CN1402981A - 用于人体外阴和阴道的消毒洗液 - Google Patents

用于人体外阴和阴道的消毒洗液 Download PDF

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CN1402981A
CN1402981A CN 02133884 CN02133884A CN1402981A CN 1402981 A CN1402981 A CN 1402981A CN 02133884 CN02133884 CN 02133884 CN 02133884 A CN02133884 A CN 02133884A CN 1402981 A CN1402981 A CN 1402981A
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disinfectant
vulva
vagina
lotion
disinfectant lotion
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CN1185934C (zh
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余京儒
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Chengdu Rosun Disinfection Pharmaceutical Co ltd
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Abstract

本发明提供了一种用于人体外阴和阴道的消毒洗液。按重量百分比包括三氯新0.1～0.3％、丙二醇2～10％、丙三醇2～15％、乙醇1～15％、黄莲素0.01～0.1％、苦参碱0.01～0.1％、蛇床子素0.01～0.1％、蒸馏水余量。本消毒洗液能迅速杀灭金黄色萄葡球菌、大肠杆菌、白色念珠菌等致病菌，杀毒效果佳。

Description

用于人体外阴和阴道的消毒洗液
技术领域：
本发明涉及的是一种消毒洗液，特别涉及的是一种用于人体外阴和阴道的消毒洗液。
背景技术：
人们常用洁尔阴对外阴和阴道进行消毒。
发明内容：
本发明的目的是为了提供一种能迅速杀灭金黄色萄葡球菌、大肠杆菌、白色念珠菌等致病菌，消毒效果佳的用于人体外阴和阴道的消毒洗液。
本发明的目的是这样来实现的：
本发明用于人体外阴和阴道的消毒洗液，按重量百分比包括如下组分：
     三氯新                          0.1～0.3％
     丙二醇                          2～10％
     丙三醇                          2～15％
     乙  醇                          1～15％
     黄莲素                          0.01～0.1％
     苦参碱                          0.01～0.1％
     蛇床子素                        0.01～0.1％
     蒸馏水                          余量。
本发明消毒洗液是以三氯新为主要杀菌成分，辅以辅助杀菌的黄莲素、止痒的苦参碱、杀菌消炎止痒的蛇床子素、润肤的丙三醇、作溶剂的丙二醇、乙醇和稀释剂蒸馏水配制而成。经四川省卫生防疫站试验，本洗液能迅速灭金黄色萄葡球菌、大肠杆菌、白色念珠菌等致病菌(见表1～表3)，消毒效果佳，无毒性，无刺激(表4～表5)。表1：对金黄色葡萄球菌的杀灭效果药物浓度                作用不同时间(min)的平均杀灭率及范围(％)(％)            5              10                15             20
          99.95           99.99             99.99          100.0040         (99.93～99.96)  (99.97～99.99)   (99,99～100.00)
          99.55           99.94             99.99          99.9920         (99.48～99.63)  (99.92～99.96)   (99.98～99.99)  (99.99～99.99)
          99.19           99.77             99.94          99.9910         (99.02～99.39)  (99.60～99.87)   (99.93～99.96)  (99.99～99.99)
阳性对照组平均菌数为1.930×106(1.700×106～2.150×106)cfu/片。
阴性对照组无菌生长。
结论：
1、在载体法试验条件下用1％卵磷脂+1％吐温-80+1％甘氨酸+0.5％Na2S2O3的PBS溶液作为中和剂，可有效中和残留该消毒剂40％浓度对金黄色葡萄球菌的杀灭作用，且该中和剂对金黄色葡萄球菌的生长繁殖和培养基无影响。
2、在20±2℃温度下采用载体法，该消毒剂40％浓度对金黄色葡萄球菌作用5min，杀灭率为99.95％(99.93％～99.96％)，10％浓度作用15min，杀灭率为99.94％(99.93％～99.96％)。
表2：对大肠杆菌的杀灭效果药物浓度              作用不同时间(min)的平均杀灭率及范围(％)(％)            5               10             15             20
          99.99           99.99           100.00         100.0020        (99.98～99.99)   (99.99～99.99)
         99.96            99.99           99.99          100.0010        (99.94～99.97)   (99.99～99.99)  (99.99～100.00)
         99.86            99.94           99.99          99.995         (99.85～99.88)   (99.92～99.97)  (99.99～99.99) (99.99～100.00)
阳性对照组平均菌数为1.700×106(1.500×106～1.950×106)cfu/片。
阴性对照组无菌生长。
结论：
在20±2℃温度下采用载体法，该消毒剂10％浓度对大肠杆菌作用5min，杀灭率为99.96％(99.94％～99.97％)，5％浓度作用10min，杀灭率为99.94％(99.92％～99.97％)。表3：对白色念珠菌的杀灭效果药物浓度               作用不同时间(min)的平均杀灭率及范围(％)(％)           5               10               15            20
         99.95           99.99            99.99         100.0080        (99.94～99.96)  (99.99～99.99)   (99.99～100.00)
         99.67           99.95            99.99         100.0060        (99.55～99.87)  (99.95～99.95)   (99.99～99.99)
         99.88           99.72            99.93         99.9940        (98.55～99.08)  (99.66～99.79)   (99.92～99.94) (99.99～99.99)
阳性对照组平均菌数为1.600×106(1.350×106～1.800×106)cfu/片。
阴性对照组无菌生长。
结论：
1、在载体法试验条件下用1％卵磷脂+1％吐温-80+1％甘氨酸+0.5％Na2S2O3的PBS溶液作为中和剂，可有效中和残留该消毒剂80％浓度对白色念珠菌的杀灭作用，且该中和剂对白色念珠菌的生长繁殖和培养基无影响。
2、在20±2℃温度下采用载体法，该消毒剂80％浓度对白色念珠菌作用5min，杀灭率为99.95％(99.94％～99.96％)，40％浓度作用15min，杀灭率为99.93％(99.92％～99.94％)。
表4：千玉洁牌消毒洗液小鼠急性经口毒性试验结果
  性     剂  量    试验动物数   死亡动物数    死亡率别    (mg/kg)       (只)        (只)         (％)
         1000          5            0            02150          5            0            0雌      4640          5            0            010000         5            0            0
         1000          5            0            02150          5            0            0雄      4640          5            0            010000         5            0            0
结论：
千玉洁牌消毒洗液对小鼠急性经口毒性试验结果，LD50值大于10000mg/kg，按化学物质急性毒性分级，属实际无毒级。表5：动                  1h                              24h                  48h物  性  体       样   品      对   照      样  品      对   照     样   品     对  照编  别  重    红   水   总  红   水  总  红  水  总  红  水  总  红  水  总  红  水   总号    (kg)    斑   肿   分  斑   肿  分  斑  肿  分  斑  肿  分  斑  肿  分  斑  肿   分1 雌  2.5     0    0    0   0    0   0   0   0   0   0   0   0   0   0   0   0   0    02 雌  2.3     0    0    0   0    0   0   0   0   0   0   0   0   0   0   0   0   0    03 雄  2.4     0    0    0   0    0   0   0   0   0   0   0   0   0   0   0   0   0    04 雄  2.3     0    0    0   0    0   0   0   0   0   0   0   0   0   0   0   0   0    0总积分均值    0    0    0   0    0   0   0   0   0   0   0   0   0   0   0   0   0    0
所有家兔皮肤均未出现红斑、水肿等炎性反应，急性皮肤刺激指数为0。
结论：千玉洁牌消毒洗液对家兔皮肤无刺激性。
本发明消毒原液作用手上自然菌3min，消除率为91.25％(90.40％～100.00％)，手上残留菌数达国家标准人数为26人，残留菌数范围：0～500cfu/手。
具体实施方式：
本发明消毒洗液实施例见表6：
表6：上述各实施例的生产工艺如下：①，配料；②，将三氯新放入乙醇、丙二醇、丙三醇，充分搅拌混匀；③，将黄莲素、苦参碱、蛇床子素放入，充分搅拌混均；④，加蒸馏水混合均匀；⑤，净置、过滤、灌装、包装、成品入库。

