CN1465383A - Medical external appliation preparation containing Artemisia apiacea extract - Google Patents
Medical external appliation preparation containing Artemisia apiacea extract Download PDFInfo
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- CN1465383A CN1465383A CNA021342725A CN02134272A CN1465383A CN 1465383 A CN1465383 A CN 1465383A CN A021342725 A CNA021342725 A CN A021342725A CN 02134272 A CN02134272 A CN 02134272A CN 1465383 A CN1465383 A CN 1465383A
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Abstract
The medicine preparation containing artemisia apracea extracted by using aerial part of sweet wormwood and organic solvent extract of aerial part of sweet wormwood or its CO2 supercritical extract and added auxiliary material can be used for external application, can be made into the skin-protecting cosmetics or medicine preparation for external application, including limiment, emulsion, gels, ointment, plaster, mask and cream agent for curing acne, pimple and comedo, and it can obtain obvious therapeutic effect.
Description
Technical field
The extract that the present invention relates to by natural plants Herba Artemisiae Annuae (Artemisia anua L.) is the new purposes of the external goods of constituent, specifically, is to be used for the treatment of the novel medical use of acne (acne) and to the new health-care effect of skin of face.
Background technology
Acne (comedo) is common chronic leather bag sebaceous gland inflammation dermatoses, the sickness rate height, and 90% above adolescence men and women can have skin lesion in various degree, and 15% state of an illness is heavier to need treatment, and severe patient can cause disfeatures.So acne treatment is skin medical treatment and one of heat subject that keeps healthy always.Think that at present the generation of acne is hyperfunction relevant with the male hormone metabolism in the skin, be on the increase with the report of androgen antagonist treatment acne that domestic also have similar report abroad, but effect is still dissatisfied; The second, the intrusion of microorganisms such as propionibacterium acnes makes sebum be decomposed to form fat acid, and chafe produces various erythra, microorganism hair follicle stimulating epithelial proliferation and hyperkeratosis, and stop up follicular orifice formation acne; In addition, acne is a kind of rejection of patient to the intradermal foreign body, and the delayed hypersensitivity of T cell mediated may participate in the inflammation that causes of acne, also has the report acarid that acne is had certain dependency, but is not principal element.
The medicine of therefore treating acne should have the inhibition sebaceous gland, suppresses to cause scorching microbial growth with propionibacterium acnes, staphylococcus aureus etc., reduces sebaceous secretion, reduces the keratinization of hair follicle tube chamber and piles up and the dissipation inflammatory effect.
Common method of treatment has (1) topical therapeutic at present, as put 5% sulfur white lotion, tetracycline ointment or 10% dibenzoyl peroxide gel etc., (2) oral antibiotic class (as erythromycin, metronidazole etc.), anti-androgens medicine (Norethisterone Compound etc.) and vitamin B complex on the skin.Curative effect is all not ideal enough.
Summary of the invention
Herba Artemisiae Annuae extract of the present invention is used for remedy of acne, is used to suppress that propionibacterium acnes etc. is relevant causes scorching microorganism, carry out the novel medical use of treatment acne targetedly and to the exploitation of the new health-care effect of face protection, this disclosed the invention belongs to first.Of the present invention from the new external goods of Herba Artemisiae Annuae extract be fabricated onto pharmacological toxicology and clinical research is finished by the inventor.Document and market are not seen as yet Chinese medicine preparation and the skin protection cosmetics that utilizes Herba Artemisiae Annuae extract to develop the treatment acne as active component.
The objective of the invention is at the limitation (as the side effect of using hormone, chemicals to bring) and the curative effect of existing medicine or cosmetics existence not good enough, have heat-clearing and toxic substances removing for society provides a kind of, the furuncle that disappears pain relieving effect, short treating period, good effect, have no side effect, economical and practical medical external goods that contain Herba Artemisiae Annuae extract.
