CN1418104A - 啤酒花和鸟氨酸的美容用途 - Google Patents
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Abstract
一种用作增强乳房生长和稳固乳房组织的美容剂的组合物，其至少包括啤酒花和鸟氨酸。优选进一步向其中添加茴香或例如茴香叶或茴香籽的茴香衍生物。这种组合物也可用作抑制和预防良性囊肿的药物。这种组合物可以制备成方便的片剂形式并完全由天然组分配制。摄取该组合物几个月后大多数情形下会产生初步效果。
Description
本发明涉及至少包含啤酒花的组合物，它可用作特别适于增强乳房组织的生长和稳固的美容剂，或者作为适于抑制和防止良性囊肿以及可能适于抑制恶性癌细胞的药物。
很多个世纪以来啤酒花已经被不同的人掺入包括面包的食品中。这样做明显地是为了刺激母乳的产生。通过使用足够的啤酒花，乳腺组织的体积增加，乳房增大，其中母乳的生成增加。当停止啤酒花的摄取，乳腺组织减小，由此乳房尺寸减少。
在女性人群中对于丰乳方法有极大的需求。贯穿这个时代，显著的乳房大小已经成为适于许多女人的漂亮的理想特征之一。丰乳手术因此是整形手术中必然发生之事，并且甚至是最平常的手术之一。适于丰乳的手段通常必须是硅植入，它的缺点已经是已知的，它在中期或长期有时仅仅自己出现，与手术本身的不适无关。
在导言中声明的已知生长剂类型不具有这些缺点，这是由于根本不包括手术，并且该药剂的活性组分即使不完全也主要由完全天然的农产品组成。在组合物中，啤酒花起活化乳房组织中乳腺的作用，这接着引起乳房生长。
由J.Agric.Food Chem.，47(1)，1999和国际专利申请WO00/53205，已知一种含有具有抗生长作用的啤酒花物质。然而，继续存在对其它基于天然物质、具有更好的抗良好囊肿作用的药剂的需要。
仅含有啤酒花的已知物质不是理想的，因为其作用不强、结果不持久。
本发明的目的在于提供导言声明类型的具有增强作用的美容剂和/或药剂，由此提供更好和持久的结果。为了达到预期的目的，增强乳房生长和作为抑制导言声明类型的囊肿的药剂的组合物还含有鸟氨酸。这包括组合物的不同成分之间平衡的相互作用。其中含有的啤酒花刺激乳房组织的乳腺活性，而鸟氨酸，尤其是L-鸟氨酸，作为氨基酸是细胞构建物质，负责乳房组织的更好发育。亦出人意料地发现鸟氨酸在引起良性囊肿消退中以及可能的抗癌生长活性上具有协同作用。在囊肿和乳腺感染等情形下，这种组合物进一步改善和稳定了女性乳房的症状。与啤酒花单独作用相比的另一显著优点是啤酒花和鸟氨酸的组合使用具有持久作用，尤其在用于增强乳房组织的生长和稳固时。
组合物中的啤酒花包括众多有助于乳房生长的物质和微量元素，其中如金雀异黄素和大豆黄素的植物激素是重要的例子。进一步假定啤酒花的成分，金雀异黄素和大豆黄素，它们属于植物雌激素物质或异黄酮，具有肿瘤抑制作用。正如人体自身的雌激素，金雀异黄素能够结合被损坏细胞的雌激素受体，这里进一步的分裂被抑制。发育取决于像乳房组织、前列腺和肠内的雌激素的肿瘤，会因此在其生长中被抑制。这种理论由亚洲女性中乳癌的低死亡率支持，它通常归因于大豆异黄酮类(如金雀异黄素和大豆黄素)的植物雌激素活性，她们比西方女性消耗更多的大豆。
在组合物优选的实施方案中，向啤酒花和鸟氨酸中加入谷物。谷物的纤维提供更好的肠活性，这样组合物的成分更容易被人体吸收。对于谷物，优选使用完整、去壳(包括表皮)的谷物。因此得到组合物作用的显著增强。按照本发明的组合物的一项特别的实施方案具有这样的特征，即谷类包括至少一种源自包括荞麦、黑麦、玉米、小麦和大麦的组的谷类，更特别地是大麦。这些谷类都含有或多或少程度的刺激肠道增强活性的物质，这样以致于达到更有效的新陈代谢。
按照本发明一项重要的优选实施方案具有这样的特征，即其中亦含有茴香或其衍生物。茴香衍生物理解成普通(干燥)的茴香叶、茴香叶的提取物以及特别是茴香籽。在组合物中包含的这些组分致使显著改善其作用。茴香籽，像啤酒花一样，含有植物激素。这些植物激素补充啤酒花的植物激素。按照本发明组合物的进一步优选实施方案的特征在于包括茴香籽的茴香衍生物。
按照本发明的组合物的特别的实施方案已经获得良好结果，这种组合物的特征在于它的活性组分至少包括25-40重量％啤酒花，1-10重量％茴香，5-15重量％荞麦，1-10重量％黑麦，20-35重量％大麦，5-15重量％麦芽和5-15重量％L-鸟氨酸。
按照本发明的组合物可以制备成不同形式，液体形式以及干燥形式。该组合物的特别实用的实施方案的特征在于组合物制成胶囊或片剂形式，其中通常也采用一种或多种赋形剂，例如二氧化硅、磷酸钙、硬脂酸镁、燕麦或淀粉。可任选以溶液或作为悬浮液摄取这种组合物。
