CN1362168A - Nano resurrecting bezoar medicine and its preparation - Google Patents
Nano resurrecting bezoar medicine and its preparation Download PDFInfo
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- CN1362168A CN1362168A CN 01100323 CN01100323A CN1362168A CN 1362168 A CN1362168 A CN 1362168A CN 01100323 CN01100323 CN 01100323 CN 01100323 A CN01100323 A CN 01100323A CN 1362168 A CN1362168 A CN 1362168A
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Abstract
The present invention discloses a nano peaceful-palace-bovine-bezoar preparation medicine. It is made up by using 10 Chinese medicinal materials of nano bovine bezoar, nano musk, nano borneol, nano realgar, nano curcuma and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain finenss is up to 1200-1500 mehses, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of heat-clearing and toxic substances removing, relieving convulsionly have one's ideas straightened out, cure mainly the nano An ' gong bovis compound preparation medicine of calentura, the invasion of pericardium by evil, hyperpyrexia convulsion, the invention still further relates to the method for this medication preparation.
The 'An Gong Niu Huang Wan ' capsule is a kind of classical Chinese patent medicine, mainly contains effects such as calmness, convulsion, analgesia, analgesic, antiinflammatory, is used for calentura, the invasion of pericardium by evil, hyperpyrexia convulsion, unconsciousness and delirium etc.But traditional 'An Gong Niu Huang Wan ' capsule absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano An ' gong bovis compound preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano An ' gong bovis compound preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano bezoar 15-45 part nano musk 4-12 part nanometer Borneolum Syntheticum 4-12 part
Nanometer-size realgar 15-45 part nanometer Radix Curcumae 15-45 part nanometer Cinnabaris 15-45 part
The female 5-25 part of nano-pearl nanometer coptis 15-45 part nanometer Radix Scutellariae 15-45 part
Nanometer Fructus Gardeniae 15-45 part nanometer Cornu Bubali 40-80 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano bezoar 25-35 part nano musk 6-9 part nanometer Borneolum Syntheticum 6-9 part
Nanometer-size realgar 25-35 part nanometer Radix Curcumae 25-35 part nanometer Cinnabaris 25-35 part
The female 10-20 part of nano-pearl nanometer coptis 25-35 part nanometer Radix Scutellariae 25-35 part
Nanometer Fructus Gardeniae 25-35 part nanometer Cornu Bubali 50-70 part
The optimum weight proportioning of medicine of the present invention is:
7.5 parts of 7.5 parts of nanometer Borneolum Syntheticums of 30 parts of nano musks of nano bezoar
30 parts in 30 parts of nanometer Cinnabaris of 30 parts of nanometer Radix Curcumaes of nanometer-size realgar
30 parts of 30 parts of nanometer Radix Scutellariaes of the female 15 parts of nanometer coptis of nano-pearl
60 parts of 30 parts of nanometer Cornu Bubalis of nanometer Fructus Gardeniae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material--the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, get 'An Gong Niu Huang Wan ' preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano An ' gong bovis compound preparation medicine is identical.
A kind of important feature of the present invention is; the made drug material of the present invention has reached nanoscale; common 'An Gong Niu Huang Wan ' capsule preparations material is micron or the above particle diameter of millimeter; can only cross the 80-120 mesh sieve; the drug material that the present invention is made; particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorbs fully, and the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup of nano An ' gong bovis compound preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for epidemic cerebrospinal meningitis, encephalitis B, and toxic dysentery, hepatic coma, cerebrovascular accident, toxic pneumonitis, treatment of conditions such as icterohepatitis, clinical efficacy significantly is better than traditional 'An Gong Niu Huang Wan ' capsule.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
7.5 parts of 7.5 parts of nanometer Borneolum Syntheticums of 30 parts of nano musks of nano bezoar
30 parts in 30 parts of nanometer Cinnabaris of 30 parts of nanometer Radix Curcumaes of nanometer-size realgar
30 parts of 30 parts of nanometer Radix Scutellariaes of the female 15 parts of nanometer coptis of nano-pearl
60 parts of 30 parts of nanometer Cornu Bubalis of nanometer Fructus Gardeniae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and is every with 1-4 time.
