CN1460508A - Medicine for curing diseases of digestive system and its preparation method - Google Patents
Medicine for curing diseases of digestive system and its preparation method Download PDFInfo
- Publication number
- CN1460508A CN1460508A CN 03137425 CN03137425A CN1460508A CN 1460508 A CN1460508 A CN 1460508A CN 03137425 CN03137425 CN 03137425 CN 03137425 A CN03137425 A CN 03137425A CN 1460508 A CN1460508 A CN 1460508A
- Authority
- CN
- China
- Prior art keywords
- preparation
- rhizoma
- parts
- chinese medicine
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a medicine for curing diseases of digestive system and its preparation method. It is made up by using 10 Chinese medicinal materials of notoginseng, corydalis tuber, cyperus root, evodia fruit, ark shell, calcined alum, licorice, white peony root, bletilla tuber and toosendan fruit and other medicines of magnesium oxide, sodium hydrogen carbonate and belladonna liquid extract.
Description
Technical field:
The present invention relates to a kind of Chinese medicine for the treatment of gastrointestinal disease, the particularly Chinese medicine made from medicines such as Radix Notoginseng, Rhizoma Corydalis, Rhizoma Cyperi, Fructus Evodiae, Concha Arcae, dried Alumen, Radix Glycyrrhizae, the Radix Paeoniae Alba, Pseudobulbus Bletillae (Rhizoma Bletillae), Fructus Toosendan, magnesium oxide, sodium bicarbonate, Semen daturae fluid extracts.
Background technology:
Chronic gastritis, gastric ulcer and duodenal ulcer are a kind of pilosity, common digestive system disease.The male is more than the women.Often bring out because of the factors such as ill effect of anxious state of mind, overworked, drinking and eating irregularly, smoking, excessive drinking, some drugs.The course of disease is longer, and outbreak repeatedly, prolonged illness meeting cause pathogenesis complicated more, come bigger difficulty for the medicine treatment belt.Now analyze the cause of disease of digestive system disease, the characteristics of pathology, according to Chinese medical theory, in conjunction with the modern pharmaceutical technology, make full use of local natural resources of Chinese medicinal materials, develop a kind of medicine for the treatment of chronic gastritis, gastric ulcer, duodenal ulcer, determined curative effect, drug safety, quality controllable.
In recent years, along with going deep into of clinical research, also occur on the market some the treatment digestive system disease medicine, existing medicine belongs to a bit cures the symptoms, not the disease, some uses expensive composition, some in application process since uncertain therapeutic efficacy cut interrupt the use.
The invention provides a kind of determined curative effect, safe ready, little, the cheap pure traditional Chinese compound medicine of side effect.
Summary of the invention:
The invention provides a kind of Chinese medicine for the treatment of gastrointestinal disease, this Chinese medicine is to make with medicine materials such as Radix Notoginseng, Rhizoma Corydalis, Rhizoma Cyperi, Fructus Evodiae, Concha Arcae, dried Alumen, Radix Glycyrrhizae, the Radix Paeoniae Alba, Pseudobulbus Bletillae (Rhizoma Bletillae), Fructus Toosendan, magnesium oxide, sodium bicarbonate, Semen daturae fluid extracts.
Chinese medicine preparation of the present invention has relieving gastric hyperacidity to alleviate stomachache, regulating the flow of QI to dissipate blood stasis, warming middle-JIAO and strengthening the spleen, astringing to arrest bleeding.Be used for hyperchlorhydria, gastric abscess, gastric ulcer, duodenal bulbar ulcer and chronic gastritis.
