoxyschisandrin, wuweizisu B, puppet-wuweizisu B; Protein 1.1%, fat 0.9%, reducing sugar 10.9%, total anthocyanidin 0.2% and organic acid, volatile oil, sterol and free fatty etc.
7. Radix Et Rhizoma Nardostachyos: warm in nature, acrid in the mouth, sweet.Regulating QI to relieve pain, relieving stagnation and activating the spleen.Contain that 1 (10)-aristolene, 9 (10)-aristolenes, Radix Et Rhizoma Nardostachyos are aromatic, aristolone, β-olivetol, β-Fructus Canarii albi alkene, jatamansone, narchinol A, desoxynarchinol, nardosinone etc.
8. Rhizoma Polygonati Odorati: property is flat, sweet in the mouth, nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst; Contain mucopolysaccharide-fragrant solomonseal rhizome polyoses, D-fructose, D-mannose, D-glucose and galacturonic acid, Rhizoma Polygonati Odorati levan.
9. the Radix Aucklandiae: warm in nature, acrid in the mouth, hardship, promoting the circulation of QI to relieve pain, warming middle-JIAO for easing the stomach.Contain volatile oil 0.3～3%, the composition of volatile oil has: acid in aplotaxene, α-Zi Luolantong, selinene, costic acid, costol, α-costene, β-costene, constuslactone, phellandrene, Dehydrocostunolide lactone, the dihydro dehydrogenation; Other contains stigmasterol, stigmasterol inulin, saussurine, betulin and resin, 22-dihydrostigmasterol etc.
The perfect combination of several drugs has significant therapeutic effect to the neurasthenia symptom of tired weak, the hypomnesis of insomnia and dreamful sleep, forgetful vexed, dizzy, body, lassitude etc.
By 153 routine clinical observations, child's 35 examples wherein, adult's 118 examples.Therapeutic Method: each oral 10ml that is grown up, every day 2 times; The each oral 5ml of child, every day 2 times.Be one month the course of treatment.Total effective rate reaches 92.16%, and 48 people that wherein fully recover account for 31.37%; Produce effects 46 people account for 30.07%; Effective 47 people account for 30.72%; Invalid 12 people account for 7.84%.Treatment teenager memory quotient forgetful and the raising middle-aged and elderly people has remarkable result, and interaction energy hypermnesis and the intelligence that promotes appetite and growth promoter is arranged, and improves learning efficiency, and has no side effect.Because so significant drug effect is arranged, makes the present invention obtain National Drug Administration's approval number of the drug: the accurate word B20020457 of traditional Chinese medicines in JIUYUE, 2002.
Below in conjunction with drawings and Examples the present invention is further described:
Fig. 1 is for making the process chart of mind calming nootropic drug oral liquid.
Fig. 2 is the process chart of the capsule of making mind calming nootropic drug.
Fig. 3 is for making the process chart of mind calming nootropic drug tablet.
Embodiment one mind calming nootropic drug oral liquid: press Radix Ginseng 50g Radix Astragali 200g Carapax Et Plastrum Testudinis 100g Rhizoma Acori Graminei 75g Fructus Alpiniae Oxyphyllae 50g
Radix Polygalae 75g Fructus Schisandrae Chinensis 150g Radix Et Rhizoma Nardostachyos 75g Rhizoma Polygonati Odorati 75g Radix Aucklandiae 150g weighing
A, Radix Ginseng powder are broken into coarse powder, carry out percolation with ethanol, are condensed into thick paste; Its medicinal residues and the Radix Astragali, Rhizoma Polygonati Odorati, Radix Polygalae decoct with water, and merge decoction liquor;
B, Carapax Et Plastrum Testudinis decoct with water, and collecting decoction is concentrated into an amount of;
C, Rhizoma Acori Graminei, Fructus Schisandrae Chinensis, Fructus Alpiniae Oxyphyllae, the Radix Aucklandiae, Radix Et Rhizoma Nardostachyos add water and carry volatile oil, and its medicinal residues decoct with water again, merge decoction liquor;
D, merge above-mentioned a, c item decoction liquor, be concentrated in right amount, add and get supernatant after ethanol leaves standstill, reclaim ethanol, concentrate; Add adjuvants such as Radix Ginseng thick paste, Carapax Et Plastrum Testudinis concentrated solution, volatile oil and sucrose, essence, sorbic acid, tween 80, add water to be adjusted to 1000ml, and regulate pH value, sterilization, fill 10ml/ prop up oral solutions.The adult takes one every day sooner or later, and the child reduces by half.
Embodiment two mind calming nootropic drug capsules: press Radix Ginseng 50g Radix Astragali 150g Carapax Et Plastrum Testudinis 125g Rhizoma Acori Graminei 50g Fructus Alpiniae Oxyphyllae 50g Radix Polygalae 50g Fructus Schisandrae Chinensis 125g Radix Et Rhizoma Nardostachyos 50g Rhizoma Polygonati Odorati 50g Radix Aucklandiae 150g weighing
Mind calming nootropic drug capsule manufacture method is:
After a, the weighing, Radix Ginseng, the Radix Astragali, Rhizoma Polygonati Odorati powder are broken into fine powder, cross 100 mesh sieves;
B, Rhizoma Acori Graminei, Fructus Schisandrae Chinensis, Fructus Alpiniae Oxyphyllae, the Radix Aucklandiae, Radix Et Rhizoma Nardostachyos add water and carry volatile oil, and its medicinal residues and Carapax Et Plastrum Testudinis, Radix Polygalae decoct with water, and filter, and collecting decoction is condensed into thick paste;
C, fine powder mix with thick paste, granulate, and add volatile oil, and granule is packed into Capsules with capsule filling machine, 0.3g/ seed lac wafer.The adult takes four every day sooner or later, and the child reduces by half.
Embodiment three: press Radix Ginseng 50g Radix Astragali 550g Carapax Et Plastrum Testudinis 250g Rhizoma Acori Graminei 200g Fructus Alpiniae Oxyphyllae 50g Radix Polygalae 200g Fructus Schisandrae Chinensis 400g Radix Et Rhizoma Nardostachyos 200g Rhizoma Polygonati Odorati 350g Radix Aucklandiae 150g weighing
Mind calming nootropic drug tablet manufacture method is:
After a, the weighing, Radix Ginseng, the Radix Astragali, Rhizoma Polygonati Odorati powder are broken into fine powder, cross 100 mesh sieves;
B, Rhizoma Acori Graminei, Fructus Schisandrae Chinensis, Fructus Alpiniae Oxyphyllae, the Radix Aucklandiae, Radix Et Rhizoma Nardostachyos add water and carry volatile oil, and its medicinal residues and Carapax Et Plastrum Testudinis, Radix Polygalae decoct with water, and filter, and collecting decoction is condensed into thick paste;
C, fine powder mix with thick paste, granulate, and add volatile oil, and granule is pressed into the 0.25g/ sheet with the medicine tablet machine, and the adult takes four every day sooner or later, and the child reduces by half
The present invention also can be processed into various forms such as granule.
Also can be according to the s own situation or the formulation dose of following the doctor's advice.
Claims (6)
1, a kind of boosting qi and nourishing yin, the neurasthenic pure Chinese medicinal preparation mind calming nootropic drug of treatment is characterized in that contained main component comprises by ratio of weight and the number of copies: Radix Ginseng 1-3 Radix Astragali 2-15 Carapax Et Plastrum Testudinis 2-6 Rhizoma Acori Graminei 1-4 Fructus Alpiniae Oxyphyllae 1-3 Radix Polygalae 1-4 Fructus Schisandrae Chinensis 2-10 Radix Et Rhizoma Nardostachyos 1-5 Rhizoma Polygonati Odorati 2-10 Radix Aucklandiae 1-4.
2, mind calming nootropic drug as claimed in claim 1 is characterized in that contained main component comprises by ratio of weight and the number of copies: Radix Ginseng 1-2 Radix Astragali 3-10 Carapax Et Plastrum Testudinis 3-4 Rhizoma Acori Graminei 1-3 Fructus Alpiniae Oxyphyllae 1-2 Radix Polygalae 1-3 Fructus Schisandrae Chinensis 3-8 Radix Et Rhizoma Nardostachyos 1-3 Rhizoma Polygonati Odorati 3-8 Radix Aucklandiae 1-3.
3, mind calming nootropic drug as claimed in claim 1 is characterized in that contained main component comprises by ratio of weight and the number of copies:
Radix Ginseng 2 Radixs Astragali 8 Carapax Et Plastrum Testudiniss 4 Rhizoma Acori Graminei 3 Fructus Alpiniae Oxyphyllae 2
Radix Polygalae 3 Fructus Schisandrae Chinensis 6 Radix Et Rhizoma Nardostachyos 3 Rhizoma Polygonati Odorati 6 Radix Aucklandiae 3.
