CN111116942A - Controllable self-crosslinking oxygen release hydrogel composition and application thereof - Google Patents
Controllable self-crosslinking oxygen release hydrogel composition and application thereof Download PDFInfo
- Publication number
- CN111116942A CN111116942A CN201911390687.3A CN201911390687A CN111116942A CN 111116942 A CN111116942 A CN 111116942A CN 201911390687 A CN201911390687 A CN 201911390687A CN 111116942 A CN111116942 A CN 111116942A
- Authority
- CN
- China
- Prior art keywords
- component
- hydrogen peroxide
- chitosan
- hydrogel
- hydrogel composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
- C08J3/246—Intercrosslinking of at least two polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/02—Dextran; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/04—Alginic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2371/00—Characterised by the use of polyethers obtained by reactions forming an ether link in the main chain; Derivatives of such polymers
- C08J2371/02—Polyalkylene oxides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2405/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2401/00 or C08J2403/00
- C08J2405/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2439/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Derivatives of such polymers
- C08J2439/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
- C08J2439/06—Homopolymers or copolymers of N-vinyl-pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2489/00—Characterised by the use of proteins; Derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
The invention provides a hydrogel composition capable of controlling self-crosslinking oxygen release, which comprises a component A and a component B, wherein the active component of the component A comprises chitosan and/or derivatives thereof, a macromolecular crosslinking agent and a hydrogen peroxide source catalyst, and the active component of the component B comprises a hydrophilic monomer, a photoinitiator, a crosslinking agent and a hydrogen peroxide source. The hydrogel is a carrier of a hydrogen peroxide source and a catalyst thereof, the crosslinking time, the hydrogel strength, the hydrogel air permeability and the like of the in-situ self-crosslinking of the hydrogel are controlled by controlling the proportion and the type of the chitosan and/or the derivative thereof and the macromolecular crosslinking agent, so that the oxygen release controllability of the hydrogel is realized, and the oxygen release condition (such as concentration, oxygen release continuity and the like) is controlled by controlling the proportion of the hydrogen peroxide source and the catalyst thereof in the hydrogel.
Description
Technical Field
The invention belongs to the field of medicines, and particularly relates to a controllable self-crosslinking oxygen-release hydrogel composition and application thereof.
Background
The effect of oxygen on wound healing is increasingly understood as the theory of wound healing develops. One important reason for the difficulty in healing chronic wounds, such as diabetic feet, is that the poor blood supply at the wound site results in the inability of oxygen to be transmitted through the blood to the wound site. Also, tetanus is likely to occur when the wound is narrow and deep, ischemic, has many necrotic tissues, has poor drainage, and is mixed with other aerobic bacterial infections to cause local hypoxia in the wound. The function of oxygen in the process of wound healing is manifold, wound healing is an energy-consuming process, and oxygen can provide energy support required by the process; promoting the synthesis of collagen and the generation of new blood vessels in the process of tissue regeneration; oxygen also plays a major role in the antimicrobial properties of wounds, and its presence can kill some pathogenic and malodorous bacteria. Although a certain degree of hypoxia may initiate the physiological repair process of the body, the adverse effects of hypoxia on wound healing, hypoxia-limited wound healing, cannot be ignored. Wound healing requires blood perfusion and oxygen supply by tissue reorganization. The correction of the hypoxic state present by improving oxygen has a clear benefit in wound healing.
The wound dressing is divided into traditional dressing, interactive dressing and bioactive dressing, the dressing widely used at present is mostly bioactive dressing, and in order to prevent inflammatory reaction, accelerate wound healing and the like, medicines and cytokines are added. Most of the existing bioactive dressings have single function, provide moisture retention and isolation functions, some dressings with functions of diminishing inflammation and accelerating wound healing rely on substances such as an antibacterial agent and cell growth factors added in the dressings to play a role, the preparation process is complex, small molecular substances with cytotoxicity are easy to carry, the biocompatibility is poor, the dressings added with the antibacterial agent have poor using effect due to the possibility of drug resistance, and the dressings are not ideal bioactive dressings. However, dressings capable of releasing active oxygen are still reported, and patent application CN104706659A discloses a preparation method of oxygen-enriched wound surface protection coating, which forms a carrier for releasing oxygen, but the oxygen of the system is released by oxygenating the carrier, and the process of releasing oxygen is complex and is not easy to operate.
Disclosure of Invention
In order to solve the existing problems, the invention aims to provide a controllable self-crosslinking oxygen-release hydrogel composition and application thereof.