Its prescription of Chinese medicine preparation of the present invention consists of: pseudo-ginseng 1-9 part corydalis tuber 15-70 part rhizoma cyperi 10-50 part evodia rutaecarpa 10-50 part blood clam 80-150 part alumen 120-200 part Radix Glycyrrhizae 50-120 part root of herbaceous peony 50-120 part bletilla 10-50 part Fructus meliae toosendan 8-30 part magnesia 50-120 part sodium acid carbonate 25-80 part belladonna liquid extract 1-10 part is pseudo-ginseng 3-7 part corydalis tuber 29-56 part rhizoma cyperi 20-40 part evodia rutaecarpa 20-40 part blood clam 100-130 part alumen 140-180 part Radix Glycyrrhizae 70-100 part root of herbaceous peony 70-100 part bletilla 20-40 part Fructus meliae toosendan 13-24 part magnesia 70-100 part sodium acid carbonate 45-60 part belladonna liquid extract 4-7 part 5.5 parts of 52.5 portions of belladonna liquid extracts of 85 parts of sodium acid carbonates of 19 parts of magnesia of 30 parts of Fructus meliae toosendans of 85 parts of bletillas of 85 portions of root of herbaceous peonys of 160 portions of Radix Glycyrrhizaes of 115 parts of alumens of 30 parts of blood clams of 30 portions of evodia rutaecarpas of 42.5 portions of rhizoma cyperis of 5 parts of corydalis tubers of pseudo-ginseng more preferably preferably
In more than forming, every part of representative be weight portion, weight is calculated with crude drug, and as if being unit (Semen daturae fluid extract is unit with ml simultaneously) with the gram, more than composition can be made into 1000 doses of pharmaceutical preparatioies, described 1000 doses of fingers, the final drug preparation of making, as make 1000 of capsule preparations, 1000 in tablet, 1000 bags of granules, oral liquid 1000ml etc. also can make big packing as granule, as the 100-500 bag, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time, and oral liquid can be made Different Package such as 5ml/ bottle, 200ml/ bottle, the 100ml/ bottle, the 50ml/ bottle.
More than form, as if being unit with the gram, can be made into the preparation of 50-1000 taking dose, as tablet, make 1000, each taking dose can be the 1-20 sheet, can take 50-1000 time altogether.As granule, make 125 bags, take the 1-2 bag at every turn, can take 62.5-125 time altogether.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the gram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
Single medicinal material, especially ministerial drug and adjuvant drug in more than forming also can be replaced by the suitable Chinese medicine with identical property of medicine, and its drug effect of the Chinese medicine preparation after the replacement is constant.
Chinese medicine preparation of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, peroral dosage form preferably, as: capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum etc., preferably capsule, tablet.
Preparation of the present invention is determined usage and dosage according to patient's situation in use, but obeys every day three times, each 1-20 agent, as: 1-20 bag or grain or sheet.
Chinese medicine preparation of the present invention prepares by the following method.
1), above 13 flavors, Six-elements such as Radix Notoginseng, Rhizoma Corydalis, Concha Arcae, Rhizoma Cyperi, Fructus Evodiae, dried Alumen are ground into fine powder, add magnesium oxide, sodium bicarbonate be mixed even, medicated powder A;
2), coarse powder and Radix Glycyrrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Fructus Toosendan, the Radix Paeoniae Alba of step 1) remainder decocted with water 2-4 time, each 1-4 hour, filter merging filtrate, be condensed into thick paste B according to a conventional method.
3), add A medicated powder, Semen daturae fluid extract and an amount of mucilago salep at thick paste B, mixing is made granule, makes capsule or tablets and other formulations more as required.
Below by effect experiment beneficial effect of the present invention is described.
Test the medicine that used medicine prepares for the method according to the embodiment of the invention 1, experimental result is as follows.Pharmacodynamics: pharmacodynamics test shows that medicine of the present invention has the rat stress ulcer of alleviating, the effect of aspirin ulcer; Rat stomach mucosa injury due to the ethanol there is the certain protection effect, and can reduces the crooked sample bacterial number of gastric mucosa, have to promote the burn effect trend of gastric ulcer healing of rat acetic acid; Can reduce the total acidity of rat gastric juice, mouse peritoneum acetic acid is caused pain certain analgesic activity; Stereotest to rat stomach at the bottom of smooth muscle A Ach cause the convulsion backward pull certain analgesic activity arranged, can reduce the rat stomach protease activities; To the rat stomach liquid measure, the rat clotting time, the rat bleeding time there is no obvious influence.The external drug sensitive experiment of HP (helicobacter pylori), find in the single medicinal