CN1372593A - 具有空间保护的表位区域的蛋白酶缀合物 - Google Patents

具有空间保护的表位区域的蛋白酶缀合物 Download PDF

Info

Publication number
CN1372593A
CN1372593A CN00810746A CN00810746A CN1372593A CN 1372593 A CN1372593 A CN 1372593A CN 00810746 A CN00810746 A CN 00810746A CN 00810746 A CN00810746 A CN 00810746A CN 1372593 A CN1372593 A CN 1372593A
Authority
CN
China
Prior art keywords
proteolytic enzyme
protease
epi
protease conjugates
epitope regions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00810746A
Other languages
English (en)
Chinese (zh)
Inventor
D·N·鲁宾夫
D·J·维斯格伯
P·E·克雷
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Ltd
Procter and Gamble Co
Original Assignee
Procter and Gamble Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Ltd filed Critical Procter and Gamble Ltd
Publication of CN1372593A publication Critical patent/CN1372593A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Detergent Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cosmetics (AREA)
CN00810746A 1999-07-22 2000-07-11 具有空间保护的表位区域的蛋白酶缀合物 Pending CN1372593A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14497999P 1999-07-22 1999-07-22
US60/144,979 1999-07-22

Publications (1)

Publication Number Publication Date
CN1372593A true CN1372593A (zh) 2002-10-02

Family

ID=22511045

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00810746A Pending CN1372593A (zh) 1999-07-22 2000-07-11 具有空间保护的表位区域的蛋白酶缀合物

Country Status (10)

Country Link
EP (1) EP1196547A2 (fr)
JP (1) JP2003505069A (fr)
KR (1) KR20020021396A (fr)
CN (1) CN1372593A (fr)
AU (1) AU777550B2 (fr)
BR (1) BR0012692A (fr)
CA (1) CA2379723A1 (fr)
CZ (1) CZ2002211A3 (fr)
MX (1) MXPA02000837A (fr)
WO (1) WO2001007577A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103396904A (zh) * 2008-11-11 2013-11-20 宝洁公司 包含丝氨酸蛋白酶变体的组合物和方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7432331B2 (en) 2002-12-31 2008-10-07 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
EP2105493B1 (fr) 2008-03-25 2014-05-14 Diversey, Inc. Procédé de lubrification solide utilisant des lubrifiants à base d'huile
EP2105494B1 (fr) 2008-03-25 2019-05-08 Diversey, Inc. Procédé de lubrification d'une courroie de transporteur
CN106399280B (zh) 2008-11-11 2020-12-22 丹尼斯科美国公司 包含一种或多种可组合的突变的芽孢杆菌属枯草杆菌蛋白酶

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4844897A (en) * 1985-09-13 1989-07-04 Hiroshi Maeda Anti-tumor protease preparations
JPH02219571A (ja) * 1989-02-20 1990-09-03 Kanebo Ltd 修飾プロテアーゼ及びその製造法
DE69130113T2 (de) * 1990-12-05 1999-05-12 Novo Nordisk As Proteine mit geänderten epitopen und verfahren zur deren herstellung
WO1996017929A1 (fr) * 1994-12-07 1996-06-13 Novo Nordisk A/S Polypeptide a allergenicite reduite
US6946280B1 (en) * 1996-03-29 2005-09-20 Genencor International, Inc. Enzyme multimer and process of producing same
JP2002506342A (ja) * 1996-11-26 2002-02-26 ジェネンコー インターナショナル インコーポレイテッド 化学修飾された酵素
CA2294567A1 (fr) * 1997-06-25 1999-01-07 Novo Nordisk A/S Polypeptide modifie
EP1047445B1 (fr) * 1998-01-23 2013-08-28 The Governing Council Of The University Of Toronto Enzymes modifiees et leur utilisation pour la synthese peptidique
US6495136B1 (en) * 1998-03-26 2002-12-17 The Procter & Gamble Company Proteases having modified amino acid sequences conjugated to addition moieties
CA2348014A1 (fr) * 1998-11-10 2000-05-18 John Bryan Jones Serines hydrolases mutantes chimiquement modifiees presentant une activite catalytique et une selectivite chirale ameliorees
DK1141335T3 (da) * 1998-12-21 2009-11-09 Genencor Int Kemisk modificerede enzymer med multipelt ladede varianter

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103396904A (zh) * 2008-11-11 2013-11-20 宝洁公司 包含丝氨酸蛋白酶变体的组合物和方法
CN102209778B (zh) * 2008-11-11 2014-10-15 丹尼斯科美国公司 包含丝氨酸蛋白酶变体的组合物和方法
CN103396904B (zh) * 2008-11-11 2015-12-23 宝洁公司 包含丝氨酸蛋白酶变体的组合物和方法

Also Published As

Publication number Publication date
WO2001007577A3 (fr) 2001-08-30
KR20020021396A (ko) 2002-03-20
AU5928300A (en) 2001-02-13
BR0012692A (pt) 2002-04-09
WO2001007577A2 (fr) 2001-02-01
EP1196547A2 (fr) 2002-04-17
AU777550B2 (en) 2004-10-21
MXPA02000837A (es) 2002-07-30
CA2379723A1 (fr) 2001-02-01
JP2003505069A (ja) 2003-02-12
CZ2002211A3 (cs) 2002-05-15

Similar Documents

Publication Publication Date Title
CN1163507C (zh) 蛋白酶缀合物
CN1301305A (zh) 具有氨基酸取代的丝氨酸蛋白酶变体
CZ2002212A3 (cs) Varianty subtilisinové proteasy mající aminokyselinové substituce v definovaných epitopových oblastech
CN1377406A (zh) 具有空间保护的切割位点的蛋白酶缀合物
CN1373802A (zh) 在特定表位区域具有氨基酸缺失和取代的枯草杆菌蛋白酶变体
CN1268062A (zh) 具有高活性和降低的变应原性的修饰多肽
CN1303437A (zh) 有氨基酸缺失和替代的丝氨酸蛋白酶变体
CN1372593A (zh) 具有空间保护的表位区域的蛋白酶缀合物
US6946128B1 (en) Protease conjugates having sterically protected epitope regions
CN1426469A (zh) 具有一个或多个d－氨基酸取代的酶变体
CN1369008A (zh) 免疫原性降低的分子内交联的枯草杆菌蛋白酶
CZ20003396A3 (cs) Proteázový konjugát a prostředek osobní hygieny
MXPA00009385A (en) Protease conjugates

Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication