CN1465365A - Hypotensor paint for curing hypertension - Google Patents

Abstract

The present invention relates to a Chinese medicine paint for curing hypertension. It can quickly reduce blood pressure, and is convenient for application. Said Chinese medicine paint can be made into powder and liquor for external application, and is made of 11 Chinese medicinal materials of tribulus fruit, fetid cassia, earthworm, dogbane, codonopsis root and others through a certain preparation process.

Description

Treatment hypertension painting liquid

The invention belongs to a kind of inner disease outer treat medicine of specially controlling hypertension.A kind of treatment hypertension one baste external used medicine of main proposition.

Existing in the market specially controlling hypertensively has medicinal treatment and blood pressure lowering treatment often to utilize Drug therapy can cause reducing disease-resistant factor, can thoroughly not effect a radical cure, increase according to lazy burden to patient, medication is many more, strong more according to lazyness, resistance against diseases weakens gradually, and gastric ulcer and twelve earthly branches intestinal ulcer patient are played serious secondary retroaction sometimes.Utilize reducing transformer to lead and put patient's pressure reducing mechanical, cost is high again, and the root and in a single day inactive of not only can not dispelling causes the state of an illness to go from bad to worse, and more than is to treat hypertensive weak point at present.

The objective of the invention is to utilize the Chinese herbal medicine inner disease outer treat, propose a kind of utilize Chinese herbal medicine juice stimulating acupoint and design a kind of blood pressure lowering one baste be mainly used in and cure the disease, fall end hypertension.Simplicity of design, safe in utilization, there is not secondary toxic action, the obvious results characteristics.

Technical solution of the present invention is with contained active ingredient in the Chinese herbal medicine, and adopting Fructus Tribuli, Semen Cassiae, Pheretima, Herba Apocyni veneti, Radix Codonopsis, Flos Chrysanthemi, Spica Prunellae, Rhizoma Coptidis, Cornu Saigae Tataricae, Rhizoma Gastrodiae, Fructus Evodiae, Scolopendra is that Main Ingredients and Appearance is made powdery or paste or pasty state.Other adds a certain proportion of dissolving liquid, makes blood pressure lowering one baste.

This medicine includes: volatile oil evodene, ocimene sieve, alkaloids such as lactone, a pure water enchroachment (invasion) liquid, trimethylamine, betanin, Niu Wanhuang, palmitic acid, stearic acid, cholesterol, lecithin, ammonium salt, Pheretima tincture, isoquercitin, yellow alkali, methyl yellow limit alkali (berberine), Borneolum Syntheticum, Camphora, chrysanthenone etc.

Select materials: Rhizoma Gastrodiae, Fructus Tribuli, Pheretima, Herba Apocyni veneti, Radix Codonopsis, Flos Chrysanthemi, Cornu Saigae Tataricae, Rhizoma Coptidis, Spica Prunellae, Scorpio, Scolopendra, Semen Cassiae each 4%, Fructus Evodiae 52%, and catechin, anthraquinone, glutamic acid (Herba Apocyni veneti); Carthamin glycoside (Flos Carthami); Little Pi.

Mediation spice and proportion scale: medicine and adhesive plaster non-woven fabrics and plastic foil 30%-30%-30%-30%-.Can reach optimum efficiency, and good stability, chafe does not have no side effect.

The drug effect and the clinical analysis of the various Chinese herbal medicine of foundation of the present invention:

Analyze: Fructus Tribuli＜modern study (1) composition: fatty oily 3.5% and a small amount of volatile oil, tannin, resin, sterol, potassium salt, micro-alkaloid, contain Saponin [" Jiangsu medicine village will " 253,1965] (2) effect of bringing high blood pressure down again:------water-leach liquor 30% alcohol leaching liquid has hypotensive effect to anesthetized animal for Fructus Atriplicis Sibiricae infusion, ethanol." Chinese medicine research literature summary " 723,1963 selected from [" newly organized property of medicine song is drawn together 400 flavors " " 355 pages, 1993]

Semen Cassiae [modern study] this product contains various anthraquinone classes and phlegmatic temperament, protein, fatty oil, pigment and Hus such as emodin, aloe-emodin, chrysophanol, chrysophanic acid

Luo Busu etc.[" Chinese materia medica " Science and Technology of Shanghai publishing house 1978] (2), the effect of blood base pressure is fallen: the infusion of Semen Cassiae, alcohol-infusion, pure immersion all have hypotensive effect to anesthetized dog, cat, rabbit etc.Select from 355 pages of " new piece of writing property of medicine song is drawn together 400 flavors " China Traditional Chinese Medicine Publishing House, 1993 more than [Chinese Academy of Medical Sciences, paper report abstract of a thesis 2:70 in 1956,1956].]

Pheretima: [modern study] be hypotensive effect 2.: LUMBRICUS tincture, dry powder suspension, hot dipping liquid, decoct etc. all show slow and persistent hypotensive effect to anesthetized dog, rat, cat and chronic renal hypertension rat, hypotensive effect behind anesthetized dog and the cat injection Pheretima had tolerate phenomenon rapidly, [pacify little medical institute journal (2-3): 18.1960] (select from " property of medicine song is drawn together 400 flavors in newly organized " China Traditional Chinese Medicine Publishing House 365,1993]

Herba Apocyni veneti: flavonoids such as [modern study] be composition 1.: Folium Apocyni Veneti contains Isoquercitrin, Quercetin and catechin, anthraquinone, glutamic acid, potassium chloride, steroid etc.Root contains cymarin, convallatoxigenin and K-strophanthus time glycoside β.Herb contains neoisorutin, [" Chinese materia medica " Chinese Medicine science and technology publishing house, 1990].

2. treat hypertension: use Folium Apocyni Veneti 1-2 money every day, the boiled water bubble is worked as dish and is eaten, or regularly decoction sooner or later, control 596 examples altogether, wherein single with Folium Apocyni Veneti 169 examples, use Herba Apocyni veneti or depressor and Herba Apocyni veneti are used with other depressor effect is unstable, and blood pressure drops to a certain degree back reuse Herba Apocyni veneti, and the person of consolidation counts 427 examples.If transference cure or remarkable alleviator's 259 examples alleviate 212 examples; Following person 143 people of blood pressure drops to 140/90 millimetres of mercury wherein, systolic pressure or diastolic pressure above person 268 people of 20 millimetress of mercury that descend, effective percentage reaches 88.3%; Medicine time, long more then curative effect was high more, and what surpass half a year reaches 93.3%; But curative effect of Herba Apocyni veneti and course of disease length do not have obvious relation.[" Chinese herbal medicine communication " (4): 12,1972] [selecting from " newly organized property of medicine song is drawn together 400 flavors " China Traditional Chinese Medicine Publishing House 367,368-1993]

Fructus Evodiae: [modern study] 1. this product contains volatile oil, is mainly evodene, ocimene, sieve Fructus Evodiae lactone, evodol etc. and alkaloid." research of Chinese herbal medicine effective ingredients " (first fascicle) 396,307]

4. external treatment hypertension: Fructus Evodiae grinds not, transfers with vinegar and applies arch of the foot, generally can descend with the back blood pressure, and doing well,improving, hypopathia people applies once, and deposited 2-3 time of weight person controls 21 examples altogether, and effect is remarkable.[" new medical science " (4): 55,1972]

Radix Codonopsis: [modern study] 1. root contains Saponin, micro-alkaloid, sucrose, glucose, inulin, starch, mucus and resin etc.[Lou Zhicen " pharmacognosy " 161,1965]

3. hypotensive effect: alcohol, aqueous extract vein or lumbar injection, can reduce the blood pressure of anesthetized dog, according to preliminary analysis, think to belong to not property slightly; And some adrenolytic arranged.[state-run Beijing academy's Physiologic Studies institute Chinese report transactions, 1:63,1936] (selecting from " newly organized property of medicine song is drawn together 400 flavors " Chinese medicine publishing house 382,1993)