The technical scheme adopted by the invention is as follows:
a controlled self-crosslinking oxygen-releasing hydrogel composition characterized by: the chitosan/hydrogen peroxide composite material comprises an A component and a B component, wherein the active ingredient of the A component comprises chitosan and/or derivatives thereof, a macromolecular cross-linking agent and a hydrogen peroxide source catalyst, and the active ingredient of the B component comprises a hydrophilic monomer, a photoinitiator, a cross-linking agent and a hydrogen peroxide source.
Preferably, the volume ratio of the chitosan and/or the derivative thereof to the macromolecular crosslinking agent is 1:1-20, and the mass concentration ratio of the hydrogen peroxide source catalyst to the hydrogen peroxide source is 1: 10-50.
Preferably, the volume ratio of the chitosan and/or the derivative thereof to the macromolecular crosslinking agent is 1:5-15, and the mass concentration ratio of the hydrogen peroxide source catalyst to the hydrogen peroxide source is 1: 20-35.
Preferably, the mass concentration of the chitosan and/or the derivative thereof is 1 to 10%, and the mass concentration of the macromolecular crosslinking agent is 5 to 20%.
Preferably, the active component of the component B comprises 10-30 parts of hydrophilic monomer, 0.1-2 parts of photoinitiator, 0.1-2 parts of cross-linking agent and 5-20 parts of hydrogen peroxide source.
Preferably, the chitosan derivative is at least one selected from hydroxyethyl chitosan, hydroxypropyl chitosan, carboxymethyl chitosan and hydroxyethyl chitosan; the macromolecular crosslinking agent is at least one selected from sodium alginate oxide, dextran oxide, sodium hyaluronate oxide, gellan gum oxide, pectin oxide and dialdehyde polyethylene glycol.
Preferably, the hydrophilic monomer is at least one selected from the group consisting of an acrylamide compound and an acrylated gelatin compound; the hydrogen peroxide source is at least one selected from hydrogen peroxide, hydrogen peroxide complex, calcium peroxide and polyvinylpyrrolidone.
Preferably, the above-mentioned a component may further comprise a growth factor.
The invention also provides a controllable self-crosslinking oxygen-release hydrogel which is prepared by uniformly mixing the component B, curing by light and contacting the component B with the component A.
The invention also provides application of the hydrogel composition in preparing skin care medicines.
The invention also provides application of the hydrogel composition in preparing a medicament for delivering oxygen to skin.
The invention also provides application of the controllable self-crosslinking oxygen release hydrogel in preparing a medicament for delivering oxygen to skin.
The invention has the beneficial effects that:
(1) the hydrogel is a carrier of a hydrogen peroxide source and a catalyst thereof, the crosslinking time, the hydrogel strength, the hydrogel air permeability and the like of the in-situ self-crosslinking of the hydrogel are controlled by controlling the proportion and the type of the chitosan and/or the derivative thereof and the macromolecular crosslinking agent, so that the oxygen release controllability of the hydrogel is realized, and the oxygen release condition (such as concentration, oxygen release continuity and the like) is controlled by controlling the proportion of the hydrogen peroxide source and the catalyst thereof in the hydrogel.
(2) The hydrogel capable of releasing oxygen disclosed by the invention can slowly and continuously release active oxygen, has a moisturizing effect, can provide a local low-oxygen moist healing environment for a wound surface, and is beneficial to healing of the wound surface. The hydrogel disclosed by the invention has the bacteriostatic function of the selected raw materials, is mild in preparation conditions, simple and easy to operate, adopts a macromolecular cross-linking agent in the system, does not contain small molecular substances with cytotoxicity, has no skin irritation and good biocompatibility, can be added with substances for promoting wound healing such as growth factors according to needs, and has a remarkable advantage in the aspect of promoting wound healing, particularly chronic wound nursing.
(3) The controllable oxygen release hydrogel system consists of two parts of gel, namely the component A and the component B, and the released oxygen is generated by mild chemical reaction of the gel system, so that side reaction and side effect are not generated.
(4) The hydrogel of the invention can be independently stored in the A component and the B component before use, thereby avoiding the actual effect of an oxygen release system and ensuring the long-acting stable release of active oxygen during use.
Detailed Description
The present invention will be described in further detail with reference to specific examples. The starting materials, reagents or apparatus used in the examples were obtained from conventional commercial sources unless otherwise specified. Unless otherwise indicated, the testing or testing methods are conventional in the art.
The hydrogel composition and the oxygen release mechanism of the hydrogel of the present invention: the gel formed by the component A and the component B can trigger a chemical reaction to occur when contacting, the catalyst of the component A catalyzes the hydrogen peroxide source of the component B to decompose and react to release oxygen, the self-crosslinking time, the hydrogel strength, the hydrogel air permeability and the like of the component B are regulated and controlled by controlling the proportion of chitosan and/or derivatives thereof and macromolecular crosslinking agents in the component A and the component B in the system, and the oxygen release rate and the release amount of the oxygen are regulated and controlled by controlling the proportion of the catalyst in the component A and the hydrogen peroxide source in the component B.
Oxygen release determination method: the reaction device is placed in a gas collecting bottle, the gas collecting bottle is connected with a trace oxygen tester, and the release condition of oxygen in the reaction process can be obtained through a pressure sensor.
Example 1:
weighing a certain amount of hydrogen peroxide source catalyst, adding into hydroxypropyl chitosan solution with the mass concentration of 2% to prepare solution with the mass concentration of 100ug/mL, mixing with sodium alginate oxide solution with the mass concentration of 20% according to the volume ratio of the solution of 1:20, stirring and mixing uniformly, injecting into a mold, and standing for 1min to obtain the component A.
Respectively weighing 30 parts by mass of acrylamide, 0.1 part by mass of photoinitiator, 0.1 part by mass of cross-linking agent, 20 parts by mass of polyvinylpyrrolidone/hydrogen peroxide complex and the balance of ultrapure water, uniformly mixing, injecting into a mold, and carrying out UV curing to obtain a component B. Covering the component B on the component A, contacting the component B and the component A to generate oxygen, and measuring that the sustained release time of the oxygen is 72h and the oxygen flow reaches 0.5mL/cm2H, partial oxygen pressure up to 40 mmHg.
Example 2:
weighing a certain amount of hydrogen peroxide source catalyst, adding into 4% by volume of carboxymethyl chitosan solution to prepare 200ug/mL solution, mixing with 10% by volume of oxidized dextran solution according to the volume ratio of 1:10, stirring, mixing, injecting into a mold, and standing for 0.8min to obtain component A.
Respectively weighing 20 parts by mass of methacrylamide, 0.3 part by mass of photoinitiator, 0.2 part by mass of cross-linking agent, 10 parts by mass of polyvinylpyrrolidone/hydrogen peroxide complex and the balance of ultrapure water, uniformly mixing, injecting into a mold, and carrying out UV curing to obtain a component B. Covering the component B on the component A, contacting the component B and the component A to generate oxygen, and measuring to obtain oxygen sustained release time of 120h and oxygen flow rate of 0.4mL/cm2H, partial oxygen pressure up to 50 mmHg.
Example 3:
weighing a certain amount of hydrogen peroxide source catalyst, adding the hydrogen peroxide source catalyst into 5% of chitosan solution by volume fraction to prepare solution with the mass concentration of 1000ug/mL, mixing the solution with 5% of dialdehyde polyethylene glycol solution by volume fraction according to the volume ratio of 1:5, stirring and mixing uniformly, injecting into a mold, and standing for 0.5min to obtain the component A.
Respectively weighing 10 parts by mass of acryloyl gelatin, 1.5 parts by mass of photoinitiator, 0.5 part by mass of cross-linking agent, 5 parts by mass of calcium peroxide and the balance of ultrapure water, uniformly mixing, injecting into a mold, and carrying out UV curing to obtain a component B. Covering the component B on the component A, contacting the component B and the component A to generate oxygen, and measuring that the sustained release time of the oxygen is 56h and the oxygen flow reaches 0.5mL/cm2H, partial oxygen pressure up to 30 mmHg.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (12)
1. A controlled self-crosslinking oxygen-releasing hydrogel composition characterized by: the chitosan/hydrogen peroxide composite material comprises an A component and a B component, wherein the active ingredient of the A component comprises chitosan and/or derivatives thereof, a macromolecular cross-linking agent and a hydrogen peroxide source catalyst, and the active ingredient of the B component comprises a hydrophilic monomer, a photoinitiator, a cross-linking agent and a hydrogen peroxide source.
2. The hydrogel composition of claim 1, wherein: the volume ratio of the chitosan and/or the derivatives thereof to the macromolecular cross-linking agent is 1:1-20, and the mass concentration ratio of the hydrogen peroxide source catalyst to the hydrogen peroxide source is 1: 10-50.
3. The hydrogel composition of claim 2, wherein: the volume ratio of the chitosan and/or the derivatives thereof to the macromolecular cross-linking agent is 1:5-15, and the mass concentration ratio of the hydrogen peroxide source catalyst to the hydrogen peroxide source is 1: 20-35.
4. The hydrogel composition of claim 2 or 3, wherein: the mass concentration of the chitosan and/or the derivatives thereof is 1-10%, and the mass concentration of the macromolecular cross-linking agent is 5-20%.
5. The hydrogel composition of claim 1, wherein: the active component of the component B comprises 10-30 parts of hydrophilic monomer, 0.1-2 parts of photoinitiator, 0.1-2 parts of cross-linking agent and 5-20 parts of hydrogen peroxide source by mass.
6. The hydrogel composition according to any one of claims 1 to 4, wherein: the chitosan derivative is at least one selected from hydroxyethyl chitosan, hydroxypropyl chitosan, carboxymethyl chitosan and hydroxyethyl chitosan; the macromolecular cross-linking agent is at least one selected from oxidized sodium alginate, oxidized dextran, oxidized sodium hyaluronate, oxidized gellan gum, oxidized pectin and dialdehyde polyethylene glycol.
7. The hydrogel composition of claim 1 or 5, wherein: the hydrophilic monomer is selected from at least one of acrylamide compounds and acryloyl gelatin compounds; the hydrogen peroxide source is selected from at least one of hydrogen peroxide, calcium peroxide and polyvinylpyrrolidone/hydrogen peroxide complex.
8. The hydrogel composition of claim 1, wherein: the a component may further comprise a growth factor.
9. A controllable self-crosslinking oxygen release hydrogel is characterized in that: is prepared by the following steps: a composition according to any one of claims 1 to 8, wherein the component B is mixed and allowed to photocure before being contacted with the component A.
10. Use of the hydrogel composition of any one of claims 1 to 8 for the preparation of a skin care medicament.
11. Use of a hydrogel composition as claimed in any one of claims 1 to 8 in the manufacture of a medicament for delivering oxygen to the skin.
12. Use of the controlled self-crosslinking oxygen-releasing hydrogel of claim 9 for the preparation of a medicament for delivering oxygen to the skin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911390687.3A CN111116942B (en) | 2019-12-30 | 2019-12-30 | Controllable self-crosslinking oxygen-releasing hydrogel composition and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911390687.3A CN111116942B (en) | 2019-12-30 | 2019-12-30 | Controllable self-crosslinking oxygen-releasing hydrogel composition and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111116942A true CN111116942A (en) | 2020-05-08 |
| CN111116942B CN111116942B (en) | 2023-05-30 |
Family
ID=70504715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911390687.3A Active CN111116942B (en) | 2019-12-30 | 2019-12-30 | Controllable self-crosslinking oxygen-releasing hydrogel composition and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111116942B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113248736A (en) * | 2021-05-31 | 2021-08-13 | 华中科技大学 | Anti-adhesion hydrogel, preparation method and application of anti-adhesion hydrogel in preparation of epidermal wound dressing |
| CN113797380A (en) * | 2021-08-30 | 2021-12-17 | 佛山职业技术学院 | Oxygen release dressing and preparation method and application thereof |
| CN114097788A (en) * | 2021-11-25 | 2022-03-01 | 华南农业大学 | Fenton-like slow-release antibacterial hydrogel and preparation method and application thereof |
| CN116570760A (en) * | 2023-07-11 | 2023-08-11 | 吉林农业科技学院 | Multifunctional slow-release dressing for promoting chronic wound healing and preparation method and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104117057A (en) * | 2014-07-09 | 2014-10-29 | 广东省医疗器械研究所 | Loaded enzyme hydrogel composition with oxygen releasing function and hydrogel prepared from hydrogel composition |
| CN107823691A (en) * | 2017-11-06 | 2018-03-23 | 河南汇博医疗股份有限公司 | A kind of oxygen-containing dressing and preparation method thereof |
| TW201914952A (en) * | 2017-09-18 | 2019-04-16 | 國立中山大學 | Composition for releasing oxygen |
| CN109847089A (en) * | 2019-01-30 | 2019-06-07 | 郑岩 | A kind of high molecular material is the wound oxygen supply dressing of carrier multiple film composition |
-
2019
- 2019-12-30 CN CN201911390687.3A patent/CN111116942B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104117057A (en) * | 2014-07-09 | 2014-10-29 | 广东省医疗器械研究所 | Loaded enzyme hydrogel composition with oxygen releasing function and hydrogel prepared from hydrogel composition |
| TW201914952A (en) * | 2017-09-18 | 2019-04-16 | 國立中山大學 | Composition for releasing oxygen |
| CN107823691A (en) * | 2017-11-06 | 2018-03-23 | 河南汇博医疗股份有限公司 | A kind of oxygen-containing dressing and preparation method thereof |
| CN109847089A (en) * | 2019-01-30 | 2019-06-07 | 郑岩 | A kind of high molecular material is the wound oxygen supply dressing of carrier multiple film composition |
Non-Patent Citations (2)
| Title |
|---|
| MAZAHER GHOLIPOURMALEKABADI ET AL.: "Oxygen-Generating Biomaterials:A New,Viable Paradigm forTissue Engineering?", 《TRENDS IN BIOTECHNOLOGY》 * |
| 樊李红等: "羟丙基壳聚糖／氧化海藻酸钠水凝胶的制备及表征", 《武汉大学学报（理学版）》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113248736A (en) * | 2021-05-31 | 2021-08-13 | 华中科技大学 | Anti-adhesion hydrogel, preparation method and application of anti-adhesion hydrogel in preparation of epidermal wound dressing |
| CN113248736B (en) * | 2021-05-31 | 2022-01-07 | 华中科技大学 | Anti-adhesion hydrogel, preparation method and application of anti-adhesion hydrogel in preparation of epidermal wound dressing |
| CN113797380A (en) * | 2021-08-30 | 2021-12-17 | 佛山职业技术学院 | Oxygen release dressing and preparation method and application thereof |
| CN114097788A (en) * | 2021-11-25 | 2022-03-01 | 华南农业大学 | Fenton-like slow-release antibacterial hydrogel and preparation method and application thereof |
| CN114097788B (en) * | 2021-11-25 | 2023-01-10 | 华南农业大学 | Fenton-like slow-release antibacterial hydrogel and preparation method and application thereof |
| CN116570760A (en) * | 2023-07-11 | 2023-08-11 | 吉林农业科技学院 | Multifunctional slow-release dressing for promoting chronic wound healing and preparation method and application thereof |
| CN116570760B (en) * | 2023-07-11 | 2023-09-05 | 吉林农业科技学院 | Multifunctional slow-release dressing for promoting chronic wound healing and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111116942B (en) | 2023-05-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111116942B (en) | Controllable self-crosslinking oxygen-releasing hydrogel composition and application thereof | |
| EP1244476B1 (en) | Methods and compositions for improved delivery devices | |
| CN1320931C (en) | Dressing material containing medicine chitoholosida and its preparation method | |
| AU2006221794B2 (en) | Improvements relating to skin dressings | |
| EP1216065B1 (en) | Silver-containing compositions, devices and methods for making | |
| EP1631328B1 (en) | Skin dressings containing oxidoreductase enzyme | |
| CN109793919B (en) | Hydrogen sulfide slow-release dressing and manufacturing method thereof | |
| RU2422133C1 (en) | Hydrophylic gel, method of its obtaining (versions), wound covering and based on it bandage means | |
| EP2313118B1 (en) | Compositions for use as or in wound dressings | |
| CN114230817B (en) | Hydrogel dressing for repairing chronic wounds of diabetic feet and preparation method thereof | |
| CN111905142A (en) | Oxygen-releasing hydrogel dressing and preparation method thereof | |
| CN112999410B (en) | Nano oxygenated hydrogel healing-promoting dressing containing perfluorodecalin and preparation method and application thereof | |
| EP0716098A2 (en) | Wound dressing | |
| CN111718451A (en) | Hydrogel material with self-repairing performance and preparation method and application thereof | |
| CN107049930A (en) | A kind of promoting healing wound gel and preparation method thereof | |
| CN106937941B (en) | Medical gel for diminishing inflammation of skin wound and preparation method thereof | |
| CN113679874B (en) | Multi-segment release dressing | |
| CN107296976B (en) | Medical multifunctional hemostatic dressing and preparation method thereof | |
| CN113521380B (en) | Rapid polymerization hydrogel material and preparation method and application thereof | |
| CN116019970B (en) | Method for producing high-oxygen-content aqueous gel | |
| CN115177783B (en) | Double-load intelligent hydrogel | |
| CN116440066A (en) | Hydrogel for wound repair and preparation method and application thereof | |
| KR20230053937A (en) | Method for producing a porous biodegradable support containing citrus oil, and a method for producing an antibacterial silicone dressing using the porous biodegradable support | |
| CN111643721A (en) | Cyclosporin A-loaded hydrogel for healing burn wounds and preparation method thereof | |
| WO2015069955A2 (en) | Oxygen generating biomaterial |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |