CN1229125C - Medication for irregular menses and dysmenorrhea and preparation method - Google Patents
Medication for irregular menses and dysmenorrhea and preparation method Download PDFInfo
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- CN1229125C CN1229125C CN 02134713 CN02134713A CN1229125C CN 1229125 C CN1229125 C CN 1229125C CN 02134713 CN02134713 CN 02134713 CN 02134713 A CN02134713 A CN 02134713A CN 1229125 C CN1229125 C CN 1229125C
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- rhizoma cyperi
- radix angelicae
- angelicae sinensis
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Abstract
The present invention discloses a medicine for treating menoxenia and dysmenorrhea and a preparation method thereof. The effective active substances of rhizoma cyperi and angelica are extracted with a supercritical carbon dioxide fluid extraction device and mixed according to a proportion; proper amount of medicinal supplementary materials are added to the mixed substances, and the mixture is pressed into soft capsules with a cylindrical grain press machine. The present invention has the advantages of unique formula, unique preparation method and obvious curative effect.
Description
The present invention relates to a kind of medicine for the treatment of menoxenia and dysmenorrhea, specifically a kind of is the Chinese patent medicine of feedstock production with the Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.
Menoxenia is the cycle of menstruation, one group of gynopathic general name of abnormal change took place through amount and persistent period.Clinical common having: 6 sick kinds such as preceeded menorrhea, delayed menstrual cycle, menstruation do not have earlier regularly, menorrhagia, hypomenorrhea and menostaxis.Behind the metropathia hemorrhagica of modern medicine, polycystic ovarian syndrome, hysteromyoma, urogenital tract infection and the family planning operation all menoxenia can appear.Dysmenorrhea is meant that the women in menstrual period and front and back thereof, lower abdomen or flank pain occur, even pain and waist sacrum, whenever sends out with menstrual cycle, and severe patient can be accompanied nausea and vomiting, dripping cold sweat, deadly cold hand and foot, even faints, and brings influence to the work life.Dysmenorrhea is sent out after 15～25 years old and menophania 6 months well in two years, is one of adolescence common sympton.Its sickness rate accounts for 42%～90%, and wherein severe pain is through accounting for 18%.
At present the western medical treatment dysmenorrhea comprises oral relieving spasm to stop pain class medicine before the menstrual onset, takes estrogen, progestogen, contraceptive in the process of passing through, or transvaginal gives prostaglandin antagonist etc., the severe patient treatment that can undergo surgery.The western medical treatment of menoxenia mainly is the gonadal hormone alternative medicine.The traditional Chinese medical science to the understanding of dysmenorrhea and menoxenia for a long time, treatment comprises Coryza Treated by Syndrome Differentiation, special side's treatment, acupuncture and other therapy.Traditional Chinese medical herbal treatment dysmenorrhea and menoxenia have sure curative effect, and few side effects.Pure Chinese medicinal preparation is treated the occupation mode of dysmenorrhea and menoxenia at present, be at most water decocting method or decoction and alcohol sedimentation technique, the medicinal liquid that obtains directly uses or is processed into required dosage form, volatile position of active component in the crude drug or water soluble part then are difficult to keep, that is to say that the active component in the raw material is difficult to farthest extract and keep, thereby affect the treatment.
The purpose of this invention is to provide a kind of pure Chinese medicinal preparation for the treatment of dysmenorrhea and menoxenia, another kind of purpose provides the preparation technology of this Chinese medicine preparation.
Solution of the present invention is based on understanding and the Therapeutic Principle of motherland's medical science to dysmenorrhea, menoxenia, achieve with reference to modern pharmacological research, from motherland's medicine treasure-house, filter out the resolving depression of regulating the flow of vital energy, the Chinese medicine Rhizoma Cyperi of menstruction regulating and pain relieving, and enrich blood, invigorate blood circulation, the Chinese medicine angelica of menstruction regulating and pain relieving, adopt modern biological medicine technology, extract the effective active composition in the Chinese crude drug (Rhizoma Cyperi and Radix Angelicae Sinensis) to greatest extent, and the screening of the best proportioning of process, pure Chinese medicinal preparation made, treatment dysmenorrhea, menoxenia, effect is remarkable.
Medicine of the present invention is made by following compositions in weight percentage:
Rhizoma Cyperi extract 20%～80% Radix Angelicae Sinensis extract 20%～80%
The formula optimization weight percent ratio range of preparation medicine of the present invention is:
Rhizoma Cyperi extract 40%～60% Radix Angelicae Sinensis extract 40%～60%
The optimum weight percentage ratio proportioning of preparation medicine of the present invention is:
Rhizoma Cyperi extract 50% Radix Angelicae Sinensis extract 50%
The preparation method of medicine of the present invention is:
1, Rhizoma Cyperi, the Radix Angelicae Sinensis powder after will purifying respectively is broken to 20 order fine powders;
2, Rhizoma Cyperi, the Radix Angelicae Sinensis powder after will pulverizing adopts the supercritical carbon dioxide extraction device to extract effective active matter respectively, and wherein the extraction temperature of Rhizoma Cyperi powder is 41～50 ℃, and extracting pressure is 25～30mPa, and the extraction time is 2.5～4.5 hours; 51～60 ℃ of the extraction temperature of Radix Angelicae Sinensis powder, extracting pressure 25～30mPa, the extraction time is 3.5～4.5 hours.
3, the Rhizoma Cyperi extract, Radix Angelicae Sinensis extract that will extract gained adds proper quantity of medicinal auxiliary material by after the described mixed, and reuse cylinder particle pressing machine is made soft capsule.
The present invention compared with prior art has following advantage: 1, employing co_2 supercritical fluid extraction device extracts the effective active composition (being volatile oil) in Rhizoma Cyperi, the Radix Angelicae Sinensis respectively, the extraction efficiency height, no solvent residue toxicity, active skull cap components and heat-sensitive ingredients are difficult for decomposing to be destroyed, and can keep the extract natural feature to greatest extent; 2, component of the present invention is few, and preparation technology is simple; 3, experimental result shows that analgesia, regulating menstruation effect are remarkable.
Test 1 mice glacial acetic acid writhing method, on the mouse writhing model, irritate stomach separately and give Rhizoma Cyperi extract or the Radix Angelicae Sinensis extract that deal is equivalent to median lethal dose(LD 50), do not have obvious analgesic activity; When uniting when giving to give Rhizoma Cyperi extract and Radix Angelicae Sinensis extract in described ratio, showing all has obvious analgesic activity.
Test 2 mice ear, rat chronic granuloma method, on mice ear, rat chronic granuloma model, irritate stomach separately and give Rhizoma Cyperi extract or the Radix Angelicae Sinensis extract that deal is equivalent to median lethal dose(LD 50), no obvious anti-inflammatory and anti effect; When uniting when giving to give Rhizoma Cyperi extract and Radix Angelicae Sinensis extract in described ratio, showing all has remarkable antiphlogistic effects.
Testing 3 rats and suppress the uterine contraction method, is index with record whole body shrinkage amplitude with frequency, and when the filling stomach gave rat and gives Rhizoma Cyperi extract and Radix Angelicae Sinensis extract in described ratio, the result showed that rat uterus has obvious contraction.
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment one:
1, Rhizoma Cyperi, the Radix Angelicae Sinensis powder after will purifying respectively is broken to 20 order fine powders;
2, the model that adopts Chinese dimension (HANDWAY) company to make respectively of Rhizoma Cyperi, the Radix Angelicae Sinensis powder after will pulverizing is that 100ml-SPE supercritical carbon dioxide extraction device extracts effective active matter, wherein the extraction temperature of Rhizoma Cyperi powder is 41 ℃, extracting pressure is 25MPa, and the extraction time is 2.5 hours; The extraction temperature of Radix Angelicae Sinensis powder is 60 ℃, and extracting pressure is 28MPa, and the extraction time is 3.7 hours.
3, will extract 6 kilograms of the Rhizoma Cyperi extracts of gained, and after 4 kilograms of mixing of Radix Angelicae Sinensis extract, add proper quantity of medicinal auxiliary material, reuse cylinder particle pressing machine is made soft capsule.
Embodiment two:
1, Rhizoma Cyperi, the Radix Angelicae Sinensis powder after will purifying respectively is broken to 20 order fine powders;
2, the model that adopts Chinese dimension (HANDWAY) company to make respectively of Rhizoma Cyperi, the Radix Angelicae Sinensis powder after will pulverizing is that 100ml-SPE supercritical carbon dioxide extraction device extracts effective active matter, wherein the extraction temperature of Rhizoma Cyperi powder is 50 ℃, extracting pressure is 30mPa, and the extraction time is 2.5 hours; The extraction temperature of Radix Angelicae Sinensis powder is 51 ℃, and extracting pressure is 25mPa, and the extraction time is 3.5 hours.
3, will extract 4.5 kilograms of the Rhizoma Cyperi extracts of gained, and after 5.5 kilograms of mixing of Radix Angelicae Sinensis extract, add proper quantity of medicinal auxiliary material, reuse cylinder particle pressing machine is made soft capsule.
Embodiment three:
1, Rhizoma Cyperi, the Radix Angelicae Sinensis powder after will purifying respectively is broken to 20 order fine powders;
2, the model that adopts Chinese dimension (HANDWAY) company to make respectively of Rhizoma Cyperi, the Radix Angelicae Sinensis powder after will pulverizing is that 100ml-SPE supercritical carbon dioxide extraction device extracts effective active matter, wherein the extraction temperature of Rhizoma Cyperi powder is 45 ℃, extracting pressure is 28mPa, and the extraction time is 3.5 hours; The extraction temperature of Radix Angelicae Sinensis powder is 55 ℃, and extracting pressure is 30mPa, and the extraction time is 4.5 hours.
3, will extract 5.5 kilograms of the Rhizoma Cyperi extracts of gained, and after 4.5 kilograms of mixing of Radix Angelicae Sinensis extract, add proper quantity of medicinal auxiliary material, reuse cylinder particle pressing machine is made soft capsule.
Embodiment four:
1, Rhizoma Cyperi, the Radix Angelicae Sinensis powder after will purifying respectively is broken to 20 order fine powders;
2, the model that adopts Chinese dimension (HANDWAY) company to make respectively of Rhizoma Cyperi, the Radix Angelicae Sinensis powder after will pulverizing is that 100ml-SPE supercritical carbon dioxide extraction device extracts effective active matter, wherein the extraction temperature of Rhizoma Cyperi powder is 47 ℃, extracting pressure is 26mPa, the extraction time is 4.5 hours: the extraction temperature of Radix Angelicae Sinensis powder is 57 ℃, extracting pressure is 26mPa, and the extraction time is 4 hours.
3, will extract 5 kilograms of the Rhizoma Cyperi extracts of gained, and after 5 kilograms of mixing of Radix Angelicae Sinensis extract, add proper quantity of medicinal auxiliary material, reuse cylinder particle pressing machine is made soft capsule.
Embodiment five:
1, Rhizoma Cyperi, the Radix Angelicae Sinensis powder after will purifying respectively is broken to 20 order fine powders;
2, the model that adopts Chinese dimension (HANDWAY) company to make respectively of Rhizoma Cyperi, the Radix Angelicae Sinensis powder after will pulverizing is that 100ml-SPE supercritical carbon dioxide extraction device extracts effective active matter, wherein the extraction temperature of Rhizoma Cyperi powder is 43 ℃, extracting pressure is 28mPa, and the extraction time is 2.5 hours; The extraction temperature of Radix Angelicae Sinensis powder is 53 ℃, and extracting pressure is 30mPa, and the extraction time is 4.5 hours.
3, will extract 4 kilograms of the Rhizoma Cyperi extracts of gained, and after 6 kilograms of mixing of Radix Angelicae Sinensis extract, add proper quantity of medicinal auxiliary material, reuse cylinder particle pressing machine is made soft capsule.
Claims (2)
1, a kind of medicine for the treatment of menoxenia and dysmenorrhea is characterized in that being made by following compositions in weight percentage:
The Rhizoma Cyperi extract 40%～60% of supercritical carbon dioxide extraction
The Radix Angelicae Sinensis extract 40%～60% of supercritical carbon dioxide extraction;
Making step is:
(1) Rhizoma Cyperi, the Radix Angelicae Sinensis powder after will purifying respectively is broken to 20 order fine powders;
(2) Rhizoma Cyperi, the Radix Angelicae Sinensis powder after will pulverizing adopts the supercritical carbon dioxide extraction device to extract effective active matter respectively, and wherein the extraction temperature of Rhizoma Cyperi powder is 41～50 ℃, and extracting pressure is 25～30mPa, and the extraction time is 2.5～4.5 hours; 51～60 ℃ of the extraction temperature of Radix Angelicae Sinensis powder, extracting pressure 25～30mPa, the extraction time is 3.5～4.5 hours;
(3) Rhizoma Cyperi extract, Radix Angelicae Sinensis extract that will extract gained adds pharmaceutic adjuvant by after the described mixed, and reuse cylinder particle pressing machine is made soft capsule.
2, the medicine of treatment menoxenia according to claim 1 and dysmenorrhea, it is characterized in that: the percentage by weight of each component is
The Rhizoma Cyperi extract 50% of supercritical carbon dioxide extraction
The Radix Angelicae Sinensis extract 50% of supercritical carbon dioxide extraction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02134713 CN1229125C (en) | 2002-09-12 | 2002-09-12 | Medication for irregular menses and dysmenorrhea and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02134713 CN1229125C (en) | 2002-09-12 | 2002-09-12 | Medication for irregular menses and dysmenorrhea and preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1481839A CN1481839A (en) | 2004-03-17 |
| CN1229125C true CN1229125C (en) | 2005-11-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 02134713 Expired - Fee Related CN1229125C (en) | 2002-09-12 | 2002-09-12 | Medication for irregular menses and dysmenorrhea and preparation method |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100450517C (en) * | 2003-12-02 | 2009-01-14 | 胡惠平 | Dysmenorrhea treating Chinese traditional medicine preparation |
| CN102205025B (en) * | 2011-05-06 | 2012-11-07 | 烟台渤海制药集团有限公司 | Preparation method of traditional Chinese medicine preparation for treating dysmenorrhea and irregular menstruation |
| CN106692591A (en) * | 2017-03-08 | 2017-05-24 | 王本晓 | Traditional Chinese medicine composition for irregular menstruation |
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2002
- 2002-09-12 CN CN 02134713 patent/CN1229125C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1481839A (en) | 2004-03-17 |
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Granted publication date: 20051130 Termination date: 20110912 |