The objective of the invention is to contain that the external goods with medical efficacy of Herba Artemisiae Annuae extract realize by manufacturing:
The extract of Herba Artemisiae Annuae of the present invention is that the volatile oil of Herba Artemisiae Annuae aerial parts extraction and the extractive with organic solvent or the carbon dioxide supercritical fluid extraction thing of Herba Artemisiae Annuae aerial parts constitute with any part by weight.External goods of the present invention are meant that the extract of Herba Artemisiae Annuae adds adjuvant, meet external used medicine dosage form that preparation requires and skin protection cosmetics according to what routine or special process were made.Comprise liniment, Emulsion, gel, ointment, patch, membrane, cream etc.Common process of the present invention is meant the common process of preparation said medicine dosage form or cosmetics; Special process of the present invention be meant be used for the preparation have nano-scale (10～200nm) and the following size microgranule of 200～1000nm the said medicine dosage form or the special process of cosmetics.This external preparation has heat-clearing and toxic substances removing, the furuncle that disappears pain relieving effect.Find to have the effect of significant inhibition antibacterial (especially causing pathogenic bacterium propionibacterium acnes, staphylococcus aureus and the pityrosporum furfur of acne) growth through pharmacological testing; Can be used for the treatment of acne, furuncle and phyma (suppurative dermatitis) through clinical verification, can be used for the skin-protection and health-care of skin of face simultaneously, determined curative effect has no side effect.
The present invention relates to a kind of external goods that contain Herba Artemisiae Annuae extract that are used for the treatment of acne or are used for skin protection cosmetics, it is characterized in that Herba Artemisiae Annuae extract is that the volatile oil of Herba Artemisiae Annuae (Artemisia annuaL.) aerial parts extraction and the extractive with organic solvent or the carbon dioxide supercritical fluid extraction thing of Herba Artemisiae Annuae aerial parts constitute with any part by weight.The volatile oil that described Herba Artemisiae Annuae aerial parts extracts, be faint yellow yellow or pale brown color clear liquid, difficulty is dissolved in water, relative density 0.94～0.96 (lighter) than water, aromatic odor is arranged, specific chemical composition is arranged, and characteristics are to contain the chemical constituent that is no less than available gas chromatogram of kind surplus in the of 80 or the online detection of gas chromatography/mass spectrometry.Main chemical compositions wherein is that (β-Caryophyllene), Borneolum Syntheticum (Borneol) etc., these materials account for the 60%-70% of volatile oil total amount for left-handed Camphora (1-Camphor), camphene (Camphene), different artemisia ketone (Isoartemisia Ketone), β-Flos Caryophylli alkene.The extractive with organic solvent of described Herba Artemisiae Annuae aerial parts is pale brown color or dark brown green oil paste solid, and difficulty is dissolved in water, and special odor is arranged.Specific chemical composition is arranged, characteristics are that the main chemical compositions that contains has sesquiterpene, flavone, coumarin, types such as sterol, concrete feature chemical constituent has artelinic acid (Artemisinic Acid), arteannuin (Artemisinin, Arteannuin, Qinghaosu), Qinghaosu I (ArteamisinineI, Qinghaosu I), Qinghaosu II (Arteamisinine II, Qinghaosu II), Qinghaosu III (Arteamisinine III, Qinghaosu III), Herba Artemisiae Annuae fourth element (Arteamisinine IV, Qinghaosu IV), Artemisitene (+)-Artemisitene sesquiterpenes such as (MethyleneQinghaosu); Tamarixetin (Tamarixetin), rhamnocitrin (Rhamnetin), chrysoeriol (Chrysoeriol), chrysosplenetin (Chrysosplenetin), eupatorin flavone such as (Eupatorin); Scopoletin (Scopoletin), scopolin coumarins such as (Scopolin); Cupreol (β-Sitosterol), Hu Luobu glycoside (Daucosterol), stigmasterol sterols such as (Stigmasterol).
Organic solvent of the present invention is meant gasoline (No. 6 industrial napthas) or industrial alcohol (containing alcoholic acid concentration expressed in percentage by volume is 50% to 99%).The carbon dioxide supercritical fluid extraction thing of described Herba Artemisiae Annuae aerial parts, be faint yellow or yellow or brown oil paste solid, difficulty is dissolved in water, specific scent is arranged and specific chemical composition is arranged, the main chemical compositions that contains has sesquiterpene, flavone, coumarin, types such as sterol, concrete feature chemical constituent has artelinic acid (Artemisinic Acid), arteannuin (Artemisinin, Arteannuin, Qinghaosu), Qinghaosu I (Arteamisinine I, Qinghaosu I), Qinghaosu II (Arteamisinine II, Qinghaosu II), Qinghaosu III (Arteamisinine III, Qinghaosu III), Herba Artemisiae Annuae fourth element (Arteamisinine IV, Qinghaosu IV), Artemisitene (+)-Artemisitene sesquiterpenes such as (Methylene Qinghaosu); Tamarixetin (Tamarixetin), rhamnocitrin (Rhamnetin), chrysoeriol (Chrysoeriol), chrysosplenetin (Chrysosplenetin), eupatorin flavone such as (Eupatorin); Scopoletin (Scopoletin), scopolin coumarins such as (Scopolin); Cupreol (β-Sitosterol), Hu Luobu glycoside (Daucosterol), stigmasterol sterols such as (Stigmasterol).
External goods of the present invention are meant that the extract of Herba Artemisiae Annuae adds adjuvant, meet external used medicine dosage form or the skin protection cosmetics that preparation requires according to what common process was made, make liniment, Emulsion, gel, ointment, patch, membrane or cream.
External goods of the present invention, the extract that is meant Herba Artemisiae Annuae adds adjuvant, according to special process make have nano-scale (10～200nm) and the external used medicine dosage form or the skin protection cosmetics of the following size microgranule of 200～1000nm, make liniment liniment, Emulsion, gel, ointment, patch, membrane or cream.
Common process of the present invention is included in the extraction pot, adds ethanol or gasoline, merceration or heating and refluxing extraction, decolouring and concentrated; Or at supercritical CO
2Extract in the extraction kettle.
Special process of the present invention comprises that emulsifying agents such as Herba Artemisiae Annuae extract and PEG is together mixed, dissolving and with the above power ultrasonic processing of 150W.
Medical external goods of the present invention is characterized in that the prescription (percentage by weight) of nanometer cream is:
Stearic acid 2%～40% glycerol 0～7.5% PEG 5%～50%
Glyceryl monostearate 2.5%～40% liquid paraffin 2.5%～40%
Herba Artemisiae Annuae extract 0.1%～10% Purified Water (surplus)
Described medical external goods of the present invention is characterized in that the prescription (percentage by weight) of nanometer liniment is:
Soybean lecithin 0.5%～10% NaTDC 0.05%～10%
Herba Artemisiae Annuae extract 0.05%～10% Purified Water (surplus)
Described medical external goods of the present invention is characterized in that the prescription (percentage by weight) of compound recipe nanometer liniment is:
Soybean lecithin 0.5%～10% NaTDC 0.5%～10%
Herba Artemisiae Annuae extract 0.05%～10% glycerol 0.5%～10% tween 80 0～10%
Isopropyl alcohol 2.5%～50% Radix Notoginseng total arasaponins 0～5%
Purified Water (surplus)
The specific embodiment
Describe the present invention in detail with embodiment below, but these embodiment must not be interpreted as the restriction to claim of the present invention of going up in all senses.
Embodiment 1: the preparation of Herba Artemisiae Annuae volatile oil (abbreviation Herba Artemisiae Annuae oil)
Artemisia leaf and sprig are cut into broken section of 3-5cm, put in the multipotency extraction pot, add water to the medical material face, heating decocts, and collects Aromatic water, separatory from the volatile oil catcher; Or with petroleum ether (bp 30-60 ℃) extraction, divide and get oil reservoir or steam and remove petroleum ether, the oil reservoir that obtains is Herba Artemisiae Annuae oil through anhydrous sodium sulfate dehydration.
