CN1353597A - 含珍珠岩的口腔组合物 - Google Patents
含珍珠岩的口腔组合物 Download PDFInfo
- Publication number
- CN1353597A CN1353597A CN00808319A CN00808319A CN1353597A CN 1353597 A CN1353597 A CN 1353597A CN 00808319 A CN00808319 A CN 00808319A CN 00808319 A CN00808319 A CN 00808319A CN 1353597 A CN1353597 A CN 1353597A
- Authority
- CN
- China
- Prior art keywords
- perlite
- oral cavity
- agent
- oral composition
- composition containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 235000019362 perlite Nutrition 0.000 title claims abstract description 21
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- 229910001562 pearlite Inorganic materials 0.000 claims description 7
- 239000012459 cleaning agent Substances 0.000 claims 1
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- 238000004140 cleaning Methods 0.000 description 8
- -1 hydrogen salt Chemical class 0.000 description 8
- 239000000606 toothpaste Substances 0.000 description 8
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- 208000006558 Dental Calculus Diseases 0.000 description 3
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- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical group [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
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- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical class [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
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- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- General Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
一种含珍珠岩的口腔组合物,其特征在于,其中含0.01%－0.9%重量的珍珠岩。
Description
本发明涉及含少量珍珠岩的口腔组合物。
在口腔组合物如牙膏中包含磨料是众所周知的。磨料具有清洁和擦亮/增白作用。去除牙齿表面的牙垢被认为能减少龋齿的发生。
牙科医生建议应该每年专业性地清除牙垢至少两次，最好更多，但是承认可以通过有效地刷牙减少牙垢的形成。
牙膏中使用的典型磨料包括二氧化硅和白垩，然而现有技术也公开了在牙膏配方中使用珍珠岩。EP-B1-0 268 763(Hawe-Neos)描述了一种用于牙齿预防保健的牙齿护理介质，其中含有珍珠岩和一种合成得到的沉淀硅酸。US 5,266,304(Baffe-lli)描述了一种牙齿护理和清洁组合物，在无水部分含至少40％重量的珍珠岩作为仅有的或组合物的清洗与擦亮体。US 5,597,553(Baffe lli)描述了一种含有膨化的珍珠岩作为磨料、优选作为唯一磨料的牙膏，该珍珠岩的粒度通常为1-150μm，其主要级分在20μm的范围内。这种珍珠岩构成组合物重量的1％至15％以下。
牙膏的磨蚀度按照牙科研究杂志(Journal of DentalResearch)(1976)55(4)，563中所述的规定测量。它说明了如何评价牙齿相对磨耗(RDA)和牙釉质相对磨耗(REA)。
最好是，牙膏能清洁牙齿而又不磨掉牙釉和牙质。因此，虽然对于具有清洁效力而言确有必要，但牙膏的RDA太高并不理想。在先进牙科研究(Advanced Dental Research)11(4)576-579中介绍了一种对于通常作为清洁量度的表膜清洁比(PCR)的评价方法。
使用高含量的珍珠岩也有缺点。珍珠岩是一种天然产物，虽然在掺加到口腔护理制剂中之前已被纯化到合理的程度，但它仍含有杂质。这些杂质常为灰色并使制剂带有斑点。在产品是白色膏体时尤为显著。这同样被看作是消费者否定的一个重要方面。高含量珍珠岩的另一缺点是它起着调味剂成分的降解催化剂的作用，特别是在pH较高的产品中，例如在含碳酸氢盐的口腔组合物中。这对于消费者是一个明显的缺点，而且对于制造商也是不可接受的，因为香料的成本常常占原料成本的大部分。还知道高含量的珍珠岩会引起常见的洁齿剂脱水收缩。
我们意想不到地发现，珍珠岩可以作为剂以比现有技术中公开的更少的量加入，而仍然具有有效的清洁效果。另外，这样减量的珍珠岩的研磨作用比高含量的珍珠岩具有更大的清洁/擦亮效果，即，由于使用较少量的珍珠岩，PCR基本上不变或只是部分减小，而ADR则显著降低。
因此，本发明提供了一种口腔组合物，其中含0.01-0.9％重量的珍珠岩。
本发明组合物优选含0.1-0.8％、特别是0.3-0.7％重量的珍珠岩。
珍珠岩是天然存在的钠/钾/铝硅酸盐，市售品有Seitzfilterwerke的Perlite C，Elfatochem的Ceka FloMA/P/2A/R，和World Mineral的Europearl 475/900S/E50。
