CN1394640A - Compound containing animal embryo extract with action of regulating immunologic function - Google Patents

Abstract

The animal embryon extract composite with immunoregulation function is a solid micropowder mixture, its composition contains (wt%) 50-90% of animal embryon extract in the differentiation period and 10-50% of astragalus root or its extract. Said animal embryon extract is the embryon extract of sheep, chicken, rabbit, cattle, swine and pigeon, specially it is the embryon extract of black chicken. Said invented embryon extract composite possesses good immuno-regulation function, and has good therapeutic effect, contains no any chemical additive, and its preparation method is simple.

Description

A kind of compositions with animal embryo extract of immunoregulation effect

Technical field the present invention relates to a kind of compositions with animal embryo extract of immunoregulation effect, relates in particular to a kind of black boned chicken extract and the Radix Astragali or the compatible compositions of Radix Astragali extract.

The background technology modern medicine proves that the animal embryo extract contains amounts of protein and peptide, also contains trace element such as a large amount of ferrum, phosphorus, calcium, has cosmetology and health, blood clean function, has YIN nourishing and YANG strengthening and keeps fit the function of QI invigorating; The Radix Astragali is one of traditional Chinese medical science strengthening the body resistance commonly used, invigorating the spleen and replenishing QI medicine, has the effect of protecting stomach, body shaping body-building, improving immunity, modern clinical research shows, the Radix Astragali has been widely used in and has anti-ly cured cold, asthmatic tracheitis, bronchial asthma, leukopenia, chronic gastritis, asthenic cold type gastritis and diseases such as duodenal ulcer, atrophic gastritis, cervical erosion, hepatitis B, coronary heart disease, diabetes and aging; But do not find the compositions that the animal embryo extract and the Radix Astragali share as yet, so the two the application of animal embryo extract and the Radix Astragali is restricted.

Summary of the invention the object of the present invention is to provide a kind of immunoregulation effect that has, and can be made into powder, tablet or capsular animal embryo extractive composition, and the manufacture method of this compositions is provided.

In order to achieve the above object, the invention provides following technical scheme: make a kind of animal embryo extractive composition with immunoregulation effect, be the solid micro-powder mixture, the composition of said composition and weight percentage are: embryo extract 50-90, the Radix Astragali or Radix Astragali extract 10-50, described animal embryo extract is the animal embryo extract that is in the idiophase, be when the protein wt content of molecular weight more than or equal to 10,000 time be that 60%-90% or the molecular weight peptide weight content when being less than or equal to 10,000 is the embryo extract of 1%-10%.Described animal embryo extract plays human body is replenished protein, peptide and various effect of trace elements, the Radix Astragali or Radix Astragali extract then play regulating action, as long as add in described ratio, the effect of the two is combined, potentiation each other just can be played good immunoregulation effect and even treatment various diseases.The weight percentage of the two should be: embryo extract 50-90, the Radix Astragali or Radix Astragali extract 10-50, when embryo extract content is crossed when low, then not obvious to the compensating action of human body, otherwise then reduced the content of the Radix Astragali or Radix Astragali extract, the regulating action of the Radix Astragali or its extract is not obvious in the case.

Inventing preferably, technical scheme can be: described animal embryo extract is the embryo extract of sheep, chicken, rabbit, cattle, pig or pigeon.The protein and the peptide content of this class embryo extract are higher, and raw material is easy to get and cost is low, are Ideal Match raw materials comparatively.

