CN1352980A - Medicine for treating hemicrania and its preparing process - Google Patents
Medicine for treating hemicrania and its preparing process Download PDFInfo
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- CN1352980A CN1352980A CN 01130010 CN01130010A CN1352980A CN 1352980 A CN1352980 A CN 1352980A CN 01130010 CN01130010 CN 01130010 CN 01130010 A CN01130010 A CN 01130010A CN 1352980 A CN1352980 A CN 1352980A
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- rhizoma chuanxiong
- rhizoma cyperi
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Abstract
A Chinese-medicine in the form of soft capsule for treating hemicrania is prepared from cyperus tuber and Chuanxiong rhizome through extracting by supercritical CO2 fluid, proportional mixing, adding medicinal plant oil and shaping into soft capsule. Its advantages include unique preparing process and high antalgic effect.
Description
The present invention relates to the migrainous medicine of a kind of treatment, specifically a kind of pure with medium-height grass be the Chinese patent medicine of feedstock production, the invention still further relates to the preparation method of this medicine.
Migraine is a kind of headache of periodical attack, and the international association of having a headache is defined as intermittent headache outbreak with migraine and with autonomic imbalance, has or absence of aura.Migraine has two major types: migraine also has other rare type with tendency (being once called as classical migraine) and Migraine without aura (being once called as common migraine).Morbidity can be estimated to account for 15%～20% in general crowd.Prevalence women is 20%～25%, and the male is 15%～20%.The patient is in the majority with the women, accounts for 72%.Falling ill first, it is extremely rare to account for 25%, 45 years old sequela of patient person below 10 years old.There is family history person to account for 45%～55%.
The migrainous Western medicine of treatment mainly is the triptan medicine at present, but costs an arm and a leg, and side effect is arranged.The traditional Chinese medical science to migrainous understanding for a long time, the treatment comprise Coryza Treated by Syndrome Differentiation, special side's treatment, acupuncture and other therapy, the traditional Chinese medical herbal treatment migraine has sure curative effect, and few side effects; Pure Chinese medicinal preparation is treated migrainous occupation mode at present, maximum decocting cooking method or decoction and alcohol sedimentation technique, the medicinal liquid that obtains directly uses or is processed into required dosage form, volatile position or water soluble part then are difficult to keep in the active component of crude drug, also are to say that the active component in the raw material is difficult to farthest extract and keep.
The purpose of this invention is to provide the migrainous pure Chinese medicinal preparation of a kind of treatment, another kind of purpose provides the preparation technology of this Chinese medicine preparation.
Solution of the present invention is based on motherland's medical science to migrainous understanding and Therapeutic Principle, achieve with reference to modern pharmacological research, from motherland's medicine treasure-house, filter out blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, the Chinese medicine Rhizoma Chuanxiong of wind-expelling pain-stopping, and the resolving depression of regulating the flow of vital energy, the Chinese medicine Rhizoma Cyperi of menstruction regulating and pain relieving is under traditional Chinese medicine theory instructs, adopt modern biological medicine technology, extract the effective active composition of Chinese crude drug (Rhizoma Cyperi and Rhizoma Chuanxiong) to greatest extent, and the screening of the best proportioning of process, pure Chinese medicinal preparation made, the treatment migraine has good effect.
Medicine of the present invention is made by following compositions in weight percentage:
Rhizoma Cyperi extract 30%～90% Rhizoma Chuanxiong extract 10%～70%
The formula optimization weight percent ratio range of preparation medicine of the present invention is:
Rhizoma Cyperi extract 60%～80% Rhizoma Chuanxiong extract 20%～40%
The optimum weight per distribution ratio of preparation medicine of the present invention is:
Rhizoma Cyperi extract 70% Rhizoma Chuanxiong extract 30%
The preparation method of medicine of the present invention is:
1, respectively Rhizoma Cyperi, Rhizoma Chuanxiong are cleaned up with clear water;
2, with Rhizoma Cyperi, Rhizoma Chuanxiong respectively at 40～60 ℃ of following oven drying at low temperatures of low temperature state;
3, Rhizoma Cyperi, the Rhizoma Chuanxiong power after will drying respectively is broken to 20 order fine powders;
4, Rhizoma Cyperi powder, the Rhizoma Chuanxiong power after will pulverizing adopts the supercritical carbon dioxide extraction device to extract effective active matter respectively, be volatile oil, wherein the extraction temperature of Rhizoma Cyperi powder is 41～50 ℃, and extracting pressure is 25～30mPa, and the extraction time is 1.5～2.5 hours; The extraction temperature of Rhizoma Chuanxiong power is 51～60 ℃, and extracting pressure is 25～30mPa, and the extraction time is 1.5～2.5 hours;
5, will extract gained Rhizoma Cyperi extract, Rhizoma Chuanxiong extract by after the described mixed, add the medicinal plant oil adjuvant, reuse cylinder particle pressing machine is pressed into soft capsule.
The present invention compared with prior art has following advantage: 1, employing co_2 supercritical fluid extraction device extracts the effective active composition (being volatile oil) in Rhizoma Cyperi, the Rhizoma Chuanxiong respectively, the extraction efficiency height, no solvent residue toxicity, active skull cap components and heat-sensitive ingredients are difficult for decomposing to be destroyed, and can keep the extract natural feature to greatest extent; 2, component of the present invention is few, and preparation technology is very simple; 3, experimental result shows that analgesic effect is remarkable.
Test 1 mice glacial acetic acid writhing method, on the mouse writhing model, irritate stomach separately and give Rhizoma Cyperi extract or the Rhizoma Chuanxiong extract that deal is equivalent to median lethal dose(LD 50), no analgesic activity; When uniting when giving to give Rhizoma Cyperi extract and Rhizoma Chuanxiong extract in described ratio, showing all has analgesic activity.
Test the experiment of 2 mice formalin, penetrate on the formalin model in the rising pouring of mice metapedes, to lick the metapedes time is index, Rhizoma Cyperi extract, Rhizoma Chuanxiong extract be in described ratio use in conjunction, the result show to I phase reaction (nerve stimulation pain) and II mutually pain (struvite pain) analgesic activity of highly significant is all arranged.
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment one:
1, respectively Rhizoma Cyperi, Rhizoma Chuanxiong are cleaned up with clear water;
2, with Rhizoma Cyperi, Rhizoma Chuanxiong respectively at 50 ℃ of following oven drying at low temperatures of low temperature state;
3, Rhizoma Cyperi, the Rhizoma Chuanxiong power after will drying respectively is broken to 20 order fine powders;
4, the model that adopts Chinese dimension (HANDWAY) company to make respectively of Rhizoma Cyperi powder, the Rhizoma Chuanxiong power after will pulverizing is that the supercritical carbon dioxide extraction device of 100ml-SPE extracts effective active matter, wherein the extraction temperature of Rhizoma Cyperi powder is 45 ℃, extracting pressure is 28mPa, and the extraction time is 2 hours; The extraction temperature of Rhizoma Chuanxiong power is 55 ℃, and extracting pressure is 28mPa, and the extraction time is 2 hours;
5, will extract gained 7 kilograms of Rhizoma Cyperi extracts and 3 kilograms of mixing of Rhizoma Chuanxiong extract after, add the medicinal plant oil adjuvant, reuse cylinder particle pressing machine is pressed into soft capsule.
Embodiment two:
1, respectively Rhizoma Cyperi, Rhizoma Chuanxiong are cleaned up with clear water;
2, with Rhizoma Cyperi, Rhizoma Chuanxiong respectively at 40 ℃ of following oven drying at low temperatures of low temperature state;
3, Rhizoma Cyperi, the Rhizoma Chuanxiong power after will drying respectively is broken to 20 order fine powders;
4, the model that adopts Chinese dimension (HANDWAY) company to make respectively of Rhizoma Cyperi powder, the Rhizoma Chuanxiong power after will pulverizing is that the supercritical carbon dioxide extraction device of 100ml-SPE extracts effective active matter, wherein the extraction temperature of Rhizoma Cyperi powder is 41 ℃, extracting pressure is 25mPa, and the extraction time is 1.5 hours; The extraction temperature of Rhizoma Chuanxiong power is 51 ℃, and extracting pressure is 25mPa, and the extraction time is 1.5 hours;
5, will extract gained 6 kilograms of Rhizoma Cyperi extracts and 4 kilograms of mixing of Rhizoma Chuanxiong extract after, add the medicinal plant oil adjuvant, reuse cylinder particle pressing machine is pressed into soft capsule.
Embodiment three:
1, respectively Rhizoma Cyperi, Rhizoma Chuanxiong are cleaned up with clear water;
2, with Rhizoma Cyperi, Rhizoma Chuanxiong respectively at 60 ℃ of following oven drying at low temperatures of low temperature state;
3, Rhizoma Cyperi, the Rhizoma Chuanxiong power after will drying respectively is broken to 20 order fine powders;
4, the model that adopts Chinese dimension (HANDWAY) company to make respectively of Rhizoma Cyperi powder, the Rhizoma Chuanxiong power after will pulverizing is that the supercritical carbon dioxide extraction device of 100ml-SPE extracts effective active matter, wherein the extraction temperature of Rhizoma Cyperi powder is 50 ℃, extracting pressure is 30mPa, and the extraction time is 2.5 hours; The extraction temperature of Rhizoma Chuanxiong power is 60 ℃, and extracting pressure is 30mPa, and the extraction time is 2.5 hours;
5, will extract gained 9 kilograms of Rhizoma Cyperi extracts and 1 kilogram of mixing of Rhizoma Chuanxiong extract after, add the medicinal plant oil adjuvant, reuse cylinder particle pressing machine is pressed into soft capsule.