一种优选的珍珠岩含有平均粒径小于300μm、优选小于200μm的颗粒。当然，以直径表示的粒度是近似值，因为颗粒的形状是无规的，不一定是球形。如果样品中含有更大的珍珠岩颗粒，则样品在掺加到制剂中之前最好先用合适量器进行筛分。
本发明的组合物可以是任何口腔用的非食品组合物，例如牙膏，并且可以是凝胶、膏、胶或任何其它合适类型的形式。
本发明组合物还可以含有洁齿剂中的常用成分。这些成分的实例包括：
抗微生物剂，例如，三氯羟基二苯醚，洗必泰，铜、锌和亚锡盐如柠檬酸锌、硫酸锌、甘氨酸锌、柠檬酸锌钠和焦磷酸亚锡；血根碱提取物，甲硝唑，季铵化合物如氯化十六烷基吡啶；双胍化合物，例如二葡糖酸洗必泰、双辛氢啶、癸双辛胺啶、双胍定；以及卤化的双酚化合物，例如2，2’-亚甲基双(4-氯-6-溴苯酚)；
消炎药，例如布洛芬、氟比洛芬、阿斯匹林、消炎痛等；
防龋齿剂，例如氟化钠、钙、镁和亚锡，氟化胺类，氟基磷酸二钠，三偏磷酸钠和酷蛋白；
牙斑缓冲剂，如尿素、乳酸钙、甘油磷酸钙和聚丙烯酸锶；
维生素，如维生素C；
植物提取物；
脱敏剂，例如，柠檬酸钾、氯化钾、酒石酸钾、碳酸氢钾、草酸钾、硝酸钾以及锶盐；
防结石剂，例如，含次磷酸盐的聚合物、有机膦酸盐和磷酸柠檬酸盐等；
齿龈保护剂，例如，植物油，如葵花子油、菜籽油、豆油和红花油；硅油；和烃油。齿龈保护剂可以是能改善齿龈通透屏障的试剂。在我们的共同未决的英国专利申请中有关于能改善齿龈通透屏障的全面描述；
生物分子，例如，杆菌素、抗体、酶等；
调味剂，例如，薄荷油和留兰香油；
防腐剂；
遮光剂；
着色剂；
pH调节剂；
甜味剂；
可药用的载体，例如，淀粉、蔗糖、水或水/醇体系等；
表面活性剂，例如阴离子、非离子、阳离子和两性离子型或两性表面活性剂；
粒状磨料，如二氧化硅、氧化铝、碳酸钙、磷酸氢二钙、焦磷酸钙、羟基磷灰石、三偏磷酸盐、不溶性六偏磷酸盐等，包括团聚的粒状磨料；
湿润剂，如甘油、山梨醇、丙二醇、木糖醇、乳糖醇等；
粘合剂和增稠剂，例如，羧甲基纤维素钠、黄原胶、阿拉位胶等，以及合成的聚合物，如聚丙烯酸酯和羧乙烯基聚合物，如crbopol；
缓冲剂和盐；及
其它可任选加入的成分，例如，漂白剂，如过氧化合物(例如过氧化二烯酸钾)；泡腾体系，如碳酸氢钠/柠檬酸体系；变色体系等。
这种口腔组合物也可以采用本领域常见的任何产品形式，例如，洁齿剂(凝胶或膏)、锭剂、口香糖等。
参照以下的非限制性实施例对本发明作进一步的说明：实施例1
以下是本发明的一种制剂，用常规方法制备。
实施例2
| 组分 | 含量(％重量) |
| 四焦磷酸钾甘油氟化钠糖精钠聚乙二醇二氧化钛增稠二氧化硅磨料二氧化硅碳酸氢盐珍珠岩十二烷基硫酸钠(SLS)香料水 | 3.0030.000.320.254.001.008.008.008.000.701.801.00至100％ |
下表列出了含不同量珍珠岩的典型洁齿剂的PCR和ADR值。
可以清楚地看出，通过将珍珠岩含量由占组合物重量的3％降至0.5％，PCR可保持93％，而磨蚀度降至78％。
| 珍珠岩％(w/w) | RDA | PCR | RDA/PCR |
| 0.5 | 78 | 91 | 0.85 |
| 3.0 | 100 | 98 | 1.02 |
Claims (4)
1.一种含珍珠岩的口腔组合物，其特征在于，其中含0.01-0.9％重量的珍珠岩。
2.权利要求1的口腔组合物，其特征在于，其中含0.1-0.8％重量的珍珠岩。
3.权利要求1的口腔组合物，其特征在于，其中含0.3-0.7％重量的珍珠岩。
4.在口腔组合物中使用珍珠岩作为清洁剂，其特征在于，组合物中含0.01-0.9％重量的珍珠岩。
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105997599A (zh) * | 2010-02-11 | 2016-10-12 | 英默里斯筛选矿物公司 | 用于清洁牙齿的包含天然玻璃的组合物及相关方法 |
| CN106236597A (zh) * | 2016-08-16 | 2016-12-21 | 好来化工(中山)有限公司 | 一种口腔护理组合物及其应用 |
| CN106361626A (zh) * | 2016-08-29 | 2017-02-01 | 陈思 | 制备具有消炎功效的牙膏的方法 |
| CN106726773A (zh) * | 2016-12-28 | 2017-05-31 | 安徽檀鑫科技有限公司 | 一种美白去渍牙膏及其制备方法 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7303600B2 (en) | 2002-04-25 | 2007-12-04 | Advanced Minerals Corporation | Unexpanded perlite ore polishing composition and methods |
| EP1499693A2 (en) * | 2002-04-25 | 2005-01-26 | Advanced Minerals Corporation | Polishing composition and methods |
| WO2004064795A1 (en) * | 2003-01-22 | 2004-08-05 | Unilever N.V. | Oral composition |
| JP4744269B2 (ja) * | 2005-11-02 | 2011-08-10 | パナソニック株式会社 | 半導体装置とその製造方法 |
| DE212014000241U1 (de) * | 2013-12-23 | 2016-09-08 | Imerys Minerals Ltd. | Reinigungszusammensetzungen |
| US20180296447A1 (en) * | 2015-04-28 | 2018-10-18 | Imerys Filtration Minerals, Inc. | Biocidal compositions and related methods |
Family Cites Families (15)
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| GB1495549A (en) * | 1974-04-17 | 1977-12-21 | Procter & Gamble | Scouring compositions |
