CN111166930A - Sodium alginate hydrogel medical dressing and preparation method thereof - Google Patents
Sodium alginate hydrogel medical dressing and preparation method thereof Download PDFInfo
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
Abstract
A sodium alginate hydrogel medical dressing and a preparation method thereof. The invention provides 3 types of sodium alginate hydrogel medical dressings in the forms of powder, spray and rubber pad and a preparation method thereof, aiming at achieving the purpose of effectively regulating and controlling the dissolution speed and the crosslinking reaction time of sodium alginate by controlling the proportion of sodium alginate to soluble calcium salt, functional drug ingredients and other various auxiliary additives.
Description
Technical Field
The invention belongs to the technical field of medical dressing preparation, and particularly relates to 3 types of sodium alginate hydrogel medical dressings in powder form, spray form and rubber pad form and a preparation method thereof.
Background
The hydrogel dressing is a three-dimensional network structure polymer gel with performance superior to that of the traditional gauze dressing, and is mainly formed by crosslinking hydrophilic polymers through physical or chemical reaction. When acting on the wound surface, the utility model has the functions of debridement, absorbing the exudate of the wound surface and providing a moist healing environment to accelerate the healing of the wound surface; moreover, the wound surface is slightly affected in the replacement process, the hydrogel can be directly torn off or washed away by normal saline, which is incomparable with various medical gauzes, and the damage of the dressing change process to the new epithelium and granulation tissue can be effectively avoided. However, most of the existing hydrogel dressings have weak adhesion with the skin surface, and when the hydrogel dressings are applied, the hydrogel dressings need to be attached to the skin surface of a patient and then fixed on wounds by using adhesive tapes or polyurethane films, which brings troubles to practical application; moreover, the dressings which are put into clinical use at present generally have the problems of unsatisfactory itching relieving, bleeding stopping and antibacterial effects, poor skin healing effect after use and the like.
Disclosure of Invention
In view of the above, the main object of the present invention is to provide a class of sodium alginate hydrogel medical dressing and a preparation method thereof, so as to at least partially solve at least one of the above technical problems.
In order to achieve the above object, as a first aspect of the present invention, there is provided a powder type sodium alginate hydrogel medical dressing comprising:
A. sodium alginate;
B. a solubilizer;
C. a soluble calcium salt;
D. a crosslinking modifier;
E. a functional pharmaceutical ingredient;
F. a plasticizer;
G. a gelling agent;
wherein the mass ratio of the components A to B to C to D to E to F to G is 1 to (2.5-6.5) to (0.02-0.5) to (0-0.2) to (0.001-0.5) to (0-0.2).
As a second aspect of the invention, a preparation method of a powder type sodium alginate hydrogel medical dressing is provided, which comprises the following steps:
the components of the powder type sodium alginate hydrogel medical dressing are fully mixed according to the mass ratio, so that the powder type sodium alginate hydrogel medical dressing is obtained.
As a third aspect of the invention, a sodium alginate hydrogel medical dressing solution is provided, which is obtained by dissolving 1 part of the above powder type sodium alginate hydrogel medical dressing in 2-10 parts of water.
As a fourth aspect of the present invention, there is provided a spray type sodium alginate hydrogel medical dressing, comprising:
A. sodium alginate;
B. a functional pharmaceutical ingredient;
C. a soluble calcium salt;
wherein the mass ratio of the A, B components is 1: B (0.001-0.5).
As a fifth aspect of the invention, a preparation method of a spray type sodium alginate hydrogel medical dressing is provided, which comprises the following steps:
fully mixing the sodium alginate and the functional medicine component according to the mass ratio, taking 1 part of the mixture, and dissolving the mixture in 40-100 parts of water to obtain a solution 1;
dissolving the soluble calcium salt in a proper amount of water to prepare an aqueous solution with the mass fraction of 2 per mill to 3 percent by weight to obtain a solution 2;
wherein, the two steps are not divided into sequence.
As a sixth aspect of the present invention, there is provided a cushion-type sodium alginate hydrogel medical dressing, comprising:
A. sodium alginate;
B. a soluble calcium salt;
C. a functional pharmaceutical ingredient;
D. (ii) acrylamide;
E. a crosslinking agent;
F. an initiator;
G. a catalyst;
wherein the mass fraction of the sodium alginate is 0.5-1.5 wt%, and the mass fraction of the soluble calcium salt is 0.5-3 wt%; the mass fraction of the functional medicine component is 0.0005-0.75 wt%; the mass fraction of the acrylamide is 10-20 wt%; the mass fraction of the cross-linking agent is 0.02-0.1 wt%; the mass fraction of the initiator is 0.01-0.2 wt%; the mass fraction of the catalyst is 0.001-0.02 wt%.
As a seventh aspect of the present invention, a preparation method of a cushion type sodium alginate hydrogel medical dressing is provided, which comprises the following steps:
step 1, dissolving sodium alginate, functional drug ingredients, acrylamide, a cross-linking agent and an initiator in the components of the rubber pad type sodium alginate hydrogel medical dressing in water, uniformly stirring, and degassing in vacuum;
step 2, pouring the solution obtained in the step 1 into a mold, spraying a catalyst with a preset ratio, and heating or irradiating by ultraviolet light to obtain the acrylamide single-network rubber mat type hydrogel medical dressing;
and 3, soaking the acrylamide single-network adhesive pad type sodium alginate hydrogel medical dressing obtained in the step 2 in a soluble calcium salt solution for 1-10 hours to obtain the acrylamide-sodium alginate double-network structure adhesive pad type hydrogel medical dressing.
Based on the technical scheme, the three sodium alginate hydrogel medical dressings have at least one of the following advantages and positive effects:
(1) the dissolution speed and the crosslinking reaction time of the sodium alginate can be effectively regulated and controlled so as to meet the requirements of practical application;
(2) the preparation process is simple, the use is convenient, and secondary damage to the affected part can be avoided; the powder, the spray and the gel pad type functional sodium alginate hydrogel medical dressing can be tightly attached to the surface of the skin, and only needs to be slightly removed after use;
(3) is rich in various functional medicinal components, has the effects of relieving itching, stopping bleeding, resisting bacteria, promoting wound healing and the like, and belongs to functional hydrogel medical dressing.
Detailed Description
For better clarity of the objects, technical solutions and advantages of the present invention, the present invention will be described in further detail with reference to specific embodiments.
The medical dressing comprises three functional sodium alginate hydrogel medical dressings of powder type, spray type and rubber pad type, and can achieve at least one of the beneficial technical effects of strong adhesion with the surface of the skin, ideal itching relieving, bleeding stopping and antibacterial effects, good skin healing effect after use and the like.
Powder type sodium alginate hydrogel medical dressing
1. The invention discloses a powder type sodium alginate hydrogel medical dressing, which comprises the following components:
A. sodium alginate;
B. solubilizer (one or more of white soft sugar, glucose, fructose, maltose, sucrose and lactose);
C. soluble calcium salt (one or more of calcium sulfate, calcium chloride, calcium bromide, calcium iodide, calcium nitrate, calcium formate, and calcium acetate);
D. crosslinking regulators (tetrasodium pyrophosphate);
E. functional medicinal components (one or more of menthol, mupirocin powder, Notoginseng radix powder, radix Angelicae Dahuricae, and rhizoma Bletillae);
F. plasticizers (one or more of corn starch, tapioca starch, wheat flour, diatomaceous earth);
G. gelling agent (one or more of xanthan gum, pectin, carrageenan);
wherein the mass ratio of A, B is 1: 2.5-6.5; A. the mass ratio of the component C is 1: 0.02-0.5; A. the mass ratio of the component D is 1: 0-0.2; A. the mass ratio of the component E is 1: 0.001-0.5; A. the mass ratio of the component F is 1: 0.0-0.2; A. the mass ratio of the G component is 1: 0-0.2. Wherein, the addition of the solubilizer can reduce or block the swelling process of the sodium alginate, thereby effectively increasing the solubility of the sodium alginate and regulating and controlling the dissolution time of the sodium alginate; the addition of crosslinking regulator tetrasodium pyrophosphate can effectively regulate and control the ionic crosslinking reaction time of sodium alginate and soluble calcium salt so as to meet the requirement of practical application.
2. The preparation method of the powder type sodium alginate hydrogel medical dressing comprises the following steps:
the components of the powder type sodium alginate hydrogel medical dressing are fully mixed according to the mass ratio, so that the powder type sodium alginate hydrogel medical dressing is obtained.
3. The invention also discloses the use of the powder sodium alginate hydrogel medical dressing and a post-treatment method. Before use, 1 part of the sodium alginate hydrogel medical dressing is dissolved in 2-10 parts of water to obtain a sodium alginate hydrogel medical dressing solution; when in use, the solution is only needed to be coated on an affected part, and a complete hydrogel film can be formed in a short time and is tightly attached to the surface of a wound; after the wound dressing is used, the wound dressing only needs to be slightly taken off, and secondary damage to the wound can not be caused. The water used is selected from one or more of deionized water, tap water and purified water.
Experiments show that the powder sodium alginate hydrogel medical dressing is not affected by water quality in the using process and has good using effect.
Second, spray type sodium alginate hydrogel medical dressing
1. The invention discloses a spray type sodium alginate hydrogel medical dressing, which comprises the following components:
A. sodium alginate;
B. functional medicinal components (one or more of menthol, mupirocin powder, Notoginseng radix powder, radix Angelicae Dahuricae, and rhizoma Bletillae);
C. soluble calcium salt (one or more of calcium sulfate, calcium chloride, calcium bromide, calcium iodide, calcium nitrate, calcium formate, and calcium acetate);
wherein the mass ratio of the A, B components is 1: B (0.001-0.5).
2. The invention also discloses a preparation, application and post-use treatment method of the spray type sodium alginate hydrogel medical dressing, which comprises the following steps:
(1) fully mixing the sodium alginate and the functional medicine components according to the mass ratio, and dissolving 1 part of the mixture in 40-100 parts of water to obtain a solution 1;
(2) dissolving the soluble calcium salt in a proper amount of water to prepare an aqueous solution with the mass fraction of 2 per mill to 3 percent by weight to obtain a solution 2;
(3) when in use, the solution 1 is firstly sprayed on an affected part, then the solution 2 is uniformly sprayed, and at the moment, the sodium alginate in the solution 1 and the calcium ions in the solution 2 are instantly crosslinked to form a hydrogel film which is tightly attached to the surface of a wound;
(4) after the wound dressing is used, the wound dressing can be taken off slightly, and secondary damage to the wound can not be caused.
The water used in the invention is selected from one or more of deionized water, tap water and purified water. Experiments show that the spray-type sodium alginate hydrogel medical dressing is not affected by water quality in the using process and has better using effect.
Third, the medical dressing of sodium alginate hydrogel of cushion type
1. The invention discloses a rubber pad type sodium alginate hydrogel medical dressing, which comprises the following components:
A. sodium alginate;
B. soluble calcium salt (one or more of calcium sulfate, calcium chloride, calcium bromide, calcium iodide, calcium nitrate, calcium formate, and calcium acetate);
C. functional medicinal components (menthol, mupirocin powder and one or more of Notoginseng radix powder, radix Angelicae Dahuricae, and rhizoma Bletillae);
D. (ii) acrylamide;
E. a cross-linking agent (one or more of N, N-methylene bisacrylamide, N-methylol acrylamide, diacetone acrylamide, hydroxyethyl methacrylate, or hydroxypropyl methacrylate);
F. an initiator (the initiator is a thermal initiator or a photoinitiator, the thermal initiator is selected from one or more of potassium persulfate, sodium persulfate and ammonium persulfate, and the photoinitiator is selected from one or more of 2-ketoglutaric acid and 2-hydroxy-4- (2-hydroxyethoxy) -2-methyl propiophenone);
G. catalyst (tetramethylethylenediamine);
wherein the mass fraction of the sodium alginate is 0.5-1.5 wt%, and the mass fraction of the soluble calcium salt is 0.5-3 wt%; the mass fraction of the functional medicine component is 0.0005-0.75 wt%; the mass fraction of the acrylamide is 10-20 wt%; the mass fraction of the cross-linking agent is 0.02-0.1 wt%; the mass fraction of the initiator is 0.01-0.2 wt%; the mass fraction of the catalyst is 0.001-0.02 wt%.
2. The invention also discloses a preparation, application and post-use treatment method of the cushion type sodium alginate hydrogel medical dressing, which comprises the following steps:
(1) dissolving the sodium alginate, the functional medicinal component, the acrylamide, the cross-linking agent and the initiator in water according to a certain proportion, uniformly stirring, and degassing in vacuum;
(2) pouring the solution obtained in the step (1) into a mould, spraying a catalyst with a preset ratio, and heating or irradiating by ultraviolet light to obtain the acrylamide single-network rubber mat type hydrogel medical dressing;
(3) and (3) soaking the acrylamide single-network rubber pad type sodium alginate hydrogel medical dressing in a soluble calcium salt solution for 1-10 hours to obtain the acrylamide-sodium alginate double-network rubber pad type sodium alginate hydrogel medical dressing.
Wherein the heating temperature in the step (2) is 40-70 ℃, and the heating time is 1-3 h; the ultraviolet irradiation conditions were: the wavelength is 365nm, and the irradiation time is 0.5-2 h.
(4) When in use, the medical dressing of the rubber cushion type sodium alginate hydrogel is only needed to be pasted on the affected part; after the use, the wound dressing is gently torn off, and no secondary damage is caused to the wound.
The water used in the invention is selected from one or more of deionized water, tap water and purified water. Experiments show that the spray-type sodium alginate hydrogel medical dressing is not affected by water quality in the using process and has better using effect.
In order to further understand the summary, features and advantages of the present invention, the following description is further provided with several preferred embodiments. The chemical reagents used in the following examples are either commercially available or prepared by themselves by methods reported in the literature. The following examples are intended to illustrate the present invention and are not intended to limit the present invention.
Example 1
A powder type sodium alginate hydrogel medical dressing comprises the following components:
fully mixing the components to obtain the powder type sodium alginate hydrogel medical dressing; before use, the sodium alginate hydrogel medical dressing solution is dissolved in 15ml of water.
Example 2
A powder type sodium alginate hydrogel medical dressing comprises the following components:
fully mixing the components to obtain the powder type sodium alginate hydrogel medical dressing; before use, the sodium alginate hydrogel medical dressing solution is dissolved in 20ml of water.
Example 3
A powder type sodium alginate hydrogel medical dressing comprises the following components:
fully mixing the components to obtain the powder type sodium alginate hydrogel medical dressing; before use, the sodium alginate hydrogel medical dressing solution is dissolved in 15ml of water.
Example 4
A powder type sodium alginate hydrogel medical dressing comprises the following components:
fully mixing the components to obtain the powder type sodium alginate hydrogel medical dressing; before use, the sodium alginate hydrogel medical dressing solution is dissolved in 20ml of water.
Example 5
A powder type sodium alginate hydrogel medical dressing comprises the following components:
fully mixing the components to obtain the powder type sodium alginate hydrogel medical dressing; before use, the sodium alginate hydrogel medical dressing solution is dissolved in 25ml of water.
Example 6
A powder type sodium alginate hydrogel medical dressing comprises the following components:
fully mixing the components to obtain the powder type sodium alginate hydrogel medical dressing; before use, the sodium alginate hydrogel medical dressing solution is dissolved in 25ml of water.
Example 7
A powder type sodium alginate hydrogel medical dressing comprises the following components:
fully mixing the components to obtain the powder type sodium alginate hydrogel medical dressing; before use, the sodium alginate hydrogel medical dressing solution is dissolved in 25ml of water.
Example 8
A powder type sodium alginate hydrogel medical dressing comprises the following components:
fully mixing the components to obtain the powder type sodium alginate hydrogel medical dressing; before use, the sodium alginate hydrogel medical dressing solution is obtained by dissolving the sodium alginate hydrogel medical dressing solution in 30ml of water.
Example 9
A spray type sodium alginate hydrogel medical dressing comprises the following components:
A. sodium alginate 1g
B. Menthol 0.1g
C. Calcium chloride 1g
Fully mixing the A, B components, and dissolving in 100ml to obtain a solution 1;
and dissolving the component C in 100ml of water to prepare an aqueous solution with the mass fraction of 1 percent by weight to obtain a solution 2.
Example 10
A spray type sodium alginate hydrogel medical dressing comprises the following components:
A. sodium alginate 1g
B. 0.15g mupirocin powder
C. Calcium sulfate 1.5g
Fully mixing the A, B components, and dissolving in 100ml to obtain a solution 1;
and dissolving the component C in 100ml of water to prepare an aqueous solution with the mass fraction of 1.5 percent by weight to obtain a solution 2.
Example 11
A spray type sodium alginate hydrogel medical dressing comprises the following components:
A. sodium alginate 1g
B. 0.01g mupirocin powder
C. Calcium sulfate 2g
Fully mixing the A, B components, and dissolving in 40ml to obtain a solution 1;
and dissolving the component C in 100ml of water to prepare an aqueous solution with the mass fraction of 2% wt, thereby obtaining a solution 2.
Example 12
A spray type sodium alginate hydrogel medical dressing comprises the following components:
A. sodium alginate 1g
B. 0.2g mupirocin powder
C. Calcium sulfate 0.2g
Fully mixing the A, B components, and dissolving in 50ml to obtain a solution 1;
and dissolving the component C in 100ml of water to prepare an aqueous solution with the mass fraction of 2 per thousand wt, thereby obtaining a solution 2.
Example 13
A spray type sodium alginate hydrogel medical dressing comprises the following components:
A. sodium alginate 1g
B. 0.4g mupirocin powder
C. Calcium sulfate 2g
The A, B fine powder is fully mixed and dissolved in 50ml to obtain solution 1;
and dissolving the component C in 100ml of water to prepare an aqueous solution with the mass fraction of 2% wt, thereby obtaining a solution 2.
Example 14
A spray type sodium alginate hydrogel medical dressing comprises the following components:
A. sodium alginate 1g
B. 0.5g mupirocin powder
C. Calcium sulfate 3g
Fully mixing the A, B components, and dissolving in 100ml to obtain a solution 1;
and dissolving the component C in 100ml of water to prepare an aqueous solution with the mass fraction of 3 percent by weight to obtain a solution 2.
Example 15
A rubber pad type sodium alginate hydrogel medical dressing composition comprises the following components:
(1) dissolving the sodium alginate, the menthol, the acrylamide, the N, N-methylene bisacrylamide and the potassium persulfate in 100ml of deionized water, and removing air bubbles in the solution by vacuum degassing;
(2) pouring the degassed solution into a mould, spraying the tetramethylethylenediamine, and heating at 65 ℃ for 3h to obtain the acrylamide single-network rubber pad type hydrogel medical dressing;
(3) dissolving the calcium sulfate in 100ml of deionized water to obtain a soluble calcium salt aqueous solution with the mass fraction of 5 per mill wt;
(4) and (3) soaking the acrylamide single-network rubber mat type hydrogel medical dressing in the step (2) in the soluble calcium salt aqueous solution for 5 hours to obtain the sodium alginate-acrylamide double-network rubber mat type hydrogel medical dressing.
Example 16
A rubber pad type sodium alginate hydrogel medical dressing composition comprises the following components:
(1) dissolving the sodium alginate, mupirocin powder, acrylamide, N-hydroxymethyl acrylamide and sodium persulfate in 100ml of deionized water, and removing bubbles in the solution by vacuum degassing;
(2) pouring the degassed solution into a mould, spraying the tetramethylethylenediamine, and heating at 50 ℃ for 2h to obtain the acrylamide single-network rubber pad type hydrogel medical dressing;
(3) dissolving the calcium sulfate in 100ml of deionized water to obtain a soluble calcium salt aqueous solution with the mass fraction of 1 percent by weight;
(4) and (3) soaking the acrylamide single-network rubber mat type hydrogel medical dressing in the soluble calcium salt aqueous solution for 1h to obtain the sodium alginate-acrylamide double-network rubber mat type hydrogel medical dressing.
Example 17
A rubber pad type sodium alginate hydrogel medical dressing composition comprises the following components:
(1) dissolving the sodium alginate, mupirocin powder, acrylamide, N-hydroxymethyl acrylamide and sodium persulfate in 100ml of deionized water, and removing bubbles in the solution by vacuum degassing;
(2) pouring the degassed solution into a mould, spraying the tetramethylethylenediamine, and heating at 65 ℃ for 1h to obtain the acrylamide single-network rubber pad type hydrogel medical dressing;
(3) dissolving the calcium sulfate in 100ml of deionized water to obtain a soluble calcium salt aqueous solution with the mass fraction of 5 per mill wt;
(4) and (3) soaking the acrylamide single-network rubber mat type hydrogel medical dressing in the step (2) in the soluble calcium salt aqueous solution for 5 hours to obtain the sodium alginate-acrylamide double-network rubber mat type hydrogel medical dressing.
Example 18
A rubber pad type sodium alginate hydrogel medical dressing composition comprises the following components:
(1) dissolving the sodium alginate, the angelica dahurica, the acrylamide, the hydroxyethyl methacrylate and the 2-ketoglutaric acid in 100ml of deionized water, and removing air bubbles in the solution by vacuum degassing;
(2) pouring the degassed solution into a mould, spraying the tetramethylethylenediamine, and irradiating by ultraviolet light for 0.5h to obtain the acrylamide single-network rubber pad type hydrogel medical dressing;
(3) dissolving the calcium bromide in 100ml of deionized water to obtain a soluble calcium salt aqueous solution with the mass fraction of 1 percent wt;
(4) and (3) soaking the acrylamide single-network rubber mat type hydrogel medical dressing in the step (2) in the soluble calcium salt aqueous solution for 5 hours to obtain the sodium alginate-acrylamide double-network rubber mat type hydrogel medical dressing.
Example 19
A rubber pad type sodium alginate hydrogel medical dressing composition comprises the following components:
(1) dissolving the sodium alginate, the angelica dahurica, the acrylamide, the hydroxyethyl methacrylate and the 2-ketoglutaric acid in 100ml of deionized water, and removing air bubbles in the solution by vacuum degassing;
(2) pouring the degassed solution into a mould, spraying the tetramethylethylenediamine, and irradiating for 2 hours by ultraviolet light to obtain the acrylamide single-network rubber pad type hydrogel medical dressing;
(3) dissolving the calcium nitrate in 100ml of deionized water to obtain a soluble calcium salt aqueous solution with the mass fraction of 1.5 percent by weight;
(4) and (3) soaking the acrylamide single-network rubber mat type hydrogel medical dressing in the step (2) in the soluble calcium salt aqueous solution for 10 hours to obtain the sodium alginate-acrylamide double-network rubber mat type hydrogel medical dressing.
Example 20
A rubber pad type sodium alginate hydrogel medical dressing composition comprises the following components:
(1) dissolving the sodium alginate, the menthol, the acrylamide, the N, N-methylene bisacrylamide and the ammonium persulfate in 100ml of deionized water, and removing bubbles in the solution by vacuum degassing;
(2) pouring the degassed solution into a mould, spraying the tetramethylethylenediamine, and curing at 65 ℃ for 2h to obtain the acrylamide single-network rubber pad type hydrogel medical dressing;
(3) dissolving the calcium formate in 100ml of deionized water to obtain a soluble calcium salt aqueous solution with the mass fraction of 1.5 percent by weight;
(4) and (3) soaking the acrylamide single-network rubber mat type hydrogel medical dressing in the step (2) in the soluble calcium salt aqueous solution for 10 hours to obtain the sodium alginate-acrylamide double-network rubber mat type hydrogel medical dressing.
Example 21
A rubber pad type sodium alginate hydrogel medical dressing composition comprises the following components:
(1) dissolving the sodium alginate, the menthol, the acrylamide, the N, N-methylene bisacrylamide and the ammonium persulfate in 100ml of deionized water, and removing bubbles in the solution by vacuum degassing;
(2) pouring the degassed solution into a mould, spraying the tetramethylethylenediamine, and curing at 65 ℃ for 2h to obtain the acrylamide single-network rubber pad type hydrogel medical dressing;
(3) dissolving the calcium acetate in 100ml of deionized water to obtain a soluble calcium salt aqueous solution with the mass fraction of 1.5 percent by weight;
(4) and (3) soaking the acrylamide single-network rubber mat type hydrogel medical dressing in the step (2) in the soluble calcium salt aqueous solution for 10 hours to obtain the sodium alginate-acrylamide double-network rubber mat type hydrogel medical dressing.
The sodium alginate hydrogel medical dressings prepared in examples 1 to 21 were subjected to skin adhesion experiments and skin sensitivity experiments, and the results are shown in table 1 below.
TABLE 1 results of skin adhesion test and skin sensitivity test
| Serial number | Skin adhesion test | Skin sensitivity test |
| Example 1 | ++ | ++ |
| Example 2 | ++ | ++ |
| Practice ofExample 3 | ++ | ++ |
| Example 4 | ++ | ++ |
| Example 5 | ++ | ++ |
| Example 6 | ++ | ++ |
| Example 7 | ++ | ++ |
| Example 8 | ++ | ++ |
| Example 9 | ++ | ++ |
| Example 10 | ++ | ++ |
| Example 11 | ++ | ++ |
| Example 12 | ++ | ++ |
| Example 13 | ++ | ++ |
| Example 14 | ++ | ++ |
| Example 15 | + | ++ |
| Example 16 | + | ++ |
| Example 17 | + | ++ |
| Example 18 | + | ++ |
| Example 19 | + | ++ |
| Example 20 | + | ++ |
| Example 21 | + | ++ |
Wherein "+ +" indicates excellent experimental effect; "+" indicates good results.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are only exemplary embodiments of the present invention and are not intended to limit the present invention, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A powder type sodium alginate hydrogel medical dressing is characterized by comprising:
A. sodium alginate;
B. a solubilizer;
C. a soluble calcium salt;
D. a crosslinking modifier;
E. a functional pharmaceutical ingredient;
F. a plasticizer;
G. a gelling agent;
wherein the mass ratio of the components A to B to C to D to E to F to G is 1 to (2.5-6.5) to (0.02-0.5) to (0-0.2) to (0.001-0.5) to (0-0.2).
2. The powder-form sodium alginate hydrogel medical dressing as claimed in claim 1, wherein the solubilizer is selected from one or more of soft sugar, glucose, fructose, maltose, sucrose and lactose;
preferably, the soluble calcium salt is selected from one or more of calcium sulfate, calcium chloride, calcium bromide, calcium iodide, calcium nitrate, calcium formate and calcium acetate;
preferably, the crosslinking regulator is tetrasodium pyrophosphate;
preferably, the functional pharmaceutical ingredient is one or more selected from menthol, mupirocin powder, notoginseng powder, radix angelicae and bletilla striata;
preferably, the plasticizer is selected from one or more of corn starch, tapioca starch, wheat flour and diatomite;
preferably, the gelling agent is selected from one or more of xanthan gum, pectin and carrageenan.
3. A preparation method of a powder type sodium alginate hydrogel medical dressing is characterized by comprising the following steps:
the powder type sodium alginate hydrogel medical dressing as claimed in claim 1 or 2 is obtained by thoroughly mixing the components in mass ratio.
4. A sodium alginate hydrogel medical dressing solution, which is characterized in that the sodium alginate hydrogel medical dressing solution is obtained by dissolving 1 part of the powder type sodium alginate hydrogel medical dressing as claimed in claim 3 in 2-10 parts of water;
preferably, the water is selected from one or more of deionized water, tap water and purified water.
5. A spray type sodium alginate hydrogel medical dressing is characterized by comprising:
A. sodium alginate;
B. a functional pharmaceutical ingredient;
C. a soluble calcium salt;
wherein the mass ratio of the A, B components is 1: B (0.001-0.5).
6. The spray type sodium alginate hydrogel medical dressing as claimed in claim 5, wherein the functional pharmaceutical ingredient is selected from one or more of menthol, mupirocin powder, notoginseng powder, dahurian angelica root and bletilla striata;
preferably, the soluble calcium salt is selected from one or more of calcium sulfate, calcium chloride, calcium bromide, calcium iodide, calcium nitrate, calcium formate and calcium acetate.
7. A preparation method of a spray type sodium alginate hydrogel medical dressing is characterized by comprising the following steps:
fully mixing the sodium alginate and the functional medicine component according to the mass ratio of 5 or 6, taking 1 part of the mixture, and dissolving the mixture in 40-100 parts of water to obtain a solution 1;
dissolving the soluble calcium salt of claim 5 or 6 in a proper amount of water to prepare an aqueous solution with the mass fraction of 2-3% wt to obtain a solution 2;
wherein, the two steps are not divided into sequence;
preferably, the water is selected from one or more of deionized water, tap water and purified water.
8. A medical dressing of cushion type sodium alginate aquogel which is characterized in that includes:
A. sodium alginate;
B. a soluble calcium salt;
C. a functional pharmaceutical ingredient;
D. (ii) acrylamide;
E. a crosslinking agent;
F. an initiator;
G. a catalyst;
wherein the mass fraction of the sodium alginate is 0.5-1.5 wt%, and the mass fraction of the soluble calcium salt is 0.5-3 wt%; the mass fraction of the functional medicine component is 0.0005-0.75 wt%; the mass fraction of the acrylamide is 10-20 wt%; the mass fraction of the cross-linking agent is 0.02-0.1 wt%; the mass fraction of the initiator is 0.01-0.2 wt%; the mass fraction of the catalyst is 0.001-0.02 wt%.
9. The gel pad type sodium alginate hydrogel medical dressing according to claim 8, wherein the soluble calcium salt is selected from one or more of calcium sulfate, calcium chloride, calcium bromide, calcium iodide, calcium nitrate, calcium formate and calcium acetate;
preferably, the functional pharmaceutical ingredient is one or more selected from menthol, mupirocin powder, notoginseng powder, radix angelicae and bletilla striata;
preferably, the cross-linking agent is selected from one or more of N, N-methylene bisacrylamide, N-hydroxymethyl acrylamide, diacetone acrylamide, hydroxyethyl methacrylate or hydroxypropyl methacrylate;
preferably, the initiator is a thermal initiator or a photoinitiator; the thermal initiator is selected from one or more of potassium persulfate, sodium persulfate and ammonium persulfate; the photoinitiator is selected from one or more of 2-ketoglutaric acid and 2-hydroxy-4- (2-hydroxyethoxy) -2-methyl propiophenone;
preferably, the catalyst is tetramethylethylenediamine.
10. A preparation method of the cushion type sodium alginate hydrogel medical dressing is characterized by comprising the following steps:
step 1, dissolving sodium alginate, functional drug ingredients, acrylamide, a cross-linking agent and an initiator in the components of the rubber pad type sodium alginate hydrogel medical dressing as claimed in claim 8 or 9 in water, uniformly stirring, and degassing in vacuum;
step 2, pouring the solution obtained in the step 1 into a mold, spraying a catalyst with a preset ratio, and heating or irradiating by ultraviolet light to obtain the acrylamide single-network rubber mat type hydrogel medical dressing;
step 3, soaking the acrylamide single-network adhesive pad type sodium alginate hydrogel medical dressing in the step 2 in a soluble calcium salt solution for 1-10 hours to obtain an acrylamide-sodium alginate double-network structure adhesive pad type hydrogel medical dressing;
preferably, the heating temperature in the step 2 is 40-70 ℃, and the heating time is 1-3 h; the ultraviolet irradiation conditions were: the wavelength is 365nm, and the irradiation time is 0.5-2 h.
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