Embodiment four:
1, respectively Rhizoma Cyperi, Rhizoma Chuanxiong are cleaned up with clear water;
2, with Rhizoma Cyperi, Rhizoma Chuanxiong respectively at 50 ℃ of following oven drying at low temperatures of low temperature state;
3, Rhizoma Cyperi, the Rhizoma Chuanxiong power after will drying respectively is broken to 20 order fine powders;
4, the model that adopts Chinese dimension (HANDWAY) company to make respectively of Rhizoma Cyperi powder, the Rhizoma Chuanxiong power after will pulverizing is that the supercritical carbon dioxide extraction device of 100ml-SPE extracts effective active matter, wherein the extraction temperature of Rhizoma Cyperi powder is 45 ℃, extracting pressure is 28mPa, and the extraction time is 2 hours; The extraction temperature of Rhizoma Chuanxiong power is 55 ℃, and extracting pressure is 28mPa, and the extraction time is 2 hours;
5, will extract gained 8 kilograms of Rhizoma Cyperi extracts and 2 kilograms of mixing of Rhizoma Chuanxiong extract after, add the medicinal plant oil adjuvant, reuse cylinder particle pressing machine is pressed into soft capsule.
Embodiment five:
1, respectively Rhizoma Cyperi, Rhizoma Chuanxiong are cleaned up with clear water;
2, with Rhizoma Cyperi, Rhizoma Chuanxiong respectively at 55 ℃ of following oven drying at low temperatures of low temperature state;
3, Rhizoma Cyperi, the Rhizoma Chuanxiong power after will drying respectively is broken to 20 order fine powders;
4, the model that adopts Chinese dimension (HANDWAY) company to make respectively of Rhizoma Cyperi powder, the Rhizoma Chuanxiong power after will pulverizing is that the supercritical carbon dioxide extraction device of 100ml-SPE extracts effective active matter, wherein the extraction temperature of Rhizoma Cyperi powder is 47 ℃, extracting pressure is 26mPa, and the extraction time is 2 hours; The extraction temperature of Rhizoma Chuanxiong power is 58 ℃, and extracting pressure is 28mPa, and the extraction time is 2 hours;
5, will extract gained 3 kilograms of Rhizoma Cyperi extracts and 7 kilograms of mixing of Rhizoma Chuanxiong extract after, add the medicinal plant oil adjuvant, reuse cylinder particle pressing machine is pressed into soft capsule.
Claims (6)
1, the migrainous medicine of a kind of treatment is characterized in that: the medicament of being made by following compositions in weight percentage
Rhizoma Cyperi extract 30%～90% Rhizoma Chuanxiong extract 10%～70%
2, the migrainous medicine of treatment according to claim 1 is characterized in that: the preferred weight per distribution ratio of each component is
Rhizoma Cyperi extract 60%～80% Rhizoma Chuanxiong extract 20%～40%
3, the migrainous medicine of treatment according to claim 1 is characterized in that: the optimum weight per distribution ratio of each component is
Rhizoma Cyperi extract 70% Rhizoma Chuanxiong extract 30%
4, according to claim 1, the migrainous medicine of 2 or 3 described treatments, it is characterized in that: described medicament is a said dosage form on any pharmaceutics.
5, the migrainous medicine of treatment according to claim 4, it is characterized in that: described medicament is a soft capsule.
