CN1450994A - 用于治疗青光眼的6－羟基－吲唑衍生物 - Google Patents

用于治疗青光眼的6－羟基－吲唑衍生物 Download PDF

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Publication number
CN1450994A
CN1450994A CN00819346A CN00819346A CN1450994A CN 1450994 A CN1450994 A CN 1450994A CN 00819346 A CN00819346 A CN 00819346A CN 00819346 A CN00819346 A CN 00819346A CN 1450994 A CN1450994 A CN 1450994A
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CN
China
Prior art keywords
alkyl
hydrogen
independently selected
halogen
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00819346A
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English (en)
Chinese (zh)
Inventor
J·A·梅
A·P·丹塔纳拉亚纳
冯子侠
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Alcon Universal Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Universal Ltd filed Critical Alcon Universal Ltd
Publication of CN1450994A publication Critical patent/CN1450994A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN00819346A 2000-03-17 2000-11-14 用于治疗青光眼的6－羟基－吲唑衍生物 Pending CN1450994A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19038000P 2000-03-17 2000-03-17
US60/190,380 2000-03-17

Publications (1)

Publication Number Publication Date
CN1450994A true CN1450994A (zh) 2003-10-22

Family

ID=22701093

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00819346A Pending CN1450994A (zh) 2000-03-17 2000-11-14 用于治疗青光眼的6－羟基－吲唑衍生物

Country Status (14)

Country Link
EP (1) EP1268438A1 (https=)
JP (1) JP2003528085A (https=)
KR (1) KR20030065304A (https=)
CN (1) CN1450994A (https=)
AR (1) AR032138A1 (https=)
AU (1) AU2001216072A1 (https=)
BR (1) BR0017157A (https=)
CA (1) CA2402403A1 (https=)
GC (1) GC0000155A (https=)
MX (1) MXPA02008547A (https=)
PL (1) PL358481A1 (https=)
TW (1) TWI221839B (https=)
WO (1) WO2001070702A1 (https=)
ZA (1) ZA200206851B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101704785B (zh) * 2009-11-16 2012-02-29 东南大学 有机二羧酸和其盐及其制备方法

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
AU2002360819A1 (en) * 2001-12-28 2003-07-24 Bayer Corporation Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor
AU2003287481B2 (en) 2002-11-08 2009-04-23 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
US7196082B2 (en) 2002-11-08 2007-03-27 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
CN100384827C (zh) * 2002-11-08 2008-04-30 默克公司 用于治疗高眼压症的眼用组合物
US7053085B2 (en) 2003-03-26 2006-05-30 Merck & Co. Inc. EP4 receptor agonist, compositions and methods thereof
BR0316775A (pt) 2002-12-13 2005-11-01 Alcon Inc Novos análogos de benzopirano e seu uso para o tratamento de glaucoma
JP2004262812A (ja) * 2003-02-28 2004-09-24 Rohto Pharmaceut Co Ltd 眼圧低下剤
AU2004268012B2 (en) 2003-09-02 2008-11-20 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
DE602004020079D1 (de) 2003-09-04 2009-04-30 Merck & Co Inc Ophthalmische zusammensetzungen zur behandlung der okularen hypertonie
AU2004271978B2 (en) 2003-09-04 2009-02-05 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
TW200520760A (en) 2003-12-15 2005-07-01 Alcon Inc Substituted [1,4] oxazino [2,3-g] indazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
CN1988903A (zh) 2004-07-20 2007-06-27 默克公司 用于治疗高眼压症的眼用组合物
ATE460415T1 (de) 2004-11-29 2010-03-15 Warner Lambert Co Therapeutische pyrazoloä3,4-büpyridine und - indazole
US7425572B2 (en) 2004-12-08 2008-09-16 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
CN105884687B (zh) * 2016-04-14 2018-06-22 梯尔希（南京）药物研发有限公司 一种5-苄基苄达明的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1301161A (zh) * 1998-05-19 2001-06-27 艾尔科实验室公司 用于治疗眼睛和中枢神经系统障碍的血清素激活的5ht7受体化合物
ATE247963T1 (de) * 1998-05-26 2003-09-15 Pfizer Prod Inc Medikament zur behandlung von glaukoma und ischämischer retinopathie
GB9819032D0 (en) * 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds IV
CN1269484C (zh) * 1998-09-18 2006-08-16 艾尔科实验室公司 用于治疗青光眼的5－羟色胺激活性激动剂
GB9820767D0 (en) * 1998-09-23 1998-11-18 Cerebrus Ltd Chemical compounds VIII

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101704785B (zh) * 2009-11-16 2012-02-29 东南大学 有机二羧酸和其盐及其制备方法

Also Published As

Publication number Publication date
CA2402403A1 (en) 2001-09-27
AR032138A1 (es) 2003-10-29
JP2003528085A (ja) 2003-09-24
PL358481A1 (en) 2004-08-09
ZA200206851B (en) 2003-10-21
WO2001070702A1 (en) 2001-09-27
TWI221839B (en) 2004-10-11
MXPA02008547A (es) 2003-03-12
AU2001216072A1 (en) 2001-10-03
BR0017157A (pt) 2002-11-26
EP1268438A1 (en) 2003-01-02
KR20030065304A (ko) 2003-08-06
GC0000155A (en) 2005-06-29

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