The present invention's technical scheme preferably also can be: described animal embryo extract is the black boned chicken extract.A large amount of studies show that: contain DHA, EPA in the Gallus Domesticus, they all are the materials that constitutes unsaturated fatty acid, vitamin A content in the Gallus Domesticus is 10 times of Anguillar japonica, iron content is higher 10 times than Herba Spinaciae, protein accounts for 60% in the Gallus Domesticus, Gallus Domesticus has cosmetology and health, blood clean function, have YIN nourishing and YANG strengthening and keep fit the function of QI invigorating, and can enrich blood, suppressing the hyperactive liver dispels the wind, tonify deficiency removes labor, the heat of dispelling is promoted the production of body fluid, quench one's thirst and control seminal emission, chronic dysentery, fracture, the kidney tonifying nourishing YIN, treatment women irregular menstruation, metrorrhagia band blood, deficient all diseases.The black boned chicken extract and the Radix Astragali or its extract compatibility, can be rated as and to treat women's all kinds of diseases and ailments, its compositions can be breathed heavily treatment cerebral thrombosis, diabetes, apoplexy, children's, viral encephalitis, angina pectoris, hypertension, C type hepatitis, nephropathy, migraine, seriously take in the diseases such as sour disease and heart disease, plays better therapeutic and has better immunoregulation effect.

Make the method for the described present composition, similar with prior art, under 0-10 ℃ temperature, screening earlier is healthy and be in the period of development and do not contain the embryo of heavy metal, then through pulverizing, biological treatment, cold drying and check, be mixed in proportion with the Radix Astragali powder that is ground into more than granularity 50 orders, but should make Radix Astragali extract: the mixture 1 ± 0.5 hour of heating Radix Astragali powder and water under 90-100 ℃ temperature by following process, filtering residue, clear liquid is cooled to room temperature, press Radix Astragali powder and alcoholic acid weight ratio 1: 0.9-1.1 and add ethanol, the crystalline deposit drying gets the Radix Astragali extract of wet weight below 0.1%.With the Radix Astragali extract that the method makes, shared with embryo extract, its regulating action is better, can use low limiting the quantity of in aforesaid weight range, thereby obtain better immunoregulation effect or therapeutic effect.

Compared with prior art, the present invention has following tangible advantage: 1, two kinds of components of the present invention organically combine mutually, have significantly potentiation each other, and its immunoregulation effect is good, the effect of curing the disease is good; 2, the patient's use that is suitable for various all ages and classes levels and has various symptoms, its applied range; 3, adopt all-natural product to make raw material, do not have any chemical additives, and do not destroy Animal resources and ecology is planted; 4, manufacture method is simple, is easy to realize industrialization.Below be illustrated by concrete example:

Tong Ran, the woman, 28 years old now, people from Xi'an, crossed wind-engaging behind the child 2 year previous existence, be afraid of cold, the hot summer also wears thick woollen sweater and woolen pants, take in March, 2002 electuary 2 gram of embodiment 1/time, every day 1-2 time, one week the back recover ordinary person and feel, be not afraid of cold, begin to wear short sleeved blouse April in this year, Jin wears skirt in the summer, does not have the situation that aversion to wind is afraid of cold so far again.

Few eyebrow, the woman, 47 years old now, people from suburbs, Xi'an played menstruation disorder always in 40 years old, do not have rule, took this composition capsule of embodiment 2 in 1999,3 * 2 of every days, every 200mg, menstruation recovery is normally so far after one month.

Li Hongna, woman, 32 years old now, people from Nantong City, Jiangsu Province, after sound was crossed child, face was covered with the yellowish-brown freckle of lamellar, in January, 2002, take this composition tablet of embodiment 3,2 * 2 * 2 of every days, every 250mg, the lamellar freckle begins to fade away after 15 days, obviously reduces after 30 days, the basic recovery, substantially disappear after 60 days, similar ordinary person almost can't see.

The following specific embodiment by " the precious cellulose health product of embryo " of the specific embodiment is carried out more detailed description to the present invention:

Embodiment 1

Get the not broken chicken son of the normal Placenta Hominis of Signs, directly put to death, get its embryo's sample 1g, dissolve in the PBS of 20mmol/L solution, lysate is divided into two parts, and is a with Kjeldahl mensuration total protein content W1, another part sent out with gel chromatography, with the sample separation of molecular weight more than 10,000, the reuse Kjeldahl is measured total protein content W2, and molecular weight is lower than 10,000 peptide content W3=W1-W2.The molecular weight of this sample is 84.6% more than or equal to 10,000 o'clock protein wt content after measured, it is 9.7% embryo extract that molecular weight is less than or equal to 10,000 o'clock peptide weight content, all the other are trace element such as water and ferrum, phosphorus, calcium, and this sample does not detect heavy metal ion.