Cornu Saigae Tataricae: [modern study] be composition 1.: phosphoric acid calcium, keratin and insoluble inorganic salt etc.[Xu Guojun " pharmacognosy " 748,1963]

2. Cornu Saigae Tataricae crust leachate (makes 100% sulfur extractum with 50% alcohol, boil off ethanol before the experiment) can reduce the mice oriented locomotor reaction, the central nervous system there is inhibitory action, can quicken the commencing speed of barbital and etherization, significantly reduce sensitivity, but do not cause muscular flaccidity leptazol, strychnine, galvanic shock.[φa-pmakor.ntokcnkor.34(1)：36，1971]

3. the Cornu Saigae Tataricae decoct can reduce the convulsions rate of Bufo siccus and mice due to the caffeine, and sets up recovery rate, but then invalid to fainting from fear due to soil peaceful, also can not strengthen phenobarbital and receive toxicity to Bufo siccus and mice.[" the Harbin traditional Chinese medical science ".6 (3): 36,1963] [select from, newly organized property of medicine song is drawn together 400 flavors " Chinese Chinese medicine publishing house 341,1996]

Rhizoma Coptidis [modern study] 1. contains multiple alkaloids such as little Pi's alkali (berberine), 13-methyl-.psi.-coptisine., and wherein berberine accounts for 5-8%.[＜plant medicines chemistry〉108,1956]

4. treat hypertension, with coptisine every day 0.75-4 gram, divides 3-4 time oral, treat 13 examples the 6-14 days course of treatment, the result has 12 examples to reduce to normal range in treating in a couple of days afterwards blood pressure.It is introduced that coptisine can suppress streptococcus, and the effect of blood vessel dilating is arranged, thus think, the hypertension of coptisine treatment acute nephritis, and when being used for hypertension and angina pectoris and coronary insufficiency being arranged, may receive double effects.[" Chinese medical ", 41 (10): 918,1955] (selecting from " newly organized property of medicine song is drawn together 400 flavors " China Traditional Chinese Medicine Publishing House, 1996)

Spica Prunellae: [modern study] 1. herb contains triterpenoid saponin and caffeic acid, alkaloid and water soluble salt.[" Chinese medicinal herbal " 3:357,1961]

2. this product water and alcohol extract all have hypotensive effect, and its hypotensive effect has substantial connection with contained inorganic salt wherein; [" Chinese Academy of Medical Sciences's free paper session abstract of a thesis in 1956 " 11:70,1956] Spica Prunellae decoct all has in various degree inhibitory action to the random vibrio of dysentery bacterium, Bacillus typhi, the leaves of pulse plants, escherichia coli, Bacillus tuberculosis, staphylococcus etc.[" Shandong medical college journal " (8): 42,1959] are in addition along antitumor action is arranged.

It is 4. modern that clinical many to treat vascular hypertension, lymphoid tuberculosis, thyromegaly, thyroid adenoma and acute icterohepatitis with this product effective.[selecting from " newly organized property of medicine song is drawn together 400 flavors " China Traditional Chinese Medicine Publishing House, 1996]

Flos Chrysanthemi: [modern study] 1. contains volatile oil, is Borneolum Syntheticum, Camphora, chrysanthenone etc. in the oil; [" C.A。" 52 (9): 7163d, 1958] in addition, still contain chrysanthemum glycoside, adenine, choline, mcg vitamin A, B, aminoacid etc.[" pharmacognosy " 605,1963] (selecting from " newly organized property of medicine song is drawn together 400 flavors " Chinese medicine publishing house 341,1996)

4. treat hypertension: every day with Flos Chrysanthemi, Flos Lonicerae each 0.8-1 two (dizziness obviously adds Folium Mori 4 money, and arteriosclerosis, the high person of serum ornitrol add Fructus Crataegi 4-8 money), mixing divides 4 boiling boiled water of usefulness to brew after 10-15 minute and works as tea-drinking.Can not decoct, otherwise can break the ring effective ingredient.[" new medicine and pharmacology magazine " (2): 32,1972] (selecting from " newly organized property of medicine song is drawn together 400 flavors " China Traditional Chinese Medicine Publishing House 1996)

Scorpio: [modern study] be composition 1.: containing scorpion venom, is the Neurotoxic material of a kind of similar snake venom.In addition, and contain trimethylamine, betanin, taurine, palmitic acid, stearic acid, cholesterol, lecithin and ammonium salt etc.[" Chinese medicinal herbal " 4:37,1961]

3. to the effect of blood circulation: intravenous injection Scorpio preserved material and decoct all can make rabbit, the momentary decline of dog blood pressure (visible temporary transient rising of minority), but persistent gradually blood pressure drops then appears in very fast recovery, keeps more than 1-3 hour.Irritate stomach or administered intramuscular and still have remarkable persistent hypotensive effect, tachylaxis does not appear in repeated drug taking.Decompression principle has obvious sedation to clear-headed animal, but animal is fallen asleep for suppressing vasomotor center, blood vessel dilating, directly suppressing heart and to adrenolytic boosting, also may be relevant with blood pressure lowering.[hypertension and Vasculocardiology Deparment academic conference compilation of data 131,1964]

Rhizoma Gastrodiae: [modern study] 1. contains vanillyl alcohol, vanillin, retinoid material, glycoside, crystallinity neutral substance and micro-biological alkali, phlegmatic temperament.[" Chinese materia medica " Chinese Medicine science and technology publishing house, 1990]

4. hemodynamics effect: the quiet notes Rhizoma Gastrodiae of anesthetized dog injection 1 or 2g/kg or armillaria mellea mycelium injection 1g/kg, all can obviously reduce external perihaemal canal and coronary vascular resistance, blood flow increasing.Mycelium also can reduce cerebrovascular cloudy power, stingy cerebral blood flow, but Rhizoma Gastrodiae does not see that then cerebrovascular is had dilating effect, under above-mentioned experiment condition, the two unit does not all have obvious hypotensive effect.When Rhizoma Gastrodiae or mycelium injection are directly injected coronary artery or carotid artery, reduce the cloudy power of blood vessel and increase the effect of arteria coronaria and cerebral blood flow more remarkable.Mycelial effect is better than Rhizoma Gastrodiae.[institute of Materia Medica,Chinese Academy of Medical Sciences pharmacological room; Rhizoma Gastrodiae and armillaria mellea mycelium are to the effect 1975 of anesthetized dog hemodynamic].

The embodiment of the invention: Rhizoma Gastrodiae, fructus tribuli, Pheretima, Herba Apocyni veneti, Radix Codonopsis, Flos Chrysanthemi, Cornu Saigae Tataricae, Rhizoma Coptidis, Spica Prunellae, Scorpio, Scolopendra, Semen Cassiae each 4%, Fructus Evodiae 52%.

Processing technology of the present invention takes traditional processing technology to make in conjunction with advanced processing technology of modern times and this product character.

The present invention is easy to use, good effect, and instant effect is a kind of unique special-purpose baste of controlling hypertension.

Claims (3)

1, a kind ofly is used for to treat the quick-acting blood pressure lowering one brush of hypertension (being coated with) spirit.。The distiller liquor cooperation forms; It is characterized in that: join paste, pasty state, the liquid that face becomes by Fructus Tribuli, Semen Cassiae, Pheretima, Herba Apocyni veneti, Radix Codonopsis, Flos Chrysanthemi, Spica Prunellae, golden scorpion, Scolopendra, Cornu Saigae Tataricae, Rhizoma Coptidis, Fructus Evodiae.

2, treatment hypertension one according to claim 1 is smeared masking liquid and be it is characterized in that, is that major ingredient is made powder or paste or pasty state with Rhizoma Gastrodiae, Fructus Tribuli, Semen Cassiae, Pheretima, Herba Apocyni veneti, Radix Codonopsis, Flos Chrysanthemi, Scorpio, Cornu Saigae Tataricae, Spica Prunellae, Fructus Evodiae.

3, treatment hypertension one baste according to claim 1 is characterized in that disjunctor does not design in the bottle and debugs and medicinal liquid.