Embodiment 2: the preparation of Herba Artemisiae Annuae ethanol extraction
Get the artemisia leaf powder, put in the multipotency extraction pot, add ethanol (containing 50%～99% ethanol) merceration or heating and refluxing extraction, extracting solution adds activated carbon decolorizing, and decompression recycling ethanol is concentrated into 1/4～1/8 volume, leaves standstill 1/2～1 day, and inclining supernatant, gets extractum, promptly.
Embodiment 3: the preparation of Herba Artemisiae Annuae gasoline extraction thing
Get the artemisia leaf powder, put in the multipotency extraction pot, add No. 6 industrial naptha ethanol in 60 ℃ of heating and refluxing extraction 3-5 time (4,4,3,2～0 hour), the extracting solution decompression and solvent recovery is to there not being smell of petrol, add dissolve with ethanol, alcoholic solution filters through activated carbon decolorizing, gets the filtrate decompression distillating recovering solvent, make extractum, promptly.
Embodiment 4: the preparation of Herba Artemisiae Annuae supercritical carbon dioxide fluid extract
Get the artemisia leaf powder, put supercritical CO
2In the extraction kettle, cycling extraction 0.5～10 hour, pressure are 5～12Mpa, 25 ℃～65 ℃ of extraction-container temperature, pressure 1～5Mpa, 4～10 ℃ of cooling reactor temperature.Gained extractum is the supercritical carbon dioxide extraction extract (being called for short the Herba Artemisiae Annuae supercritical extract) of Herba Artemisiae Annuae.
Embodiment 5: the preparation of Herba Artemisiae Annuae extract nanometer cream
Get stearic acid, glycerol, glyceryl monostearate, PEG, liquid paraffin heating for dissolving, add Herba Artemisiae Annuae extract, stir and make mix homogeneously; Other gets Bo Luosha, alginate jelly is dissolved in the calculating water gaging, is added in the said mixture, stirs and makes mix homogeneously.Supersound process 10～60 minutes, the power of use is 150W-3000W.The nanometer cream that is Herba Artemisiae Annuae extract that obtains like this.The proportioning of each component of example of the present invention (percentage by weight) is:
Stearic acid 20% glycerol 0.5% PEG30%
Glyceryl monostearate 15% liquid paraffin 20%
Herba Artemisiae Annuae extract 3% Purified Water (surplus)
Embodiment 6: the preparation of Herba Artemisiae Annuae extract nanometer liniment
Take by weighing soybean lecithin, NaTDC, Herba Artemisiae Annuae extract, put in the round-bottomed flask, and the adding chloroform-methanol (1: 1, v/v) make dissolving.The decompression rotary evaporation removes and desolvates, and makes residue form homogeneous film in flask walls.It is an amount of to add 0.9% sodium-chloride water solution, gets the flexible lipidosome suspension after the jolting, supersound process 10～60 minutes, and the power of use is 150W-3000W.Add water to appropriate volume, shake up.The nanometer liposome colloid solution that is Herba Artemisiae Annuae extract that obtains like this.The proportioning of each component of example of the present invention (percentage by weight) is:
Soybean lecithin 5% NaTDC 6%
Herba Artemisiae Annuae extract 4% Purified Water (surplus)
Embodiment 7: the preparation of the nanometer liniment of compound Herba Artemisiae Annuae extract
Take by weighing soybean lecithin, NaTDC, Radix Notoginseng total arasaponins, Herba Artemisiae Annuae extract, put in the round-bottomed flask, and the adding chloroform-methanol (1: 1, v/v) make dissolving.The decompression rotary evaporation removes and desolvates, and makes residue form homogeneous film in flask walls.It is an amount of to add glycerol, isopropyl alcohol, tween 80 and 0.9% sodium-chloride water solution, gets the flexible lipidosome suspension after the jolting, supersound process 5～60 minutes, and the power of use is 150W-3000W.Add water to appropriate volume, shake up.The nanometer liposome colloid solution that is Herba Artemisiae Annuae extract that obtains like this.The proportioning of each component of example of the present invention (percentage by weight) is:
Soybean lecithin 5% NaTDC 4%
Herba Artemisiae Annuae extract 3% glycerol 5% tween 6%
Isopropyl alcohol 10% Radix Notoginseng total arasaponins 3%
Purified Water (surplus)
Embodiment 8: the effect of Herba Artemisiae Annuae extract anti-acne propionibacterium
This research purpose is to test Herba Artemisiae Annuae oil to the inhibitory action of three kinds of main pathogenic bacterium staphylococcus aureuses causing acne, pityrosporum furfur, propionibacterium acnes and determine minimal effective concentration.Herba Artemisiae Annuae oil does not still have report in the past to the inhibitory action of propionibacterium acnes.
Experiment material
Medicine: Herba Artemisiae Annuae extract;
Strain: propionibacterium acnes (providing) by Nat'l Pharmaceutical ﹠ Biological Products Control Institute
Staphylococcus aureus (providing) by Nat'l Pharmaceutical ﹠ Biological Products Control Institute
Pityrosporum furfur (providing) by the skin disease prevention and treatment institute, Guangdong Province
Culture medium: plain agar culture medium sabouraud culture medium
Experimental technique
Adopt test tube medicine base method.For measuring the minimum inhibitory concentration of Herba Artemisiae Annuae oil, be starting point with 100% concentration, with 10 times of dilutions of successively decreasing to three kinds of bacterium.
Experimental arrangement and operation
Medicine base preparation: get Nutrient agar 3.3 grams, yeast hydrolyate 0.5 gram is put in the triangular flask, adding distil water 100ml, and fully mixing is heated to agar and melts the back packing fully, and every test tube packing 1.8ml adds each concentration Herba Artemisiae Annuae extract 0.2g, jumps a queue, labelling.Calculate 4 concentration of 3 strains, shared 3 * 4 * 2 medicine parent tubes by a concentration medicine of a kind of strain base two pipes.
Contrast is provided with: establish ordinary culture medium and add bacterium and compare.
Autoclaving: medicine parent tube and control tube be equal autoclaving 10.5kg/cm before inoculation
215 minutes, put the inclined-plane.
Bacterium liquid preparation: will shift to an earlier date the strain that transferred species is cultivated, and wash into bacteria suspension with LB meat soup earlier.
Inoculation: every medicine parent tube adds 1 about 0.5ml of bacterium liquid, splashes into Pasteur's pipe.Wherein after the propionibacterium acnes inoculation, fill in the test tube middle part, add the about 10mg of pyrogallic acid again, cover, splash into 50% Na again with another cotton balls with aseptic cotton balls
2CO
3, about 0.4ml makes it to form anaerobic environment, adds airtight rubber closure, is inverted.
Cultivate: propionibacterium acnes and staphylococcus aureus are put 37 ℃ of incubators, and pityrosporum furfur is put 26 ℃ of incubators, and observe once every day, continuous 2 weeks.
The result judges: being cultured to the 6th day, is standard with the blank pipe that does not add bacterium, and the medicine parent tube concentration of the no culture growth of a minimum pipe is the minimum bacteria concentration to this kind bacterium, and bacteriostatic experiment repeats 3 times, and final result is got its reproduction value or intermediate value.The result is as follows:
(1) the drugs with function concentration propionibacterium acnes staphylococcus aureus Portugal bacterium pityrosporum furfur 10%---1%---0.1%+-+0.01%+++0.001% of Artemisinin ++ ++ ++
Illustrate: medicine is a Herba Artemisiae Annuae extract; "-" expression antibacterial does not have growth, and "+" expression antibacterial has growth, but the degree of its growth is suppressed, and the degree of " ++ " expression bacterial growth is consistent when not being subjected to drug influence.