material, Fructus Toosendan, dried Alumen, Radix Glycyrrhizae, the Radix Paeoniae Alba etc. are external all to have certain inhibitory action to HP, the average inhibition zone diameter of this medicine is greater than hydrochloric acid thunder Buddhist nun and Chinese medicine extract, minimum inhibitory concentration is less than single medicinal material, as seen this medicine is external the effect that suppresses HP, and effect is better than single medicinal material.Toxicity: the disposable mouse stomach administration of medicine of the present invention, maximum tolerated dose is crude drug in whole 35.04g/kg (352 times of a clinical daily dose), press crude drug 8.73g/kg, 4.37g/kg dosage (be respectively 60 times of clinical daily doses, 30 times), give 12 weeks of rat continuous irrigation stomach respectively, there is no overt toxicity reaction, drug withdrawal is observed and was not also seen in 2 weeks and significantly delay toxic reaction.Clinical research:
Defend medicine according to Guangxi Zhuang Autonomous Region Department of Public Health osmanthus and criticize literary composition (1996) No. 108, first Affiliated Hospital of Colleges Of Traditional Chinese Medicine Of Guangxi, Guilin hospital attached to a medical college, the People's Hospital, Guilin city, Guilin city institute of traditional Chinese medicine have carried out clinical verification year February in October, 1996 to 1997 to 480 routine patients.The result shows that medicine of the present invention has the effect of regulating the flow of QI to dissipate blood stasis, warming middle-JIAO and strengthening the spleen, astringing to arrest bleeding; pain relieving is arranged; antacid; be good for the stomach; antiinflammatory, hemostasis, protection ulcer spot; promote the effect of ulcer healing, can be used for the chronic superficial gastritis or the peptic ulcer patient of syndrome of stagnation of QI, deficiency-cold syndrome, syndrome of blood stasis gastric abscess.300 examples are organized in treatment, and total effective rate and total obvious effective rate of treatment syndrome of stagnation of QI gastric abscess are respectively 92.5% and 73.3%; Total effective rate and total obvious effective rate of treatment deficiency-cold syndrome gastric abscess are respectively 91.1% and 68.9%; Total effective rate and total obvious effective rate of treatment blood stasis symptom gastric abscess are respectively 96.7% and 70.0%; Matched group 180 examples, total effective rate and total obvious effective rate of treatment syndrome of stagnation of QI gastric abscess are respectively 96.7% and 81.7%; Total effective rate and total obvious effective rate of treatment deficiency-cold syndrome gastric abscess are respectively 91.7% and 73.3%; Total effective rate and total obvious effective rate of treatment blood stasis symptom gastric abscess are respectively 98.3% and 78.3%.Two groups of curative effects compare no significant difference.
The specific embodiment:
Further specify the present invention by the following examples
Embodiment 1: the preparation prescription of capsule: Radix Notoginseng 5g Rhizoma Corydalis 42.5g Rhizoma Cyperi 30g Fructus Evodiae 30g Concha Arcae 115g dried Alumen 160g Radix Glycyrrhizae 85g Radix Paeoniae Alba 85g Pseudobulbus Bletillae (Rhizoma Bletillae) 30g Fructus Toosendan 19g magnesium oxide 85g sodium bicarbonate 52.5g Semen daturae fluid extract 5.5ml preparation method:
1), above 13 flavors, Six-elements such as Radix Notoginseng, Rhizoma Corydalis, Concha Arcae, Rhizoma Cyperi, Fructus Evodiae, dried Alumen are ground into fine powder, add magnesium oxide, sodium bicarbonate be mixed even, medicated powder A;
2), coarse powder and Radix Glycyrrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Fructus Toosendan, the Radix Paeoniae Alba of step 1) remainder decocted with water 3 times, each 2 hours, filter merging filtrate, be condensed into thick paste B.
3), add A medicated powder, Semen daturae fluid extract and an amount of mucilago salep at thick paste B, mixing is made granule, makes 1000 of capsules again.
Embodiment 2: the preparation prescription of granule: Radix Notoginseng 5g Rhizoma Corydalis 42.5g Rhizoma Cyperi 30g Fructus Evodiae 30g Concha Arcae 115g dried Alumen 160g Radix Glycyrrhizae 85g Radix Paeoniae Alba 85g Pseudobulbus Bletillae (Rhizoma Bletillae) 30g Fructus Toosendan 19g magnesium oxide 85g sodium bicarbonate 52.5g Semen daturae fluid extract 5.5ml preparation method:
1), above 13 flavors, Six-elements such as Radix Notoginseng, Rhizoma Corydalis, Concha Arcae, Rhizoma Cyperi, Fructus Evodiae, dried Alumen are ground into fine powder, add magnesium oxide, sodium bicarbonate be mixed even, medicated powder A;
2), coarse powder and Radix Glycyrrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Fructus Toosendan, the Radix Paeoniae Alba of step 1) remainder decocted with water 3 times, each 2 hours, filter merging filtrate, be condensed into thick paste B.