Embodiment 2:
Prepare nano raw material by preceding method:
7.5 parts of 7.5 parts of nanometer Borneolum Syntheticums of 30 parts of nano musks of nano bezoar
30 parts in 30 parts of nanometer Cinnabaris of 30 parts of nanometer Radix Curcumaes of nanometer-size realgar
30 parts of 30 parts of nanometer Radix Scutellariaes of the female 15 parts of nanometer coptis of nano-pearl
60 parts of 30 parts of nanometer Cornu Bubalis of nanometer Fructus Gardeniae
Production method is as follows:
In the GMP cleaning shop; after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio; according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard; do not add adjuvant; make nano An ' gong bovine calculus powder needle injection; every injection content 5-20 milligram, each consumption is that 1-2 props up, use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
7.5 parts of 7.5 parts of nanometer Borneolum Syntheticums of 30 parts of nano musks of nano bezoar
30 parts in 30 parts of nanometer Cinnabaris of 30 parts of nanometer Radix Curcumaes of nanometer-size realgar
30 parts of 30 parts of nanometer Radix Scutellariaes of the female 15 parts of nanometer coptis of nano-pearl
60 parts of 30 parts of nanometer Cornu Bubalis of nanometer Fructus Gardeniae
Production method is as follows:
In the GMP cleaning shop; after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio; according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard; filmogen adopts polyvinyl alcohol; make nano An ' gong Calculus Bovis membrane, every membrane area size 2-100 square centimeter, content of dispersion is the 1-50 gram; every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano An ' gong bovis compound preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano bezoar 15-45 part nano musk 4-12 part nanometer Borneolum Syntheticum 4-12 part
Nanometer-size realgar 15-45 part nanometer Radix Curcumae 15-45 part nanometer Cinnabaris 15-45 part
The female 5-25 part of nano-pearl nanometer coptis 15-45 part nanometer Radix Scutellariae 15-45 part
Nanometer Fructus Gardeniae 15-45 part nanometer Cornu Bubali 40-80 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano An ' gong bovis compound preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano bezoar 25-35 part nano musk 6-9 part nanometer Borneolum Syntheticum 6-9 part
Nanometer-size realgar 25-35 part nanometer Radix Curcumae 25-35 part nanometer Cinnabaris 25-35 part
The female 10-20 part of nano-pearl nanometer coptis 25-35 part nanometer Radix Scutellariae 25-35 part
Nanometer Fructus Gardeniae 25-35 part nanometer Cornu Bubali 50-70 part
3, nano An ' gong bovis compound preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
7.5 parts of 7.5 parts of nanometer Borneolum Syntheticums of 30 parts of nano musks of nano bezoar
30 parts in 30 parts of nanometer Cinnabaris of 30 parts of nanometer Radix Curcumaes of nanometer-size realgar
30 parts of 30 parts of nanometer Radix Scutellariaes of the female 15 parts of nanometer coptis of nano-pearl
60 parts of 30 parts of nanometer Cornu Bubalis of nanometer Fructus Gardeniae
4, according to claim 1 or 2 or 3 described nano An ' gong bovis compound preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano An ' gong bovis compound preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100323 CN1362168A (en) | 2001-01-02 | 2001-01-02 | Nano resurrecting bezoar medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100323 CN1362168A (en) | 2001-01-02 | 2001-01-02 | Nano resurrecting bezoar medicine and its preparation |
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| Publication Number | Publication Date |
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| CN1362168A true CN1362168A (en) | 2002-08-07 |
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| CN 01100323 Pending CN1362168A (en) | 2001-01-02 | 2001-01-02 | Nano resurrecting bezoar medicine and its preparation |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007053982A1 (en) * | 2005-11-10 | 2007-05-18 | Wen Cao | Chinese pharmaceutical compositions for treating epidemic cerebrospinal meningitis and processes for preparation thereof |
| CN104101522A (en) * | 2013-04-10 | 2014-10-15 | 付士明 | Composite efficient blood coagulation promoting powder |
| CN104162109A (en) * | 2014-08-18 | 2014-11-26 | 济南环太机电技术有限公司 | Traditional Chinese medicine preparation for treating rabies vaccine reactive paralysis |
| CN104435417A (en) * | 2014-10-30 | 2015-03-25 | 王布和 | Mongolian medicine composition for treating hepatitis B |
-
2001
- 2001-01-02 CN CN 01100323 patent/CN1362168A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007053982A1 (en) * | 2005-11-10 | 2007-05-18 | Wen Cao | Chinese pharmaceutical compositions for treating epidemic cerebrospinal meningitis and processes for preparation thereof |
| CN104101522A (en) * | 2013-04-10 | 2014-10-15 | 付士明 | Composite efficient blood coagulation promoting powder |
| CN104162109A (en) * | 2014-08-18 | 2014-11-26 | 济南环太机电技术有限公司 | Traditional Chinese medicine preparation for treating rabies vaccine reactive paralysis |
| CN104435417A (en) * | 2014-10-30 | 2015-03-25 | 王布和 | Mongolian medicine composition for treating hepatitis B |
| CN104435417B (en) * | 2014-10-30 | 2018-05-01 | 王布和 | A kind of anaesthetic composition for treating hepatitis B |
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