CN110404040A - It is a kind of using Chinese fiber crops as composition of the treatment rheumatic bone joint pain of raw material and its gel and preparation method thereof - Google Patents
It is a kind of using Chinese fiber crops as composition of the treatment rheumatic bone joint pain of raw material and its gel and preparation method thereof Download PDFInfo
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Abstract
It is a kind of using Chinese fiber crops as composition of the treatment rheumatic bone joint pain of raw material and its gel and preparation method thereof, it belong to treatment bone joint pain gel preparation technical field.Inventive gel is mainly made of achyranthes bidentata extract, Ginger P.E, Astragalus Root P.E, angelica extract, mulberry-leaf extract, Chinese sesame slices extract, hemp stalk matrix activated carbon, Sodium Hyaluronate, sodium carboxymethylcellulose, glycerine, pure water.Hemp stalk matrix activated carbon of the present invention surface has cellular structure abundant and surface functional group, has chemical stability, can promote the absorptivity of infrared irridiation therapy and absorb depth, improve the absorptivity of local diffusate.The present invention utilizes scientific compatibility, reaches good therapeutic effect, assists infrared radiation instrument, reaches 100% to the effective percentage of rheumatic arthralgia.
Description
Technical field
The invention belongs to treat bone joint pain gel preparation technical field；More particularly to a kind of controlling using Chinese fiber crops as raw material
Treat composition and its gel and preparation method thereof of rheumatic bone joint pain.
Background technique
Rheumatism bone disease is after wind-cold damp pathogen invades human body, to lead to tendon and vessel blocking barrier caused by wind-cold damp pathogen intrusion human body,
" not general rule pain ", thus often causes the positions such as human synovial, periosteum, muscle that congestion and swelling pain occurs.The cold ground of the elderly and the north
The common morbidity in area seriously affects the movable function of patient, reduces quality of life.Pass is mainly involved in the morbidity of rheumatic bone joint pain
Cartilage, subchondral bone and synovium of joint are saved, knee joint is additionally related to and cuts the soft tissues such as band, muscle and tendon, morbidity mainly may be used
To cause patient's knee pain, based on the pain of kneecap stock and chamber femoral joint loading conditions, walking, it is upper downstairs and under tie up and stand up
When the pain increased；Stripping off for articular cartilage can cause muscular tone, patient when walking can knee joint can breakthrough pain, beat it is soft
Leg is so that the presence of walking disorder, meniscus injury and joint bodies can cause joint to twist lock symptom, the hyperplasia of synovial membrane, fertilizer
Thickness can cause the spleen-distension joint, pain and limitation of activity.
The treatment method of general Western medicine is to take analgesic drug product, if ammonia phenol Oxycodone is that Oxycodone and paracetamol are multiple
Square analgesia preparation etc., some patients for receiving long-term treatment report that its pain is improved, but a portion patient understand because
Adverse events and stop to treat.
Summary of the invention
It is an object of the present invention to provide a kind of using Chinese fiber crops as the combination of the treatment rheumatic bone joint pain of raw material of external application
Object and its gel and preparation method thereof.
The invention is realized by the following technical scheme:
It is a kind of using Chinese fiber crops as the composition of the treatment rheumatic bone joint pain of raw material, described one kind is using Chinese fiber crops as raw material
The composition for the treatment of rheumatic bone joint pain mainly include that achyranthes bidentata extract, Ginger P.E, Astragalus Root P.E, Radix Angelicae Sinensis mention
Object, mulberry-leaf extract, Chinese sesame slices extract, hemp stalk matrix activated carbon are taken, parts by weight are respectively that 20~40 parts of radix achyranthis bidentatae mentions
Take object, 30~70 parts of Ginger P.E, 20~30 parts of Astragalus Root P.E, 15~30 parts of angelica extract, 15~30 parts
Mulberry-leaf extract, 3~10 parts of Chinese sesame slices extract, 10~20 parts of hemp stalk matrix activated carbon, the Chinese sesame slices extract
Object is to be extracted by Chinese sesame slices by supercritical carbon dioxide purifying.
It is of the present invention a kind of using Chinese fiber crops as the composition of the treatment rheumatic bone joint pain of raw material, described one kind
Using Chinese fiber crops as the parts by weight of achyranthes bidentata extract in the composition of the treatment rheumatic bone joint pain of raw material be 35 parts, ginger mentions
The parts by weight for taking object are 50 parts, the parts by weight of Astragalus Root P.E are 25 parts, the parts by weight of angelica extract are 20 parts, mulberry
The parts by weight of leaf extract are 20 parts, the parts by weight of Chinese sesame slices extract are 4 parts, the heavy number of hemp stalk matrix activated carbon is
14 parts.
It is of the present invention a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material, mainly by radix achyranthis bidentatae
Extract, Ginger P.E, Astragalus Root P.E, angelica extract, mulberry-leaf extract, Chinese sesame slices extract, hemp stalk base activity
Charcoal, Sodium Hyaluronate, sodium carboxymethylcellulose, glycerine, pure water are made, 20~40 parts of achyranthes bidentata extract, 30~70 parts
Ginger P.E, 20~30 parts of Astragalus Root P.E, 15~30 parts of angelica extract, 15~30 parts of mulberry-leaf extract, 3
~10 parts of Chinese sesame slices extract, 10~20 parts of hemp stalk matrix activated carbon, parts by weight are respectively 2.0~4.0 parts of ox
Knee extract, 3.0~7.0 parts of Ginger P.E, 2.0~3.0 parts of Astragalus Root P.E, 1.5~3.0 parts of Radix Angelicae Sinensis extract
Object, 1.5~3.0 parts of mulberry-leaf extract, 0.3~1.0 part of Chinese sesame slices extract, 1.0~2.0 parts of hemp stalk base activity
Charcoal, 5.0~10.0 parts of Sodium Hyaluronate, 5.0~10.0 parts of sodium carboxymethylcellulose, 5.0~10.0 parts of glycerine,
180~300 parts of pure water, the Chinese sesame slices extract be by Chinese sesame slices by supercritical carbon dioxide purifying extraction and
At.
It is of the present invention a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material, it is described it is a kind of with
Chinese fiber crops be the parts by weight of achyranthes bidentata extract in the gel of the treatment rheumatic bone joint pain of raw material be 3.5 parts, ginger extract
The parts by weight of object are 5.0 parts, the parts by weight of Astragalus Root P.E are 2.5 parts, the parts by weight of angelica extract are 2.0 parts,
The weight that the parts by weight of mulberry-leaf extract are 2.0 parts, the parts by weight of Chinese sesame slices extract are 4.0 parts, hemp stalk matrix activated carbon
Amount number is 1.4 parts, the parts by weight of Sodium Hyaluronate are 6 parts, the parts by weight of sodium carboxymethylcellulose are 7 parts, glycerine
Parts by weight be 6 parts, the parts by weight of pure water are 260 parts.
It is of the present invention a kind of using Chinese fiber crops as the preparation method of the gel of the treatment rheumatic bone joint pain of raw material, packet
Include following steps:
Step a, it prepares achyranthes bidentata extract: taking the radix achyranthis bidentatae of certain mass, clean after drying, be put into pulverizer and crush, it will
Smashed Radix Astragali sieves with 100 mesh sieve, and is the ethanol solution that certain volume is added in 1:15 according to solid-liquid ratio, extracts 2 under ultrasound condition
Secondary, combined extract obtains achyranthes bidentata extract, for use after rotary evaporation is concentrated；
Step b, it prepares Ginger P.E: taking the ginger of certain mass, clean after drying, be put into pulverizer and crush, it will
Smashed Radix Astragali sieves with 100 mesh sieve, and is the ethanol solution that certain volume is added in 1:8 according to solid-liquid ratio, extracts 2 under ultrasound condition
Secondary, combined extract obtains Ginger P.E, for use after rotary evaporation is concentrated；
Step c, it prepares Astragalus Root P.E: taking the Radix Astragali of certain mass, clean after drying, be put into pulverizer and crush, it will
Smashed Radix Astragali sieves with 100 mesh sieve, and is the ethanol solution that certain volume is added in 1:12 according to solid-liquid ratio, extracts 2 under ultrasound condition
Secondary, combined extract obtains Astragalus Root P.E, for use after rotary evaporation is concentrated；
Step d, it prepares angelica extract: taking the Radix Angelicae Sinensis of certain mass, clean after drying, be put into pulverizer and crush, it will
Smashed Radix Angelicae Sinensis sieves with 100 mesh sieve, and is the pure water that certain volume is added in 1:18 according to solid-liquid ratio, extracts 2 times under ultrasound condition,
Combined extract obtains angelica extract, for use after rotary evaporation is concentrated；
Step e, it prepares mulberry-leaf extract: taking the mulberry leaf of certain mass, clean after drying, be put into pulverizer and crush, press
Taking care of liquor ratio is the ethanol solution that certain volume is added in 1:20, is extracted 2 times under ultrasound condition, combined extract, through rotary evaporation
After concentration, mulberry-leaf extract is obtained, for use；
Step f, it prepares Chinese sesame slices extract, Chinese sesame slices is cut into the segment of 1~2cm, in 110 DEG C of 2~4h of drying, then
It is the Chinese sesame slices and distilled water that 1g:10~12ml is added after drying in flask according to solid-liquid ratio, then add 0.3~
The cellulase of 0.5wt%, be added after digesting a period of time, in the enzymolysis liquid that is obtained by filtration be added by certain solid-liquid ratio extract it is molten
The Extraction solvent on upper layer is then demultiplex out in agent, the circumfluence distillation under the temperature of setting, time, and revolving removes solvent, obtains oil
Methanol is added according to the ratio that volume ratio is 1:8~10 in grease and methanol, in the temperature condition of mixture of ice and water in shape object
Under, certain time is stirred, then centrifugation obtains supernatant under the conditions of -10 DEG C, is rotated extract to get to Chinese sesame slices again
Object；
Step g, it prepares hemp stalk matrix activated carbon: hemp stalk being cut into the segment of 1~2cm, in 110 DEG C of 2~4h of drying, so
It is heated to reflux 3~5h with 2mol/l phosphoric acid afterwards, drying to constant weight, then it is carbonized under nitrogen protection, carburizing temperature 600
DEG C, carbonization time 2h, product cleans 6~7 times, after drying with deionized water after carbonization, obtained hemp stalk matrix activated carbon；
Step h, achyranthes bidentata extract, Ginger P.E, Astragalus Root P.E, Radix Angelicae Sinensis is weighed respectively according to parts by weight to extract
It is object, mulberry-leaf extract, Chinese sesame slices extract, hemp stalk matrix activated carbon, Sodium Hyaluronate, sodium carboxymethylcellulose, glycerine, pure
Water purification, under agitation, by achyranthes bidentata extract, Ginger P.E, Astragalus Root P.E, angelica extract, mulberry-leaf extract, third
Triol after mixing, adds Chinese sesame slices extract, Sodium Hyaluronate, and pure water, hemp stalk base are then added in sequence
Active carbon, sodium carboxymethylcellulose, continue stirring in it is uniform it is thick after, obtain described a kind of using Chinese fiber crops as raw material
The gel for treating rheumatic bone joint pain.