3), add A medicated powder, Semen daturae fluid extract, 50g sucrose and an amount of mucilago salep at thick paste B, mixing is made granule 1000g, is distributed into 250 bags.
Claims (10)
1, a kind of Chinese traditional compound medicine, it is characterized in that, it is made by the medicine material of following component, Radix Notoginseng 1-9 part Rhizoma Corydalis 15-70 part Rhizoma Cyperi 10-50 part Fructus Evodiae 10-50 part Concha Arcae 80-150 part dried Alumen 120-200 part Radix Glycyrrhizae 50-120 part Radix Paeoniae Alba 50-120 part Pseudobulbus Bletillae (Rhizoma Bletillae) 10-50 part Fructus Toosendan 8-30 part magnesium oxide 50-120 part sodium bicarbonate 25-80 part Semen daturae fluid extract 1-10 part.
2, according to the Chinese medicine preparation of claim 1, it is characterized in that, it is made by the medicine material of following component, Radix Notoginseng 3-7 part Rhizoma Corydalis 29-56 part Rhizoma Cyperi 20-40 part Fructus Evodiae 20-40 part Concha Arcae 100-130 part dried Alumen 140-180 part Radix Glycyrrhizae 70-100 part Radix Paeoniae Alba 70-100 part Pseudobulbus Bletillae (Rhizoma Bletillae) 20-40 part Fructus Toosendan 13-24 part magnesium oxide 70-100 part sodium bicarbonate 45-60 part Semen daturae fluid extract 4-7 part.
3, according to the Chinese medicine preparation of claim 1, it is characterized in that, it is made by the medicine material of following component, 5.5 parts of 52.5 portions of Semen daturae fluid extracts of 85 parts of sodium bicarbonate of 19 parts of magnesium oxide of 30 parts of Fructus Toosendans of 85 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) of 85 portions of Radix Paeoniae Albas of 160 portions of Radix Glycyrrhizaes of 115 parts of dried Alumens of 30 parts of Concha Arcaes of 30 parts of Fructus Evodiaes of 42.5 portions of Rhizoma Cyperis of 5 parts of Rhizoma Corydalis of Radix Notoginseng.
4, the Chinese medicine preparation of claim 1-3 is to be fit to medicinal various dosage forms.
5, the Chinese medicine preparation of claim 4 is tablet, capsule, oral liquid, buccal tablet, granule, electuary, pill, powder, suspensoid, injection, solution, drop, drop pill.
6, the Chinese medicine preparation of claim 4 is capsule, tablet.
7, the Chinese medicine preparation of claim 1 prevents and/or treats application in the medicine of gastrointestinal disease in preparation.
8, the preparation method of the Chinese medicine preparation of claim 1 is characterized in that, through following steps,
1), Six-elements such as Radix Notoginseng, Rhizoma Corydalis, Concha Arcae, Rhizoma Cyperi, Fructus Evodiae, dried Alumen are ground into fine powder, add magnesium oxide, sodium bicarbonate be mixed even, medicated powder A;
2), coarse powder and Radix Glycyrrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Fructus Toosendan, the Radix Paeoniae Alba of step 1) remainder decocted with water 2-4 time, each 1-4 hour, filter merging filtrate, be condensed into thick paste B according to a conventional method;
3), add A medicated powder, Semen daturae fluid extract and medicine acceptable carrier at thick paste B, mixing is made preparation.
9, preparation method according to Claim 8 is characterized in that, decocts with water in the step 2 totally 3 times.
10, according to the preparation method of claim 9, it is characterized in that, decoct with water in the step 23 times, each 2 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03137425 CN1220508C (en) | 2003-06-20 | 2003-06-20 | Medicine for curing diseases of digestive system and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03137425 CN1220508C (en) | 2003-06-20 | 2003-06-20 | Medicine for curing diseases of digestive system and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1460508A true CN1460508A (en) | 2003-12-10 |
| CN1220508C CN1220508C (en) | 2005-09-28 |
Family
ID=29591326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03137425 Expired - Lifetime CN1220508C (en) | 2003-06-20 | 2003-06-20 | Medicine for curing diseases of digestive system and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1220508C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1966036B (en) * | 2006-11-25 | 2011-05-25 | 李勇奇 | Chinese medicine for treating gastrointestinal disease and preparation method thereof |
| CN104083467A (en) * | 2014-06-30 | 2014-10-08 | 咸洪震 | Traditional Chinese medicine preparation for treating chronic gastritis and preparation method of traditional Chinese medicine preparation |
-
2003
- 2003-06-20 CN CN 03137425 patent/CN1220508C/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1966036B (en) * | 2006-11-25 | 2011-05-25 | 李勇奇 | Chinese medicine for treating gastrointestinal disease and preparation method thereof |
| CN104083467A (en) * | 2014-06-30 | 2014-10-08 | 咸洪震 | Traditional Chinese medicine preparation for treating chronic gastritis and preparation method of traditional Chinese medicine preparation |
| CN104083467B (en) * | 2014-06-30 | 2016-08-24 | 咸洪震 | A kind of Chinese medicine preparation treating chronic gastritis and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1220508C (en) | 2005-09-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102370950A (en) | Chinese medicinal compound preparation for treating gall-stone and preparation method thereof | |
| CN107616501A (en) | A kind of composition with clearing lung-heat function and preparation method thereof | |
| CN101284064A (en) | Preparation method of kudzuvine root and indigowoad root tablets for reducing fat and alleviating hangover | |
| CN101199639B (en) | Chinese medicine for treating irritable | |
| CN106361993A (en) | Medicinal composition for preventing and treating gastric mucosal lesion and preparation method of medicinal composition | |
| CN101797295B (en) | Medicinal composition for treating infantile cough and preparation method thereof | |
| CN101342282B (en) | Chinese medicinal composition for treating gastropathy and preparation method | |
| CN101837093B (en) | Chinese medicinal composition for curing gout | |
| CN101850065B (en) | Chinese medicinal composition for treating gout | |
| CN1220508C (en) | Medicine for curing diseases of digestive system and its preparation method | |
| CN1233364C (en) | Chinese medicine for treating digestive ulcerating sore and its preparation method | |
| CN107773695A (en) | A kind of Chinese medicine for being used to treat flat wart | |
| CN102091138B (en) | Gastrointestinal tablet and preparation process thereof | |
| CN103356798A (en) | Application of chronic-gastritis-treating traditional Chinese medicine in preparing medicine used for preventing gastric ulcer | |
| CN110898170B (en) | Traditional Chinese medicine composition for treating metabolic syndrome and preparation thereof | |
| CN102512652B (en) | Medicinal composition for treating peptic ulcer | |
| CN101015616A (en) | Chinese medicine composition for treating children pneumonia and preparing method thereof | |
| CN102362879B (en) | Traditional Chinese herbal medicinal preparation for relieving ulcer by inhibiting gastric acid and preparation method thereof | |
| CN101607061A (en) | A kind of drug regimen of protecting gastric mucosa and preparation method thereof | |
| CN101670046A (en) | Chinese medicinal composition for gastritis and esophagitis and preparation process thereof | |
| CN105125985A (en) | Chinese and western medicine compound preparation for treating senile chronic bronchitis and preparation method thereof | |
| CN1440802A (en) | Gastritis treating Chinese medicine | |
| CN114984179A (en) | Composition for treating or preventing mitiglinide adverse reaction and preparation method and application thereof | |
| CN1319591C (en) | Medicinal composition for treating hilar pulmonistuberculosis and its preparation method | |
| CN107596245A (en) | A kind of Chinese medicine containing gallic treatment gastric ulcer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: SANJIN PHARMACEUTICAL CO., LTD., GUILIN Free format text: FORMER OWNER: GUILIN SANJIN BIOLOGICAL PHARMACEUTICAL CO., LTD., SANJIN GROUP Effective date: 20130424 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 541100 GUILIN, GUANGXI ZHUANG AUTONOMOUS REGION TO: 541004 GUILIN, GUANGXI ZHUANG AUTONOMOUS REGION |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20130424 Address after: 541004 No. 1 Jinxing Road, Guilin, the Guangxi Zhuang Autonomous Region Patentee after: GUILIN SANJIN PHARMACEUTICAL Co.,Ltd. Address before: 541100 No. 112 Renmin Avenue, the Guangxi Zhuang Autonomous Region, Guilin, Xicheng District Patentee before: GUILIN SANJIN BIOLOG PHARMACEU |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20050928 |