CN1382475A

CN1382475A - Chinese-medicinal aqueogel for treating burn and its preparing process

Info

Publication number: CN1382475A
Application number: CN 02111762
Authority: CN
Inventors: 田建广; 唐洪泰; 夏照帆; 王光毅; 程大胜
Original assignee: Second Military Medical University SMMU
Current assignee: Second Military Medical University SMMU
Priority date: 2002-05-21
Filing date: 2002-05-21
Publication date: 2002-12-04
Anticipated expiration: 2022-05-21
Also published as: CN1235618C

Abstract

A Chinese medicine in the form of aqueogel for treating burn wound is prepared from 5 Chinese-medicinal materials includign coptis root, Sichuan phellodendron bark, sanguisorba root, siphonostegia, etc. Its advantages are high curative effect, simple preparing process and convenient application.

Description

Chinese medicine extract aqueogel of treatment burn wound and preparation method thereof

Technical field: the present invention relates to medical technical field, is a kind of Chinese medicine extract aqueogel that is used for burn wound's treatment and preparation method thereof.

Background technology: burn wound is the crux of burn patient whole body or localized variation, can threaten patient's life in severe case.Thereby, actively promote wound repair to save patient's life, reduce complication, to improve therapeutic effect significant.Motherland's medical science extensive knowledge and profound scholarship has accumulated rich experience aspect burn treating, some proved recipe has demonstrated effect preferably in the deep burn treatment.The Chinese medicine preparation that is used for burn wound at present mostly is oil preparation, unguentum, paste or powder etc., and sensory properties is relatively poor, uses inconvenience, pollutes dressing, sheet bedding and medicated clothing easily.

Summary of the invention: the modern Chinese medicine pharmaceutical research shows that Rhizoma Coptidis has eliminating fire and detoxication, heat clearing and damp drying effect; Cortex Phellodendri has heat clearing and damp drying, pathogenic fire purging removes and steams, detoxifies and treat the skin ulcer effect; Charred Radix Sanguisorbae has cooling blood for hemostasis, the skin ulcer effect is held back in detoxifcation; Herba Artemisiae Anomalae has clearing away summer-heat and eliminating dampness, blood circulation promoting competent silt, inducing menstruation to relieve menalgia effect; Rhizoma Polygoni Cuspidati has the analgesic therapy of invigorating blood circulation, eliminating damp-heat, relieving cough and resolving phlegm effect, and Mentholum has itching-relieving action.The pharmacological action of these Chinese medicines conforms to the requirement of burn wound's treatment.The present invention is prepared into the sodium alginate aqueogel from Rhizoma Coptidis, Cortex Phellodendri, charred Radix Sanguisorbae, Herba Artemisiae Anomalae, Rhizoma Polygoni Cuspidati effective component extracting, is used for the treatment of burn wound.Compare with oil preparation, unguentum, paste, the powder of similar Chinese medicine preparation, the present invention has the advantages such as pollution that preparation method is simple, easy to use, sensory properties is good, be convenient to clean, be difficult for causing dressing, sheet bedding and medicated clothing.Clinic trial result shows, preparation of the present invention has anti-inflammation, antipyretic-antalgic, hemostasia and dissipation blood stasis, promotion wound healing, effect such as antipruritic, is the good medicine of treatment burn wound.

Preparation method of the present invention is:

1. prepare the Chinese medicine extract concentrated solution: get equivalent Rhizoma Coptidis, Cortex Phellodendri, charred Radix Sanguisorbae, Herba Artemisiae Anomalae, Rhizoma Polygoni Cuspidati raw medicinal material, it is pulverized, put in the chloroform of 2 times of volumes with mechanical means, soaking at room temperature 12 hours, filtered through gauze repeats merging filtrate 2 times; 95% ethanol of 2 times of volumes of filtering residue reuse, soaking at room temperature 12 hours, filtered through gauze repeats merging filtrate 2 times; Use the distilled water of 2 times of volumes at last, soaking at room temperature filtering residue 12 hours, filtered through gauze repeats merging filtrate 2 times.Above-mentioned filtrate combines behind the concentrating under reduced pressure respectively, is the Chinese medicine extract concentrated solution.

2. preparation Chinese medicine extract aqueogel: in above-mentioned Chinese medicine extract concentrated solution, add glycerol (amount of glycerol be final volume 30～40%), calcium chloride solution and sodium alginate successively, the attention addition sequence can not be put upside down, stir into even heavy-gravity gel, get the Chinese medicine extract aqueogel.

The specific embodiment:

Embodiment 1: gets Rhizoma Coptidis, Cortex Phellodendri, charred Radix Sanguisorbae, Herba Artemisiae Anomalae, each 20g of Rhizoma Polygoni Cuspidati raw medicinal material, it pulverized, add the chloroform of 2 times of volumes with mechanical means, and soaking at room temperature 12 hours, filtered through gauze repeats merging filtrate, concentrating under reduced pressure 2 times; 95% ethanol that adds 2 times of volumes in the filtering residue, soaking at room temperature 12 hours, filtered through gauze repeats merging filtrate, concentrating under reduced pressure 2 times; The distilled water that adds 2 times of volumes in the filtering residue again, soaking at room temperature 12 hours, filtered through gauze repeats merging filtrate, concentrating under reduced pressure 2 times.Merge all filtrates, be evaporated to final volume 350ml.In concentrated solution, add glycerol 150ml, 1mol/L CaCl ₂Solution 10ml, sodium alginate 10g stirs, and makes sodium alginate be swelled into even, heavy-gravity gel.In addition Mentholum 3g is ground into fine powder, joins in the gel, stir, promptly get Chinese medicine extract aqueogel 500ml.

Claims

1. preparation method for the treatment of the Chinese medicine extract aqueogel of burn wound, operating procedure is as follows:

(1). preparation Chinese medicine extract concentrated solution: get equivalent Rhizoma Coptidis, Cortex Phellodendri, charred Radix Sanguisorbae, Herba Artemisiae Anomalae, Rhizoma Polygoni Cuspidati raw medicinal material, it is pulverized, put in the chloroform of 2 times of volumes with mechanical means, soaking at room temperature 12 hours, filtered through gauze repeats merging filtrate 2 times; 95% ethanol soaking at room temperature of 2 times of volumes of filtering residue reuse 12 hours, filtered through gauze repeats merging filtrate 2 times; Use the distilled water of 2 times of volumes at last, soaking at room temperature filtering residue 12 hours, filtered through gauze repeats 2 times, merging filtrate, above-mentioned filtrate combines behind the concentrating under reduced pressure respectively, is the Chinese medicine extract concentrated solution;

(2). preparation Chinese medicine extract aqueogel: in above-mentioned Chinese medicine extract concentrated solution, add glycerol, calcium chloride solution and sodium alginate successively, stir into even heavy-gravity gel, get the Chinese medicine extract aqueogel.

2. the Chinese medicine extract aqueogel that makes of the described preparation method of claim 1.

3. the described Chinese medicine extract aqueogel of claim 2 is as the purposes of treatment burn wound medicine.