关于这种组合物优选的出发点是纯天然产物和得自天然产物的成分。然而这会有活性物质浓度有时低的缺点，因此必须摄取大量的组合物以确保充分的效应。这种组合物的特别实施方案具有这方面的特征，即该干燥形式的组合物被加工成片剂，它的活性物质最小含量是80重量％，剩余的是赋形剂，其中片剂优选具有不超过850毫克的重量。已经确定850毫克以下的片剂仍然易于摄取，而更重的片剂有时会引起消化不良问题。因此最大量的组合物仍然以可接受的方式按每片给药。
同样落入本发明范围之内的是在以下一种或多种情形下起作用的溶液或悬浮液的制备：为乳房组织的生长或稳固起见，或以便防止或帮助乳房组织内不希望的肿块痊愈，或者抑制或防止良性囊肿及其生长或可能的恶性癌细胞，其中如上所述的片剂或胶囊与水混合以形成这样的溶液或悬浮液。
现在参考大量的实施方案进一步的说明本发明：
实施例I
每制备1000克的活性物质，将约350克啤酒花，100克荞麦，60克黑麦，270克大麦和150克麦芽一起放入容器并研磨成均匀的混合物。对于每1000克的待制备的活性物质于此加入约70克的L-鸟氨酸。这是天然左旋鸟氨酸变体，它可从甜菜中提取。接着对混合物整个进行很好地混合，并且以700∶120的比率与二氧化硅、磷酸钙和硬脂酸镁组成的赋形剂混合。然后由此混合物制成每片820mg的片剂。
实施例II
每制备1000克的活性物质，将约330克啤酒花，100克荞麦，60克黑麦，270克大麦，150克麦芽和40克茴香在容器内细致地研磨并添加50克L-鸟氨酸。这种组合物以700∶120的比率与适当的赋形剂混合，并加工成每片800mg的片剂。
实施例III
每制备1000克的活性物质，将约465克啤酒花，50克荞麦，50克黑麦，200克大麦，85克麦芽和50克茴香在容器内细致地研磨并添加100克L-鸟氨酸。这种组合物以700∶120的比率与适当的赋形剂混合，并加工成每片500mg的片剂。这些片剂中啤酒花，鸟氨酸和茴香的浓度显著高于前述实施方案，因此使较小的片剂尺寸成为可能。这促进其摄取。优选地，可以选择性地加入天然香料以掩盖这些片剂中强烈的啤酒花味道。
一个月至几个月的摄取期之后，这些实施例中所有的组合物显示增强乳房发育形式的初步效果，继续延长使用组合物，直到获得最大作用。接着削减组合物的使用并且任选地停止。
实施例IV
在研究中研究一组20-35岁年龄组、乳房未有囊肿的女性摄取ERDIC(含有啤酒花，L-鸟氨酸，茴香，荞麦，黑麦，麦芽，大麦和赋形剂的制剂)对乳房生长和硬度的影响。这些女性中的半数按规定使用所述的ERDIC片剂，即一天10-15片和至少2升水。另一半以同样方式使用安慰剂。以主观和客观的两种方式测定乳房的增大和硬度，即通过测量乳房大小和估计乳房的弹性和松弛来测定。
结果如下表1和2所示。
表1
| 乳房增大 | 2个月之后 | 4个月之后 | 6个月之后 |
| ERDIC | 30％ | 50％ | 60％ |
| 安慰剂 | 10％ | 10％ | 20％ |
表2
| 乳房硬度 | 2个月之后 | 4个月之后 | 6个月之后 |
| ERDIC | 20％ | 50％ | 80％ |
| 安慰剂 | 0％ | 10％ | 20％ |
此数据显示，在大多数的女性中，本发明的ERDIC制剂对乳房的大小以及特别是硬度具有明显的正面作用。
实施例V
在研究中研究一组38-52岁年龄组、她们的乳房中有良性囊肿的女性摄取ERDIC(实施例IV所述)对这些囊肿发育的作用。主观(参见表3)和采用超声图记录仪和乳腺X线照片(参见表4)客观地监测这种发育。月份表示ERDIC的摄取期。
表3
| 开始 | 1个月 | 3个月 | 6个月 | |
| 囊肿 | 100％ | 50％ | 15％ | 10％ |
| 疼痛减轻 | 0％ | 30％ | 60％ | 60％ |
| 消失 | 0％ | 20％ | 25％ | 30％ |
表4
| 开始 | 6个月 | |
| 恶化 | 5％ | |
| 不变 | 100％ | 65％ |
| 改善 | 35％ |
该研究显示，如表3所示较主观的观察结果通过如表4所示的客观观察结果证实。
尽管参照这五个实施方案进一步单独说明本发明，很明显本发明绝不受其限制。相反，对于本领域普通技术人员在本发明范围内的许多变化是可能的。除了片剂形式之外，组合物能够以其它形式使用，例如液体。在给出例子的药剂中声明的组分和其数量也能够进一步增加和变化，以便进一步优化组合物的作用。
Claims (18)