| US4051056A (en) * | 1974-09-09 | 1977-09-27 | The Procter & Gamble Company | Abrasive scouring compositions |
| US4051055A (en) * | 1976-12-21 | 1977-09-27 | The Procter & Gamble Company | Cleansing compositions |
| US4240919A (en) * | 1978-11-29 | 1980-12-23 | S. C. Johnson & Son, Inc. | Thixotropic abrasive liquid scouring composition |
| US4457856A (en) * | 1980-01-07 | 1984-07-03 | The Procter & Gamble Company | Liquid detergent composition contains abrasive particles, anionic and nonionic surfactants |
| US4526701A (en) * | 1981-08-31 | 1985-07-02 | Lever Brothers Company | Dye stabilized detergent compositions |
| US4786432A (en) * | 1986-05-05 | 1988-11-22 | Go-Jo Industries, Inc. | Integral dry abrasive soap powders |
| US4786369A (en) * | 1986-05-05 | 1988-11-22 | Go-Jo Industries, Inc. | Integral dry abrasive soap powders |
| DE3639844A1 (de) | 1986-11-21 | 1988-06-01 | Degussa | Zahnpflegemittel |
| EP0528756B1 (en) * | 1991-08-19 | 1995-09-20 | HAWE NEOS DENTAL Dr. H. V. WEISSENFLUH AG | Tooth cleaning composition |
| EP0630227B1 (de) * | 1993-01-14 | 1999-04-14 | HAWE NEOS DENTAL Dr. H. V. WEISSENFLUH AG | Zahnpasta |
| AU3565195A (en) * | 1994-09-21 | 1996-04-09 | Crosfield Limited | Granular compositions |
| DE69518331T2 (de) * | 1994-09-21 | 2000-12-14 | Unilever Nv | Orale zubereitungen |
| US6010683A (en) * | 1997-11-05 | 2000-01-04 | Ultradent Products, Inc. | Compositions and methods for reducing the quantity but not the concentration of active ingredients delivered by a dentifrice |
| JPH11152216A (ja) * | 1997-11-20 | 1999-06-08 | Kureitsu:Kk | 歯磨き剤 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105997599A (zh) * | 2010-02-11 | 2016-10-12 | 英默里斯筛选矿物公司 | 用于清洁牙齿的包含天然玻璃的组合物及相关方法 |
| CN106236597A (zh) * | 2016-08-16 | 2016-12-21 | 好来化工(中山)有限公司 | 一种口腔护理组合物及其应用 |
| CN106236597B (zh) * | 2016-08-16 | 2019-03-19 | 好来化工(中山)有限公司 | 一种口腔护理组合物及其应用 |
| CN106361626A (zh) * | 2016-08-29 | 2017-02-01 | 陈思 | 制备具有消炎功效的牙膏的方法 |
| CN106726773A (zh) * | 2016-12-28 | 2017-05-31 | 安徽檀鑫科技有限公司 | 一种美白去渍牙膏及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1191053C (zh) | 2005-03-02 |
| BR0011261A (pt) | 2002-03-19 |
| DE60001366T2 (de) | 2003-07-03 |
| HUP0201605A3 (en) | 2006-06-28 |
| HU228797B1 (hu) | 2013-05-28 |
| EP1183006B1 (en) | 2003-02-05 |
| DE60001366D1 (de) | 2003-03-13 |
| ES2191625T3 (es) | 2003-09-16 |
| PL352104A1 (en) | 2003-07-28 |
| BR0011261B1 (pt) | 2013-07-09 |
| ZA200108728B (en) | 2002-10-23 |
| PL197860B1 (pl) | 2008-05-30 |
| AU4925200A (en) | 2000-12-28 |
| WO2000074638A1 (en) | 2000-12-14 |
| US6355227B1 (en) | 2002-03-12 |
| HUP0201605A2 (en) | 2002-09-28 |
| EP1183006A1 (en) | 2002-03-06 |
| RU2001135821A (ru) | 2004-02-20 |
| ATE232081T1 (de) | 2003-02-15 |
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