Claims (1)

1、用于人体外阴和阴道的消毒洗液，其特征在于按重量百分比包括如下组分：
    三氯新                              0.1～0.3％
    丙二醇                              2～10％
    丙三醇                              2～15％
    乙  醇                              1～15％
    黄莲素                              0.01～0.1％
    苦参碱                              0.01～0.1％
    蛇床子素                            0.01～0.1％
    蒸馏水                              余量。
CNB021338841A 2002-10-10 2002-10-10 用于人体外阴和阴道的消毒洗液 Expired - Lifetime CN1185934C (zh)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102743404A (zh) * 2011-12-28 2012-10-24 宁波市鄞州奥胜生物科技有限公司 一种用于杀灭母藏獒生殖器微生物、辅助生育的组合药物
CN103372039A (zh) * 2012-04-26 2013-10-30 中国人民解放军第二军医大学 蛇床子香豆素用于制备抗真菌药物增效剂产品的用途
CN106538608A (zh) * 2016-09-29 2017-03-29 四川三和医用材料有限公司 一种医用手套消毒液
US9884049B2 (en) 2014-07-14 2018-02-06 Orion Biotechnology Canada Ltd. Microbicidal composition comprising an octoxynol and a quinolizidine alkaloid compound or a source thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102743404A (zh) * 2011-12-28 2012-10-24 宁波市鄞州奥胜生物科技有限公司 一种用于杀灭母藏獒生殖器微生物、辅助生育的组合药物
CN102743404B (zh) * 2011-12-28 2013-06-19 宁波市鄞州奥胜生物科技有限公司 一种用于杀灭母藏獒生殖器微生物、辅助生育的组合药物
CN103372039A (zh) * 2012-04-26 2013-10-30 中国人民解放军第二军医大学 蛇床子香豆素用于制备抗真菌药物增效剂产品的用途
CN103372039B (zh) * 2012-04-26 2018-01-05 中国人民解放军第二军医大学 蛇床子香豆素用于制备抗真菌药物增效剂产品的用途
US9884049B2 (en) 2014-07-14 2018-02-06 Orion Biotechnology Canada Ltd. Microbicidal composition comprising an octoxynol and a quinolizidine alkaloid compound or a source thereof
CN106538608A (zh) * 2016-09-29 2017-03-29 四川三和医用材料有限公司 一种医用手套消毒液

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