It is of the present invention a kind of using Chinese fiber crops as the preparation method of the gel of the treatment rheumatic bone joint pain of raw material, institute
The concentration for the ethanol solution stated is 70%.
It is of the present invention a kind of using Chinese fiber crops as the preparation method of the gel of the treatment rheumatic bone joint pain of raw material, institute
The ultrasonic extraction temperature stated is 40~70 DEG C, 1.5~3h of ultrasonic extraction time.
It is of the present invention a kind of using Chinese fiber crops as the preparation method of the gel of the treatment rheumatic bone joint pain of raw material, step
Extraction solvent in rapid f is the mixture of n-hexane and dehydrated alcohol, and the volume ratio of the n-hexane and dehydrated alcohol is 10:
1, in solid-liquid ratio 1g:12~18ml of enzymolysis liquid and Extraction solvent, 3~3.5h of extraction time, 75~80 DEG C of Extracting temperature；Ice water
Mixing time is 30~60min in mixture.
The invention has the benefit that
It is of the present invention a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material, in achyranthes bidentata extract
Containing saponin, and contain ecdysterone and Inokosterone, there is dispelling stasis of blood and stimulating the menstrual flow, easing joint movement, inducing diuresis for treating strangurtia.It is used for the mass amenorrhea due to blood stasis dredging,
Placenta retension, arthralgia, sufficient impotence muscle contraction, cards such as hematuria blood drenches, the effect of injury from falling down.
Of the present invention a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material, ginger is a kind of
Edible and medicinal plant, application is very extensive, and raw juice of ginger liquid also has good anti-oxidation characteristics, Ginger P.E
In contain zingiberol (zingiberol), zingiberene (zingiberene), heerabolene (bisabolene), α-curcumene (α-
Curcumene), linalool (linalool), cineole (cineole) and α-borneol；Another gingerol containing piquancy component
(gingerol) and decomposition product zingiberone (gingerone), it is used for co-treatment arthritis.
Of the present invention a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material, Radix Astragali is sweet in flavor, property
Temperature, return lung, the spleen channel.There is the effect of invigorating qi for strengthening superficies, promoting pus discharge and tissue regeneration.Astragalus Root P.E main component has flavones, isoflavones, isoflavan
Class compound.The confirmation of modern age pharmacological research, influence of the Radix Astragali to blood pressure and nervous centralis peptide, Re-A-A
System, carnosine release enzyme-carnosine system, and hydroxyproline etc. have relationship.Radix Astragali can promote intravascular in various degree
Chrotoplast migration and proliferation may advantageously facilitate the raw process of blood vessel.
It is of the present invention a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material, in angelica extract
Predominantly Radix Angelicae Sinensis polysaccharide, Radix Angelicae Sinensis polysaccharide can promote platelet aggregation, have stronger anticoagulation and anastalsis.Radix Angelicae Sinensis polysaccharide
It can promote immune function by influencing Immune Organs of Body and immune cell function.Can not only immune cell activated, also
Cell factor can be promoted to generate, activating complement system promotes antibody to generate, and plays various adjustment effects to immune system and works as
Returning polysaccharide also has the function of that damage is penetrated in analgesia, anti-good fortune.
It is of the present invention a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material, mulberry-leaf extract
It is antibacterial for acting on, and the vitamin in mulberry leaf, which has, inhibits to become original effect, and the SOD in mulberry leaf has anticancer activity, the Huang in mulberry leaf
Ketone compounds also have the function of anti-cancer, and the mulberrin in mulberry leaf has anticancer activity, and play the role of inhibiting fungi；Contain in mulberry leaf
Some SOD, chromocor compound, which have, removes free radical, enhances the effect of Abwehrkraft des Koepers and anti-aging.Mulberry-leaf extract for
Typical gram-positive bacterium: staphylococcus aureus and gramnegative bacterium: Escherichia coli have stronger inhibition to make
With being nontoxic, non-stimulated, the natural antiseptic agent of no skin allergy.
It is of the present invention a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material, Chinese sesame slices extract
In containing cannabidiol 54.00mg/g or so, yield is stablized 4.9%, and cannabidiol is main listless in industrial hemp
Active constituent medically has the function of mitigating inflammation, convulsions and anxiety, pain and vomiting, in antidepression, anti-epileptic, resist
Cancer, analgesic, calm aspect significant effect.
It is of the present invention a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material, hemp stalk base activity
Carbon surface has cellular structure abundant and surface functional group, has chemical stability, can promote infrared irridiation therapy
Absorptivity and absorption depth, improve the absorptivity of local diffusate.The infrared therapy that hemp stalk matrix activated carbon table combines is also known as
Heat ray therapy is the method that disease is treated using infrared radiation human body.Infrared ray is invisible ray, and medical wavelength exists
Between 760nm~15 μm, biological effect is mainly heat.Infrared radiation human body can improve local blood circulation and tissue generation
It thanks, promotes the absorption of local exudate, reduce Muscle tensility and anti-inflammatory, analgesia etc., be mainly used for treating various types of chronic
Arthritis, muscular strain are dampened, Buerger's disease shallower neuritis and neuralgia etc..
Of the present invention a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material, Sodium Hyaluronate is
The main component of articular cavity synovia is one of the ingredient of cartilage matrix, plays lubricating action in joint, reduces the mill between tissue
It wipes, can obviously improve the inflammatory reaction of synovial tissue in articular cavity after injection, enhance the toughness and lubricating function of joint fluid, protect
Articular cartilage is protected, promotes the healing and regeneration of articular cartilage, relieves pain, increase the mobility in joint.It is inhaled by skin surface
Receive, can mild dilation capillary, the effect for increasing blood circulation, improving intermediate supersession also has thickening and steady after addition
It is set for using.
It is of the present invention a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material, matched using science
5, reach good therapeutic effect, assists infrared radiation instrument, 100% is reached to the effective percentage of rheumatic arthralgia.
Specific embodiment
Specific embodiment 1:
It is a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material, described is a kind of using Chinese fiber crops as raw material
The parts by weight for treating achyranthes bidentata extract in the gel of rheumatic bone joint pain are the parts by weight of 3.5 parts, Ginger P.E
Parts by weight for 5.0 parts, Astragalus Root P.E are 2.5 parts, the parts by weight of angelica extract are 2.0 parts, mulberry-leaf extract
Parts by weight are 2.0 parts, the parts by weight of Chinese sesame slices extract are 4.0 parts, the parts by weight of hemp stalk matrix activated carbon are 1.4
Part, the parts by weight of Sodium Hyaluronate be 6 parts, the parts by weight of sodium carboxymethylcellulose are 7 parts, the parts by weight of glycerine are
6 parts, the parts by weight of pure water be 260 parts.
It is a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material described in present embodiment, it is ink black
Semi-solid material, lotion exquisiteness have certain viscosity without agglomerate, and stretchability is preferable.
A kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material described in present embodiment, pH value exists
Between 6.50~7.0, meet the pH value requirement of 2010 editions " Chinese Pharmacopoeia " exterior-applied gels.
It is a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material described in present embodiment, 30~32
DEG C, under conditions of relative humidity is 65~70%, its character, viscosity, pH value, content and synthesis are antibacterial after placing 6 months
Significant changes do not occur for activity, have good stability；Long term test has carried out the measurement that keeps sample in 12 months, as a result again shows that,
Gel is at 25~27 DEG C, its character, viscosity, pH value, content after relative humidity is placed 12 months under conditions of being 60~70%
And significant changes do not occur for comprehensive bacteriostatic activity, have good stability.
It is a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material described in present embodiment, to 400
The patient of rheumatic bone joint pain carries out clinical test, and the test period 4 weeks, in the patient of 400 rheumatic bone joint pains
166 people of male patient, 234 people of female patient, age between 45 years old~60 years old, are divided into four groups, carry out present embodiment respectively
Group smears treatment, present embodiment group smearing+infrared radiation treatment group, Chinese medical extract group are smeared, Chinese medical extract smearing+red
External radiotherapy group, prevents other drugs treatment during treatment, infrared radiation treatment group carries out 30 points after smearing gel daily
The infrared radiation of clock is treated, and Chinese sesame slices extract, hemp stalk matrix activated carbon are not contained in the gel component of Chinese medical extract group,
Remaining component and preparation method are identical as the component of present embodiment and preparation method, and gel, which is smeared, to be twined at posterior joint with preservative film
Around keeping being cleaned after a hour with 45~55 DEG C of hot water, dry, smear daily or the treatment of smearing+infrared radiation is primary, control
It treats the period 4 weeks, carries out Knee Joint Fluid chemical examination detection before and after treatment, testing result is as shown in table 1:
1 treatment results Knee Joint Fluid of the table chemical examination detection table of comparisons
, it can be seen that the content of pretherapy and post-treatment IL-1 β of patient, MMP3 have significant difference, by this implementation from table 1
Mode group, which is smeared, combines the pretherapy and post-treatment otherness of infrared radiation the most significant, significantly reduces before horizontal relatively treatment after treatment, explanation
By treatment, IL-1 β, the MMP3 that can be significantly reduced in Knee Joint Fluid are horizontal.
It is a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material described in present embodiment, by 4 weeks
The treatment of smearing combination infrared radiation, 100% is reached to the effective percentage of rheumatic arthralgia, painful swelling of joints disappears, after treatment
Patient can work normally and live.
Specific embodiment 2:
It is a kind of using Chinese fiber crops as the composition of the treatment rheumatic bone joint pain of raw material, described one kind is using Chinese fiber crops as raw material
The composition for the treatment of rheumatic bone joint pain mainly include that achyranthes bidentata extract, Ginger P.E, Astragalus Root P.E, Radix Angelicae Sinensis mention
Object, mulberry-leaf extract, Chinese sesame slices extract, hemp stalk matrix activated carbon are taken, parts by weight are respectively that 20~40 parts of radix achyranthis bidentatae mentions
Take object, 30~70 parts of Ginger P.E, 20~30 parts of Astragalus Root P.E, 15~30 parts of angelica extract, 15~30 parts
Mulberry-leaf extract, 3~10 parts of Chinese sesame slices extract, 10~20 parts of hemp stalk matrix activated carbon, the Chinese sesame slices extract
Object is to be extracted by Chinese sesame slices by supercritical carbon dioxide purifying.
Specific embodiment 2:
It is a kind of using Chinese fiber crops as the combination of the treatment rheumatic bone joint pain of raw material according to specific embodiment one
Object, described is a kind of using Chinese fiber crops as the parts by weight of achyranthes bidentata extract in the composition of the treatment rheumatic bone joint pain of raw material
The weight that parts by weight for 35 parts, Ginger P.E are 50 parts, the parts by weight of Astragalus Root P.E are 25 parts, angelica extract
Number is 20 parts, the parts by weight of mulberry-leaf extract are 20 parts, the parts by weight of Chinese sesame slices extract are 4 parts, hemp stalk base is living
Property charcoal weight number be 14 parts.
Specific embodiment 3:
It is a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material, mainly by achyranthes bidentata extract, ginger
Extract, Astragalus Root P.E, angelica extract, mulberry-leaf extract, Chinese sesame slices extract, hemp stalk matrix activated carbon, hyaluronic acid
Sodium, sodium carboxymethylcellulose, glycerine, pure water are made, and 20~40 parts of achyranthes bidentata extract, 30~70 parts of ginger extract
Object, 20~30 parts of Astragalus Root P.E, 15~30 parts of angelica extract, 15~30 parts of mulberry-leaf extract, 3~10 parts of the Chinese
Sesame slices extract, 10~20 parts of hemp stalk matrix activated carbon, parts by weight be respectively 2.0~4.0 parts achyranthes bidentata extract,
3.0~7.0 parts of Ginger P.E, 2.0~3.0 parts of Astragalus Root P.E, 1.5~3.0 parts of angelica extract, 1.5~3.0
Mulberry-leaf extract, 0.3~1.0 part of the Chinese sesame slices extract, 1.0~2.0 parts of hemp stalk matrix activated carbon, 5.0~10.0 of part
Part Sodium Hyaluronate, 5.0~10.0 parts of sodium carboxymethylcellulose, 5.0~10.0 parts of glycerine, 180~300 parts pure
Water purification, the Chinese sesame slices extract are to be extracted by Chinese sesame slices by supercritical carbon dioxide purifying.
Specific embodiment 4:
It is a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material according to specific embodiment three,
It is described it is a kind of by the parts by weight of achyranthes bidentata extract in the gel of the treatment rheumatic bone joint pain of raw material of Chinese fiber crops be 3.5
Part, the parts by weight of Ginger P.E be 5.0 parts, the parts by weight that the parts by weight of Astragalus Root P.E are 2.5 parts, angelica extract
Number is 2.0 parts, the parts by weight of mulberry-leaf extract are 2.0 parts, the parts by weight of Chinese sesame slices extract are 4.0 parts, hemp stalk base
The parts by weight of active carbon are 1.4 parts, the parts by weight of Sodium Hyaluronate are 6 parts, the parts by weight of sodium carboxymethylcellulose are 7
Part, the parts by weight of glycerine be 6 parts, the parts by weight of pure water are 260 parts.
Specific embodiment 5:
It is a kind of using Chinese fiber crops as the treatment rheumatic bone joint pain of raw material described in a kind of specific embodiment one to four
The preparation method of gel, includes the following steps:
Step a, it prepares achyranthes bidentata extract: taking the radix achyranthis bidentatae of certain mass, clean after drying, be put into pulverizer and crush, it will
Smashed Radix Astragali sieves with 100 mesh sieve, and is the ethanol solution that certain volume is added in 1:15 according to solid-liquid ratio, extracts 2 under ultrasound condition
Secondary, combined extract obtains achyranthes bidentata extract, for use after rotary evaporation is concentrated；
Step b, it prepares Ginger P.E: taking the ginger of certain mass, clean after drying, be put into pulverizer and crush, it will
Smashed Radix Astragali sieves with 100 mesh sieve, and is the ethanol solution that certain volume is added in 1:8 according to solid-liquid ratio, extracts 2 under ultrasound condition
Secondary, combined extract obtains Ginger P.E, for use after rotary evaporation is concentrated；
Step c, it prepares Astragalus Root P.E: taking the Radix Astragali of certain mass, clean after drying, be put into pulverizer and crush, it will
Smashed Radix Astragali sieves with 100 mesh sieve, and is the ethanol solution that certain volume is added in 1:12 according to solid-liquid ratio, extracts 2 under ultrasound condition
Secondary, combined extract obtains Astragalus Root P.E, for use after rotary evaporation is concentrated；
Step d, it prepares angelica extract: taking the Radix Angelicae Sinensis of certain mass, clean after drying, be put into pulverizer and crush, it will
Smashed Radix Angelicae Sinensis sieves with 100 mesh sieve, and is the pure water that certain volume is added in 1:18 according to solid-liquid ratio, extracts 2 times under ultrasound condition,
Combined extract obtains angelica extract, for use after rotary evaporation is concentrated；
Step e, it prepares mulberry-leaf extract: taking the mulberry leaf of certain mass, clean after drying, be put into pulverizer and crush, press
Taking care of liquor ratio is the ethanol solution that certain volume is added in 1:20, is extracted 2 times under ultrasound condition, combined extract, through rotary evaporation
After concentration, mulberry-leaf extract is obtained, for use；
Step f, it prepares Chinese sesame slices extract, Chinese sesame slices is cut into the segment of 1~2cm, in 110 DEG C of 2~4h of drying, then
It is the Chinese sesame slices and distilled water that 1g:10~12ml is added after drying in flask according to solid-liquid ratio, then add 0.3~
The cellulase of 0.5wt%, be added after digesting a period of time, in the enzymolysis liquid that is obtained by filtration be added by certain solid-liquid ratio extract it is molten
The Extraction solvent on upper layer is then demultiplex out in agent, the circumfluence distillation under the temperature of setting, time, and revolving removes solvent, obtains oil
Methanol is added according to the ratio that volume ratio is 1:8~10 in grease and methanol, in the temperature condition of mixture of ice and water in shape object
Under, certain time is stirred, then centrifugation obtains supernatant under the conditions of -10 DEG C, is rotated extract to get to Chinese sesame slices again
Object；
Step g, it prepares hemp stalk matrix activated carbon: hemp stalk being cut into the segment of 1~2cm, in 110 DEG C of 2~4h of drying, so
It is heated to reflux 3~5h with 2mol/l phosphoric acid afterwards, drying to constant weight, then it is carbonized under nitrogen protection, carburizing temperature 600
DEG C, carbonization time 2h, product cleans 6~7 times, after drying with deionized water after carbonization, obtained hemp stalk matrix activated carbon；
Step h, achyranthes bidentata extract, Ginger P.E, Astragalus Root P.E, Radix Angelicae Sinensis is weighed respectively according to parts by weight to extract
It is object, mulberry-leaf extract, Chinese sesame slices extract, hemp stalk matrix activated carbon, Sodium Hyaluronate, sodium carboxymethylcellulose, glycerine, pure
Water purification, under agitation, by achyranthes bidentata extract, Ginger P.E, Astragalus Root P.E, angelica extract, mulberry-leaf extract, third
Triol after mixing, adds Chinese sesame slices extract, Sodium Hyaluronate, and pure water, hemp stalk base are then added in sequence
Active carbon, sodium carboxymethylcellulose, continue stirring in it is uniform it is thick after, obtain described a kind of using Chinese fiber crops as raw material
The gel for treating rheumatic bone joint pain.
Specific embodiment 6:
It is a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material according to specific embodiment five
Preparation method, the concentration of the ethanol solution is 70%.
Specific embodiment 7:
It is a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material according to specific embodiment five
Preparation method, the ultrasonic extraction temperature be 40~70 DEG C, 1.5~3h of ultrasonic extraction time.
Specific embodiment 8:
It is a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material according to specific embodiment five
Preparation method, the Extraction solvent in step f is the mixture of n-hexane and dehydrated alcohol, the n-hexane and dehydrated alcohol
Volume ratio be 10:1, in solid-liquid ratio 1g:12~18ml of enzymolysis liquid and Extraction solvent, 3~3.5h of extraction time, Extracting temperature
75~80 DEG C；Mixing time is 30~60min in mixture of ice and water.
Claims (8)
1. a kind of using Chinese fiber crops as the composition of the treatment rheumatic bone joint pain of raw material, it is characterised in that: it is described it is a kind of with
Chinese fiber crops are that the composition of the treatment rheumatic bone joint pain of raw material mainly includes that achyranthes bidentata extract, Ginger P.E, Radix Astragali mention
Object, angelica extract, mulberry-leaf extract, Chinese sesame slices extract, hemp stalk matrix activated carbon are taken, parts by weight are respectively 20~40
The achyranthes bidentata extract, 30~70 parts of Ginger P.E, 20~30 parts of Astragalus Root P.E, 15~30 parts of Radix Angelicae Sinensis of part extract
Object, 15~30 parts of mulberry-leaf extract, 3~10 parts of Chinese sesame slices extract, 10~20 parts of hemp stalk matrix activated carbon, it is described
Chinese sesame slices extract is to be extracted by Chinese sesame slices by supercritical carbon dioxide purifying.
2. it is according to claim 1 a kind of using Chinese fiber crops as the composition of the treatment rheumatic bone joint pain of raw material, it is special
Sign is: described is a kind of using Chinese fiber crops as the weight of achyranthes bidentata extract in the composition of the treatment rheumatic bone joint pain of raw material
Number is 35 parts, the parts by weight of Ginger P.E are 50 parts, the parts by weight of Astragalus Root P.E are 25 parts, angelica extract
Parts by weight are 20 parts, the parts by weight of mulberry-leaf extract are 20 parts, the parts by weight of Chinese sesame slices extract are 4 parts, hemp stalk
The weight number of matrix activated carbon is 14 parts.
3. a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material, it is characterised in that: mainly mentioned by radix achyranthis bidentatae
Take object, Ginger P.E, Astragalus Root P.E, angelica extract, mulberry-leaf extract, Chinese sesame slices extract, hemp stalk matrix activated carbon,
Sodium Hyaluronate, sodium carboxymethylcellulose, glycerine, pure water are made, 20~40 parts of achyranthes bidentata extract, 30~70 parts of life
Ginger extract, 20~30 parts of Astragalus Root P.E, 15~30 parts of angelica extract, 15~30 parts of mulberry-leaf extract, 3~10
The Chinese sesame slices extract, 10~20 parts of hemp stalk matrix activated carbon of part, parts by weight are respectively that 2.0~4.0 parts of radix achyranthis bidentatae mentions
Take object, 3.0~7.0 parts of Ginger P.E, 2.0~3.0 parts of Astragalus Root P.E, 1.5~3.0 parts of angelica extract, 1.5
~3.0 parts of mulberry-leaf extract, 0.3~1.0 part of Chinese sesame slices extract, 1.0~2.0 parts of hemp stalk matrix activated carbon, 5.0~
10.0 parts of Sodium Hyaluronate, 5.0~10.0 parts of sodium carboxymethylcellulose, 5.0~10.0 parts of glycerine, 180~300 parts
Pure water, the Chinese sesame slices extract be by Chinese sesame slices by supercritical carbon dioxide purifying extract.
4. according to claim 3 a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material, feature
Be: described is a kind of using Chinese fiber crops as the parts by weight of achyranthes bidentata extract in the gel of the treatment rheumatic bone joint pain of raw material
Parts by weight for 3.5 parts, Ginger P.E are 5.0 parts, the parts by weight of Astragalus Root P.E are 2.5 parts, angelica extract
Parts by weight are 2.0 parts, the parts by weight of mulberry-leaf extract are 2.0 parts, the parts by weight of Chinese sesame slices extract are 4.0 parts, the Chinese
The weight that the parts by weight of waste of flax matrix activated carbon are 1.4 parts, the parts by weight of Sodium Hyaluronate are 6 parts, sodium carboxymethylcellulose
Number is 7 parts, the parts by weight of glycerine are 6 parts, the parts by weight of pure water are 260 parts.
5. a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material described in a kind of one of claim 1-4
Preparation method, characterized by the following steps:
Step a, it prepares achyranthes bidentata extract: taking the radix achyranthis bidentatae of certain mass, clean after drying, be put into pulverizer and crush, will crush
Radix Astragali afterwards sieves with 100 mesh sieve, and is the ethanol solution that certain volume is added in 1:15 according to solid-liquid ratio, extracts 2 times under ultrasound condition, closes
And extracting solution obtains achyranthes bidentata extract, for use after rotary evaporation is concentrated；
Step b, it prepares Ginger P.E: taking the ginger of certain mass, clean after drying, be put into pulverizer and crush, will crush
Radix Astragali afterwards sieves with 100 mesh sieve, and is the ethanol solution that certain volume is added in 1:8 according to solid-liquid ratio, extracts 2 times under ultrasound condition, closes
And extracting solution obtains Ginger P.E, for use after rotary evaporation is concentrated；
Step c, it prepares Astragalus Root P.E: taking the Radix Astragali of certain mass, clean after drying, be put into pulverizer and crush, will crush
Radix Astragali afterwards sieves with 100 mesh sieve, and is the ethanol solution that certain volume is added in 1:12 according to solid-liquid ratio, extracts 2 times under ultrasound condition, closes
And extracting solution obtains Astragalus Root P.E, for use after rotary evaporation is concentrated；
Step d, it prepares angelica extract: taking the Radix Angelicae Sinensis of certain mass, clean after drying, be put into pulverizer and crush, will crush
Radix Angelicae Sinensis afterwards sieves with 100 mesh sieve, and is the pure water that certain volume is added in 1:18 according to solid-liquid ratio, extracts 2 times under ultrasound condition, merges
Extracting solution obtains angelica extract, for use after rotary evaporation is concentrated；
Step e, it prepares mulberry-leaf extract: taking the mulberry leaf of certain mass, clean after drying, be put into pulverizer and crush, according to material
Liquor ratio is the ethanol solution that certain volume is added in 1:20, is extracted 2 times under ultrasound condition, combined extract is concentrated through rotary evaporation
Afterwards, mulberry-leaf extract is obtained, for use；
Step f, prepare Chinese sesame slices extract, Chinese sesame slices be cut into the segment of 1~2cm, in 110 DEG C of 2~4h of drying, then according to
Solid-liquid ratio is the Chinese sesame slices and distilled water that 1g:10~12ml is added after drying in flask, then adds 0.3~0.5wt%
Cellulase, after digesting a period of time, be added in the enzymolysis liquid that is obtained by filtration and Extraction solvent be added by certain solid-liquid ratio, set
Fixed temperature, circumfluence distillation under the time, are then demultiplex out the Extraction solvent on upper layer, and revolving removes solvent, obtains grease, press
Grease and methanol are according to the ratio addition methanol that volume ratio is 1:8~10, under the conditions of the temperature of mixture of ice and water, stirring one
It fixes time, then centrifugation obtains supernatant under the conditions of -10 DEG C, is rotated again to get Chinese sesame slices extract is arrived；
Step g, it prepares hemp stalk matrix activated carbon: hemp stalk being cut into the segment of 1~2cm, in 110 DEG C of 2~4h of drying, is then used
2mol/l phosphoric acid is heated to reflux 3~5h, and drying to constant weight, is then carbonized under nitrogen protection, and 600 DEG C of carburizing temperature, carbon
Change time 2h, after product clean 6~7 times, is dried with deionized water after carbonization, obtained hemp stalk matrix activated carbon；
Step h, achyranthes bidentata extract, Ginger P.E, Astragalus Root P.E, angelica extract, mulberry are weighed respectively according to parts by weight
Leaf extract, Chinese sesame slices extract, hemp stalk matrix activated carbon, Sodium Hyaluronate, sodium carboxymethylcellulose, glycerine, pure water,
Under agitation, by achyranthes bidentata extract, Ginger P.E, Astragalus Root P.E, angelica extract, mulberry-leaf extract, glycerine
After mixing, Chinese sesame slices extract, Sodium Hyaluronate are added, pure water, hemp stalk base activity are then added in sequence
Charcoal, sodium carboxymethylcellulose, continue stirring in it is uniform it is thick after, obtain described a kind of using Chinese fiber crops as the treatment of raw material
The gel of rheumatic bone joint pain.
6. according to claim 5 a kind of using Chinese fiber crops as the preparation side of the gel of the treatment rheumatic bone joint pain of raw material
Method, it is characterised in that: the concentration of the ethanol solution is 70%.
7. a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material described according to claim 5
Preparation method, it is characterised in that: the ultrasonic extraction temperature is 40~70 DEG C, 1.5~3h of ultrasonic extraction time.
8. a kind of using Chinese fiber crops as the gel of the treatment rheumatic bone joint pain of raw material described according to claim 5
Preparation method, it is characterised in that: the Extraction solvent in step f is the mixture of n-hexane and dehydrated alcohol, the n-hexane
Be 10:1 with the volume ratio of dehydrated alcohol, solid-liquid ratio 1g:12~18ml of enzymolysis liquid and Extraction solvent, extraction time 3~
75~80 DEG C of 3.5h, Extracting temperature；Mixing time is 30~60min in mixture of ice and water.
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| CN201910773141.XA Pending CN110404040A (en) | 2019-07-03 | 2019-08-21 | It is a kind of using Chinese fiber crops as composition of the treatment rheumatic bone joint pain of raw material and its gel and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105480975A (en) * | 2016-02-25 | 2016-04-13 | 黑龙江省科学院大庆分院 | Method for preparing high-specific-surface-area porous carbon with hemp stems as carbon source |
| CN107337586A (en) * | 2017-08-28 | 2017-11-10 | 黑龙江省科学院大庆分院 | A kind of method of extraction purification cannabidiol in fiber crops from the Chinese |
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2019
- 2019-07-03 CN CN201910594872.8A patent/CN110201137A/en not_active Withdrawn
- 2019-08-21 CN CN201910773141.XA patent/CN110404040A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105480975A (en) * | 2016-02-25 | 2016-04-13 | 黑龙江省科学院大庆分院 | Method for preparing high-specific-surface-area porous carbon with hemp stems as carbon source |
| CN107337586A (en) * | 2017-08-28 | 2017-11-10 | 黑龙江省科学院大庆分院 | A kind of method of extraction purification cannabidiol in fiber crops from the Chinese |
Non-Patent Citations (2)
| Title |
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| 倪飞等: "益气养血愈风汤临床验证报告", 《浙江创伤外科》 * |
| 石雨等: "汉麻秆基活性炭研究进展", 《黑龙江科学》 * |
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