6, the preparation method of the migrainous medicine of the described treatment of claim 5 is characterized in that may further comprise the steps:
(1) respectively Rhizoma Cyperi, Rhizoma Chuanxiong are cleaned up with clear water;
(2) with Rhizoma Cyperi, Rhizoma Chuanxiong respectively at 40～60 ℃ of following oven drying at low temperatures of low temperature state;
(3) Rhizoma Cyperi, the Rhizoma Chuanxiong power after will drying respectively is broken to 20 order fine powders;
(4) Rhizoma Cyperi powder, the Rhizoma Chuanxiong power after will pulverizing adopts the supercritical carbon dioxide extraction device to extract effective active matter respectively, and wherein the extraction temperature of Rhizoma Cyperi powder is 41～50 ℃, and extracting pressure is 25～30mPa, and the extraction time is 1.5～2.5 hours; The extraction temperature of Rhizoma Chuanxiong power is 51～60 ℃, and extracting pressure is 25～30mPa, and the extraction time is 1.5～2.5 hours;
(5) will extract gained Rhizoma Cyperi extract, Rhizoma Chuanxiong extract by after the described mixed, add the medicinal plant oil adjuvant, reuse cylinder particle pressing machine is pressed into soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01130010 CN1132614C (en) | 2001-11-30 | 2001-11-30 | Medicine for treating hemicrania and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01130010 CN1132614C (en) | 2001-11-30 | 2001-11-30 | Medicine for treating hemicrania and its preparing process |
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| CN1352980A true CN1352980A (en) | 2002-06-12 |
| CN1132614C CN1132614C (en) | 2003-12-31 |
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| CN 01130010 Expired - Fee Related CN1132614C (en) | 2001-11-30 | 2001-11-30 | Medicine for treating hemicrania and its preparing process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101375983B (en) * | 2008-09-28 | 2010-12-08 | 张登科 | Chinese medicinal composition for treating dysmenorrhea and preparation method thereof |
| CN103484254A (en) * | 2013-09-18 | 2014-01-01 | 上海中医药大学 | Method for extraction of ligusticum chuanxiong hort. volatile oil by utilizing supercritical carbon dioxide |
-
2001
- 2001-11-30 CN CN 01130010 patent/CN1132614C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101375983B (en) * | 2008-09-28 | 2010-12-08 | 张登科 | Chinese medicinal composition for treating dysmenorrhea and preparation method thereof |
| CN103484254A (en) * | 2013-09-18 | 2014-01-01 | 上海中医药大学 | Method for extraction of ligusticum chuanxiong hort. volatile oil by utilizing supercritical carbon dioxide |
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| Publication number | Publication date |
|---|---|
| CN1132614C (en) | 2003-12-31 |
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Owner name: BEIJING YIHEAN MEDICINE SCIENCE DEVELOPMENT CO., Free format text: FORMER OWNER: SCIENCE + TECHNOLOGY INDUSTRY GARDEN CO LTD, GUANGZHOU TRADITIONAL CHINESE MEDIC Effective date: 20061222 |
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Effective date of registration: 20061222 Address after: 100037, room 800, block B, Century Economic & Trade Building, No. 72 West Third Ring Road North, Beijing, Haidian District Patentee after: Beijing Yihe medical science and Technology Development Co Ltd Address before: 510445 east side of Chen Tai Road, Yongxing village, long dragon town, Baiyun District, Guangdong, Guangzhou Patentee before: Science & Technology Industry Garden Co., Ltd., Guangzhou Traditional Chinese medic |
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Owner name: SCIENCE & TECHNOLOGY INDUSTRY GARDEN CO LTD, GUAN Free format text: FORMER OWNER: BEIJING YIHEAN MEDICINE SCIENCE DEVELOPMENT CO., LTD. Effective date: 20070615 |
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Effective date of registration: 20070615 Address after: 510445 east side of Chen Tai Road, Dongxing village, long dragon town, Baiyun District, Guangdong, Guangzhou Patentee after: Science & Technology Industry Garden Co., Ltd., Guangzhou Traditional Chinese medic Address before: 100037, room 800, block B, Century Economic & Trade Building, No. 72 West Third Ring Road North, Beijing, Haidian District Patentee before: Beijing Yihe medical science and Technology Development Co Ltd |
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Owner name: LIAONING ZHENGXIN PHARMACEUTICAL RESEARCH LTD. Free format text: FORMER OWNER: SCIENCE + TECHNOLOGY INDUSTRY GARDEN CO LTD, GUANGZHOU TRADITIONAL CHINESE MEDIC Effective date: 20080418 |
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Effective date of registration: 20080418 Address after: Shenyang Hunnan New Long Street No. 10-1 (intellectual property Park building two) Patentee after: Liaoning Zhengxin Drug Research Co., Ltd. Address before: East of Chen Tai Road, Dongxing village, long dragon town, Baiyun District, Guangzhou, Guangdong Patentee before: Science & Technology Industry Garden Co., Ltd., Guangzhou Traditional Chinese medic |
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Effective date of registration: 20101216 Address after: 116110 Dalian city Jinzhou District daweijia street after Patentee after: Dalian Tianyu Olson Pharmaceutical Co. Ltd. Address before: 110179 Shenyang Hunnan New Long Street No. 10-1 (intellectual property Park building two) Patentee before: Liaoning Zhengxin Drug Research Co., Ltd. |
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