4, as claim 1,2 or 3 described mind calming nootropic drug manufacture methods be:
After a, the weighing, the Radix Ginseng powder is broken into coarse powder, carries out percolation, be condensed into thick paste with ethanol; Its medicinal residues and the Radix Astragali, Rhizoma Polygonati Odorati, Radix Polygalae decoct with water, and merge decoction liquor;
B, Carapax Et Plastrum Testudinis decoct with water, and collecting decoction is concentrated into an amount of;
C, Rhizoma Acori Graminei, Fructus Schisandrae Chinensis, Fructus Alpiniae Oxyphyllae, the Radix Aucklandiae, Radix Et Rhizoma Nardostachyos add water and carry volatile oil, and its medicinal residues decoct with water again, merge decoction liquor;
D, merge above-mentioned a, c item decoction liquor, be concentrated in right amount, add and get supernatant after ethanol leaves standstill, reclaim ethanol, concentrate; Add adjuvants such as Radix Ginseng thick paste, Carapax Et Plastrum Testudinis concentrated solution, volatile oil and sucrose, essence, sorbic acid, tween 80, add water to be adjusted to total amount, and regulate pH value, sterilization, fill oral solutions.
5, as claim 1,2 or 3 described mind calming nootropic drug manufacture methods be:
After a, the weighing, Radix Ginseng, the Radix Astragali, Rhizoma Polygonati Odorati powder are broken into fine powder, cross 100 mesh sieves;
B, Rhizoma Acori Graminei, Fructus Schisandrae Chinensis, Fructus Alpiniae Oxyphyllae, the Radix Aucklandiae, Radix Et Rhizoma Nardostachyos add water and carry volatile oil, and its medicinal residues and Carapax Et Plastrum Testudinis, Radix Polygalae decoct with water, and filter, and collecting decoction is condensed into thick paste;
C, fine powder mix with thick paste, granulate, and add volatile oil, and granule is packed into Capsules with capsule filling machine, capsule.
6, mind calming nootropic drug manufacture method as claimed in claim 5 is characterized in that: with the granule in c step in flakes with the compacting of medicine tablet machine, tablet.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 03135564 CN1225274C (en) | 2003-08-05 | 2003-08-05 | Medicine for reieving methal stress and promoting intelligence growth and producing method |
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| CN 03135564 CN1225274C (en) | 2003-08-05 | 2003-08-05 | Medicine for reieving methal stress and promoting intelligence growth and producing method |
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| CN1473605A true CN1473605A (en) | 2004-02-11 |
| CN1225274C CN1225274C (en) | 2005-11-02 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940750A (en) * | 2010-09-14 | 2011-01-12 | 浙江省中药研究所有限公司 | Traditional Chinese medicine for senile dementia and preparation method thereof |
| CN105288412A (en) * | 2015-12-06 | 2016-02-03 | 黎余英 | Traditional Chinese medicine for treating neurasthenia |
| CN105878934A (en) * | 2016-05-27 | 2016-08-24 | 王淑芳 | Brain-invigorating and intelligence-benefiting prescription and brain-invigorating and intelligence-benefiting pillow prepared from prescription |
| CN115737761A (en) * | 2022-11-25 | 2023-03-07 | 重庆市中药研究院 | A Chinese medicinal composition for strengthening brain and improving intelligence, and its preparation method |
-
2003
- 2003-08-05 CN CN 03135564 patent/CN1225274C/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940750A (en) * | 2010-09-14 | 2011-01-12 | 浙江省中药研究所有限公司 | Traditional Chinese medicine for senile dementia and preparation method thereof |
| CN101940750B (en) * | 2010-09-14 | 2011-09-28 | 浙江省中药研究所有限公司 | Traditional Chinese medicine for senile dementia and preparation method thereof |
| CN105288412A (en) * | 2015-12-06 | 2016-02-03 | 黎余英 | Traditional Chinese medicine for treating neurasthenia |
| CN105878934A (en) * | 2016-05-27 | 2016-08-24 | 王淑芳 | Brain-invigorating and intelligence-benefiting prescription and brain-invigorating and intelligence-benefiting pillow prepared from prescription |
| CN115737761A (en) * | 2022-11-25 | 2023-03-07 | 重庆市中药研究院 | A Chinese medicinal composition for strengthening brain and improving intelligence, and its preparation method |
| CN115737761B (en) * | 2022-11-25 | 2024-05-03 | 重庆市中药研究院 | A Chinese medicinal composition for strengthening brain and improving intelligence, and its preparation method |
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| Publication number | Publication date |
|---|---|
| CN1225274C (en) | 2005-11-02 |
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Effective date of registration: 20230607 Address after: 404008 No. 5, Jingkai Avenue, Wanzhou District, Chongqing Patentee after: Chongqing Dikang Traditional Chinese Medicine Pharmaceutical Co.,Ltd. Address before: 404000, 1378 trump Road, Wanzhou District, Chongqing Patentee before: Chongqing Dongfang Pharmaceutical Co.,Ltd. |
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