1.至少含有啤酒花和鸟氨酸的用作美容剂或药物的组合物。
2.权利要求1的组合物，其中还含有谷类。
3.权利要求1或2的组合物，其中啤酒花与鸟氨酸的重量比等于1.5至10。
4.如前述权利要求的一项或多项所要求的组合物，其中还含有茴香或茴香衍生物。
5.权利要求4的组合物，其中茴香衍生物包括茴香籽。
6.权利要求4或5的组合物，其中啤酒花与茴香重量比等于2至10。
7.如权利要求2-6的一项或多项所要求的组合物，其中谷类包括至少一种选自包括荞麦、黑麦、玉米、小麦和大麦的组的谷类。
8.权利要求7的组合物，其中谷类包括大麦。
9.如前述权利要求的一项或多项所要求的组合物，其特征在于其中活性组分至少包括25-40重量％啤酒花、1-10重量％茴香、5-15重量％荞麦、1-10重量％黑麦、20-35重量％大麦、5-15重量％麦芽和5-15重量％L-鸟氨酸。
10.如前述权利要求的一项或多项所要求的组合物，其特征在于它的活性部分至少仅包括天然产物和得自天然产物的成分。
11.如任意前述权利要求所要求的组合物，其特征在于组合物以干燥形式加工成片剂，它的活性物质最少是80重量％，剩余的是赋形剂。
12.权利要求11的组合物，其特征在于片剂的重量不超过850毫克。
13.如任一前述权利要求所要求的组合物在制备用于乳房组织生长和/或稳固或者预防乳房组织内肿块或帮助其痊愈的美容剂中的用途。
14.权利要求1-12中任一项的组合物在制备抑制良性囊肿及其生长以及可能抑制和预防恶性癌细胞的药物中的用途。
15.如权利要求14所要求的用途，用于抑制和预防女性乳房或前列腺内良性囊肿以及可能抑制和预防女性乳房或前列腺内恶性癌细胞。
16.含有啤酒花、鸟氨酸、茴香或其衍生物和选择性赋形剂的片剂或胶囊。
17.含有啤酒花、鸟氨酸、茴香或其衍生物、谷类和选择性赋形剂的片剂或胶囊。
18.为了预防乳房组织肿块或帮助其痊愈或者为了乳房组织生长或稳固、或者抑制和预防良性囊肿及其生长或可能抑制和预防恶性癌细胞而制备溶液或悬浮液的方法，其中如权利要求16或17所述的片剂或胶囊与水混合。
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| NL1018637C2 (nl) * | 2001-07-26 | 2003-01-28 | Adriaan Emanuel Hendricus Wiel | Cosmetische toepassing van hop en choline en/of cystine. |
| KR101009722B1 (ko) * | 2009-05-07 | 2011-01-19 | 지상빈 | 직물 매트 |
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| DE60102142D1 (de) | 2004-04-01 |
| ES2215125T3 (es) | 2004-10-01 |
| CA2404275A1 (en) | 2001-09-27 |
| BR0109470A (pt) | 2002-12-31 |
| AU2001242882B2 (en) | 2005-07-14 |
| PT1267902E (pt) | 2004-07-30 |
| DK1267902T3 (da) | 2004-06-14 |
| ATE260110T1 (de) | 2004-03-15 |
| BR0109525A (pt) | 2002-12-31 |
| TR200401150T4 (tr) | 2004-07-21 |
| AU4288201A (en) | 2001-10-03 |
| DE60102142T2 (de) | 2004-09-09 |
| NL1014751C2 (nl) | 2001-09-25 |
| EP1267902B1 (en) | 2004-02-25 |
| KR20030013377A (ko) | 2003-02-14 |
| WO2001070249A1 (en) | 2001-09-27 |
| EP1267902A1 (en) | 2003-01-02 |
| CN1281258C (zh) | 2006-10-25 |
| RU2281782C2 (ru) | 2006-08-20 |
| JP2003530324A (ja) | 2003-10-14 |
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