Conclusion 1:0.1% Herba Artemisiae Annuae extract has inhibitory action to golden yellow Portugal Portugal coccus; 1% Herba Artemisiae Annuae extract has inhibitory action to propionibacterium acnes and pityrosporum furfur.
(2) the drugs with function concentration propionibacterium acnes staphylococcus aureus Portugal bacterium pityrosporum furfur 10%---1%---0.1%---0.01%+++0.001% of Artemisinin nanometer formulation ++ ++ ++
Illustrate: medicine is the nanometer formulation of Herba Artemisiae Annuae extract; "-" expression antibacterial does not have growth, and "+" expression antibacterial has growth, but the degree of its growth is suppressed, and the degree of " ++ " expression bacterial growth is consistent when not being subjected to drug influence.
The nanometer formulation of conclusion 2:0.1% Herba Artemisiae Annuae extract all has inhibitory action to propionibacterium acnes, golden yellow Portugal Portugal coccus and pityrosporum furfur.
Experimental result shows, Herba Artemisiae Annuae extract is to causing three kinds of The main pathogenic fungi propionibacterium acness of acne, staphylococcus aureus, and pityrosporum furfur all has inhibitory action in various degree; The nanometer formulation fungistatic effect of Herba Artemisiae Annuae extract is stronger.
Embodiment 9: the clinical effectiveness of Herba Artemisiae Annuae extract external goods treatment acne
126 routine patients with acne have been observed, 15～35 years old age, wherein 18～28 years old person's 97 example; Severe acne (pustule ulcer) person 14 examples.Allow the patient be coated with every day to put on the skin cream or liniment 8～12 times in facial affected part.Disappearing, only leave tiny pigmentation with skin lesion and inflammation is healing; With skin lesion disappear more than 70%, no new skin lesion appears as produce effects; It serves as effective disappearing more than 30% with skin lesion.Survey result, cure rate reaches 60%～85%, and effective percentage reaches 78%～96%.And be applicable to neutrality, oily skin.Therefore, the external goods that contain Herba Artemisiae Annuae extract of the present invention are at the cosmetics or the external used medicine of exploitation treatment acne, are used for having broad prospects because of the patient's of acne (comedo), acne puzzlement face protection health care.
Claims (9)
1, a kind of medical external goods that contain Herba Artemisiae Annuae extract, it is characterized in that Herba Artemisiae Annuae extract is that the volatile oil of Herba Artemisiae Annuae (Artemisia annua L.) aerial parts extraction and the extractive with organic solvent or the carbon dioxide supercritical fluid extraction thing of Herba Artemisiae Annuae aerial parts constitute with any part by weight, adds adjuvant and makes skin protection cosmetics or topical agent.
2, medical external goods according to claim 1 is characterized in that described organic solvent is meant gasoline (No. 6 industrial napthas) or medicinal alcohol (containing alcoholic acid concentration expressed in percentage by volume is 50% to 99%).
3, medical external goods according to claim 1, it is characterized in that described external goods, the extract that is meant Herba Artemisiae Annuae adds adjuvant, meet external used medicine dosage form or the skin protection cosmetics that preparation requires according to what common process was made, make liniment, Emulsion, gel, ointment, patch, membrane or cream.
4, medical external goods according to claim 1, it is characterized in that described external goods, the extract that is meant Herba Artemisiae Annuae adds adjuvant, according to special process make have nano-scale (10～200nm) and the external used medicine dosage form or the skin protection cosmetics of the following size microgranule of 200～1000nm, make liniment, Emulsion, gel, ointment, patch, membrane or cream.
5, medical external goods according to claim 1 is characterized in that described common process is included in the extraction pot, add ethanol or gasoline, merceration or heating and refluxing extraction, decolouring and concentrated; Or at supercritical CO
2Extract in the extraction kettle.
