CN1453014A

CN1453014A - Chinese medicine prepn for preventing fibrillated liver and treating hepatocirrhosis

Info

Publication number: CN1453014A
Application number: CN 02159450
Authority: CN
Inventors: 张立中
Original assignee: Individual
Current assignee: Individual
Priority date: 2002-12-31
Filing date: 2002-12-31
Publication date: 2003-11-05
Anticipated expiration: 2022-12-31
Also published as: CN1227019C

Abstract

The Chinese medicine preparation for preventing fibrillated liver and treating hepatocirrhosis is prepared with astragalus root, angelica, aweto, bupleurum root, red sage and other eight kinds of Chinese medicinal materials. It is in the form of medicinal tea, granule, oral liquid, etc. It has the functions of strengthening body's resistance, softening the dry feces, dissipating mass, eliminating blood clots, clearing away toxic matter, and invigorating vital energy and blood, so that it may be used in preventing and treating fibrillated liver and hepatocirrhosis.

Description

A kind of Chinese medicine preparation that prevents hepatic fibrosis, treatment liver cirrhosis

The present invention is a kind of preparation that is exclusively used in prevention, blocking-up hepatic fibrosis, the early, middle and late cirrhosis of treatment.It is a raw material with Chinese medicine, can be made into medicinal tea, oral liquid, electuary etc.

China has 1,500 ten thousand chronic hepatitis patients approximately, and nearly 1/3rd develop into hepatic fibrosis, finally cause liver cirrhosis even hepatocarcinoma.Prevention hepatic fibrosis, blocking-up and treatment liver cirrhosis are significant.Take a broad view of the progress of international treatment liver cirrhosis, the non-Western medicine of Chinese medicine advantage can ratio.

The present invention is the experience prescription that forms on the basis of clinical practice for many years, the constantly perfect raising of summary.In conjunction with patient's the actual state of an illness, medicament can be made medicated tea, electuary, capsule, oral liquid etc.Through clinical observation, effective percentage reaches 100%.

Medicine of the present invention is made up of the Radix Astragali, Radix Angelicae Sinensis, Cordyceps, Radix Bupleuri, Radix Salviae Miltiorrhizae, Herba Lycopi, Fructus Liquidambaris, Hirudo, Carapax Trionycis, Radix Paeoniae Rubra, Semen Persicae, Squama Manis, Radix Glycyrrhizae.

Medicine compositing range of the present invention is:

Radix Astragali 10-20 gram Radix Angelicae Sinensis 10-15 gram Cordyceps 5-10 gram Radix Bupleuri 10-15 gram Radix Salviae Miltiorrhizae 10-12 gram Herba Lycopi 12-15 gram Fructus Liquidambaris 10-12 gram Hirudo 5-10 gram Carapax Trionycis 15-20 gram Radix Paeoniae Rubra 10-15 gram Semen Persicae 10-15 gram Squama Manis 5-10 gram Radix Glycyrrhizae 5-10 gram.

Pharmaceutical formulation each component preferred weight proportioning of the present invention is:

The Radix Astragali 10% Radix Angelicae Sinensis 8% Cordyceps 7% Radix Bupleuri 10% Radix Salviae Miltiorrhizae 10% Herba Lycopi 10% Fructus Liquidambaris 5% Hirudo 5% Carapax Trionycis 10% Radix Paeoniae Rubra 10% Semen Persicae 5% Squama Manis 5% Radix Glycyrrhizae 5%.

The processing technique of medicine medicinal tea of the present invention is:

The medicine of formula ratio is chosen decontamination, and oven dry, pulverizing, mixing are sieved, and seal promptly in the sterilising filtration tea bag of packing into.Have on the tea bag to lead and carry short-term.

The preparation technology of electuary of the present invention is:

By above-mentioned formula ratio, herbal raw material is chosen decontamination, and mixed powder is broken into coarse powder (5-10 order), puts into extraction pot, the water that adds 3 times of amounts of crude drug weight, boil back slow fire and boiled again 1 hour, leach medicinal liquid, add the water of 2 times of amounts of Chinese herbal medicine weight again, boiling back slow fire boils half an hour again, leach medicinal liquid, front and back secondary medicinal liquid is merged, the cooling back adds 1-2 amount ethanol (concentration 90%) doubly and fully shakes up placement, precipitation.Get its supernatant after 20 hours, precipitate is cleaned with a small amount of (50-60%) ethanol, washing liquid and filtrate merge, decompression recycling ethanol, wait be concentrated to finite concentration after, again the cooling left standstill 12 hours, make its thorough precipitation, filter, the filtrate low-temperature evaporation is standby to the thick paste shape, and the ratio of the thick paste side (80-90 degree) of reheating is 1.30-1.35.Wear into fine powder with crystallization of sucrose, mistake 80-100 mesh sieve selects standby, and it is standby to get commercially available dextrin, and Chinese medicine thick paste, Icing Sugar, dextrin are got finished product by 1: 3: 1 weight ratio stirring and evenly mixing.

The preparation technology of oral liquid of the present invention is:

According to preparation electuary identical prepared Chinese herbal medicine thick paste, with an amount of distilled water diluting, filtration, it is 20% that diluent contains the crude drug amount, adds simple syrup, potassium sorbate (content is pressed 90 years version pharmacopeia, should be up to specification), makes the oral liquid finished product with thick paste.

The present invention uses the theory and the method for the combination of Chinese and Western medicine, forms through clinical practice for many years.Liver cirrhosis belongs to motherland's medical science and " gathers " category, and cirrhotic ascites then belongs to " tympanites " category.Primary disease is that liver,spleen,kidney is subjected to disease, and holding with the stagnation of QI, blood stasis, water is characteristics of lesion, belongs to the disease of deficiency in origin and excess in superficiality.Forefathers how with treating both the principal and the secondary aspects of a disease at the same time, reinforcement and elimination in combination, attack and mend three principles and execute and control.But with regard to therapeutic effect, the refractory that takes stopgap measures often originally.Modern medicine study discloses, some Chinese medicine such as Radix Salviae Miltiorrhizae, Herba Lycopi, Carapax Trionycis etc. have degrade collagen albumen synthetic, reduce the effect that the collagen protein deposition excessive in the Disse chamber and dissolving, absorption have formed hepatic fibrosis, and have the effect that reverses liver cirrhosis through experiment confirm.This " hard masses softening and resolving " rule of treatment with motherland's medical science is consistent.Be a course of treatment with 3 months generally, morning, noon and afternoon cirrhosis patient will take medicine 3-5 even longer time.Through clinical observation treatment 62 examples, total effective rate is 100%.

Model case:

Example 1: what so-and-so, man, 36 years old.Suffer from hepatitis B and caused cirrhosis patients in decompensation (ascites) 5 years.The state of an illness repeatedly, repeatedly because of ascites, have blood in stool and be in hospital.Confirm above-mentioned diagnosis through CT, ultrasound diagnosis, and merge hypersplenism, thrombocytopenia.Used Drug therapy of the present invention from 97 years, the state of an illness takes a turn for the better gradually, and liver function is stable.Through ultrasound diagnosis, liver cirrhosis significantly takes a turn for the better, and has not now had scleroma, and spleen dwindles, and platelet is normal, disease such as ascites do not occur, have blood in stool.So far still take medicine, can work.

Example 2: Jiang, man, 54 years old.Suffer from hepatitis B and cause early stage liver cirrhosis, once confirm above-mentioned diagnosis establishment in hospital and through inspections such as B ultrasonic, through the multi-treatment poor effect.98 years beginnings, the state of an illness progressively took a turn for the better through Drug therapy of the present invention so far, after inspections such as B ultrasonic, liver cirrhosis is healed.

Embodiment:

5 kilograms of 5 kilograms of Radix Glycyrrhizae of 5 kilograms of Squama Maniss of 10 kilograms of Semen Persicaes of 10 kilograms of Radix Paeoniae Rubra of 5 kilograms of Carapax Trionycis of 5 kilograms of Hirudos of 10 kilograms of Fructus Liquidambaris of 10 kilograms of Herba Lycopi of 10 kilograms of Radix Salviae Miltiorrhizaes of 7 kilograms of Radix Bupleuri of 8 kilograms of Cordyceps of 10 kilograms of Radix Angelicae Sinensis of the Radix Astragali.

Above-mentioned raw materials is chosen decontamination, dry, pulverize, sieve, sterilize, go up the machine zero capsule of packing into, every 0.5 gram, totally 100 kilograms.

Claims

1, a kind of Chinese medicine preparation that prevents hepatic fibrosis, treatment liver cirrhosis.It is characterized in that the component content scope that this medicine is formed is: Radix Astragali 10-20 gram Radix Angelicae Sinensis 10-15 gram Cordyceps 5-10 gram Radix Bupleuri 10-15 gram Radix Salviae Miltiorrhizae 10-12 gram Herba Lycopi 12-15 gram Fructus Liquidambaris 10-12 gram Hirudo 5-10 gram Carapax Trionycis 15-20 gram Radix Paeoniae Rubra 10-15 gram Semen Persicae 10-15 gram Squama Manis 5-10 gram Radix Glycyrrhizae 5-10 gram.

2, medicament according to claim 1 is characterized in that the each component percentage by weight is: the Radix Astragali 10% Radix Angelicae Sinensis 8% Cordyceps 7% Radix Bupleuri 10% Radix Salviae Miltiorrhizae 10% Herba Lycopi 10% Fructus Liquidambaris 5% Hirudo 5% Carapax Trionycis 10% Radix Paeoniae Rubra 10% Semen Persicae 5% Squama Manis 5% Radix Glycyrrhizae 5%.

3,, it is characterized in that it is dosage forms such as medicinal tea, electuary, oral liquid according to claim 1 and 2 described medicaments.

4, according to the preparation method of claim 3 medicinal tea, it is characterized in that the medicine of formula ratio is chosen decontamination, oven dry, pulverizing, mixing are sieved, and seal promptly in the sterilising filtration tea bag of packing into.Have on the tea bag to lead and carry short-term.

5, according to the preparation method of the described medicament electuary of claim 3, it is characterized in that the crude drug of formula ratio is pulverized, decoct with water, the gained medicinal liquid is condensed into thick paste, add Icing Sugar (succedaneum), dextrin, the mixed finished product that gets.

6,, it is characterized in that the Chinese herbal medicine dry product of formula ratio is ground into coarse powder according to the preparation method of the described oral medicine liquid of claim 3, the water boil of the triplication of adding crude drug weight one hour, go out medicinal liquid, add the qdx water boil again and go out medicinal liquid half an hour, the secondary medicinal liquid merges.The cooling back adds 1-2 and doubly measures the ethanol mixing, places post precipitation and gets supernatant.Reclaim ethanol, concentrated supernatant.Leave standstill, filter, flash to paste, add distilled water diluting liquid, make diluent contain crude drug amount 20%, add simple syrup, Pyrusussuriensis potassium alcoholate (or similar product) again, by the dosage of 90 years version pharmacopeia regulations, filter, sterilize, encapsulate the oral liquid finished product.