Get this black boned chicken 100g of aforementioned protein content and peptide weight, under 0-10 ℃ temperature earlier after historrhexis, 4000rpm/min centrifuge centrifugalize 30 minutes, abandon precipitation, supernatant carries out lyophilization; Get and be ground into granularity 60 purpose Radix Astragali powder 40g mixing, make Radix Astragali extract by following process: mixture 1 hour, filtering residue, the clear liquid of heating Radix Astragali powder and water are cooled to room temperature, add ethanol, crystalline deposit drying at 1: 1 by Radix Astragali powder and alcoholic acid weight ratio under 100 ℃ temperature, get the Radix Astragali extract of wet weight 0.05%; To fully mix, pack the 2g/ bag with Radix Astragali extract through the black boned chicken extract that said process is handled.

Embodiment 2

Make raw material with rabbit embryonic extract and astragalus root, the processing method of rabbit embryonic extract is with example 1, rabbit embryonic extract protein wt content is 63.6%, the peptide weight content is 6.2%, it is 50 purpose micropowders that root directly adopts granularity, the weight ratio of rabbit embryonic extract and astragalus root 88: 12 is made into content 0.2g/ piece capsule.

Embodiment 3

Use fertilized eggs, through hatching 15 days, select the Embryo Gallus domesticus of hatching, carry out fragmentation and aforesaid biological treatment then, make raw material with this extract and Radix Astragali extract, chick embryo extract protein wt content is 71.3%, the peptide weight content is 5.9%, the preparation process of Radix Astragali extract is with example 1, the mixture 1.5 hours of heating Radix Astragali powder and water under 90 ℃ temperature, Radix Astragali powder and alcoholic acid weight ratio 1: 1.1, the weight ratio of chick embryo extract and Radix Astragali extract 50: 50 is made into the tablet of 0.25g/ sheet.

Embodiment 4

Make raw material with goat embryo extract and astragalus root extract, the processing of goat rabbit embryonic extract is with example 1, goat embryo extract protein wt content is 69.3%, the peptide weight content is 1.5%, the preparation process of Radix Astragali extract is with example 1, the mixture 0.5 hour of heating Radix Astragali powder and water under 108 ℃ temperature, Radix Astragali powder and alcoholic acid weight ratio 1.1: 1, the weight ratio of chick embryo extract and Radix Astragali extract 70: 30 is made into content 0.2g/ piece capsule.

Claims (4)

1, a kind of animal embryo extractive composition with immunoregulation effect is the solid micro-powder mixture, and it is characterized in that: the composition of compositions and weight percentage are:

Animal embryo extract 50-90

The Radix Astragali or Radix Astragali extract 10-50

Described animal embryo extract is the animal embryo extract that is in the idiophase, be when the protein wt content of molecular weight more than or equal to 10,000 time be that 60%-90% or the molecular weight peptide weight content when being less than or equal to 10,000 is the embryo extract of 1%-10%.

2, compositions according to claim 1, it is characterized in that: described animal embryo extract is the embryo extract of sheep, chicken, rabbit, cattle, pig or pigeon.

3, compositions according to claim 1 and 2, it is characterized in that: described animal embryo extract is the black boned chicken extract.

4, make the described method for compositions of claim 1, under 0-10 ℃ temperature, screening earlier is healthy and be in the period of development and do not contain the embryo of heavy metal, then through pulverizing, biological treatment, cold drying and check, be mixed in proportion with the Radix Astragali powder that is ground into more than granularity 50 orders, it is characterized in that: make Radix Astragali extract: the mixture 1 ± 0.5 hour of heating Radix Astragali powder and water under 90-100 ℃ temperature by following process, filtering residue, clear liquid is cooled to room temperature, press Radix Astragali powder and alcoholic acid weight ratio 1: 0.9-1.1 and add ethanol, the crystalline deposit drying gets the Radix Astragali extract of wet weight below 0.1%.