6, medical external goods according to claim 1 is characterized in that described special process comprises emulsifying agents such as Herba Artemisiae Annuae extract and PEG is together mixed, dissolving and with the above power ultrasonic processing of 150W.
7, medical external goods according to claim 4 is characterized in that the prescription (percentage by weight) of nanometer cream is:
Stearic acid 2%～40% glycerol 0～7.5% PEG 5%～50%
Glyceryl monostearate 2.5%～40% liquid paraffin 2.5%～40%
Herba Artemisiae Annuae extract 0.1%～10% Purified Water (surplus)
8, medical external goods according to claim 4 is characterized in that the prescription (percentage by weight) of nanometer liniment is:
Soybean lecithin 0.5%～10% NaTDC 0.05%～10%
Herba Artemisiae Annuae extract 0.05%～10% Purified Water (surplus)
9, medical external goods according to claim 4 is characterized in that the prescription (percentage by weight) of compound recipe nanometer liniment is:
Soybean lecithin 0.5%～10% NaTDC 0.5%～10%
Herba Artemisiae Annuae extract 0.05%～10% glycerol 0.5%～10% tween 80 0～10%
Isopropyl alcohol 2.5%～50% Radix Notoginseng total arasaponins 0～5%
Purified Water (surplus)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021342725A CN1304020C (en) | 2002-06-28 | 2002-06-28 | Medical external appliation preparation containing Artemisia apiacea extract |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021342725A CN1304020C (en) | 2002-06-28 | 2002-06-28 | Medical external appliation preparation containing Artemisia apiacea extract |
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| Publication Number | Publication Date |
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| CN1465383A true CN1465383A (en) | 2004-01-07 |
| CN1304020C CN1304020C (en) | 2007-03-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021342725A Expired - Fee Related CN1304020C (en) | 2002-06-28 | 2002-06-28 | Medical external appliation preparation containing Artemisia apiacea extract |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101282722B (en) * | 2005-10-20 | 2011-03-30 | 埃皮法姆有限责任公司 | Treatment and prevention of benign pigmented moles (naevi) using artemisinine and the derivatives thereof |
| CN106389204A (en) * | 2016-10-23 | 2017-02-15 | 广东轻工职业技术学院 | Botanical drug composition with both functions of oil controlling and pox removing and application of botanical drug composition |
| CN112129721A (en) * | 2020-10-23 | 2020-12-25 | 湖南星辰生物科技股份有限公司 | Ultraviolet visible light rapid detection method for artemisinin |
| WO2023051026A1 (en) * | 2021-09-30 | 2023-04-06 | 上海家化联合股份有限公司 | Artemisia apiacea extract and use thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200137431A (en) * | 2019-05-30 | 2020-12-09 | (주)아모레퍼시픽 | Composition for skin anti-inflammation and skin moisturizing comprising artemisia extract extracted with skin cosmetic solution as a solvent |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1292412A (en) * | 1999-07-06 | 2001-04-25 | 张楚成 | Application of artemisia apiacea oil in detergent product |
-
2002
- 2002-06-28 CN CNB021342725A patent/CN1304020C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101282722B (en) * | 2005-10-20 | 2011-03-30 | 埃皮法姆有限责任公司 | Treatment and prevention of benign pigmented moles (naevi) using artemisinine and the derivatives thereof |
| CN106389204A (en) * | 2016-10-23 | 2017-02-15 | 广东轻工职业技术学院 | Botanical drug composition with both functions of oil controlling and pox removing and application of botanical drug composition |
| CN112129721A (en) * | 2020-10-23 | 2020-12-25 | 湖南星辰生物科技股份有限公司 | Ultraviolet visible light rapid detection method for artemisinin |
| WO2023051026A1 (en) * | 2021-09-30 | 2023-04-06 | 上海家化联合股份有限公司 | Artemisia apiacea extract and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1304020C (en) | 2007-03-14 |
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