CN1445224B - 制备芳基氨基丙醇的方法 - Google Patents

制备芳基氨基丙醇的方法 Download PDF

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Publication number
CN1445224B
CN1445224B CN031073166A CN03107316A CN1445224B CN 1445224 B CN1445224 B CN 1445224B CN 031073166 A CN031073166 A CN 031073166A CN 03107316 A CN03107316 A CN 03107316A CN 1445224 B CN1445224 B CN 1445224B
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CN
China
Prior art keywords
general formula
compound
ruthenium
amino
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN031073166A
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English (en)
Chinese (zh)
Other versions
CN1445224A (zh
Inventor
M·埃克尔特
C·德雷斯巴赫
B·博施
A·施托勒
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Saltigo GmbH
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Bayer AG
Saltigo GmbH
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Publication of CN1445224A publication Critical patent/CN1445224A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN031073166A 2002-03-20 2003-03-20 制备芳基氨基丙醇的方法 Expired - Fee Related CN1445224B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10212301A DE10212301A1 (de) 2002-03-20 2002-03-20 Verfahren zur Herstellung von Aryl-aminopropanolen
DE10212301.2 2002-03-20

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201110199341.2A Division CN102321066B (zh) 2002-03-20 2003-03-20 制备芳基氨基丙醇的方法

Publications (2)

Publication Number Publication Date
CN1445224A CN1445224A (zh) 2003-10-01
CN1445224B true CN1445224B (zh) 2012-07-11

Family

ID=27771441

Family Applications (2)

Application Number Title Priority Date Filing Date
CN031073166A Expired - Fee Related CN1445224B (zh) 2002-03-20 2003-03-20 制备芳基氨基丙醇的方法
CN201110199341.2A Expired - Fee Related CN102321066B (zh) 2002-03-20 2003-03-20 制备芳基氨基丙醇的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201110199341.2A Expired - Fee Related CN102321066B (zh) 2002-03-20 2003-03-20 制备芳基氨基丙醇的方法

Country Status (6)

Country Link
US (3) US7169938B2 (enExample)
EP (1) EP1346977B1 (enExample)
JP (1) JP4194865B2 (enExample)
CN (2) CN1445224B (enExample)
DE (2) DE10212301A1 (enExample)
ES (1) ES2328235T3 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7659409B2 (en) 2002-03-19 2010-02-09 Mitsubishi Chemical Corporation 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same
EP1486493A4 (en) * 2002-03-19 2007-04-04 Mitsubishi Chem Corp 3-HYDROXY-3- (2-THIENYL) PROPIONIC ACID AMID COMPOUND, METHOD FOR THE PRODUCTION THEREOF AND METHOD FOR PRODUCING A 3-AMINO-1- (2-THIENYL) -1-PROPANOL COMPOUND THEREFOR
JP2004155756A (ja) * 2002-04-30 2004-06-03 Mitsubishi Chemicals Corp 光学活性アルコールの製造方法
GB0221438D0 (en) * 2002-09-16 2002-10-23 Avecia Ltd Processes and compounds
US20050197503A1 (en) * 2004-03-05 2005-09-08 Boehringer Ingelheim International Gmbh Process for the preparation of N-alkyl-N-methyl-3-hydroxy-3-(2-thienyl)-propylamines
GB0425320D0 (en) * 2004-11-17 2004-12-22 Johnson Matthey Plc Diamines
CZ299270B6 (cs) 2006-01-04 2008-06-04 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu
CA2656128A1 (en) 2006-07-03 2008-01-10 Ranbaxy Laboratories Limited Process for the preparation of enantiomerically pure salts of n-methyl-3(1-naphthaleneoxy)-3-(2-thienyl)propanamine
WO2008077645A1 (en) * 2006-12-22 2008-07-03 Synthon B.V. Process for making duloxetine and related compounds
WO2009010238A2 (en) * 2007-07-13 2009-01-22 Synthon B.V. Duloxetine formulations
WO2009054887A1 (en) * 2007-10-22 2009-04-30 Merck & Co., Inc. Process for preparing an anti-hypercholesterolemic compound
CZ304602B6 (cs) 2009-09-02 2014-07-30 Zentiva, K. S. Způsob krystalizace hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (hydrochloridu duloxetinu)
PL2426116T3 (pl) * 2010-08-30 2013-11-29 Saltigo Gmbh Sposób wytwarzania (S)-3-N-metyloamino-1-(2-tienylo)-1-propanolu
CN104130239B (zh) * 2014-08-16 2016-05-04 瑞阳制药有限公司 度洛西汀手性中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016889A1 (en) * 1990-05-01 1991-11-14 Smithkline Beecham Corporation Five-membered ring alkanoic acid leukotriene antagonists
US5104899A (en) 1990-08-13 1992-04-14 Sepracor, Inc. Methods and compositions for treating depression using optically pure fluoxetine
DE4128787A1 (de) 1991-08-30 1993-03-04 Bayer Ag Neue zwischenprodukte und ihre verwendung bei der herstellung von s-ketoprofen
DE4209616A1 (de) * 1992-03-25 1993-09-30 Basf Ag Verfahren zur Herstellung von µ-Hydroxycarbonsäureestern
IL105716A0 (en) * 1992-06-08 1993-09-22 Richter Gedeon Vegyeszet Aminopropanol derivatives,their preparation and pharmaceutical compositions containing them
DE4330730A1 (de) 1993-09-10 1995-03-16 Bayer Ag Neue Bisphosphine für asymmetrische Hydrierkatalysatoren
US5362886A (en) 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
DE19522293A1 (de) 1995-06-20 1997-01-02 Bayer Ag Neue Bisphospine als Katalysatoren für asymmetrische Reaktionen
DE19535243A1 (de) 1995-09-22 1997-03-27 Bayer Ag Neue Zwischenprodukte für die Synthese von Bisphosphinverbindungen
US7659409B2 (en) * 2002-03-19 2010-02-09 Mitsubishi Chemical Corporation 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Tetrahedron: Asymmetry 10.1999,P4663-4666. *

Also Published As

Publication number Publication date
CN1445224A (zh) 2003-10-01
DE10212301A1 (de) 2003-10-02
EP1346977A1 (de) 2003-09-24
US20080262247A1 (en) 2008-10-23
DE50311721D1 (de) 2009-09-03
JP4194865B2 (ja) 2008-12-10
ES2328235T3 (es) 2009-11-11
US7893281B2 (en) 2011-02-22
CN102321066A (zh) 2012-01-18
CN102321066B (zh) 2014-07-23
US20030225153A1 (en) 2003-12-04
EP1346977B1 (de) 2009-07-22
JP2003313184A (ja) 2003-11-06
US7169938B2 (en) 2007-01-30
US20090286997A1 (en) 2009-11-19
US7582776B2 (en) 2009-09-01

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