CN1406225A - 用作nk－3和nk－2受体拮抗剂的喹啉－4－甲酰胺衍生物 - Google Patents

用作nk－3和nk－2受体拮抗剂的喹啉－4－甲酰胺衍生物 Download PDF

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Publication number
CN1406225A
CN1406225A CN99815753A CN99815753A CN1406225A CN 1406225 A CN1406225 A CN 1406225A CN 99815753 A CN99815753 A CN 99815753A CN 99815753 A CN99815753 A CN 99815753A CN 1406225 A CN1406225 A CN 1406225A
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Prior art keywords
compound
formula
phenyl
methyl
1har
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Pending
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CN99815753A
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Chinese (zh)
Inventor
C·法里纳
G·吉尔蒂纳
M·格鲁格尼
M·莫尔范
G·M·M·G·纳德勒
L·F·拉维格利尔
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Glaxo Smith Kline Laboratory
GlaxoSmithKline SpA
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Glaxo Smith Kline Laboratory
GlaxoSmithKline SpA
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Priority claimed from GBGB9825553.2A external-priority patent/GB9825553D0/en
Priority claimed from GBGB9825552.4A external-priority patent/GB9825552D0/en
Application filed by Glaxo Smith Kline Laboratory, GlaxoSmithKline SpA filed Critical Glaxo Smith Kline Laboratory
Publication of CN1406225A publication Critical patent/CN1406225A/zh
Pending legal-status Critical Current

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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Health & Medical Sciences (AREA)
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  • Urology & Nephrology (AREA)
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  • Nutrition Science (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
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CN99815753A 1998-11-20 1999-11-19 用作nk－3和nk－2受体拮抗剂的喹啉－4－甲酰胺衍生物 Pending CN1406225A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9825553.2A GB9825553D0 (en) 1998-11-20 1998-11-20 Novel Compounds
GB9825552.4 1998-11-20
GB9825553.2 1998-11-20
GBGB9825552.4A GB9825552D0 (en) 1998-11-20 1998-11-20 Novel compounds

Publications (1)

Publication Number Publication Date
CN1406225A true CN1406225A (zh) 2003-03-26

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CN99815753A Pending CN1406225A (zh) 1998-11-20 1999-11-19 用作nk－3和nk－2受体拮抗剂的喹啉－4－甲酰胺衍生物

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EP (1) EP1131295A1 (es)
JP (1) JP2002530377A (es)
KR (1) KR20010075726A (es)
CN (1) CN1406225A (es)
AR (2) AR021355A1 (es)
AU (1) AU768708B2 (es)
BR (1) BR9915475A (es)
CA (1) CA2351865A1 (es)
CO (1) CO5150149A1 (es)
HK (1) HK1041257A1 (es)
HU (1) HUP0104959A3 (es)
IL (1) IL143137A0 (es)
MX (1) MXPA01005095A (es)
NO (1) NO20012473L (es)
NZ (1) NZ511777A (es)
PL (1) PL347721A1 (es)
TR (1) TR200101412T2 (es)
WO (1) WO2000031037A1 (es)

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GB0027701D0 (en) * 2000-11-13 2000-12-27 Smithkline Beecham Spa Novel compounds
JP2004517062A (ja) * 2000-11-13 2004-06-10 グラクソスミスクライン・ソシエタ・ペル・アチオニ Ｎｋ−３およびｎｋ−２アンタゴニストとしてのキノリン誘導体
EP1351953A1 (en) * 2000-11-28 2003-10-15 GlaxoSmithKline S.p.A. Quinoline derivatives as nk-3 antagonists
AU2002221923A1 (en) * 2000-11-28 2002-06-11 Glaxosmithkline S.P.A. Novel compounds
GB0028964D0 (en) * 2000-11-28 2001-01-10 Smithkline Beecham Spa Novel compounds
WO2002083673A1 (en) 2001-04-10 2002-10-24 Ortho-Mcneil Pharmaceutical, Inc. 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders
ATE313539T1 (de) * 2001-04-11 2006-01-15 Glaxosmithkline Spa Chinolin-4-carboxamidderivate als nk-3 und nk-2 rezeptor antagonisten
GB0109122D0 (en) * 2001-04-11 2001-05-30 Smithkline Beecham Spa Novel compounds
MY134211A (en) * 2001-05-18 2007-11-30 Smithkline Beecham Corp Novel use
AU2003244080A1 (en) * 2002-06-26 2004-01-19 Kyowa Hakko Kogyo Co., Ltd. Phosphodiesterase inhibitor
AU2003268512A1 (en) 2002-09-09 2004-03-29 Janssen Pharmaceutica N.V. Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
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